dbPTM

MAST2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MAST2_HUMAN
UniProt AC	Q6P0Q8
Protein Name	Microtubule-associated serine/threonine-protein kinase 2
Gene Name	MAST2 {ECO:0000312\|EMBL:CAH73245.1}
Organism	Homo sapiens (Human).
Sequence Length	1798
Subcellular Localization	Cytoplasm, cytoskeleton . Cell membrane Peripheral membrane protein Cytoplasmic side . Recruited to the sub-membranous area on interaction with CDHR2.
Protein Description	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity)..
Protein Sequence	MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALVPDELLKQT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	RAAELSQSLPPRRRA HHHHHHHCCCHHHCC	39.19	24719451
63	Phosphorylation	GKEQDVVTGVSPLLF CCHHHCCCCCHHHHH	31.54	30266825
66	Phosphorylation	QDVVTGVSPLLFRKL HHCCCCCHHHHHHHC	15.92	19664994
74	Phosphorylation	PLLFRKLSNPDIFSS HHHHHHCCCCCCCCC	49.72	29255136
80	Phosphorylation	LSNPDIFSSTGKVKL CCCCCCCCCCCCHHH	27.59	25159151
81	Phosphorylation	SNPDIFSSTGKVKLQ CCCCCCCCCCCHHHH	30.35	23927012
82	Phosphorylation	NPDIFSSTGKVKLQR CCCCCCCCCCHHHHH	39.56	23927012
92	Phosphorylation	VKLQRQLSQDDCKLW HHHHHHCCCCCHHHH	24.19	25159151
105	Phosphorylation	LWRGNLASSLSGKQL HHHCCHHHHCCCCCC	34.67	25262027
106	Phosphorylation	WRGNLASSLSGKQLL HHCCHHHHCCCCCCE	22.43	25262027
108	Phosphorylation	GNLASSLSGKQLLPL CCHHHHCCCCCCEEC	45.98	29514088
130	Phosphorylation	VGQVTWQSSGEASNL CCEEEEECCCHHHHH	31.69	28348404
131	Phosphorylation	GQVTWQSSGEASNLV CEEEEECCCHHHHHH	26.08	28348404
135	Phosphorylation	WQSSGEASNLVRMRN EECCCHHHHHHHHHC	26.79	26074081
144	Phosphorylation	LVRMRNQSLGQSAPS HHHHHCCCCCCCCCH	37.71	30266825
148	Phosphorylation	RNQSLGQSAPSLTAG HCCCCCCCCCHHCHH	40.11	29255136
151	Phosphorylation	SLGQSAPSLTAGLKE CCCCCCCHHCHHCHH	37.76	30266825
153	Phosphorylation	GQSAPSLTAGLKELS CCCCCHHCHHCHHCC	24.02	30266825
160	Phosphorylation	TAGLKELSLPRRGSF CHHCHHCCCCCCCCC	37.10	21815630
163	Methylation	LKELSLPRRGSFCRT CHHCCCCCCCCCCCC	61.97	115387143
169	Methylation	PRRGSFCRTSNRKSL CCCCCCCCCCCCCEE	38.90	115387151
175	Phosphorylation	CRTSNRKSLIVTSST CCCCCCCEEEEECCC	21.79	20873877
179	Phosphorylation	NRKSLIVTSSTSPTL CCCEEEEECCCCCCC	15.23	26657352
180	Phosphorylation	RKSLIVTSSTSPTLP CCEEEEECCCCCCCC	22.26	30576142
181	Phosphorylation	KSLIVTSSTSPTLPR CEEEEECCCCCCCCC	24.44	26657352
182	Phosphorylation	SLIVTSSTSPTLPRP EEEEECCCCCCCCCC	38.19	30576142
183	Phosphorylation	LIVTSSTSPTLPRPH EEEECCCCCCCCCCC	20.17	23403867
185	Phosphorylation	VTSSTSPTLPRPHSP EECCCCCCCCCCCCC	49.51	26657352
191	Phosphorylation	PTLPRPHSPLHGHTG CCCCCCCCCCCCCCC	31.66	29255136
197	Phosphorylation	HSPLHGHTGNSPLDS CCCCCCCCCCCCCCC	42.52	23403867
200	Phosphorylation	LHGHTGNSPLDSPRN CCCCCCCCCCCCCCC	28.34	29743597
