dbPTM

SAHH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SAHH3_HUMAN
UniProt AC	Q96HN2
Protein Name	Adenosylhomocysteinase 3
Gene Name	AHCYL2
Organism	Homo sapiens (Human).
Sequence Length	611
Subcellular Localization	Cytoplasm . Microsome . Associates with membranes when phosphorylated, probably through interaction with ITPR1.
Protein Description	May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate. [PubMed: 19220705]
Protein Sequence	MSVQVVSAAAAAKVPEVELKDLSPSEAESQLGLSTAAVGAMAPPAGGGDPEAPAPAAERPPVPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVSPDGTVTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVQVVSAA ------CCHHHHHHH	22.66	22223895
2	Phosphorylation	------MSVQVVSAA ------CCHHHHHHH	22.66	29255136
7	Phosphorylation	-MSVQVVSAAAAAKV -CCHHHHHHHHHHCC	17.21	21406692
23	Phosphorylation	EVELKDLSPSEAESQ CEEEECCCHHHHHHH	36.19	28348404
25	Phosphorylation	ELKDLSPSEAESQLG EEECCCHHHHHHHHC	46.17	28348404
34	Phosphorylation	AESQLGLSTAAVGAM HHHHHCCCHHHHCCC	17.75	28348404
35	Phosphorylation	ESQLGLSTAAVGAMA HHHHCCCHHHHCCCC	24.55	28348404
67	Phosphorylation	PPVPGPGSGPAAALS CCCCCCCCCCHHHCC	44.74	28348404
74	Phosphorylation	SGPAAALSPAAGKVP CCCHHHCCCCCCCCC	14.04	28111955
84	Phosphorylation	AGKVPQASAMKRSDP CCCCCCHHHHCCCCC	24.53	25159151
89	Phosphorylation	QASAMKRSDPHHQHQ CHHHHCCCCCCCCCH	50.40	36012879
89	Ubiquitination	QASAMKRSDPHHQHQ CHHHHCCCCCCCCCH	50.40	32015554
107	Phosphorylation	DGGEALVSPDGTVTE CCCCEECCCCCCCCC	20.37	30266825
107 (in isoform 2)	Phosphorylation	-	20.37	25159151
111	Phosphorylation	ALVSPDGTVTEAPRT EECCCCCCCCCCCHH	31.47	30266825
113	Phosphorylation	VSPDGTVTEAPRTVK CCCCCCCCCCCHHHH	26.68	30266825
113 (in isoform 2)	Phosphorylation	-	26.68	25159151
118	Phosphorylation	TVTEAPRTVKKQIQF CCCCCCHHHHHHHHH	35.30	21712546
121	Acetylation	EAPRTVKKQIQFADQ CCCHHHHHHHHHHHH	48.58	-
143	Phosphorylation	PTKIGRRSLSRSISQ CCHHHHHHHHHHHCC	29.36	30576142
145	Phosphorylation	KIGRRSLSRSISQSS HHHHHHHHHHHCCCC	25.81	28102081
147	Phosphorylation	GRRSLSRSISQSSTD HHHHHHHHHCCCCCC	24.18	68734381
149	Phosphorylation	RSLSRSISQSSTDSY HHHHHHHCCCCCCCC	25.84	16793548
151	Phosphorylation	LSRSISQSSTDSYSS HHHHHCCCCCCCCCC	28.54	68737123
152	Phosphorylation	SRSISQSSTDSYSSA HHHHCCCCCCCCCCC	28.70	16793548
153	Phosphorylation	RSISQSSTDSYSSAA HHHCCCCCCCCCCCH	33.92	28270605
155	Phosphorylation	ISQSSTDSYSSAASY HCCCCCCCCCCCHHC	27.31	19220705
156	Phosphorylation	SQSSTDSYSSAASYT CCCCCCCCCCCHHCC	14.95	28270605
157	Phosphorylation	QSSTDSYSSAASYTD CCCCCCCCCCHHCCC	19.90	28270605
158	Ubiquitination	SSTDSYSSAASYTDS CCCCCCCCCHHCCCC	21.44	21963094
158	Phosphorylation	SSTDSYSSAASYTDS CCCCCCCCCHHCCCC	21.44	19220705
