dbPTM

GLI3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GLI3_HUMAN
UniProt AC	P10071
Protein Name	Transcriptional activator GLI3
Gene Name	GLI3
Organism	Homo sapiens (Human).
Sequence Length	1580
Subcellular Localization	Nucleus. Cytoplasm. Cell projection, cilium. GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Translocation to the nucleus is promoted by interac
Protein Description	Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'..
Protein Sequence	MEAQSHSSTTTEKKKVENSIVKCSTRTDVSEKAVASSTTSNEDESPGQTYHRERRNAITMQPQNVQGLSKVSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTVFAMDPRNGYMEPHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHMTSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFSSPRLSARPSRKRTLSISPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMHQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTSESAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHWEGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHSQSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKLERLKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTMLNMLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRLALLGDALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDAPGHGVRRASDPVRTGSEGLALPRVPRFSSLSSCNPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESLTMDADANLNDEDFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGDFDAPGLPDSHAGQQFHALEQPCPEGSKTDLPIQWNEVSSGSADLSSSKLKCGPRPAVPQTRAFGFCNGMVVHPQNPLRSGPAGGYQTLGENSNPYGGPEHLMLHNSPGSGTSGNAFHEQPCKAPQYGNCLNRQPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNFGLPVAPNESAGSMVNGMQNQDPVGQGYLAHQLLGDSMQHPGAGRPGQQMLGQISATSHINIYQGPESCLPGAHGMGSQPSSLAVVRGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTCRVNGIKMEMKGQPHPLCSNLQNYSGQFYDQTVGFSQQDTKAGSFSISDASCLLQGTSAKNSELLSPGANQVTSTVDSLDSHDLEGVQIDFDAIIDDGDHSSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPALSMSTTNMAIGDMSSLLTSLAEESKFLAVMQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAQSHSS -------CCCCCCCC	42.17	19413330
19	Phosphorylation	EKKKVENSIVKCSTR CHHHHHCCEEEECCC	18.43	22817900
24	Phosphorylation	ENSIVKCSTRTDVSE HCCEEEECCCCCCCH	18.40	30177828
25	Phosphorylation	NSIVKCSTRTDVSEK CCEEEECCCCCCCHH	47.24	30576142
27	Phosphorylation	IVKCSTRTDVSEKAV EEEECCCCCCCHHHH	40.62	30177828
30	Phosphorylation	CSTRTDVSEKAVASS ECCCCCCCHHHHHCC	35.87	30177828
32	Acetylation	TRTDVSEKAVASSTT CCCCCCHHHHHCCCC	40.43	23236377
37	Phosphorylation	SEKAVASSTTSNEDE CHHHHHCCCCCCCCC	26.43	27251275
38	Phosphorylation	EKAVASSTTSNEDES HHHHHCCCCCCCCCC	31.57	27251275
39	Phosphorylation	KAVASSTTSNEDESP HHHHCCCCCCCCCCC	31.35	27251275
40	Phosphorylation	AVASSTTSNEDESPG HHHCCCCCCCCCCCC	38.01	28555341
45	Phosphorylation	TTSNEDESPGQTYHR CCCCCCCCCCCCCCH	46.80	25159151
