dbPTM

CTBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CTBP1_HUMAN
UniProt AC	Q13363
Protein Name	C-terminal-binding protein 1
Gene Name	CTBP1
Organism	Homo sapiens (Human).
Sequence Length	440
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation..
Protein Sequence	MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSSHLLNKG -----CCCHHHHCCC	17.18	28348404
4	Phosphorylation	----MGSSHLLNKGL ----CCCHHHHCCCC	16.66	28348404
5 (in isoform 2)	Methylation	-	35.71	-
46	Ubiquitination	TVEMPILKDVATVAF EEECCCHHCCEEEEE	51.37	-
54	S-nitrosylation	DVATVAFCDAQSTQE CCEEEEECCCCCHHH	2.82	24105792
76	Phosphorylation	EAVGALMYHTITLTR HHHHHHHHHHHCCCH	9.17	24260401
78	Phosphorylation	VGALMYHTITLTRED HHHHHHHHHCCCHHH	9.73	24260401
80	Phosphorylation	ALMYHTITLTREDLE HHHHHHHCCCHHHHH	24.19	24260401
88	Ubiquitination	LTREDLEKFKALRII CCHHHHHHHHHHEEE	60.50	-
100	Phosphorylation	RIIVRIGSGFDNIDI EEEEECCCCCCCCCC	33.64	18184656
144	Phosphorylation	LNLYRRATWLHQALR HHHHHHHHHHHHHHH	27.09	18184656
147 (in isoform 2)	Phosphorylation	-	11.48	-
158	Phosphorylation	REGTRVQSVEQIREV HCCCCCCCHHHHHHH	25.43	12872159
194	Ubiquitination	QAVALRAKAFGFNVL HHHHHHHHHHCCEEE	37.50	-
266	Methylation	AFLVNTARGGLVDEK CEEEECCCCCCCCHH	37.36	-
269	Ubiquitination	VNTARGGLVDEKALA EECCCCCCCCHHHHH	4.96	21890473
273	Ubiquitination	RGGLVDEKALAQALK CCCCCCHHHHHHHHH	44.21	21906983
280	Ubiquitination	KALAQALKEGRIRGA HHHHHHHHHCCCCCE	62.23	21890473
280	Ubiquitination	KALAQALKEGRIRGA HHHHHHHHHCCCCCE	62.23	21890473
285	Methylation	ALKEGRIRGAALDVH HHHHCCCCCEEEEEC	27.60	-
298	Phosphorylation	VHESEPFSFSQGPLK ECCCCCCCCCCCCCC	34.40	23186163
300	Phosphorylation	ESEPFSFSQGPLKDA CCCCCCCCCCCCCCC	32.79	17525332
348	Ubiquitination	GRIPDSLKNCVNKDH CCCCHHHHHHCCHHH	52.86	-
350	S-nitrosylation	IPDSLKNCVNKDHLT CCHHHHHHCCHHHCH	3.22	24105792
381	Phosphorylation	LNGAAYRYPPGVVGV HCCCHHCCCCCEEEE	10.91	20068231
391	Phosphorylation	GVVGVAPTGIPAAVE CEEEECCCCCCHHHH	37.70	20068231
403	Phosphorylation	AVEGIVPSAMSLSHG HHHCCCCCHHHHHCC	26.21	26074081
406	Phosphorylation	GIVPSAMSLSHGLPP CCCCCHHHHHCCCCC	26.83	26074081
408	Phosphorylation	VPSAMSLSHGLPPVA CCCHHHHHCCCCCCC	14.27	26074081
422	Phosphorylation	AHPPHAPSPGQTVKP CCCCCCCCCCCCCCC	42.31	14567915
426	Phosphorylation	HAPSPGQTVKPEADR CCCCCCCCCCCCCCC	36.09	20068231
428	Sumoylation	PSPGQTVKPEADRDH CCCCCCCCCCCCCCC	40.29	-
428	Sumoylation	PSPGQTVKPEADRDH CCCCCCCCCCCCCCC	40.29	12679040
437	Phosphorylation	EADRDHASDQL---- CCCCCCCHHCC----	23.59	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
100	S	Phosphorylation	Kinase	PAK6	Q9NQU5	PSP
144	T	Phosphorylation	Kinase	PKACA	P17612	PSP
158	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
158	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
158	S	Phosphorylation	Kinase	PAK6	Q9NQU5	PSP
422	S	Phosphorylation	Kinase	HIPK2	Q9H2X6	Uniprot