160	Ubiquitination	TDSYSSAASYTDSSD CCCCCCCHHCCCCCC	12.67	22817900
161	Phosphorylation	DSYSSAASYTDSSDD CCCCCCHHCCCCCCC	28.43	28270605
162	Phosphorylation	SYSSAASYTDSSDDE CCCCCHHCCCCCCCC	15.16	28270605
163	Phosphorylation	YSSAASYTDSSDDET CCCCHHCCCCCCCCC	27.23	9469109
165	Phosphorylation	SAASYTDSSDDETSP CCHHCCCCCCCCCCH	28.06	30576142
166	Phosphorylation	AASYTDSSDDETSPR CHHCCCCCCCCCCHH	52.47	30576142
170	Phosphorylation	TDSSDDETSPRDKQQ CCCCCCCCCHHHHHH	51.53	30576142
171	Phosphorylation	DSSDDETSPRDKQQK CCCCCCCCHHHHHHH	18.85	110756339
176	Ubiquitination	ETSPRDKQQKNSKGS CCCHHHHHHHCCCCC	64.86	22817900
191	Ubiquitination	SDFCVKNIKQAEFGR CCCHHHHHHHHHHCC	2.65	32015554
192	Ubiquitination	DFCVKNIKQAEFGRR CCHHHHHHHHHHCCH	53.50	32015554
222	Ubiquitination	RKRAQGEKPLAGAKI HHHHCCCCCCCCCEE	52.75	-
245	Ubiquitination	QTAVLMETLGALGAQ HHHHHHHHHHHHHHH	19.27	32015554
248	Ubiquitination	VLMETLGALGAQCRW HHHHHHHHHHHHHHH	13.11	32015554
262	Ubiquitination	WAACNIYSTLNEVAA HHHHHHHHHHHHHHH	23.71	21963094
263	Ubiquitination	AACNIYSTLNEVAAA HHHHHHHHHHHHHHH	19.34	21963094
264	Ubiquitination	ACNIYSTLNEVAAAL HHHHHHHHHHHHHHH	4.18	22817900
265	Ubiquitination	CNIYSTLNEVAAALA HHHHHHHHHHHHHHH	41.61	22817900
280	Ubiquitination	ESGFPVFAWKGESED HCCCCEEEECCCCCC	13.80	22817900
281	Ubiquitination	SGFPVFAWKGESEDD CCCCEEEECCCCCCC	9.56	22817900
306	Ubiquitination	VEGWQPNMILDDGGD CCCCCCCEEEECCCC	4.02	22817900
319	Phosphorylation	GDLTHWIYKKYPNMF CCHHHHHHHHCCCHH	9.02	20090780
322	Phosphorylation	THWIYKKYPNMFKKI HHHHHHHCCCHHHHH	8.83	6831203
338	Phosphorylation	GIVEESVTGVHRLYQ HHHHHHCCHHHHHHH	42.64	50564075
344	Phosphorylation	VTGVHRLYQLSKAGK CCHHHHHHHHHHCCC	13.83	6831211
347	Ubiquitination	VHRLYQLSKAGKLCV HHHHHHHHHCCCEEE	12.63	32015554
348	Ubiquitination	HRLYQLSKAGKLCVP HHHHHHHHCCCEEEE	70.52	32015554
350	Ubiquitination	LYQLSKAGKLCVPAM HHHHHHCCCEEEEEC	27.49	32015554
351	Ubiquitination	YQLSKAGKLCVPAMN HHHHHCCCEEEEECC	43.50	32015554
362	Phosphorylation	PAMNVNDSVTKQKFD EECCCCCHHHHHHCC	26.87	20068231
364	Phosphorylation	MNVNDSVTKQKFDNL CCCCCHHHHHHCCCE	31.54	20068231
364	Ubiquitination	MNVNDSVTKQKFDNL CCCCCHHHHHHCCCE	31.54	21963094
365	Ubiquitination	NVNDSVTKQKFDNLY CCCCHHHHHHCCCEE	49.70	21963094
366	Ubiquitination	VNDSVTKQKFDNLYC CCCHHHHHHCCCEEE	42.13	22817900
367	Ubiquitination	NDSVTKQKFDNLYCC CCHHHHHHCCCEEEH	57.13	22817900
377	Phosphorylation	NLYCCRESILDGLKR CEEEHHHHHHHHHHH	14.75	29759185
382	Ubiquitination	RESILDGLKRTTDMM HHHHHHHHHHHHCCE	3.20	22817900
383	Ubiquitination	ESILDGLKRTTDMMF HHHHHHHHHHHCCEE	53.91	22817900
410	Ubiquitination	VGKGCCAALKAMGSI HHHHHHHHHHHCCCE	8.83	22817900
411	Ubiquitination	GKGCCAALKAMGSIV HHHHHHHHHHCCCEE	1.61	22817900
440	Acetylation	MDGFRLVKLNEVIRQ HCCEEEEEHHHHHHH	50.62	25953088
