FOXP4_HUMAN - dbPTM
FOXP4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOXP4_HUMAN
UniProt AC Q8IVH2
Protein Name Forkhead box protein P4
Gene Name FOXP4
Organism Homo sapiens (Human).
Sequence Length 680
Subcellular Localization Nucleus .
Protein Description Transcriptional repressor that represses lung-specific expression..
Protein Sequence MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAELLHFQQQQALQVARQFLLQQASGLSSPGNNDSKQSASAVQVPVSVAMMSPQMLTPQQMQQILSPPQLQALLQQQQALMLQQLQEYYKKQQEQLHLQLLTQQQAGKPQPKEALGNKQLAFQQQLLQMQQLQQQHLLNLQRQGLVSLQPNQASGPLQTLPQAAVCPTDLPQLWKGEGAPGQPAEDSVKQEGLDLTGTAATATSFAAPPKVSPPLSHHTLPNGQPTVLTSRRDSSSHEETPGSHPLYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHLHMRPSEPKPFSQPLNPVPGSSSFSKVTVSAADSFPDGLVHPPTSAAAPVTPLRPPGLGSASLHGGGPARRRSSDKFCSPISSELAQNHEFYKNADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEREYQKRRPPKMTGSPTLVKNMISGLSYGALNASYQAALAESSFPLLNSPGMLNPGSASSLLPLSHDDVGAPVEPLPSNGSSSPPRLSPPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNPSASGPPEDRDLEEELPGEELS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MMVESASETIRS
---CCCCCHHHHHHC		26.1924505115
7Phosphorylation-MMVESASETIRSAP
-CCCCCHHHHHHCCC		44.5524505115
22PhosphorylationSGQNGVGSLSGQADG
CCCCCCCCCCCCCCC		19.5630576142
37PhosphorylationSSGGATGTTASGTGR
CCCCCCCCCCCCCCC		18.1630576142
38PhosphorylationSGGATGTTASGTGRE
CCCCCCCCCCCCCCE		21.8528674151
40PhosphorylationGATGTTASGTGREVT
CCCCCCCCCCCCEEE		34.4928674151
42PhosphorylationTGTTASGTGREVTTG
CCCCCCCCCCEEECC		30.4828674151
47PhosphorylationSGTGREVTTGADSNG
CCCCCEEECCCCCCC		18.1128450419
48PhosphorylationGTGREVTTGADSNGE
CCCCEEECCCCCCCC		35.2328450419
52PhosphorylationEVTTGADSNGEMSPA
EEECCCCCCCCCCHH		46.3230576142
57PhosphorylationADSNGEMSPAELLHF
CCCCCCCCHHHHHHH		19.3628450419
82PhosphorylationQFLLQQASGLSSPGN
HHHHHHHHCCCCCCC		35.6122167270
85PhosphorylationLQQASGLSSPGNNDS
HHHHHCCCCCCCCCC		37.7022167270
86PhosphorylationQQASGLSSPGNNDSK
HHHHCCCCCCCCCCH		41.7022167270
92PhosphorylationSSPGNNDSKQSASAV
CCCCCCCCHHCCCCC		34.4222167270
148UbiquitinationQLQEYYKKQQEQLHL
HHHHHHHHHHHHHHH		40.8829967540
163UbiquitinationQLLTQQQAGKPQPKE
HHHHHHHCCCCCCHH		24.5229967540
165UbiquitinationLTQQQAGKPQPKEAL
HHHHHCCCCCCHHHH		43.4229967540
165AcetylationLTQQQAGKPQPKEAL
HHHHHCCCCCCHHHH		43.4226051181
167UbiquitinationQQQAGKPQPKEALGN
HHHCCCCCCHHHHCC		66.2529967540
169UbiquitinationQAGKPQPKEALGNKQ
HCCCCCCHHHHCCHH		50.8229967540
173UbiquitinationPQPKEALGNKQLAFQ
CCCHHHHCCHHHHHH		46.4629967540
175SumoylationPKEALGNKQLAFQQQ
CHHHHCCHHHHHHHH		44.9128112733
175UbiquitinationPKEALGNKQLAFQQQ
