S10A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S10A2_HUMAN
• UniProt AC: P29034
• Protein Name: Protein S100-A2
• Gene Name: S100A2
• Organism: Homo sapiens (Human).
• Sequence Length: 98
• Protein Description: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth..
• Protein Sequence: MMCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MMCSSLEQAL -----CCCCHHHHHH	2.11	24719451
4	Phosphorylation	----MMCSSLEQALA ----CCCCHHHHHHH	21.77	24719451
5	Phosphorylation	---MMCSSLEQALAV ---CCCCHHHHHHHH	30.88	28348404
20	Phosphorylation	LVTTFHKYSCQEGDK HHHHHHHHCCCCCCC	13.20	26267517
26	Acetylation	KYSCQEGDKFKLSKG HHCCCCCCCEECCHH	53.09	-
27	Acetylation	YSCQEGDKFKLSKGE HCCCCCCCEECCHHH	56.08	26210075
32	Ubiquitination	GDKFKLSKGEMKELL CCCEECCHHHHHHHH	70.13	-
35	Ubiquitination	FKLSKGEMKELLHKE EECCHHHHHHHHHHH	5.80	23000965
40	Ubiquitination	GEMKELLHKELPSFV HHHHHHHHHHCHHHH	33.88	23000965
40	Acetylation	GEMKELLHKELPSFV HHHHHHHHHHCHHHH	33.88	-
41	Acetylation	EMKELLHKELPSFVG HHHHHHHHHCHHHHC	62.00	22424773
41	Ubiquitination	EMKELLHKELPSFVG HHHHHHHHHCHHHHC	62.00	-
49	Ubiquitination	ELPSFVGEKVDEEGL HCHHHHCCCCCHHHH	44.60	-
62	Phosphorylation	GLKKLMGSLDENSDQ HHHHHHCCCCCCCCC	20.77	-
67	Phosphorylation	MGSLDENSDQQVDFQ HCCCCCCCCCCCCHH	34.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:23344957

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S10A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S10A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S10A2_HUMAN	S100A2	physical	16189514
S10A2_HUMAN	S100A2	physical	10951287
CHIP_HUMAN	STUB1	physical	23344957
S10A2_HUMAN	S100A2	physical	25416956
S100B_HUMAN	S100B	physical	25416956
HOP_HUMAN	HOPX	physical	24556685

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.