ZIC2_HUMAN - dbPTM
ZIC2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZIC2_HUMAN
UniProt AC O95409
Protein Name Zinc finger protein ZIC 2
Gene Name ZIC2
Organism Homo sapiens (Human).
Sequence Length 532
Subcellular Localization Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity)..
Protein Description Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos..
Protein Sequence MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSGLSSNFNEWYV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationFARHHHHSAAAAAAA
HHHHCHHHHHHHHHH		18.4221406692
70PhosphorylationNPGAHELSPGQSSAF
CCCCCCCCCCCCCCC		24.8121406692
74PhosphorylationHELSPGQSSAFTSQG
CCCCCCCCCCCCCCC		29.5521406692
75PhosphorylationELSPGQSSAFTSQGP
CCCCCCCCCCCCCCC		21.3621406692
78PhosphorylationPGQSSAFTSQGPGAY
CCCCCCCCCCCCCCC		21.6221406692
79PhosphorylationGQSSAFTSQGPGAYP
CCCCCCCCCCCCCCC		27.0421406692
85PhosphorylationTSQGPGAYPGSAAAA
CCCCCCCCCHHHHHH		17.6521406692
88PhosphorylationGPGAYPGSAAAAAAA
CCCCCCHHHHHHHHH		15.3821406692
191PhosphorylationPGEVFGRSEQYRQVA
CCCHHCCCHHHHHHC		29.4528152594
194PhosphorylationVFGRSEQYRQVASPR
HHCCCHHHHHHCCCC		10.0428152594
199PhosphorylationEQYRQVASPRTDPYS
HHHHHHCCCCCCCCC		18.9628152594
253SumoylationYMRQQCIKQELICKW
HHHHHHHHHHHHHHH		45.40-
253UbiquitinationYMRQQCIKQELICKW
HHHHHHHHHHHHHHH		45.40-
253SumoylationYMRQQCIKQELICKW
HHHHHHHHHHHHHHH		45.4028112733
267PhosphorylationWIDPEQLSNPKKSCN
HCCHHHHCCCCHHCC		51.2721406692
276PhosphorylationPKKSCNKTFSTMHEL
CCHHCCCCHHHHHHH		14.61-
278PhosphorylationKSCNKTFSTMHELVT
HHCCCCHHHHHHHHH		30.01-
328PhosphorylationVNHIRVHTGEKPFPC
EEEEEEECCCCCCCC		44.15-
342AcetylationCPFPGCGKVFARSEN
CCCCCCCCEEEECCC		37.9520167786
356PhosphorylationNLKIHKRTHTGEKPF
CEEEECCCCCCCCCE		28.70-
358PhosphorylationKIHKRTHTGEKPFQC
EEECCCCCCCCCEEC		46.56-
406PhosphorylationDKSYTHPSSLRKHMK
CCCCCCHHHHHHHHE		34.1125159151
407PhosphorylationKSYTHPSSLRKHMKV
CCCCCHHHHHHHHEC		36.3225159151
417PhosphorylationKHMKVHESSPQGSES
HHHECCCCCCCCCCC		32.2321406692
418PhosphorylationHMKVHESSPQGSESS
HHECCCCCCCCCCCC		20.4721406692
422PhosphorylationHESSPQGSESSPAAS
CCCCCCCCCCCCCHH		29.1121406692
424PhosphorylationSSPQGSESSPAASSG
CCCCCCCCCCCHHCC		43.2321406692
425PhosphorylationSPQGSESSPAASSGY
CCCCCCCCCCHHCCC		17.9521406692
429PhosphorylationSESSPAASSGYESST
CCCCCCHHCCCCCCC		26.8021406692
430PhosphorylationESSPAASSGYESSTP
CCCCCHHCCCCCCCC		40.4421406692
432PhosphorylationSPAASSGYESSTPPG
CCCHHCCCCCCCCCC		18.0021406692
434PhosphorylationAASSGYESSTPPGLV
CHHCCCCCCCCCCCC		30.9121406692
435PhosphorylationASSGYESSTPPGLVS
HHCCCCCCCCCCCCC		32.7521406692
436PhosphorylationSSGYESSTPPGLVSP
HCCCCCCCCCCCCCC		42.6621406692
442PhosphorylationSTPPGLVSPSAEPQS
CCCCCCCCCCCCCCC		20.4121406692
444PhosphorylationPPGLVSPSAEPQSSS
CCCCCCCCCCCCCCC		37.4421406692
449PhosphorylationSPSAEPQSSSNLSPA
CCCCCCCCCCCCCHH		46.5821406692
450PhosphorylationPSAEPQSSSNLSPAA
CCCCCCCCCCCCHHH		20.2821406692
451PhosphorylationSAEPQSSSNLSPAAA
CCCCCCCCCCCHHHH		47.2221406692
454PhosphorylationPQSSSNLSPAAAAAA
CCCCCCCCHHHHHHH		19.4221406692
472PhosphorylationAAAAAAVSAVHRGGG
HHHHHHHHHHHCCCC		21.6121406692
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRNF180Q86T96
PMID:18363970
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZIC2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZIC2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GLI1_HUMANGLI1physical
11238441
GLI2_HUMANGLI2physical
11238441
GLI3_HUMANGLI3physical
11238441
RN180_HUMANRNF180physical
18363970
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
609637Holoprosencephaly 5 (HPE5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZIC2_HUMAN

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Related Literatures of Post-Translational Modification

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