TF2LY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2LY_HUMAN
• UniProt AC: Q8IUE0
• Protein Name: Homeobox protein TGIF2LY
• Gene Name: TGIF2LY
• Organism: Homo sapiens (Human).
• Sequence Length: 185
• Subcellular Localization: Nucleus .
• Protein Description: May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX..
• Protein Sequence: MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTEASVPAKSGPVVQTMYKACPCGPCQRARCQERSNQIRSRPLARSSPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	AADGPAETQSPVEKD CCCCCCCCCCCCCCC	36.13	28348404
13	Phosphorylation	DGPAETQSPVEKDSP CCCCCCCCCCCCCCC	38.03	22617229
19	Phosphorylation	QSPVEKDSPAKTQSP CCCCCCCCCCCCCCC	37.51	22617229
23	Phosphorylation	EKDSPAKTQSPAQDT CCCCCCCCCCCCCCC	36.06	30266825
25	Phosphorylation	DSPAKTQSPAQDTSI CCCCCCCCCCCCCCH	27.68	30266825
30	Phosphorylation	TQSPAQDTSIMSRNN CCCCCCCCCHHCCCC	14.20	30266825
40	Phosphorylation	MSRNNADTGRVLALP HCCCCCCCCCEEECH	25.20	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF2LY_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2LY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2LY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF2LX_HUMAN	TGIF2LX	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442
PDCD4_HUMAN	PDCD4	physical	28514442
OGFR_HUMAN	OGFR	physical	28514442
CRBN_HUMAN	CRBN	physical	28514442
SAHH3_HUMAN	AHCYL2	physical	28514442
PGP_HUMAN	PGP	physical	28514442
GEMI_HUMAN	GMNN	physical	28514442
DCA16_HUMAN	DCAF16	physical	28514442
THNS1_HUMAN	THNSL1	physical	28514442
LRP5_HUMAN	LRP5	physical	28514442
IRGQ_HUMAN	IRGQ	physical	28514442
TOPK_HUMAN	PBK	physical	28514442
ARI1_HUMAN	ARIH1	physical	28514442
DPYL5_HUMAN	DPYSL5	physical	28514442
SAHH2_HUMAN	AHCYL1	physical	28514442
UBXN7_HUMAN	UBXN7	physical	28514442
RALB_HUMAN	RALB	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	28514442
DPYL2_HUMAN	DPYSL2	physical	28514442
ANR17_HUMAN	ANKRD17	physical	28514442
KLH24_HUMAN	KLHL24	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.