CHHHHCCHHHHHHHH		44.9129967540
175SumoylationPKEALGNKQLAFQQQ
CHHHHCCHHHHHHHH		44.91-
175AcetylationPKEALGNKQLAFQQQ
CHHHHCCHHHHHHHH		44.9126051181
232SumoylationTDLPQLWKGEGAPGQ
CCCCHHHCCCCCCCC		56.53-
246SumoylationQPAEDSVKQEGLDLT
CCCHHHHHHCCCCCC		46.7328112733
246SumoylationQPAEDSVKQEGLDLT
CCCHHHHHHCCCCCC		46.73-
269PhosphorylationFAAPPKVSPPLSHHT
CCCCCCCCCCCCCCC		27.2525849741
273PhosphorylationPKVSPPLSHHTLPNG
CCCCCCCCCCCCCCC		20.9929255136
276PhosphorylationSPPLSHHTLPNGQPT
CCCCCCCCCCCCCCE		38.1929255136
283PhosphorylationTLPNGQPTVLTSRRD
CCCCCCCEEEECCCC		21.9123312004
286PhosphorylationNGQPTVLTSRRDSSS
CCCCEEEECCCCCCC		18.8226074081
287PhosphorylationGQPTVLTSRRDSSSH
CCCEEEECCCCCCCC		22.5826074081
289PhosphorylationPTVLTSRRDSSSHEE
CEEEECCCCCCCCCC		48.1833259812
290PhosphorylationTVLTSRRDSSSHEET
EEEECCCCCCCCCCC		52.3333259812
291PhosphorylationVLTSRRDSSSHEETP
EEECCCCCCCCCCCC		31.7427273156
292PhosphorylationLTSRRDSSSHEETPG
EECCCCCCCCCCCCC		39.7523927012
293PhosphorylationTSRRDSSSHEETPGS
ECCCCCCCCCCCCCC		38.5823927012
297PhosphorylationDSSSHEETPGSHPLY
CCCCCCCCCCCCCCC		29.9323927012
300PhosphorylationSHEETPGSHPLYGHG
CCCCCCCCCCCCCCC		24.1223927012
304PhosphorylationTPGSHPLYGHGECKW
CCCCCCCCCCCCCCC		16.1328450419
330PhosphorylationQFIKHLNTEHALDDR
HHHHHCCCCCCCCCC		35.1923898821
360PhosphorylationEIQLAKESERLQAMM
HHHHHHHHHHHHHHH		27.5822817900
376UbiquitinationHLHMRPSEPKPFSQP
HHHCCCCCCCCCCCC		61.0929967540
378SumoylationHMRPSEPKPFSQPLN
HCCCCCCCCCCCCCC		55.4328112733
378UbiquitinationHMRPSEPKPFSQPLN
HCCCCCCCCCCCCCC		55.4329967540
390O-linked_GlycosylationPLNPVPGSSSFSKVT
CCCCCCCCCCCCEEE		19.4232574038
390PhosphorylationPLNPVPGSSSFSKVT
CCCCCCCCCCCCEEE		19.4222817900
391PhosphorylationLNPVPGSSSFSKVTV
CCCCCCCCCCCEEEE		41.1222817900
392PhosphorylationNPVPGSSSFSKVTVS
CCCCCCCCCCEEEEE		34.9222817900
394PhosphorylationVPGSSSFSKVTVSAA
CCCCCCCCEEEEEHH		28.3222817900
413PhosphorylationDGLVHPPTSAAAPVT
CCCCCCCCCCCCCCC		35.1326074081
414PhosphorylationGLVHPPTSAAAPVTP
CCCCCCCCCCCCCCC		22.9926074081
420PhosphorylationTSAAAPVTPLRPPGL
CCCCCCCCCCCCCCC		18.6226074081
429PhosphorylationLRPPGLGSASLHGGG
CCCCCCCCCCCCCCC		21.5226074081
431PhosphorylationPPGLGSASLHGGGPA
CCCCCCCCCCCCCCC		23.6926074081
432UbiquitinationPGLGSASLHGGGPAR
CCCCCCCCCCCCCCC		4.3229967540
433UbiquitinationGLGSASLHGGGPARR
CCCCCCCCCCCCCCC		30.2921890473
442PhosphorylationGGPARRRSSDKFCSP
CCCCCCCCCCCCCCC		40.8721712546
443UbiquitinationGPARRRSSDKFCSPI
CCCCCCCCCCCCCCC		42.9029967540
443PhosphorylationGPARRRSSDKFCSPI
CCCCCCCCCCCCCCC		42.9021712546
445UbiquitinationARRRSSDKFCSPISS
