RIM3A_HUMAN - dbPTM
RIM3A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIM3A_HUMAN
UniProt AC Q9UFD9
Protein Name RIMS-binding protein 3A
Gene Name RIMBP3
Organism Homo sapiens (Human).
Sequence Length 1639
Subcellular Localization Cytoplasm, cytoskeleton . In elongating spermatids, localizes to the manchette.
Protein Description Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility..
Protein Sequence MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14AcetylationSPLGASPKKPGCSSP
CCCCCCCCCCCCCCH		69.9319830935
79AcetylationLADRLRSKWEAQRSR
HHHHHHHHHHHHHHH		42.4912630427
150PhosphorylationLVNRGHCSRPGASEV
HHHCCCCCCCCHHHC		35.52-
155PhosphorylationHCSRPGASEVSAAQC
CCCCCCHHHCCHHHH		44.43-
158PhosphorylationRPGASEVSAAQCRCR
CCCHHHCCHHHHHHH		17.52-
260PhosphorylationSAEVGVRSRSLGLVS
HCCCCCCCCCCCCCC		24.66-
284PhosphorylationLLSTHASSLDCFAPA
CHHCCHHHCCCCHHH		29.07-
313PhosphorylationSKSEERPSSPDTSTP
CCCCCCCCCCCCCCC		61.8030576142
314PhosphorylationKSEERPSSPDTSTPG
CCCCCCCCCCCCCCC		29.4928634120
317PhosphorylationERPSSPDTSTPGSRR
CCCCCCCCCCCCCCC		37.5728122231
318PhosphorylationRPSSPDTSTPGSRRL
CCCCCCCCCCCCCCC		39.7328122231
326PhosphorylationTPGSRRLSPPPSPLP
CCCCCCCCCCCCCCC		33.2825693802
330PhosphorylationRRLSPPPSPLPPPPP
CCCCCCCCCCCCCCC		44.8623532336
413UbiquitinationCPYQADEKVKRLKVK
CCCCCCHHHHHHHHC		54.31-
415UbiquitinationYQADEKVKRLKVKRA
CCCCHHHHHHHHCHH		64.18-
473PhosphorylationRQRARDLSEQASAPL
HHHHHHHHHHCCCCH		31.7722210691
477PhosphorylationRDLSEQASAPLAKDK
HHHHHHCCCCHHHHH		30.0722210691
482UbiquitinationQASAPLAKDKQIEEL
HCCCCHHHHHHHHHH		73.47-
484UbiquitinationSAPLAKDKQIEELRQ
CCCHHHHHHHHHHHH		53.09-
512MethylationCSDLHTGRGGPCTQW
CCCCCCCCCCCCCCC		48.31-
611UbiquitinationQLQAALLKNAWLAEE
HHHHHHHHHHHHHHH		45.53-
625UbiquitinationENGRLQAKTDWVRKV
HCCCEEECCCHHHHH		33.7729967540
653PhosphorylationACQERDASGLIAEQL
HHHHHCCHHHHHHHH		38.1225693802
732PhosphorylationFHARPEDYAVSQPNR
CCCCHHHCCCCCCCH		13.77-
816PhosphorylationVDDLEPDSVSLALEM
CCCCCCCCHHEHHHC		25.0723879269
818PhosphorylationDLEPDSVSLALEMGG
CCCCCCHHEHHHCCC		16.3323879269
826PhosphorylationLALEMGGSAAPAAPK
EHHHCCCCCCCCCCE		18.6123879269
935UbiquitinationEDSLLSGKAQGVVDR
HCCCCCCCCCCCCCH		33.8729967540
952PhosphorylationCQMVRVGSKTEVATE
HHHEECCCCCHHHHH		33.2823186163
953UbiquitinationQMVRVGSKTEVATEI
HHEECCCCCHHHHHH		42.6629967540
964UbiquitinationATEILDTKTEACQLG
HHHHHCCCHHHHHHH		43.99-
978UbiquitinationGLLQSMGKQGLSRPL
HHHHHHCCCCCCCCC		32.3329967540
989UbiquitinationSRPLLGTKGVLRMAP
CCCCCCCHHHHHHCC		45.27-
1025PhosphorylationHRHPHVVYLDDREHA
CCCCEEEEECCCCCC		11.88-
1217UbiquitinationTFPVCPQKLSLAPPS
EECCCCCCCCCCCCC		25.78-
1226UbiquitinationSLAPPSAKASPHNPG
CCCCCCCCCCCCCCC		54.4529967540
1228PhosphorylationAPPSAKASPHNPGSC
CCCCCCCCCCCCCCC		26.4525159151
1255PhosphorylationEEPPRRQSPVSNLGS
CCCCCCCCCCCCCCC		26.0026074081
1258PhosphorylationPRRQSPVSNLGSEGE
CCCCCCCCCCCCCCC		29.7126074081
1262PhosphorylationSPVSNLGSEGECPSS
CCCCCCCCCCCCCCC		45.6626074081
1294PhosphorylationKDLLFQKSPQNHRPP
HHHHCCCCCCCCCCC		22.4225159151
1322PhosphorylationQHMGTSKSPAPGFIH
HHCCCCCCCCCCEEE		26.5125627689
1344UbiquitinationRKEPCQEKAALERVL
CCCHHHHHHHHHHHH		17.06-
1425PhosphorylationCQLHEPSSALCPAPS
CCCCCCCCCCCCCCC		35.6629116813
1434UbiquitinationLCPAPSAKVIKMPRG
CCCCCCCCEEECCCC		49.16-
1437UbiquitinationAPSAKVIKMPRGGPQ
CCCCCEEECCCCCCC		45.93-
1452PhosphorylationQLGTGANTPARVFVA
CCCCCCCCCCEEEEE		20.14-
1483UbiquitinationEEELVFQKRQLLRVW
HHHHHHCHHHHHHHH		30.55-
1492PhosphorylationQLLRVWGSQDTHDFY
HHHHHHCCCCHHHEH		14.79-
1501PhosphorylationDTHDFYLSECNRQVG
CHHHEHHHHHHHCCC		28.82-
1531PhosphorylationQTDRRWRSPAQGNLP
HCCCCCCCCCCCCCC		20.0222210691
1539PhosphorylationPAQGNLPSVAHLEDF
CCCCCCCCCEEHHHC		34.7922210691
1555PhosphorylationGLTIPQGSSLVLQGN
CCCCCCCCEEEECCC		18.4322210691
1592UbiquitinationGQMGGQGKGRLALRA
CCCCCCCCCCEEEEC		32.73-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIM3A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIM3A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIM3A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DTX2_HUMANDTX2physical
25416956
CTSR1_HUMANCATSPER1physical
25416956
ZN488_HUMANZNF488physical
25416956
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIM3A_HUMAN

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Related Literatures of Post-Translational Modification

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