FANCB_HUMAN - dbPTM
FANCB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FANCB_HUMAN
UniProt AC Q8NB91
Protein Name Fanconi anemia group B protein
Gene Name FANCB
Organism Homo sapiens (Human).
Sequence Length 859
Subcellular Localization Nucleus .
Protein Description DNA repair protein required for FANCD2 ubiquitination..
Protein Sequence MTSKQAMSSNEQERLLCYNGEVLVFQLSKGNFADKEPTKTPILHVRRMVFDRGTKVFVQKSTGFFTIKEENSHLKIMCCNCVSDFRTGINLPYIVIEKNKKNNVFEYFLLILHSTNKFEMRLSFKLGYEMKDGLRVLNGPLILWRHVKAFFFISSQTGKVVSVSGNFSSIQWAGEIENLGMVLLGLKECCLSEEECTQEPSKSDYAIWNTKFCVYSLESQEVLSDIYIIPPAYSSVVTYVHICATEIIKNQLRISLIALTRKNQLISFQNGTPKNVCQLPFGDPCAVQLMDSGGGNLFFVVSFISNNACAVWKESFQVAAKWEKLSLVLIDDFIGSGTEQVLLLFKDSLNSDCLTSFKITDLGKINYSSEPSDCNEDDLFEDKQENRYLVVPPLETGLKVCFSSFRELRQHLLLKEKIISKSYKALINLVQGKDDNTSSAEEKECLVPLCGEEENSVHILDEKLSDNFQDSEQLVEKIWYRVIDDSLVVGVKTTSSLKLSLNDVTLSLLMDQAHDSRFRLLKCQNRVIKLSTNPFPAPYLMPCEIGLEAKRVTLTPDSKKEESFVCEHPSKKECVQIITAVTSLSPLLTFSKFCCTVLLQIMERESGNCPKDRYVVCGRVFLSLEDLSTGKYLLTFPKKKPIEHMEDLFALLAAFHKSCFQITSPGYALNSMKVWLLEHMKCEIIKEFPEVYFCERPGSFYGTLFTWKQRTPFEGILIIYSRNQTVMFQCLHNLIRILPINCFLKNLKSGSENFLIDNMAFTLEKELVTLSSLSSAIAKHESNFMQRCEVSKGKSSVVAAALSDRRENIHPYRKELQREKKKMLQTNLKVSGALYREITLKVAEVQLKSDFAAQKLSNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MTSKQAMSS
------CCCHHCCCC		44.6322814378
4Ubiquitination----MTSKQAMSSNE
----CCCHHCCCCHH		32.67-
39UbiquitinationFADKEPTKTPILHVR
CCCCCCCCCCEEEEE		64.12-
68UbiquitinationSTGFFTIKEENSHLK
CCCCEEEEECCCCEE		56.79-
123PhosphorylationNKFEMRLSFKLGYEM
CCCEEEEEEECCCEE		15.2324719451
202UbiquitinationECTQEPSKSDYAIWN
HHCCCCCCCCCEEEE		59.05-
205PhosphorylationQEPSKSDYAIWNTKF
CCCCCCCCEEEECCE		13.6925159151
358UbiquitinationSDCLTSFKITDLGKI
CCCCEEEEEEECCCC		44.45-
364UbiquitinationFKITDLGKINYSSEP
EEEEECCCCCCCCCC		34.77-
383UbiquitinationEDDLFEDKQENRYLV
CCHHCCCCCCCCEEE		52.92-
415UbiquitinationLRQHLLLKEKIISKS
HHHHHHHCHHHHCHH		57.86-
421UbiquitinationLKEKIISKSYKALIN
HCHHHHCHHHHHHHH		47.60-
424UbiquitinationKIISKSYKALINLVQ
HHHCHHHHHHHHHHC		43.75-
433UbiquitinationLINLVQGKDDNTSSA
HHHHHCCCCCCCCCH		44.83-
456PhosphorylationLCGEEENSVHILDEK
CCCCCCCCEEECCHH		20.5325159151
465PhosphorylationHILDEKLSDNFQDSE
EECCHHHCCCCCCHH		41.3925159151
550UbiquitinationCEIGLEAKRVTLTPD
CCEEEEEEEEEECCC		37.72-
553PhosphorylationGLEAKRVTLTPDSKK
EEEEEEEEECCCCCC		29.0230266825
555PhosphorylationEAKRVTLTPDSKKEE
EEEEEEECCCCCCCC		18.7130266825
558PhosphorylationRVTLTPDSKKEESFV
EEEECCCCCCCCCCC		46.9930266825
559UbiquitinationVTLTPDSKKEESFVC
EEECCCCCCCCCCCC		72.14-
563PhosphorylationPDSKKEESFVCEHPS
CCCCCCCCCCCCCCC		24.8728555341
623PhosphorylationVCGRVFLSLEDLSTG
EECEEEEEHHHCCCC		20.4626546556
721PhosphorylationEGILIIYSRNQTVMF
EEEEEEEECCCEEHH		17.8524719451
745AcetylationLPINCFLKNLKSGSE
HCHHHHHHCCCCCCC		39.7326051181
748UbiquitinationNCFLKNLKSGSENFL
HHHHHCCCCCCCCEE		63.26-
795PhosphorylationCEVSKGKSSVVAAAL
CEECCCCHHHHHHHH		36.71-
796PhosphorylationEVSKGKSSVVAAALS
EECCCCHHHHHHHHH		24.8928555341
803PhosphorylationSVVAAALSDRRENIH
HHHHHHHHCCHHHCH		25.09-
831PhosphorylationLQTNLKVSGALYREI
HHHHHHHCHHHHHEE		19.4322210691
835PhosphorylationLKVSGALYREITLKV
HHHCHHHHHEEEEEE		12.9822817900
839PhosphorylationGALYREITLKVAEVQ
HHHHHEEEEEEEEEE		18.7722817900
848UbiquitinationKVAEVQLKSDFAAQK
EEEEEEECHHHHHHH		30.78-
855UbiquitinationKSDFAAQKLSNL---
CHHHHHHHHHCC---		49.51-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FANCB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FANCB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FANCB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FP100_HUMANC17orf70physical
17396147
FANCA_HUMANFANCAphysical
17396147
FANCL_HUMANFANCLphysical
17396147
FANCM_HUMANFANCMphysical
17396147
FANCG_HUMANFANCGphysical
17396147
FANCL_HUMANFANCLphysical
16720839
PP1R7_HUMANPPP1R7physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300514Fanconi anemia complementation group B (FANCB)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FANCB_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-839, AND MASSSPECTROMETRY.

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