CCCCCCCCCCCCCCH		50.6629967540
448PhosphorylationRSSDKFCSPISSELA
CCCCCCCCCCCHHHH		28.5325159151
451PhosphorylationDKFCSPISSELAQNH
CCCCCCCCHHHHHCC		22.5728387310
452PhosphorylationKFCSPISSELAQNHE
CCCCCCCHHHHHCCC		37.0323312004
461PhosphorylationLAQNHEFYKNADVRP
HHHCCCHHHCCCCCC		10.5923312004
474PhosphorylationRPPFTYASLIRQAIL
CCCCHHHHHHHHHHH		17.5728555341
507UbiquitinationMFAYFRRNTATWKNA
HHHHHHHCCHHHHHH		29.7921890473
519UbiquitinationKNAVRHNLSLHKCFV
HHHHHHHCEEEEEEE		4.7521890473
519UbiquitinationKNAVRHNLSLHKCFV
HHHHHHHCEEEEEEE		4.7521890473
520PhosphorylationNAVRHNLSLHKCFVR
HHHHHHCEEEEEEEE		33.47-
523UbiquitinationRHNLSLHKCFVRVEN
HHHCEEEEEEEEEEC		34.36-
527UbiquitinationSLHKCFVRVENVKGA
EEEEEEEEEECCCCC		15.1321890473
530UbiquitinationKCFVRVENVKGAVWT
EEEEEEECCCCCEEE		37.6321890473
530UbiquitinationKCFVRVENVKGAVWT
EEEEEEECCCCCEEE		37.6321890473
531UbiquitinationCFVRVENVKGAVWTV
EEEEEECCCCCEEEE		3.7121890473
532UbiquitinationFVRVENVKGAVWTVD
EEEEECCCCCEEEEC		53.3822817900
537UbiquitinationNVKGAVWTVDEREYQ
CCCCCEEEECHHHHH		16.1021890473
539PhosphorylationKGAVWTVDEREYQKR
CCCEEEECHHHHHHH		41.6932142685
539UbiquitinationKGAVWTVDEREYQKR
CCCEEEECHHHHHHH		41.6921890473
550PhosphorylationYQKRRPPKMTGSPTL
HHHHCCCCCCCCCHH		52.3432142685
552PhosphorylationKRRPPKMTGSPTLVK
HHCCCCCCCCCHHHH		40.4030266825
554PhosphorylationRPPKMTGSPTLVKNM
CCCCCCCCCHHHHHH		12.9230266825
556PhosphorylationPKMTGSPTLVKNMIS
CCCCCCCHHHHHHHH		45.9730266825
622PhosphorylationLPSNGSSSPPRLSPP
CCCCCCCCCCCCCCC		40.3927362937
627PhosphorylationSSSPPRLSPPQYSHQ
CCCCCCCCCCCCCCE		35.4927362937
660PhosphorylationPLGAPNPSASGPPED
CCCCCCCCCCCCCCC		41.5324719451
662PhosphorylationGAPNPSASGPPEDRD
CCCCCCCCCCCCCCC		57.0524719451
680PhosphorylationELPGEELS-------
HCCCCCCC-------		41.2628348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FOXP4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FOXP4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOXP4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FOXP4_HUMANFOXP4physical
14701752
KI67_HUMANMKI67physical
22939629
XAGE2_HUMANXAGE2physical
21516116
FOXP1_HUMANFOXP1physical
25609649
FOXP2_HUMANFOXP2physical
25609649
DX39A_HUMANDDX39Aphysical
25609649
UBA7_HUMANUBA7physical
25609649
ZMYM3_HUMANZMYM3physical
25609649
RASN_HUMANNRASphysical
25609649
NDKA_HUMANNME1physical
25609649
PFKAL_HUMANPFKLphysical
25609649
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FOXP4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND MASSSPECTROMETRY.

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