PHS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHS2_HUMAN
• UniProt AC: Q9H0N5
• Protein Name: Pterin-4-alpha-carbinolamine dehydratase 2
• Gene Name: PCBD2
• Organism: Homo sapiens (Human).
• Sequence Length: 130
• Protein Description: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).; Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity..
• Protein Sequence: MAAVLGALGATRRLLAALRGQSLGLAAMSSGTHRLTAEERNQAILDLKAAGWSELSERDAIYKEFSFHNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLAKFIEKAAASV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	VLGALGATRRLLAAL HHHHHHHHHHHHHHH	17.96	21406692
86	Acetylation	RVALQAEKMNHHPEW HHHHHHHHCCCCCHH	48.28	25953088
106	Phosphorylation	KVQITLTSHDCGELT HHEEEEEECCCCCCC	22.05	28509920
113	Phosphorylation	SHDCGELTKKDVKLA ECCCCCCCHHHHHHH	31.57	28509920
114	Acetylation	HDCGELTKKDVKLAK CCCCCCCHHHHHHHH	60.65	-
114	Succinylation	HDCGELTKKDVKLAK CCCCCCCHHHHHHHH	60.65	-
114	Succinylation	HDCGELTKKDVKLAK CCCCCCCHHHHHHHH	60.65	-
118	Acetylation	ELTKKDVKLAKFIEK CCCHHHHHHHHHHHH	53.51	-
118	Succinylation	ELTKKDVKLAKFIEK CCCHHHHHHHHHHHH	53.51	-
118	Succinylation	ELTKKDVKLAKFIEK CCCHHHHHHHHHHHH	53.51	-
121	Acetylation	KKDVKLAKFIEKAAA HHHHHHHHHHHHHHH	58.26	25953088
125	Acetylation	KLAKFIEKAAASV-- HHHHHHHHHHHCC--	38.21	27178108
125	Succinylation	KLAKFIEKAAASV-- HHHHHHHHHHHCC--	38.21	-
125	Succinylation	KLAKFIEKAAASV-- HHHHHHHHHHHCC--	38.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASCC2_HUMAN	ASCC2	physical	20211142
MED30_HUMAN	MED30	physical	20211142
TF2LY_HUMAN	TGIF2LY	physical	20211142
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-125, AND MASS SPECTROMETRY.
PubMed: 19608861