204	Phosphorylation	TGNSPLDSPRNFSPN CCCCCCCCCCCCCCC	33.18	23403867
209	Phosphorylation	LDSPRNFSPNAPAHF CCCCCCCCCCCCCCE	22.31	29255136
217	Phosphorylation	PNAPAHFSFVPARRT CCCCCCEEEECCCCC	18.57	23312004
230	Phosphorylation	RTDGRRWSLASLPSS CCCCCCEEEECCCCC	16.55	23927012
233	Phosphorylation	GRRWSLASLPSSGYG CCCEEEECCCCCCCC	46.21	23403867
236	Phosphorylation	WSLASLPSSGYGTNT EEEECCCCCCCCCCC	41.51	23403867
237	Phosphorylation	SLASLPSSGYGTNTP EEECCCCCCCCCCCC	33.81	23403867
239	Phosphorylation	ASLPSSGYGTNTPSS ECCCCCCCCCCCCCC	23.79	23403867
241	Phosphorylation	LPSSGYGTNTPSSTV CCCCCCCCCCCCCCC	27.69	23403867
243	Phosphorylation	SSGYGTNTPSSTVSS CCCCCCCCCCCCCCC	25.12	23403867
245	Phosphorylation	GYGTNTPSSTVSSSC CCCCCCCCCCCCCCC	36.28	23403867
246	Phosphorylation	YGTNTPSSTVSSSCS CCCCCCCCCCCCCCC	33.75	23403867
247	Phosphorylation	GTNTPSSTVSSSCSS CCCCCCCCCCCCCCC	28.83	23403867
249	Phosphorylation	NTPSSTVSSSCSSQE CCCCCCCCCCCCCCH	19.34	23403867
250	Phosphorylation	TPSSTVSSSCSSQEK CCCCCCCCCCCCCHH	30.90	23403867
251	Phosphorylation	PSSTVSSSCSSQEKL CCCCCCCCCCCCHHH	15.54	23403867
253	Phosphorylation	STVSSSCSSQEKLHQ CCCCCCCCCCHHHHC	36.68	23403867
254	Phosphorylation	TVSSSCSSQEKLHQL CCCCCCCCCHHHHCC	46.84	23403867
274	Phosphorylation	ADELHFLTKHFSTES HHHHHHHHHHCCCCC	22.87	-
278	Phosphorylation	HFLTKHFSTESVPDE HHHHHHCCCCCCCCC	30.86	29255136
279	Phosphorylation	FLTKHFSTESVPDEE HHHHHCCCCCCCCCC	31.19	29255136
281	Phosphorylation	TKHFSTESVPDEEGR HHHCCCCCCCCCCCC	38.75	29255136
290	Phosphorylation	PDEEGRQSPAMRPRS CCCCCCCCCCCCCCC	17.17	25159151
297	Phosphorylation	SPAMRPRSRSLSPGR CCCCCCCCCCCCCCC	28.98	23663014
299	Phosphorylation	AMRPRSRSLSPGRSP CCCCCCCCCCCCCCC	34.15	22167270
301	Phosphorylation	RPRSRSLSPGRSPVS CCCCCCCCCCCCCCC	26.93	22167270
305	Phosphorylation	RSLSPGRSPVSFDSE CCCCCCCCCCCCCCH	35.25	29523821
308	Phosphorylation	SPGRSPVSFDSEIIM CCCCCCCCCCCHHHC	27.07	24719451
311	Phosphorylation	RSPVSFDSEIIMMNH CCCCCCCCHHHCCCH	28.78	29523821
455	Ubiquitination	AKEGQGIKCDIPRYI CCCCCCCCCCCCHHH	32.45	-
461	Phosphorylation	IKCDIPRYIVSQLGL CCCCCCHHHHHHCCC	10.58	23403867
493	Phosphorylation	DTPETDDSIEGHGAS CCCCCCCCCCCCCCC	25.91	22210691
500	Phosphorylation	SIEGHGASLPSKKTP CCCCCCCCCCCCCCC	45.46	22210691
503	Phosphorylation	GHGASLPSKKTPSEE CCCCCCCCCCCCCHH	52.67	24719451
514	Phosphorylation	PSEEDFETIKLISNG CCHHHHHHEEEHHHC	24.33	25690035
519	Phosphorylation	FETIKLISNGAYGAV HHHEEEHHHCCCEEE	39.38	24719451
523	Phosphorylation	KLISNGAYGAVFLVR EEHHHCCCEEEEEEE	13.66	24719451
533	Phosphorylation	VFLVRHKSTRQRFAM EEEEECHHHHHHHHH	23.77	27251275
534	Phosphorylation	FLVRHKSTRQRFAMK EEEECHHHHHHHHHH	35.31	24719451
545	Ubiquitination	FAMKKINKQNLILRN HHHHHHCHHHHHHHH	44.00	-
625	Phosphorylation	ETVLALEYLHNYGIV HHHHHHHHHHHCCCC	17.70	22817900
