| UniProt ID | ASB3_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y575 | |
| Protein Name | Ankyrin repeat and SOCS box protein 3 | |
| Gene Name | ASB3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 518 | |
| Subcellular Localization | ||
| Protein Description | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.. | |
| Protein Sequence | MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Ubiquitination | AAREGNVKVLRKLLK HHHCCCHHHHHHHHH | 39.28 | 32015554 | |
| 35 | Phosphorylation | KLLKKGRSVDVADNR HHHHCCCCEECCCCC | 31.19 | 25159151 | |
| 62 | Ubiquitination | SVECLQMLINADSSE HHHHHHHHHCCCCCC | 1.44 | 32015554 | |
| 73 | Phosphorylation | DSSENYIKMKTFEGF CCCCCEEECCCCCCH | 24.80 | 24719451 | |
| 99 | Ubiquitination | WKIVQILLEAGADPN HHHHHHHHHCCCCCC | 4.53 | 29967540 | |
| 172 | Ubiquitination | LLRKGANKECQDDFG HHHCCCCHHCCCCCC | 60.37 | 29967540 | |
| 210 | Ubiquitination | ANVNCQALDKATPLF CCCCCHHHCCCCCEE | 2.60 | 29967540 | |
| 270 | Phosphorylation | LDLLIPLTNRACDTG HHHHHHHHCCCCCCC | 19.80 | - | |
| 351 | Phosphorylation | INELHLAYCLKYEKF CCHHHHHHHHHHCCH | 12.50 | - | |
| 483 | Phosphorylation | SERLRSDSYISQLPL HHHHCCCCCHHCCCC | 26.13 | - | |
| 486 | Phosphorylation | LRSDSYISQLPLPRS HCCCCCHHCCCCCHH | 19.89 | - | |
| 493 | Phosphorylation | SQLPLPRSLHNYLLY HCCCCCHHHHCHHHH | 31.85 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ASB3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ASB3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ASB3_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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