422	S	Phosphorylation	Kinase	MAPK8	P45983	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
422	S	Phosphorylation	14567915
Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
428	K	Sumoylation	12679040
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CTBP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PININ_HUMAN	PNN	physical	15542832
IKZF1_HUMAN	IKZF1	physical	10766745
CTIP_HUMAN	RBBP8	physical	10196224
HDAC2_HUMAN	HDAC2	physical	10766745
KAT2B_HUMAN	KAT2B	physical	9824164
NRIP1_MOUSE	Nrip1	physical	11509661
GEMI2_HUMAN	GEMIN2	physical	12714599
TBP_HUMAN	TBP	physical	11959865
TF2B_HUMAN	GTF2B	physical	11959865
FOXP1_HUMAN	FOXP1	physical	14701752
FOXP2_HUMAN	FOXP2	physical	14701752
HDAC1_HUMAN	HDAC1	physical	9650586
EVI1_HUMAN	MECOM	physical	11568182
CBX4_HUMAN	CBX4	physical	11583618
EVI1_HUMAN	MECOM	physical	11313276
ZEB1_HUMAN	ZEB1	physical	10359772
CTIP_HUMAN	RBBP8	physical	9535825
ACL6B_HUMAN	ACTL6B	physical	12565893
SATB1_HUMAN	SATB1	physical	19103759
ZN217_HUMAN	ZNF217	physical	17130829
CTBP1_HUMAN	CTBP1	physical	19754958
ITF2_HUMAN	TCF4	physical	20211142
HDAC1_HUMAN	HDAC1	physical	18765668
P53_HUMAN	TP53	physical	18765668
PLK1_HUMAN	PLK1	physical	16481748
TBG1_HUMAN	TUBG1	physical	16481748
TF7L2_HUMAN	TCF7L2	physical	12711682
CBP_HUMAN	CREBBP	physical	16122695
EP300_HUMAN	EP300	physical	16122695
KAT2B_HUMAN	KAT2B	physical	16122695
KAT2A_HUMAN	KAT2A	physical	16122695
DHI2_HUMAN	HSD11B2	physical	12082639
SP1_HUMAN	SP1	physical	16036112
EP300_HUMAN	EP300	physical	15834423
CBP_HUMAN	CREBBP	physical	15834423
KAT2B_HUMAN	KAT2B	physical	15834423
ZEB1_HUMAN	ZEB1	physical	17967884
RREB1_HUMAN	RREB1	physical	17967884
EHMT2_HUMAN	EHMT2	physical	17967884
WIZ_HUMAN	WIZ	physical	17967884
RCOR1_HUMAN	RCOR1	physical	17967884
HDAC2_HUMAN	HDAC2	physical	17967884
KDM1A_HUMAN	KDM1A	physical	17967884
CDYL_HUMAN	CDYL	physical	17967884
ZN217_HUMAN	ZNF217	physical	17967884
UBC9_HUMAN	UBE2I	physical	17967884
BCORL_HUMAN	BCORL1	physical	17379597
KDM1A_HUMAN	KDM1A	physical	20547759
AKT1_HUMAN	AKT1	physical	20361981
CBX4_HUMAN	CBX4	physical	20361981
CTBP1_HUMAN	CTBP1	physical	20361981
TGIF1_HUMAN	TGIF1	physical	20361981
HDAC9_HUMAN	HDAC9	physical	20361981
H31T_HUMAN	HIST3H3	physical	12700765
EHMT1_HUMAN	EHMT1	physical	12700765
CTIP_HUMAN	RBBP8	physical	16287852
SOBP_HUMAN	SOBP	physical	21900206
IKZF1_HUMAN	IKZF1	physical	21900206
ZN219_HUMAN	ZNF219	physical	21900206
LCORL_HUMAN	LCORL	physical	21900206
CHD3_HUMAN	CHD3	physical	21900206
RBBP5_HUMAN	RBBP5	physical	21900206
CTNA1_HUMAN	CTNNA1	physical	21900206
ZEB1_HUMAN	ZEB1	physical	10567582
BCL3_HUMAN	BCL3	physical	20800578
BCL6_HUMAN	BCL6	physical	18212045
HDAC2_HUMAN	HDAC2	physical	18212045
NCOR2_HUMAN	NCOR2	physical	18212045
APC_HUMAN	APC	physical	15525529
CTNB1_HUMAN	CTNNB1	physical	15525529
KLF4_HUMAN	KLF4	physical	19751731
NRIP1_HUMAN	NRIP1	physical	17972916
DNMT1_HUMAN	DNMT1	physical	17972916
