STK36_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STK36_HUMAN
• UniProt AC: Q9NRP7
• Protein Name: Serine/threonine-protein kinase 36
• Gene Name: STK36 {ECO:0000312|EMBL:AAH26158.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 1315
• Subcellular Localization: Cytoplasm . Nucleus . Low levels also present in the nucleus.
• Protein Description: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. [PubMed: 10806483 Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization]
• Protein Sequence: MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	EGSFGRVYKGRRKYS CCCCCCCCCCCCCCE	13.33	-
25	Phosphorylation	VYKGRRKYSAQVVAL CCCCCCCCEEEHHHH	13.87	-
26	Phosphorylation	YKGRRKYSAQVVALK CCCCCCCEEEHHHHH	18.43	27251275
37	Acetylation	VALKFIPKLGRSEKE HHHHHHHHCCCCHHH	59.77	19819203
135	Ubiquitination	PQNILLAKGGGIKLC HHHEEEEECCCEEEC	59.04	-
140	Ubiquitination	LAKGGGIKLCDFGFA EEECCCEEECCCHHH	46.46	-
151	Phosphorylation	FGFARAMSTNTMVLT CHHHEHHCCCEEEEE	19.95	30108239
152	Phosphorylation	GFARAMSTNTMVLTS HHHEHHCCCEEEEEE	22.94	28450419
154	Phosphorylation	ARAMSTNTMVLTSIK HEHHCCCEEEEEECC	14.56	30108239
158	Phosphorylation	STNTMVLTSIKGTPL CCCEEEEEECCCCCC	19.59	30108239
159	Phosphorylation	TNTMVLTSIKGTPLY CCEEEEEECCCCCCC	20.38	28450419
285	Ubiquitination	PPELQVLKDEQAHRL CCHHHCCCHHHHHHH	61.43	-
307	Ubiquitination	RILTQAYKRMAEEAM HHHHHHHHHHHHHHH	38.42	-
317	Ubiquitination	AEEAMQKKHQNTGPA HHHHHHHHHHCCCCC	33.27	-
321	Phosphorylation	MQKKHQNTGPALEQE HHHHHHCCCCCCCCC	37.66	-
331	Phosphorylation	ALEQEDKTSKVAPGT CCCCCCCCCCCCCCC	46.21	-
332	Phosphorylation	LEQEDKTSKVAPGTA CCCCCCCCCCCCCCC	30.76	-
333	Ubiquitination	EQEDKTSKVAPGTAP CCCCCCCCCCCCCCC	47.88	-
360	Phosphorylation	LLAGILASELKSSWA HHHHHHHHHHHHHHH	39.76	28348404
363	Ubiquitination	GILASELKSSWAKSG HHHHHHHHHHHHHCC	38.09	-
364	Phosphorylation	ILASELKSSWAKSGT HHHHHHHHHHHHCCC	43.68	28348404
365	Phosphorylation	LASELKSSWAKSGTG HHHHHHHHHHHCCCC	29.48	28348404
368	Ubiquitination	ELKSSWAKSGTGEVP HHHHHHHHCCCCCCC	43.06	-
416	Phosphorylation	LENEEPDSDNEWQHL CCCCCCCCCCCHHHH	53.72	27251275
426	Phosphorylation	EWQHLLETTEPVPIQ CHHHHHHCCCCCCEE	36.11	27251275
427	Phosphorylation	WQHLLETTEPVPIQL HHHHHHCCCCCCEEE	28.99	27251275
578	Phosphorylation	LLAQPDDSEQTLRRD HHCCCCCHHHHHHHH	38.70	-
581	Phosphorylation	QPDDSEQTLRRDSLM CCCCHHHHHHHHHHH	20.41	-
691	Phosphorylation	WHLANQLTEDSSQLR HHHHHHCCCCHHHHC	28.16	27732954
694	Phosphorylation	ANQLTEDSSQLRPSL HHHCCCCHHHHCHHH	17.47	27732954
695	Phosphorylation	NQLTEDSSQLRPSLI HHCCCCHHHHCHHHH	45.62	27732954
873	Phosphorylation	ASLIRDMSSSEMWTV HHHHHCCCHHHHHHH	34.69	28348404
874	Phosphorylation	SLIRDMSSSEMWTVL HHHHCCCHHHHHHHH	24.55	28348404
953	Phosphorylation	QHGSILMSILKHLLC HHHHHHHHHHHHHHC	22.71	24719451
1035	Phosphorylation	MQVELPISLLTRLAL CCCCCCHHHHHHHHH	18.52	24719451
1046	Phosphorylation	RLALMDPTSLNQFVN HHHHCCCCCHHHHHH	41.40	29449344
1047	Phosphorylation	LALMDPTSLNQFVNT HHHCCCCCHHHHHHH	30.61	29449344
1054	Phosphorylation	SLNQFVNTVSASPRT CHHHHHHHCCCCHHH	15.55	29449344
1056	Phosphorylation	NQFVNTVSASPRTIV HHHHHHCCCCHHHHH	22.46	29449344
1058	Phosphorylation	FVNTVSASPRTIVSF HHHHCCCCHHHHHHH	13.86	29449344
1149	Phosphorylation	ALRGALQSQSGLLSL HHHHHHHHHHHHHHH	27.45	22210691
1181	Phosphorylation	FAVGNAAYQAGPLGP EECCCHHHHCCCCHH	9.11	22817900
1250	Ubiquitination	GDPQPNVKEAALIAL CCCCCCHHHHHHHHH	48.56	-
1276	Phosphorylation	VLVSLGASEKLSLLS HHHHCCCCCCEEHHH	33.20	23403867
1283	Phosphorylation	SEKLSLLSLGNQSLP CCCEEHHHCCCCCCC	39.25	29514088
1288	Phosphorylation	LLSLGNQSLPHSSPR HHHCCCCCCCCCCCC	48.11	29514088
1292	Phosphorylation	GNQSLPHSSPRPASA CCCCCCCCCCCCCCH	39.85	25850435
1293	Phosphorylation	NQSLPHSSPRPASAK CCCCCCCCCCCCCHH	23.15	25850435
1298	Phosphorylation	HSSPRPASAKHCRKL CCCCCCCCHHHHHHH	40.30	29514088
1314	Phosphorylation	HLLRPAHSM------ HHHCCHHCC------	28.44	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MPG	P29372	PMID:25278022

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STK36_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STK36_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARMC6_HUMAN	ARMC6	physical	17353931
FRPD4_HUMAN	FRMPD4	physical	12421765
MAST2_HUMAN	MAST2	physical	12421765
CK5P2_HUMAN	CDK5RAP2	physical	12421765
CDC37_HUMAN	CDC37	physical	17054904
HS90A_HUMAN	HSP90AA1	physical	17054904
STK36_HUMAN	STK36	physical	25278022
HS90A_HUMAN	HSP90AA1	physical	25278022
GLI1_HUMAN	GLI1	physical	25241761
SUFU_HUMAN	SUFU	physical	25241761
GLI3_HUMAN	GLI3	physical	25241761

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.