FP100_HUMAN - dbPTM
FP100_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FP100_HUMAN
UniProt AC Q0VG06
Protein Name Fanconi anemia core complex-associated protein 100 {ECO:0000303|PubMed:17396147, ECO:0000312|HGNC:HGNC:26171}
Gene Name FAAP100 {ECO:0000303|PubMed:17396147, ECO:0000312|HGNC:HGNC:26171}
Organism Homo sapiens (Human).
Sequence Length 881
Subcellular Localization Nucleus .
Protein Description Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed..
Protein Sequence MAGAAPRVRYLAGFCCPLGGLAAGKPRVLCHEAEVFLSTGSELVYVYDQEGGLLTAAFRFPDQVWHLELLAPRRLLYALCARRGLYCLSLDHPGRSRSTSQDDRDSEDGDQPSPVIPVDPDACILPDAALCAFTLLDSVLVTLVQGPARWKMQLFEQPCPGEDPRPGGQIGEVELSSYTPPAGVPGKPAAPHFLPVLCSVSPSGSRVPHDLLGGSGGFTLEDALFGLLFGADATLLQSPVVLCGLPDGQLCCVILKALVTSRSAPGDPNALVKILHHLEEPVIFIGALKTEPQAAEAAENFLPDEDVHCDCLVAFGHHGRMLAIKASWDESGKLVPELREYCLPGPVLCAACGGGGRVYHSTPSDLCVVDLSRGSTPLGPEQPEEGPGGLPPMLCPASLNICSVVSLSASPRTHEGGTKLLALSAKGRLMTCSLDLDSEMPGPARMTTESAGQKIKELLSGIGNISERVSFLKKAVDQRNKALTSLNEAMNVSCALLSSGTGPRPISCTTSTTWSRLQTQDVLMATCVLENSSSFSLDQGWTLCIQVLTSSCALDLDSACSAITYTIPVDQLGPGARREVTLPLGPGENGGLDLPVTVSCTLFYSLREVVGGALAPSDSEDPFLDECPSDVLPEQEGVCLPLSRHTVDMLQCLRFPGLAPPHTRAPSPLGPTRDPVATFLETCREPGSQPAGPASLRAEYLPPSVASIKVSAELLRAALKDGHSGVPLCCATLQWLLAENAAVDVVRARALSSIQGVAPDGANVHLIVREVAMTDLCPAGPIQAVEIQVESSSLADICRAHHAVVGRMQTMVTEQATQGSSAPDLRVQYLRQIHANHETLLREVQTLRDRLCTEDEASSCATAQRLLQVYRQLRHPSLILL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25UbiquitinationLGGLAAGKPRVLCHE
CCHHHCCCCEEEEEE		25.56-
333UbiquitinationASWDESGKLVPELRE
EEECCCCCCCHHHHH		56.44-
426UbiquitinationKLLALSAKGRLMTCS
EEEEEECCCCEEEEE		40.98-
431PhosphorylationSAKGRLMTCSLDLDS
ECCCCEEEEECCCCC		11.9728348404
433PhosphorylationKGRLMTCSLDLDSEM
CCCEEEEECCCCCCC		18.7628348404
438PhosphorylationTCSLDLDSEMPGPAR
EEECCCCCCCCCCCC		42.9928348404
454UbiquitinationTTESAGQKIKELLSG
CCHHHHHHHHHHHHC		55.62-
456UbiquitinationESAGQKIKELLSGIG
HHHHHHHHHHHHCCC		49.71-
470PhosphorylationGNISERVSFLKKAVD
CCHHHHHHHHHHHHH		30.9624719451
605PhosphorylationVSCTLFYSLREVVGG
EEEEEEECHHHHHCC		17.3924719451
667PhosphorylationPPHTRAPSPLGPTRD
CCCCCCCCCCCCCCC		31.6030266825
672PhosphorylationAPSPLGPTRDPVATF
CCCCCCCCCCHHHHH		46.0022617229
678PhosphorylationPTRDPVATFLETCRE
CCCCHHHHHHHHHCC		29.0528450419
682PhosphorylationPVATFLETCREPGSQ
HHHHHHHHHCCCCCC		21.0029978859
688PhosphorylationETCREPGSQPAGPAS
HHHCCCCCCCCCCCH		43.6426552605
695PhosphorylationSQPAGPASLRAEYLP
CCCCCCCHHCHHHCC		22.8626552605
810PhosphorylationAVVGRMQTMVTEQAT
HHHHHHHHHHHHHHH		12.3124043423
813PhosphorylationGRMQTMVTEQATQGS
HHHHHHHHHHHHCCC		16.1424043423
817PhosphorylationTMVTEQATQGSSAPD
HHHHHHHHCCCCCCH		32.9124043423
820PhosphorylationTEQATQGSSAPDLRV
HHHHHCCCCCCHHHH		17.3224043423
821PhosphorylationEQATQGSSAPDLRVQ
HHHHCCCCCCHHHHH		51.1224043423
846PhosphorylationTLLREVQTLRDRLCT
HHHHHHHHHHHHHCC		29.0124043423
877PhosphorylationYRQLRHPSLILL---
HHHHHCCCCCCC---		23.1627251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FP100_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FP100_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FP100_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FANCA_HUMANFANCAphysical
17396147
FANCB_HUMANFANCBphysical
17396147
FANCL_HUMANFANCLphysical
17396147
FANCM_HUMANFANCMphysical
17396147
A4_HUMANAPPphysical
21832049
FANCM_HUMANFANCMphysical
22343915
BLM_HUMANBLMphysical
22343915
FANCA_HUMANFANCAphysical
22343915
TOP3A_HUMANTOP3Aphysical
22343915
FANCB_HUMANFANCBphysical
22343915
RMI1_HUMANRMI1physical
22343915
FANCC_HUMANFANCCphysical
22343915
FANCG_HUMANFANCGphysical
22343915
FANCE_HUMANFANCEphysical
22343915
FANCL_HUMANFANCLphysical
22343915
FANCF_HUMANFANCFphysical
22343915
FAP24_HUMANC19orf40physical
22343915
FAP20_HUMANC1orf86physical
22343915
RMI2_HUMANRMI2physical
22343915
CENPS_HUMANAPITD1physical
22343915
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FP100_HUMAN

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Related Literatures of Post-Translational Modification

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