456	Ubiquitination	DIVITCTGNKNVVTR CEEEECCCCCCEECH	45.31	33845483
465	Ubiquitination	KNVVTREHLDRMKNS CCEECHHHHHHHCCC	29.73	29967540
472	Phosphorylation	HLDRMKNSCIVCNMG HHHHHCCCEEEECCC	10.33	16793548
481	Phosphorylation	IVCNMGHSNTEIDVA EEECCCCCCCEEEHH	39.45	113331545
483	Phosphorylation	CNMGHSNTEIDVASL ECCCCCCCEEEHHHC	37.01	50564083
492	Phosphorylation	IDVASLRTPELTWER EEHHHCCCCCCCHHH	26.80	21406692
496	Phosphorylation	SLRTPELTWERVRSQ HCCCCCCCHHHHHHH	24.50	21406692
499	Methylation	TPELTWERVRSQVDH CCCCCHHHHHHHCCE	22.25	-
502	Phosphorylation	LTWERVRSQVDHVIW CCHHHHHHHCCEEEC	31.53	24719451
512	Ubiquitination	DHVIWPDGKRIVLLA CEEECCCCCEEEEEE	19.64	22817900
513	Ubiquitination	HVIWPDGKRIVLLAE EEECCCCCEEEEEEC	46.46	22817900
514	Methylation	VIWPDGKRIVLLAEG EECCCCCEEEEEECC	29.76	-
533	Phosphorylation	LSCSTVPTFVLSITA EECCCCCEEEEEHHH	23.26	22210691
537	Phosphorylation	TVPTFVLSITATTQA CCCEEEEEHHHHHHH	16.76	22210691
542	Phosphorylation	VLSITATTQALALIE EEEHHHHHHHHHHHH	14.91	22210691
558	Ubiquitination	YNAPEGRYKQDVYLL HCCCCCCCCCCEEEC	24.69	33845483
559	Ubiquitination	NAPEGRYKQDVYLLP CCCCCCCCCCEEECC	38.37	33845483
563	Phosphorylation	GRYKQDVYLLPKKMD CCCCCCEEECCHHHH	15.71	110736809
567	Ubiquitination	QDVYLLPKKMDEYVA CCEEECCHHHHHHHH	61.78	29967540
568	Ubiquitination	DVYLLPKKMDEYVAS CEEECCHHHHHHHHH	50.04	29967540
605	Ubiquitination	LNKNGPFKPNYYRY- CCCCCCCCCCCCCC-	35.17	-
608	Phosphorylation	NGPFKPNYYRY---- CCCCCCCCCCC----	9.61	21945579
609	Phosphorylation	GPFKPNYYRY----- CCCCCCCCCC-----	15.29	21945579
610	Methylation	PFKPNYYRY------ CCCCCCCCC------	21.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SAHH3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SAHH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SAHH3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSMD4_HUMAN	PSMD4	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
SAHH2_HUMAN	AHCYL1	physical	28514442
ZIC2_HUMAN	ZIC2	physical	28514442
FOXK2_HUMAN	FOXK2	physical	28514442
IKBL1_HUMAN	NFKBIL1	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
DUS11_HUMAN	DUSP11	physical	28514442
HXB6_HUMAN	HOXB6	physical	28514442
BANP_HUMAN	BANP	physical	28514442
PI42B_HUMAN	PIP4K2B	physical	28514442
KI18B_HUMAN	KIF18B	physical	28514442
HXB9_HUMAN	HOXB9	physical	28514442
PLCD3_HUMAN	PLCD3	physical	28514442
BCD1_HUMAN	ZNHIT6	physical	28514442
CAB39_HUMAN	CAB39	physical	28514442
PI51A_HUMAN	PIP5K1A	physical	28514442
WDR33_HUMAN	WDR33	physical	28514442
PDD2L_HUMAN	PDCD2L	physical	28514442
JUN_HUMAN	JUN	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SAHH3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND MASSSPECTROMETRY.	18669648 [Abstract]