RUNX1_HUMAN	RUNX1	physical	15897867
THA11_HUMAN	THAP11	physical	21988832
HEMGN_HUMAN	HEMGN	physical	21988832
CTBP2_HUMAN	CTBP2	physical	21988832
CTBP1_HUMAN	CTBP1	physical	21988832
NDKB_HUMAN	NME2	physical	21988832
ORC4_HUMAN	ORC4	physical	21988832
FOXP2_HUMAN	FOXP2	physical	24722188
CTBP1_HUMAN	CTBP1	physical	24722188
NOL4L_HUMAN	NOL4L	physical	24722188
CTBP2_HUMAN	CTBP2	physical	24722188
IKZF1_HUMAN	IKZF1	physical	24722188
KLF12_HUMAN	KLF12	physical	24722188
LCORL_HUMAN	LCORL	physical	24722188
NRIP1_HUMAN	NRIP1	physical	24722188
ITF2_HUMAN	TCF4	physical	24722188
ZEB2_HUMAN	ZEB2	physical	24722188
MARHA_HUMAN	MARCH10	physical	24722188
CDC23_HUMAN	CDC23	physical	24722188
FUND1_HUMAN	FUNDC1	physical	24722188
IKZF2_HUMAN	IKZF2	physical	24722188
KLF3_HUMAN	KLF3	physical	24722188
LNX1_HUMAN	LNX1	physical	24722188
PIAS2_HUMAN	PIAS2	physical	24722188
RAI2_HUMAN	RAI2	physical	24722188
RN111_HUMAN	RNF111	physical	24722188
ZBT18_HUMAN	ZBTB18	physical	24722188
CEP68_HUMAN	CEP68	physical	24722188
NOL4_HUMAN	NOL4	physical	24722188
CTBP1_HUMAN	CTBP1	physical	25416956
CTBP2_HUMAN	CTBP2	physical	25416956
HXB5_HUMAN	HOXB5	physical	25416956
AAPK1_HUMAN	PRKAA1	physical	25416956
MK09_HUMAN	MAPK9	physical	25416956
TGIF1_HUMAN	TGIF1	physical	25416956
NOL4_HUMAN	NOL4	physical	25416956
IKZF1_HUMAN	IKZF1	physical	25416956
KLF12_HUMAN	KLF12	physical	25416956
CEP68_HUMAN	CEP68	physical	25416956
PLCB1_HUMAN	PLCB1	physical	25416956
BCAS3_HUMAN	BCAS3	physical	25416956
TSH3_HUMAN	TSHZ3	physical	25416956
DMRTB_HUMAN	DMRTB1	physical	25416956
FOXP2_HUMAN	FOXP2	physical	25416956
NOL4L_HUMAN	NOL4L	physical	25416956
HIC2_HUMAN	HIC2	physical	26186194
ZEB1_HUMAN	ZEB1	physical	26186194
ZEB2_HUMAN	ZEB2	physical	26186194
WIZ_HUMAN	WIZ	physical	26186194
PRDM2_HUMAN	PRDM2	physical	26186194
EHMT1_HUMAN	EHMT1	physical	26186194
ZN217_HUMAN	ZNF217	physical	26186194
ZN516_HUMAN	ZNF516	physical	26186194
CTBP2_HUMAN	CTBP2	physical	26186194
DYR1A_HUMAN	DYRK1A	physical	26186194
NOL4L_HUMAN	NOL4L	physical	26186194
NOL4_HUMAN	NOL4	physical	26186194
TRPS1_HUMAN	TRPS1	physical	26186194
APC_HUMAN	APC	physical	26186194
LCOR_HUMAN	C10orf12	physical	26186194
RREB1_HUMAN	RREB1	physical	26186194
BCOR_HUMAN	BCOR	physical	26186194
KDM1A_HUMAN	KDM1A	physical	26186194
LCORL_HUMAN	LCORL	physical	26186194
FBX11_HUMAN	FBXO11	physical	26186194
RCOR2_HUMAN	RCOR2	physical	26186194
RCOR3_HUMAN	RCOR3	physical	26186194
RCOR1_HUMAN	RCOR1	physical	26186194
WDCP_HUMAN	C2orf44	physical	26186194
CBX4_HUMAN	CBX4	physical	26186194
RBL1_HUMAN	RBL1	physical	26186194
BCORL_HUMAN	BCORL1	physical	26186194
AINX_HUMAN	INA	physical	26186194
EVI1_HUMAN	MECOM	physical	26186194
EHMT2_HUMAN	EHMT2	physical	26186194
RB_HUMAN	RB1	physical	26186194
E2F7_HUMAN	E2F7	physical	26186194
TR61B_HUMAN	TRMT61B	physical	26186194
FOXK1_HUMAN	FOXK1	physical	26186194
CO039_HUMAN	C15orf39	physical	26186194
