FANCL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FANCL_HUMAN
• UniProt AC: Q9NW38
• Protein Name: E3 ubiquitin-protein ligase FANCL
• Gene Name: FANCL
• Organism: Homo sapiens (Human).
• Sequence Length: 375
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. [PubMed: 12973351]
• Protein Sequence: MAVTEASLLRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVLPEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQHSPDLMSFMMELKMLLEVALKNRQELYALPPPPQFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAEDASGREHLITLKLKAKYPAESPDYFVDFPVPFCASWTPQSSLISIYSQFLAAIESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEKSDFTMDCGICYAYQLDGTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNIIFGECPYCSKPITLKMSGRKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVTEASLL ------CCCCHHHHH	19.55	22814378
4	Phosphorylation	----MAVTEASLLRQ ----CCCCHHHHHHH	19.12	24719451
7	Phosphorylation	-MAVTEASLLRQCPL -CCCCHHHHHHHCCC	23.00	24719451
22 (in isoform 2)	Ubiquitination	-	38.48	-
22	Ubiquitination	LLPQNRSKTVYEGFI CCCCCCCCCEEEEEE	38.48	21906983
49 (in isoform 2)	Ubiquitination	-	35.28	-
49	Ubiquitination	LPEDLQLKNARLLCS CCHHHHCCCHHHHHH	35.28	33845483
77	Phosphorylation	VQQRMQHSPDLMSFM HHHHHHCCCCHHHHH	11.83	29038488
82	Phosphorylation	QHSPDLMSFMMELKM HCCCCHHHHHHHHHH	19.79	29038488
128	Phosphorylation	LGWDKLVYADTCFST CCCCCEEEECCCEEE	14.81	29496907
139	Sumoylation	CFSTIKLKAEDASGR CEEEEEEEEECCCCC	44.73	-
139	Ubiquitination	CFSTIKLKAEDASGR CEEEEEEEEECCCCC	44.73	-
139	Sumoylation	CFSTIKLKAEDASGR CEEEEEEEEECCCCC	44.73	-
144	Ubiquitination	KLKAEDASGREHLIT EEEEECCCCCEEEEE	51.18	21963094
149	Ubiquitination	DASGREHLITLKLKA CCCCCEEEEEEEEEE	2.47	21963094
153	Ubiquitination	REHLITLKLKAKYPA CEEEEEEEEEECCCC	39.01	29967540
154	Ubiquitination	EHLITLKLKAKYPAE EEEEEEEEEECCCCC	7.99	21963094
164	Ubiquitination	KYPAESPDYFVDFPV CCCCCCCCEEECCCC	59.80	21963094
169	Ubiquitination	SPDYFVDFPVPFCAS CCCEEECCCCCCCCC	5.74	21963094
178	Phosphorylation	VPFCASWTPQSSLIS CCCCCCCCCHHHHHH	14.68	-
218	Ubiquitination	TWVLEPEKPPRSATA EEEECCCCCCCCCCC	71.66	29967540
223	Ubiquitination	PEKPPRSATARRIAL CCCCCCCCCCCEEEC	13.42	29967540
261	Ubiquitination	LGADHVVKPLGIKLS CCCCEECCCCCCEEE	33.17	21963094
266	Ubiquitination	VVKPLGIKLSRNIHL ECCCCCCEEECCEEE	38.31	21963094
266 (in isoform 2)	Ubiquitination	-	38.31	-
271	Ubiquitination	GIKLSRNIHLWDPEN CCEEECCEEEECCCC	2.47	21963094
271 (in isoform 2)	Ubiquitination	-	2.47	-
276	Ubiquitination	RNIHLWDPENSVLQN CCEEEECCCCCHHHH	30.96	21963094
281	Ubiquitination	WDPENSVLQNLKDVL ECCCCCHHHHHHHHH	2.54	21963094
286	Ubiquitination	SVLQNLKDVLEIDFP CHHHHHHHHHCCCCC	54.09	21963094
347	Phosphorylation	EWLRGLLTSRQSFNI HHHHHHHHCCCCEEE	27.23	24719451
351	Phosphorylation	GLLTSRQSFNIIFGE HHHHCCCCEEEEEEE	21.10	-
364	Ubiquitination	GECPYCSKPITLKMS EECCCCCCCEEEEEC	36.56	-
369 (in isoform 2)	Ubiquitination	-	23.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
178	T	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FANCL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FANCL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FANCA_HUMAN	FANCA	physical	16474167
FANCG_HUMAN	FANCG	physical	16474167
FANCF_HUMAN	FANCF	physical	16474167
UBE2W_HUMAN	UBE2W	physical	21229326
PCNA_HUMAN	PCNA	physical	20937699
FANCM_HUMAN	FANCM	physical	20347429
FANCA_HUMAN	FANCA	physical	20347429
FP100_HUMAN	C17orf70	physical	20347429
FANCG_HUMAN	FANCG	physical	20347429
CENPS_HUMAN	APITD1	physical	20347429
CENPX_HUMAN	STRA13	physical	20347429
FANCA_HUMAN	FANCA	physical	18174376
FANCM_HUMAN	FANCM	physical	18174376
FANCG_HUMAN	FANCG	physical	18174376
FANCB_HUMAN	FANCB	physical	17396147
FANCA_HUMAN	FANCA	physical	17396147
FP100_HUMAN	C17orf70	physical	17396147
FANCM_HUMAN	FANCM	physical	17396147
UBE2T_HUMAN	UBE2T	physical	16916645
FANCL_HUMAN	FANCL	physical	16916645
FANCB_HUMAN	FANCB	physical	16720839
FANCM_HUMAN	FANCM	physical	16116422
FANCA_HUMAN	FANCA	physical	16116422
FANCL_HUMAN	FANCL	physical	17396147
UBE2T_HUMAN	UBE2T	physical	21775430
UBE2T_HUMAN	UBE2T	physical	24389026
FACD2_HUMAN	FANCD2	physical	24623813
FANCI_HUMAN	FANCI	physical	24623813
UBE2T_HUMAN	UBE2T	physical	19111657
UBE2W_HUMAN	UBE2W	physical	19111657
FP100_HUMAN	C17orf70	physical	24910428
4ET_HUMAN	EIF4ENIF1	physical	25416956
DOCK8_HUMAN	DOCK8	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
RIM3A_HUMAN	RIMBP3	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
RBM45_HUMAN	RBM45	physical	25416956
IHO1_HUMAN	CCDC36	physical	25416956
FANCA_HUMAN	FANCA	physical	22343915
FANCM_HUMAN	FANCM	physical	22343915
FANCG_HUMAN	FANCG	physical	22343915
FAP20_HUMAN	C1orf86	physical	22343915
FP100_HUMAN	C17orf70	physical	22343915
UBE2T_HUMAN	UBE2T	physical	26046368
FACD2_HUMAN	FANCD2	physical	28162934
UBE2T_HUMAN	UBE2T	physical	28162934
PP1R7_HUMAN	PPP1R7	physical	27173435
ATRIP_HUMAN	ATRIP	physical	23723247
FANCM_HUMAN	FANCM	physical	27398742
FANCA_HUMAN	FANCA	physical	27398742
FACD2_HUMAN	FANCD2	physical	25489943
FANCA_HUMAN	FANCA	physical	26269593

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614083: Fanconi anemia complementation group L (FANCL)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.