PGP_HUMAN - dbPTM
PGP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PGP_HUMAN
UniProt AC A6NDG6
Protein Name Glycerol-3-phosphate phosphatase {ECO:0000305}
Gene Name PGP {ECO:0000312|HGNC:HGNC:8909}
Organism Homo sapiens (Human).
Sequence Length 321
Subcellular Localization
Protein Description Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. [PubMed: 26755581 In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity]
Protein Sequence MAAAEAGGDDARCVRLSAERAQALLADVDTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTAYCTALYLRQRLAGAPAPKAYVLGSPALAAELEAVGVASVGVGPEPLQGEGPGDWLHAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDCVSKKKMVPDFYVDSIADLLPALQG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationDARCVRLSAERAQAL
CHHHHHHCHHHHHHH		19.9524719451
67PhosphorylationGKRLGFITNNSSKTR
CCEEEEEECCCHHHH		26.5323312004
70PhosphorylationLGFITNNSSKTRAAY
EEEEECCCHHHHHHH		34.9723312004
71PhosphorylationGFITNNSSKTRAAYA
EEEECCCHHHHHHHH		39.9220873877
72AcetylationFITNNSSKTRAAYAE
EEECCCHHHHHHHHH		41.6825953088
72MalonylationFITNNSSKTRAAYAE
EEECCCHHHHHHHHH		41.6832601280
72UbiquitinationFITNNSSKTRAAYAE
EEECCCHHHHHHHHH		41.6832015554
73PhosphorylationITNNSSKTRAAYAEK
EECCCHHHHHHHHHH		27.7321406692
77PhosphorylationSSKTRAAYAEKLRRL
CHHHHHHHHHHHHHC		17.8221406692
80UbiquitinationTRAAYAEKLRRLGFG
HHHHHHHHHHHCCCC		38.8427667366
177PhosphorylationVGFDPHFSYMKLTKA
EECCCCCCHHHHHHH		22.6825693802
178PhosphorylationGFDPHFSYMKLTKAL
ECCCCCCHHHHHHHH		9.4225693802
183UbiquitinationFSYMKLTKALRYLQQ
CCHHHHHHHHHHHCC		56.72-
187PhosphorylationKLTKALRYLQQPGCL
HHHHHHHHHCCCCEE		15.09-
224SulfoxidationCLVRAVEMAAQRQAD
HHHHHHHHHHHHHCH		2.7730846556
235UbiquitinationRQADIIGKPSRFIFD
HHCHHCCCCCCCHHH		29.43-
237PhosphorylationADIIGKPSRFIFDCV
CHHCCCCCCCHHHHH		43.2220068231
255PhosphorylationYGINPERTVMVGDRL
CCCCHHCEEEECCCC		15.9930387612
264PhosphorylationMVGDRLDTDILLGAT
EECCCCCHHHHHCCC		29.5430387612
276PhosphorylationGATCGLKTILTLTGV
CCCCCCCHHHHHHCC		26.6818452278
279PhosphorylationCGLKTILTLTGVSTL
CCCCHHHHHHCCCHH		20.5826074081
281PhosphorylationLKTILTLTGVSTLGD
CCHHHHHHCCCHHHC		30.2426074081
284PhosphorylationILTLTGVSTLGDVKN
HHHHHCCCHHHCCCC		21.1826074081
285PhosphorylationLTLTGVSTLGDVKNN
HHHHCCCHHHCCCCC		32.1426074081
290UbiquitinationVSTLGDVKNNQESDC
CCHHHCCCCCCCCCC		55.7221963094
295PhosphorylationDVKNNQESDCVSKKK
CCCCCCCCCCCCCCC		26.92-
299PhosphorylationNQESDCVSKKKMVPD
CCCCCCCCCCCCCCC		45.12-
300AcetylationQESDCVSKKKMVPDF
CCCCCCCCCCCCCCC		35.7023749302
301UbiquitinationESDCVSKKKMVPDFY
CCCCCCCCCCCCCCH		38.30-
302UbiquitinationSDCVSKKKMVPDFYV
CCCCCCCCCCCCCHH		49.19-
308PhosphorylationKKMVPDFYVDSIADL
CCCCCCCHHHHHHHH		15.6630622161
311PhosphorylationVPDFYVDSIADLLPA
CCCCHHHHHHHHHHH		15.0530622161
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PGP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PGP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PGP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RING2_HUMANRNF2physical
17088979
GORS2_HUMANGORASP2physical
27880917
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PGP_HUMAN

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Related Literatures of Post-Translational Modification

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