CENPK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CENPK_HUMAN
• UniProt AC: Q9BS16
• Protein Name: Centromere protein K
• Gene Name: CENPK
• Organism: Homo sapiens (Human).
• Sequence Length: 269
• Subcellular Localization: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
• Protein Description: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore..
• Protein Sequence: MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLLIMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKEDLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTLGEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWPPYVELLLRNGIALRHPEDPTRIRLEAFHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Ubiquitination	RECEEMWKDMEECQN HHHHHHHHCHHHHHH	45.98	-
76	Ubiquitination	AELSQWQKKTPETIP HHHHHHHHHCCCCCC	56.51	-
77	Ubiquitination	ELSQWQKKTPETIPL HHHHHHHHCCCCCCC	54.96	-
94	Ubiquitination	DVLITLGKEEFQKLR HHHHHCCHHHHHHHH	58.12	-
111	Ubiquitination	LEMVLSTKESKNEKL HHHHHCCCHHHCHHH	57.52	-
114	Ubiquitination	VLSTKESKNEKLKED HHCCCHHHCHHHHHH	70.93	-
119	Ubiquitination	ESKNEKLKEDLEREQ HHHCHHHHHHHHHHH	61.32	-
147	Ubiquitination	NVLHSELKNKVETFS HHHHHHHHHHHHHCC	51.15	-
149	Ubiquitination	LHSELKNKVETFSES HHHHHHHHHHHCCHH	39.60	-
163	Ubiquitination	SRIFNELKTKMLNIK HHHHHHHHHHHCCHH	39.66	-
164	Phosphorylation	RIFNELKTKMLNIKE HHHHHHHHHHCCHHH	34.02	20068231
165	Ubiquitination	IFNELKTKMLNIKEY HHHHHHHHHCCHHHH	39.54	-
170	Ubiquitination	KTKMLNIKEYKEKLL HHHHCCHHHHHHHHH	54.65	-
172	Phosphorylation	KMLNIKEYKEKLLST HHCCHHHHHHHHHHH	21.31	26074081
175	Ubiquitination	NIKEYKEKLLSTLGE CHHHHHHHHHHHHHH	51.05	-
194	Phosphorylation	HFPLPDRSVKKKKKN HCCCCCCCHHHHHCC	45.74	25159151
205	Phosphorylation	KKKNIQESSVNLITL HHCCCCHHHCCHHHH	24.18	20068231
206	Phosphorylation	KKNIQESSVNLITLH HCCCCHHHCCHHHHH	17.80	20068231
211	Phosphorylation	ESSVNLITLHEMLEI HHHCCHHHHHHHHHH	25.81	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CENPK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CENPK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CENPK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOX6_HUMAN	SOX6	physical	10996314
PHS2_HUMAN	PCBD2	physical	20211142
CENPH_HUMAN	CENPH	physical	25416956
MR1L1_HUMAN	MRFAP1L1	physical	25416956
ASSY_HUMAN	ASS1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.