| UniProt ID | CENPS_HUMAN | |
|---|---|---|
| UniProt AC | Q8N2Z9 | |
| Protein Name | Centromere protein S | |
| Gene Name | CENPS | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 138 | |
| Subcellular Localization | Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycl | |
| Protein Description | DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. [PubMed: 20347428] | |
| Protein Sequence | MEEEAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNSLLKYITDKSEEIAQINLERKAQKKKKSEDGSKNSRQPAEAGVVESEN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEEEAETE -------CHHHHHHH | 15.33 | 22814378 | |
| 67 | Sulfoxidation | NFAKDLEMFARHAKR HHHHHHHHHHHHHHC | 4.07 | 21406390 | |
| 73 | Ubiquitination | EMFARHAKRTTINTE HHHHHHHHCCCCCHH | 44.12 | PubMed | |
| 83 | Ubiquitination | TINTEDVKLLARRSN CCCHHHHHHHHHHCH | 50.54 | 29967540 | |
| 83 (in isoform 2) | Ubiquitination | - | 50.54 | - | |
| 89 | Phosphorylation | VKLLARRSNSLLKYI HHHHHHHCHHHHHHH | 25.80 | 29396449 | |
| 91 | Phosphorylation | LLARRSNSLLKYITD HHHHHCHHHHHHHHC | 36.00 | 24719451 | |
| 94 | Ubiquitination | RRSNSLLKYITDKSE HHCHHHHHHHHCCCH | 39.64 | 23000965 | |
| 94 (in isoform 1) | Ubiquitination | - | 39.64 | 21890473 | |
| 95 | Phosphorylation | RSNSLLKYITDKSEE HCHHHHHHHHCCCHH | 14.71 | 18083107 | |
| 99 | Ubiquitination | LLKYITDKSEEIAQI HHHHHHCCCHHHHHH | 51.63 | 23000965 | |
| 117 | Ubiquitination | RKAQKKKKSEDGSKN HHHHHHCCCCCCCCC | 68.88 | 24816145 | |
| 125 | Phosphorylation | SEDGSKNSRQPAEAG CCCCCCCCCCCHHHC | 35.71 | 21815630 | |
| 136 | Phosphorylation | AEAGVVESEN----- HHHCCCCCCC----- | 30.72 | 28450419 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CENPS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CENPS_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CENPS_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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