FAP24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAP24_HUMAN
• UniProt AC: Q9BTP7
• Protein Name: Fanconi anemia core complex-associated protein 24 {ECO:0000303|PubMed:17289582, ECO:0000312|HGNC:HGNC:28467}
• Gene Name: FAAP24 {ECO:0000303|PubMed:17289582, ECO:0000312|HGNC:HGNC:28467}
• Organism: Homo sapiens (Human).
• Sequence Length: 215
• Subcellular Localization: Nucleus .
• Protein Description: Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA..
• Protein Sequence: MEKNPPDDTGPVHVPLGHIVANEKWRGSQLAQEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	EKNPPDDTGPVHVPL CCCCCCCCCCCCCCC	51.25	26270265
97	Phosphorylation	VVEKTRMSEQYFPAL EEEECCCCHHHCHHH	20.46	-
142	Acetylation	EQTKEPSKNPLLGKK HHCCCCCCCCCCCHH	73.61	7308137
149	Acetylation	KNPLLGKKRALLLSE CCCCCCHHHHHHHCC	40.90	7308147

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAP24_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAP24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAP24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLK2_HUMAN	CLK2	physical	18995830
FANCM_HUMAN	FANCM	physical	18995830
ATR_HUMAN	ATR	physical	18995830
ATRIP_HUMAN	ATRIP	physical	18995830
FANCM_HUMAN	FANCM	physical	17289582
FANCA_HUMAN	FANCA	physical	17289582
FANCB_HUMAN	FANCB	physical	17289582
FANCG_HUMAN	FANCG	physical	17289582
FANCL_HUMAN	FANCL	physical	17289582
A4_HUMAN	APP	physical	21832049
FANCM_HUMAN	FANCM	physical	20347428
CENPS_HUMAN	APITD1	physical	20347428
CENPX_HUMAN	STRA13	physical	20347428
FANCA_HUMAN	FANCA	physical	20347428
FANCM_HUMAN	FANCM	physical	28514442
TELO2_HUMAN	TELO2	physical	18995830

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.