50	Phosphorylation	DESPGQTYHRERRNA CCCCCCCCCHHHHHC	7.32	30576142
59	Phosphorylation	RERRNAITMQPQNVQ HHHHHCCCCCCCCCC	13.82	22210691
69	Phosphorylation	PQNVQGLSKVSEEPS CCCCCCCHHCCCCCC	37.52	22210691
78	O-linked_Glycosylation	VSEEPSTSSDERASL CCCCCCCCHHHHHHH	39.88	28411811
84	Phosphorylation	TSSDERASLIKKEIH CCHHHHHHHHHHHHH	36.53	24719451
87	Sumoylation	DERASLIKKEIHGSL HHHHHHHHHHHHCCC	50.04	-
93	Phosphorylation	IKKEIHGSLPHVAEP HHHHHHCCCCCCCCC	25.27	28348404
101	Phosphorylation	LPHVAEPSVPYRGTV CCCCCCCCCCCCCEE	27.51	-
104	Phosphorylation	VAEPSVPYRGTVFAM CCCCCCCCCCEEEEE	21.37	-
163	Phosphorylation	LHMTSALSSSPTYPD CCCCCCCCCCCCCCC	28.61	-
164	Phosphorylation	HMTSALSSSPTYPDL CCCCCCCCCCCCCCC	40.98	24719451
165	Phosphorylation	MTSALSSSPTYPDLP CCCCCCCCCCCCCCC	20.20	28348404
167	Phosphorylation	SALSSSPTYPDLPFI CCCCCCCCCCCCCCE	50.03	28348404
168	Phosphorylation	ALSSSPTYPDLPFIR CCCCCCCCCCCCCEE	9.72	-
175	Methylation	YPDLPFIRISPHRNP CCCCCCEEECCCCCC	24.58	-
183	Phosphorylation	ISPHRNPTAASESPF ECCCCCCCCCCCCCC	38.10	29978859
186	Phosphorylation	HRNPTAASESPFSPP CCCCCCCCCCCCCCC	35.82	29978859
188	Phosphorylation	NPTAASESPFSPPHP CCCCCCCCCCCCCCC	28.84	29978859
191	Phosphorylation	AASESPFSPPHPYIN CCCCCCCCCCCCCCC	40.69	29978859
196	Phosphorylation	PFSPPHPYINPYMDY CCCCCCCCCCHHHHH	15.42	29978859
200	Phosphorylation	PHPYINPYMDYIRSL CCCCCCHHHHHHHHH	9.72	29978859
203	Phosphorylation	YINPYMDYIRSLHSS CCCHHHHHHHHHHCC	5.02	29978859
220	Methylation	LSMISATRGLSPTDA HHHHEECCCCCCCCC	43.71	-
223	Phosphorylation	ISATRGLSPTDAPHA HEECCCCCCCCCCCC	28.69	27251275
257	Phosphorylation	PYADIIPSAATAGTG CCHHCCCCCCCCCCC	21.81	-
293	Phosphorylation	ARPSRKRTLSISPLS CCCCCCCEEEECCCC	28.08	29523821
295	Phosphorylation	PSRKRTLSISPLSDH CCCCCEEEECCCCCC	22.02	29523821
297	Phosphorylation	RKRTLSISPLSDHSF CCCEEEECCCCCCCC	19.20	29523821
312	Phosphorylation	DLQTMIRTSPNSLVT CHHHHEECCCCCEEE	37.30	24719451
313	Phosphorylation	LQTMIRTSPNSLVTI HHHHEECCCCCEEEE	16.55	28348404
418	Phosphorylation	ESSQNKPTSESAVSS CCCCCCCCCHHHCCC	46.89	30206219
419	Phosphorylation	SSQNKPTSESAVSST CCCCCCCCHHHCCCC	37.77	30206219
421	Phosphorylation	QNKPTSESAVSSTGD CCCCCCHHHCCCCCC	33.46	30206219
424	Phosphorylation	PTSESAVSSTGDPMH CCCHHHCCCCCCCCC	23.15	30206219
425	Phosphorylation	TSESAVSSTGDPMHN CCHHHCCCCCCCCCC	29.79	30206219
426	Phosphorylation	SESAVSSTGDPMHNK CHHHCCCCCCCCCCC	37.79	30206219
435	Phosphorylation	DPMHNKRSKIKPDED CCCCCCCCCCCCCCC	40.10	30206219
436	Methylation	PMHNKRSKIKPDEDL CCCCCCCCCCCCCCC	59.80	-
438	Sumoylation	HNKRSKIKPDEDLPS CCCCCCCCCCCCCCC	50.59	28112733
445	Phosphorylation	KPDEDLPSPGARGQQ CCCCCCCCCCCCCCC	43.17	29255136
462	Sumoylation	PEGTTLVKEEGDKDE CCCCEEEECCCCCCC	53.84	28112733
