FOXP2_HUMAN - dbPTM
FOXP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOXP2_HUMAN
UniProt AC O15409
Protein Name Forkhead box protein P2
Gene Name FOXP2
Organism Homo sapiens (Human).
Sequence Length 715
Subcellular Localization Nucleus .
Protein Description Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language..
Protein Sequence MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
70PhosphorylationQLLLQQQTSGLKSPK
HHHHHHHHCCCCCCC		22.0328450419
71PhosphorylationLLLQQQTSGLKSPKS
HHHHHHHCCCCCCCC		37.4822167270
75PhosphorylationQQTSGLKSPKSSDKQ
HHHCCCCCCCCCCCC		42.4722167270
235PhosphorylationQQQQHLLSLQRQGLI
HHHHHHHHHHHCCCC		28.9024719451
308PhosphorylationSSNTSKASPPITHHS
CCCCCCCCCCCEEEE		34.6428450419
312PhosphorylationSKASPPITHHSIVNG
CCCCCCCEEEEECCC		21.2227080861
315PhosphorylationSPPITHHSIVNGQSS
CCCCEEEEECCCCCH		22.1927080861
321PhosphorylationHSIVNGQSSVLSARR
EEECCCCCHHHEECC		24.6627080861
322PhosphorylationSIVNGQSSVLSARRD
EECCCCCHHHEECCC		21.1327080861
330PhosphorylationVLSARRDSSSHEETG
HHEECCCCCCCCCCC		31.7429116813
331PhosphorylationLSARRDSSSHEETGA
HEECCCCCCCCCCCC		39.7529116813
332PhosphorylationSARRDSSSHEETGAS
EECCCCCCCCCCCCC		38.5829116813
336PhosphorylationDSSSHEETGASHTLY
CCCCCCCCCCCCCEE		34.7529978859
339PhosphorylationSHEETGASHTLYGHG
CCCCCCCCCCEECCC		20.5328348404
341PhosphorylationEETGASHTLYGHGVC
CCCCCCCCEECCCCC		21.1223312004
343PhosphorylationTGASHTLYGHGVCKW
CCCCCCEECCCCCCC		14.2923312004
357PhosphorylationWPGCESICEDFGQFL
CCCHHHHHHHHHHHH		5.9724719451
428PhosphorylationKPLNLVSSVTMSKNM
CCCCHHEEEEECCHH		17.7129978859
430PhosphorylationLNLVSSVTMSKNMLE
CCHHEEEEECCHHHC		20.0629978859
432PhosphorylationLVSSVTMSKNMLETS
HHEEEEECCHHHCCC		16.1229978859
438PhosphorylationMSKNMLETSPQSLPQ
ECCHHHCCCCCCCCC		41.5730377224
439PhosphorylationSKNMLETSPQSLPQT
CCHHHCCCCCCCCCC		16.1530377224
442PhosphorylationMLETSPQSLPQTPTT
HHCCCCCCCCCCCCC		45.4630377224
540PhosphorylationWFTRTFAYFRRNAAT
HHHHHHHHHHHCHHH		8.07-
557PhosphorylationNAVRHNLSLHKCFVR
HHHHHHCEEEEEEEE		33.47-
560UbiquitinationRHNLSLHKCFVRVEN
HHHCEEEEEEEEEEC		34.36-
580PhosphorylationWTVDEVEYQKRRSQK
EEHHHHHHHHHHHCC		25.22-
589PhosphorylationKRRSQKITGSPTLVK
HHHHCCCCCCCCCCC		38.3520068231
591PhosphorylationRSQKITGSPTLVKNI
HHCCCCCCCCCCCCC		13.1825159151
593PhosphorylationQKITGSPTLVKNIPT
CCCCCCCCCCCCCCC		45.9720068231
616PhosphorylationNASLQAALAESSLPL
CHHHHHHHHHCCCCC		6.4427251275
688PhosphorylationEDEDCPMSLVTTANH
CCCCCCCEEEECCCC		12.5828348404
691PhosphorylationDCPMSLVTTANHSPE
CCCCEEEECCCCCCC		26.0328348404
692PhosphorylationCPMSLVTTANHSPEL
CCCEEEECCCCCCCC		20.2728348404
696PhosphorylationLVTTANHSPELEDDR
EEECCCCCCCCCCCC		21.6328348404
711PhosphorylationEIEEEPLSEDLE---
HHCCCCCCCCCC---		39.5227499020
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FOXP2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FOXP2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOXP2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FOXP2_HUMANFOXP2physical
14701752
FOXP4_HUMANFOXP4physical
14701752
CTBP1_HUMANCTBP1physical
14701752
P66B_HUMANGATAD2Bphysical
20185820
RPIA_HUMANRPIAphysical
24722188
SP4_HUMANSP4physical
24722188
TSACC_HUMANTSACCphysical
25416956
F124A_HUMANFAM124Aphysical
25416956
FOXP1_HUMANFOXP1physical
25609649
FOXP4_HUMANFOXP4physical
25609649
FOXP1_HUMANFOXP1physical
28514442
FOXP4_HUMANFOXP4physical
28514442
H2A2C_HUMANHIST2H2ACphysical
28514442
EFHD1_HUMANEFHD1physical
28514442
DUS14_HUMANDUSP14physical
28514442
SBP1_HUMANSELENBP1physical
28514442
PKP3_HUMANPKP3physical
28514442
DSG4_HUMANDSG4physical
28514442
S10A2_HUMANS100A2physical
28514442
LRC15_HUMANLRRC15physical
28514442
KC1E_HUMANCSNK1Ephysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
602081Speech-language disorder 1 (SPCH1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FOXP2_HUMAN

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Related Literatures of Post-Translational Modification

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