AMPD2_HUMAN	AMPD2	physical	26186194
TOR2A_HUMAN	TOR2A	physical	26186194
TOR2X_HUMAN	TOR2A	physical	26186194
PURA2_HUMAN	ADSS	physical	26344197
PUR9_HUMAN	ATIC	physical	26344197
CTBP2_HUMAN	CTBP2	physical	26344197
DUT_HUMAN	DUT	physical	26344197
HYI_HUMAN	HYI	physical	26344197
SSNA1_HUMAN	SSNA1	physical	26344197
WDR1_HUMAN	WDR1	physical	26344197
CTBP2_HUMAN	CTBP2	physical	26496610
ZN217_HUMAN	ZNF217	physical	26496610
KDM1A_HUMAN	KDM1A	physical	26496610
KLF8_HUMAN	KLF8	physical	21416054
ZEB1_HUMAN	ZEB1	physical	28514442
PRDM2_HUMAN	PRDM2	physical	28514442
EVI1_HUMAN	MECOM	physical	28514442
LCORL_HUMAN	LCORL	physical	28514442
ZN217_HUMAN	ZNF217	physical	28514442
NOL4_HUMAN	NOL4	physical	28514442
LCOR_HUMAN	C10orf12	physical	28514442
TRPS1_HUMAN	TRPS1	physical	28514442
ZEB2_HUMAN	ZEB2	physical	28514442
HIC2_HUMAN	HIC2	physical	28514442
APC_HUMAN	APC	physical	28514442
ZN516_HUMAN	ZNF516	physical	28514442
NOL4L_HUMAN	NOL4L	physical	28514442
RBL1_HUMAN	RBL1	physical	28514442
RREB1_HUMAN	RREB1	physical	28514442
WIZ_HUMAN	WIZ	physical	28514442
CBX4_HUMAN	CBX4	physical	28514442
CTBP2_HUMAN	CTBP2	physical	28514442
WDCP_HUMAN	C2orf44	physical	28514442
BCORL_HUMAN	BCORL1	physical	28514442
RCOR2_HUMAN	RCOR2	physical	28514442
CO039_HUMAN	C15orf39	physical	28514442
BCOR_HUMAN	BCOR	physical	28514442
ZBT18_HUMAN	ZBTB18	physical	28514442
RB_HUMAN	RB1	physical	28514442
TOR2A_HUMAN	TOR2A	physical	28514442
TOR2X_HUMAN	TOR2A	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
RCOR1_HUMAN	RCOR1	physical	28514442
EHMT1_HUMAN	EHMT1	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
EHMT2_HUMAN	EHMT2	physical	28514442
KDM1A_HUMAN	KDM1A	physical	28514442
CHD4_HUMAN	CHD4	physical	28514442
NISCH_HUMAN	NISCH	physical	27173435
MARF1_HUMAN	KIAA0430	physical	27173435
PCGF5_HUMAN	PCGF5	physical	27173435
PAN2_HUMAN	PAN2	physical	27173435
4ET_HUMAN	EIF4ENIF1	physical	27173435
FANCC_HUMAN	FANCC	physical	23303816
FANCG_HUMAN	FANCG	physical	23303816
FANCL_HUMAN	FANCL	physical	23303816
FANCA_HUMAN	FANCA	physical	23303816
FANCE_HUMAN	FANCE	physical	23303816
FANCF_HUMAN	FANCF	physical	23303816
FACD2_HUMAN	FANCD2	physical	23303816

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CTBP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Homeodomain interacting protein kinase 2 promotes apoptosis bydownregulating the transcriptional corepressor CtBP."; Zhang Q., Yoshimatsu Y., Hildebrand J., Frisch S.M., Goodman R.H.; Cell 115:177-186(2003). Cited for: INTERACTION WITH HIPK2, PHOSPHORYLATION AT SER-422, AND MUTAGENESIS OFSER-422.	14567915 [Abstract]
Sumoylation
Reference	PubMed
"The polycomb protein Pc2 is a SUMO E3."; Kagey M.H., Melhuish T.A., Wotton D.; Cell 113:127-137(2003). Cited for: SUMOYLATION AT LYS-428, AND SUBCELLULAR LOCATION.	12679040 [Abstract]

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