541	Phosphorylation	VVHMRRHTGEKPHKC EEEEHHCCCCCCCCC	45.27	23532336
564	Ubiquitination	YSRLENLKTHLRSHT HHHHHHHHHHHHHHC	45.54	-
571	Phosphorylation	KTHLRSHTGEKPYVC HHHHHHHCCCCCEEE	48.56	29214152
595	Methylation	SNASDRAKHQNRTHS CCHHHHHHHCCCCCC	46.76	-
618	Phosphorylation	IPGCTKRYTDPSSLR CCCCCCCCCCHHHHH	19.63	29496907
619	Phosphorylation	PGCTKRYTDPSSLRK CCCCCCCCCHHHHHH	45.53	-
622	Phosphorylation	TKRYTDPSSLRKHVK CCCCCCHHHHHHHHE	44.83	21082442
623	Phosphorylation	KRYTDPSSLRKHVKT CCCCCHHHHHHHHEE	37.27	24719451
639	Phosphorylation	HGPEAHVTKKQRGDI CCCCCCCCCCCCCCC	23.74	21082442
640	Acetylation	GPEAHVTKKQRGDIH CCCCCCCCCCCCCCC	45.91	7681179
640	Ubiquitination	GPEAHVTKKQRGDIH CCCCCCCCCCCCCCC	45.91	-
641	Acetylation	PEAHVTKKQRGDIHP CCCCCCCCCCCCCCC	35.54	7681189
656	Phosphorylation	RPPPPRDSGSHSQSR CCCCCCCCCCCCCCC	43.40	23403867
658	Phosphorylation	PPPRDSGSHSQSRSP CCCCCCCCCCCCCCC	24.74	23403867
660	Phosphorylation	PRDSGSHSQSRSPGR CCCCCCCCCCCCCCC	31.39	23403867
662	Phosphorylation	DSGSHSQSRSPGRPT CCCCCCCCCCCCCCC	37.43	23403867
664	Phosphorylation	GSHSQSRSPGRPTQG CCCCCCCCCCCCCCC	36.63	30266825
669	Phosphorylation	SRSPGRPTQGALGEQ CCCCCCCCCCCCCCC	37.97	29255136
680	Phosphorylation	LGEQQDLSNTTSKRE CCCCCCCCCCCCCHH	40.18	23403867
682	Phosphorylation	EQQDLSNTTSKREEC CCCCCCCCCCCHHHH	29.13	23403867
683	Phosphorylation	QQDLSNTTSKREECL CCCCCCCCCCHHHHE	36.18	23927012
684	Phosphorylation	QDLSNTTSKREECLQ CCCCCCCCCHHHHEE	27.90	23927012
696	Sumoylation	CLQVKTVKAEKPMTS HEECEEEECCCCCCC	56.94	-
773	Ubiquitination	RRNPAGTKWMEHVKL HHCCCCCCHHHHHHH	43.56	16705181
779	Sumoylation	TKWMEHVKLERLKQV CCHHHHHHHHHHHHH	46.68	28112733
779	Ubiquitination	TKWMEHVKLERLKQV CCHHHHHHHHHHHHH	46.68	16705181
784	Ubiquitination	HVKLERLKQVNGMFP HHHHHHHHHHCCCCC	59.42	16705181
800	Ubiquitination	LNPILPPKAPAVSPL CCCCCCCCCCCCCCC	66.13	16705181
849	Phosphorylation	NMLNRRDSSASTISS HCCCCCCCCCHHHHH	26.45	30576142
850	Phosphorylation	MLNRRDSSASTISSA CCCCCCCCCHHHHHH	30.44	30576142
852	Phosphorylation	NRRDSSASTISSAYL CCCCCCCHHHHHHHH	28.37	30576142
853	Phosphorylation	RRDSSASTISSAYLS CCCCCCHHHHHHHHH	25.29	23312004
855	Phosphorylation	DSSASTISSAYLSSR CCCCHHHHHHHHHHC	14.70	30576142
856	Phosphorylation	SSASTISSAYLSSRR CCCHHHHHHHHHHCC	19.65	30576142
858	Phosphorylation	ASTISSAYLSSRRSS CHHHHHHHHHHCCCC	14.74	23312004
860	Phosphorylation	TISSAYLSSRRSSGI HHHHHHHHHCCCCCC	14.77	30576142
861	Phosphorylation	ISSAYLSSRRSSGIS HHHHHHHHCCCCCCC	29.17	23312004
864	Phosphorylation	AYLSSRRSSGISPCF HHHHHCCCCCCCCCC	31.63	23403867
865	Phosphorylation	YLSSRRSSGISPCFS HHHHCCCCCCCCCCC	38.03	23403867
868	Phosphorylation	SRRSSGISPCFSSRR HCCCCCCCCCCCCCC	21.09	23090842
872	Phosphorylation	SGISPCFSSRRSSEA CCCCCCCCCCCCHHH	29.65	-
873	Phosphorylation	GISPCFSSRRSSEAS CCCCCCCCCCCHHHH	16.09	23403867
