FRPD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRPD4_HUMAN
• UniProt AC: Q14CM0
• Protein Name: FERM and PDZ domain-containing protein 4
• Gene Name: FRMPD4
• Organism: Homo sapiens (Human).
• Sequence Length: 1322
• Subcellular Localization: Cell projection, dendritic spine .
• Protein Description: Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate..
• Protein Sequence: MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MDVFSFVKIAKLSSH CCHHHHEEHHHHHCC	34.63	-
8	"N6,N6-dimethyllysine"	MDVFSFVKIAKLSSH CCHHHHEEHHHHHCC	34.63	-
13	Phosphorylation	FVKIAKLSSHRTKSS HEEHHHHHCCCCCCC	24.32	23312004
14	Phosphorylation	VKIAKLSSHRTKSSG EEHHHHHCCCCCCCC	27.68	23312004
17	Phosphorylation	AKLSSHRTKSSGWPP HHHHCCCCCCCCCCC	29.83	-
157	Phosphorylation	TVIQPYPSPKSAFIS EEEECCCCCHHHHHH	38.83	30576142
181	Phosphorylation	NPVKVRFSEEVIING CCEEEEECEEEEECC	23.45	28387310
191	Phosphorylation	VIINGQVSETVKDNS EEECCEECCEECCCC	21.47	28387310
198	Phosphorylation	SETVKDNSLLFMPNV CCEECCCCEEECCCE	36.26	28387310
327	Phosphorylation	RFGPELKYDIALRLA HHCHHHHHHHHHHHH	25.80	-
344	Phosphorylation	QMYIATVTTKQTQKI HHHHHHCCCCCCEEE	24.74	19845377
345	Phosphorylation	MYIATVTTKQTQKIS HHHHHCCCCCCEEEE	19.47	-
352	Phosphorylation	TKQTQKISLKYIEKE CCCCEEEEEEHHHHH	26.33	25907765
355	Phosphorylation	TQKISLKYIEKEWGL CEEEEEEHHHHHHCH	21.43	25907765
364	Phosphorylation	EKEWGLETFLPSAVL HHHHCHHHHCHHHHH	35.20	25907765
368	Phosphorylation	GLETFLPSAVLQSMK CHHHHCHHHHHHHHH	32.91	25907765
373	Phosphorylation	LPSAVLQSMKEKNIK CHHHHHHHHHHHCHH	27.88	25907765
399	Acetylation	NLVPPGKKLSALQAK CCCCCCHHHHHHHHH	54.30	12429945
414	Phosphorylation	VHYLKFLSDLRLYGG HHHHHHHHHCHHCCC	37.42	24719451
445	Phosphorylation	TLLVGPRYGISHVIN EEEECCCCCHHHHEE	23.19	-
448	Phosphorylation	VGPRYGISHVINTKT ECCCCCHHHHEECHH	13.82	-
453	Phosphorylation	GISHVINTKTNLVAL CHHHHEECHHHHHHH	28.28	-
474	Phosphorylation	VNRIEMFSEEESLVR CCEEECCCCCHHHEE	42.67	25690035
478	Phosphorylation	EMFSEEESLVRVELH ECCCCCHHHEEEEEE	35.13	25690035
571	Phosphorylation	GEQEAQITYIDSKQK CCCEEEEEEEECCCC	11.44	-
585	Phosphorylation	KTVEITDSTMCPKEH CEEEECCCCCCCCCC	14.91	-
596	Phosphorylation	PKEHRHLYIDNAYSS CCCCCEEEECCCCCC	10.49	-
601	Phosphorylation	HLYIDNAYSSDGLNQ EEEECCCCCCCCHHH	18.24	-
629	Phosphorylation	YRSLAQRSLLTLSGP HHHHHHHHHHHHCCH	18.69	-
632	Phosphorylation	LAQRSLLTLSGPETL HHHHHHHHHCCHHHH	24.95	-
638	Phosphorylation	LTLSGPETLKKAQES HHHCCHHHHHHHHHC	47.19	-
641	Acetylation	SGPETLKKAQESPRG CCHHHHHHHHHCCCC	59.42	11922669
650	Acetylation	QESPRGAKVSFIFGD HHCCCCCEEEEEECC	41.03	7705903
716	Phosphorylation	QFVENSVYANIGDVK EEEECCEECCCCCHH	8.18	19690332
817	Phosphorylation	PPPGFRDSSDEEDSQ CCCCCCCCCCCCCHH	35.12	26471730
818	Phosphorylation	PPGFRDSSDEEDSQS CCCCCCCCCCCCHHH	54.02	26471730
823	Phosphorylation	DSSDEEDSQSQAASF CCCCCCCHHHHHHCC	34.70	26471730
825	Phosphorylation	SDEEDSQSQAASFPE CCCCCHHHHHHCCCC	26.24	26471730
887	Phosphorylation	SVSEEQQTSDNSGVA CCCHHHCCCCCCCEE	37.43	25332170
888	Phosphorylation	VSEEQQTSDNSGVAI CCHHHCCCCCCCEEE	30.38	25332170
900	Phosphorylation	VAILRAYSPESSSDS EEEEEEECCCCCCCC	22.62	-
904	Phosphorylation	RAYSPESSSDSGNET EEECCCCCCCCCCCC	36.18	-
992	Phosphorylation	PSKQLLHSDHMEMEP CHHHHCCCCCCCCCC	29.22	24043423
1001	Phosphorylation	HMEMEPETMETKSVT CCCCCCCHHCCCCHH	30.90	24043423
1004	Phosphorylation	MEPETMETKSVTDYF CCCCHHCCCCHHHHH	20.14	24043423
1028	Ubiquitination	YSCTSKRKSKLADGE HHCCCCCHHHCCCCC	56.53	-
1037	Ubiquitination	KLADGEGKAPPNGNT HCCCCCCCCCCCCCC	54.11	-
1047	Ubiquitination	PNGNTTGKKQQGTKT CCCCCCCCCCCCCCC	45.37	-
1073	Phosphorylation	GTVSSRDSQHLSTFN CCCCCCCCCCCEEEE	20.56	24719451
1077	Phosphorylation	SRDSQHLSTFNLERT CCCCCCCEEEEEEEC	28.91	24719451
1090	Phosphorylation	RTAFRKDSQRWYVAT ECEEECCCCCEEEEE	25.36	24719451
1094	Phosphorylation	RKDSQRWYVATEGGM ECCCCCEEEEECCCC	5.17	-
1105	Phosphorylation	EGGMAEKSGLEAATG CCCCHHHCCCHHHCC	39.86	-
1114	Phosphorylation	LEAATGKTFPRASGL CHHHCCCCCCCCCCC	39.97	-
1171	Phosphorylation	DNPEDADSSTCDHPS CCHHHCCCCCCCCHH	29.30	30576142
1172	Phosphorylation	NPEDADSSTCDHPSK CHHHCCCCCCCCHHH	33.33	30576142
1178	Phosphorylation	SSTCDHPSKLPEADE CCCCCCHHHCCCCCH	43.32	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRPD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRPD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRPD4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FRPD4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.