876	Phosphorylation	PCFSSRRSSEASQAE CCCCCCCCHHHHHCC	31.27	27251275
877	Phosphorylation	CFSSRRSSEASQAEG CCCCCCCHHHHHCCC	35.06	10693759
880	Phosphorylation	SRRSSEASQAEGRPQ CCCCHHHHHCCCCCC	26.35	28348404
895	Phosphorylation	NVSVADSYDPISTDA CCCCCCCCCCCCCCH	26.70	27642862
899	Phosphorylation	ADSYDPISTDASRRS CCCCCCCCCCHHHHC	26.14	-
900	Phosphorylation	DSYDPISTDASRRSS CCCCCCCCCHHHHCC	35.98	-
903	Phosphorylation	DPISTDASRRSSEAS CCCCCCHHHHCCHHH	30.91	-
906	Phosphorylation	STDASRRSSEASQSD CCCHHHHCCHHHHCC	31.27	25850435
907	Phosphorylation	TDASRRSSEASQSDG CCHHHHCCHHHHCCC	35.06	25850435
910	Phosphorylation	SRRSSEASQSDGLPS HHHCCHHHHCCCCCH	26.60	25850435
912	Phosphorylation	RSSEASQSDGLPSLL HCCHHHHCCCCCHHH	31.02	23403867
917	Phosphorylation	SQSDGLPSLLSLTPA HHCCCCCHHHHCCHH	47.16	23090842
920	Phosphorylation	DGLPSLLSLTPAQQY CCCCHHHHCCHHHHH	35.17	23090842
933	Phosphorylation	QYRLKAKYAAATGGP HHHHHHHHHHHHCCC	13.31	28634298
937	Phosphorylation	KAKYAAATGGPPPTP HHHHHHHHCCCCCCC	37.63	28634298
943	Phosphorylation	ATGGPPPTPLPNMER HHCCCCCCCCCCHHH	43.14	28634298
980	Phosphorylation	VHAPRRCSDGGAHGY CCCCCCCCCCCCCCC	37.16	26699800
987	Phosphorylation	SDGGAHGYGRRHLQP CCCCCCCCCCCCCCC	9.52	26699800
1006	Phosphorylation	GHGVRRASDPVRTGS CCCCCCCCCCCCCCC	40.41	9302279
1013	Phosphorylation	SDPVRTGSEGLALPR CCCCCCCCCCCCCCC	28.07	22210691
1025	Phosphorylation	LPRVPRFSSLSSCNP CCCCCCCCCCCCCCC	31.48	22210691
1026	Phosphorylation	PRVPRFSSLSSCNPP CCCCCCCCCCCCCCC	29.56	28348404
1028	Phosphorylation	VPRFSSLSSCNPPAM CCCCCCCCCCCCCHH	34.49	28348404
1029	Phosphorylation	PRFSSLSSCNPPAMA CCCCCCCCCCCCHHC	24.17	28348404
1254	Phosphorylation	QPCKAPQYGNCLNRQ CCCCCCCCCCCCCCC	14.83	-
1401	Phosphorylation	RQAMPRDSLALQSGQ CCCCCCCCEEHHCCC	19.47	-
1412	Phosphorylation	QSGQLSDTSQTCRVN HCCCCCCCCCEEEEC	21.25	-
1413	Phosphorylation	SGQLSDTSQTCRVNG CCCCCCCCCEEEECC	28.60	-
1415	Phosphorylation	QLSDTSQTCRVNGIK CCCCCCCEEEECCEE	11.31	-
1422	Sumoylation	TCRVNGIKMEMKGQP EEEECCEEEEECCCC	30.15	-
1444	Phosphorylation	QNYSGQFYDQTVGFS HHCCCCCCCCCCCCC	10.15	27642862
1459	Phosphorylation	QQDTKAGSFSISDAS CCCCCCCEEECHHHH	22.23	27732954
1461	Phosphorylation	DTKAGSFSISDASCL CCCCCEEECHHHHHH	23.92	27732954
1463	Phosphorylation	KAGSFSISDASCLLQ CCCEEECHHHHHHHC	26.40	27732954
1466	Phosphorylation	SFSISDASCLLQGTS EEECHHHHHHHCCCC	15.41	27732954
1539	Phosphorylation	SHSSSRLTTPRASLP CCCCCCCCCCCCCCC	33.37	24719451
1563	Phosphorylation	NMAIGDMSSLLTSLA CCHHHCHHHHHHHHH	23.67	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
849	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
849	S	Phosphorylation	Kinase	PKA	-	Uniprot
849	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
865	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
865	S	Phosphorylation	Kinase	PKA	-	Uniprot
865	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
877	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
877	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
877	S	Phosphorylation	Kinase	PKA	-	Uniprot
907	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
907	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
907	S	Phosphorylation	Kinase	PKA	-	Uniprot
980	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
980	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
980	S	Phosphorylation	Kinase	PKA	-	Uniprot
1006	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1006	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1006	S	Phosphorylation	Kinase	PKA	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GLI3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GLI3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZIC1_HUMAN	ZIC1	physical	11238441
ZIC2_HUMAN	ZIC2	physical	11238441
ZIC3_HUMAN	ZIC3	physical	11238441
STK36_HUMAN	STK36	physical	10806483
SAP18_HUMAN	SAP18	genetic	11960000
SUFU_MOUSE	Sufu	genetic	11960000
SIN3A_MOUSE	Sin3a	genetic	11960000
MED12_HUMAN	MED12	physical	17000779
CBP_HUMAN	CREBBP	physical	17000779
FBW1A_HUMAN	BTRC	physical	16705181
SKI_HUMAN	SKI	physical	12435627
FBW1A_HUMAN	BTRC	physical	16371461
UBP7_HUMAN	USP7	physical	26120032

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
175700	Greig cephalo-poly-syndactyly syndrome (GCPS)
146510	Pallister-Hall syndrome (PHS)
174200	Polydactyly, postaxial A1 (PAPA1)
174200	Polydactyly, postaxial B (PAPB)
174700	Polydactyly preaxial 4 (POP4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GLI3_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Hedgehog-regulated processing of Gli3 produces an anterior/posteriorrepressor gradient in the developing vertebrate limb."; Wang B., Fallon J.F., Beachy P.A.; Cell 100:423-434(2000). Cited for: FUNCTION, PROTEOLYTIC PROCESSING, PHOSPHORYLATION AT SER-849; SER-865;SER-877; SER-907; SER-980 AND SER-1006, AND MUTAGENESIS OF SER-849;SER-865; SER-877; SER-907; SER-980 AND SER-1006.	10693759 [Abstract]
Ubiquitylation
Reference	PubMed
"Multisite protein kinase A and glycogen synthase kinase 3betaphosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP."; Tempe D., Casas M., Karaz S., Blanchet-Tournier M.F., Concordet J.P.; Mol. Cell. Biol. 26:4316-4326(2006). Cited for: PROTEOLYTIC PROCESSING, PHOSPHORYLATION, INTERACTION WITH BTRC,UBIQUITINATION AT LYS-773; LYS-779; LYS-784 AND LYS-800, ANDMUTAGENESIS OF LYS-773; LYS-779; LYS-784; LYS-800; SER-849; SER-855;SER-856; SER-861; SER-864; SER-873; SER-877; SER-903 AND SER-907.	16705181 [Abstract]