629	Phosphorylation	ALEYLHNYGIVHRDL HHHHHHHCCCCCCCC	9.47	22817900
652	Phosphorylation	SMGHIKLTDFGLSKI ECCCEEECCCCCHHH	25.04	21082442
657	Phosphorylation	KLTDFGLSKIGLMSL EECCCCCHHHCCEEC	23.70	21082442
683	Ubiquitination	DAREFLDKQVCGTPE HHHHHHHHHCCCCHH	46.94	-
791	Phosphorylation	FFTGLDWTGLLRQKA CCCCCCHHHHHHHHH	20.02	30576142
797	Ubiquitination	WTGLLRQKAEFIPQL HHHHHHHHHHHHHHC	43.37	-
806	Phosphorylation	EFIPQLESEDDTSYF HHHHHCCCCCCCCCC	55.72	26657352
810	Phosphorylation	QLESEDDTSYFDTRS HCCCCCCCCCCCCCH	37.33	27251275
811	Phosphorylation	LESEDDTSYFDTRSE CCCCCCCCCCCCCHH	30.69	27251275
812	Phosphorylation	ESEDDTSYFDTRSER CCCCCCCCCCCCHHH	13.94	23403867
815	Phosphorylation	DDTSYFDTRSERYHH CCCCCCCCCHHHCCC	26.62	27251275
825	Phosphorylation	ERYHHMDSEDEEEVS HHCCCCCCCCHHHHC	39.10	30576142
843	Phosphorylation	CLEIRQFSSCSPRFN CEEEHHHHCCCHHHH	23.30	27732954
844	Phosphorylation	LEIRQFSSCSPRFNK EEEHHHHCCCHHHHH	21.65	27732954
846	Phosphorylation	IRQFSSCSPRFNKVY EHHHHCCCHHHHHHH	22.51	27050516
853	Phosphorylation	SPRFNKVYSSMERLS CHHHHHHHHHHHHHH	9.17	21214269
854	Phosphorylation	PRFNKVYSSMERLSL HHHHHHHHHHHHHHH	26.62	25850435
855	Phosphorylation	RFNKVYSSMERLSLL HHHHHHHHHHHHHHH	13.63	25850435
860	Phosphorylation	YSSMERLSLLEERRT HHHHHHHHHHHHHCC	36.81	21815630
867	Phosphorylation	SLLEERRTPPPTKRS HHHHHHCCCCCCCCC	46.50	23403867
871	Phosphorylation	ERRTPPPTKRSLSEE HHCCCCCCCCCCCHH	44.88	23403867
874	Phosphorylation	TPPPTKRSLSEEKED CCCCCCCCCCHHCCC	37.49	30266825
876	Phosphorylation	PPTKRSLSEEKEDHS CCCCCCCCHHCCCCC	44.98	23401153
883	Phosphorylation	SEEKEDHSDGLAGLK CHHCCCCCCCCCCCC	45.77	30266825
890	Ubiquitination	SDGLAGLKGRDRSWV CCCCCCCCCCCCCEE	51.48	-
895	Phosphorylation	GLKGRDRSWVIGSPE CCCCCCCCEEECCHH	29.95	23927012
900	Phosphorylation	DRSWVIGSPEILRKR CCCEEECCHHHHHHH	14.29	19664994
909	Phosphorylation	EILRKRLSVSESSHT HHHHHHHCCCCCCCC	27.85	27050516
911	Phosphorylation	LRKRLSVSESSHTES HHHHHCCCCCCCCCC	28.52	27080861
913	Phosphorylation	KRLSVSESSHTESDS HHHCCCCCCCCCCCC	21.66	27080861
914	Phosphorylation	RLSVSESSHTESDSS HHCCCCCCCCCCCCC	30.31	27080861
916	Phosphorylation	SVSESSHTESDSSPP CCCCCCCCCCCCCCC	38.85	27080861
918	Phosphorylation	SESSHTESDSSPPMT CCCCCCCCCCCCCCC	43.90	28348404
920	Phosphorylation	SSHTESDSSPPMTVR CCCCCCCCCCCCCHH	54.76	23312004
921	Phosphorylation	SHTESDSSPPMTVRR CCCCCCCCCCCCHHH	37.70	27080861
931	Phosphorylation	MTVRRRCSGLLDAPR CCHHHHHCCCCCCCC	30.57	30266825
962	Phosphorylation	QEGIWVLTPPSGEGV CCCEEEECCCCCCCC	24.43	28985074
993	Phosphorylation	EEAVGRSSGSSPAME HHHHCCCCCCCCCHH	41.14	22817900
995	Phosphorylation	AVGRSSGSSPAMETR HHCCCCCCCCCHHCC	34.79	22817900
996	Phosphorylation	VGRSSGSSPAMETRG HCCCCCCCCCHHCCC	21.87	28985074
1004	Methylation	PAMETRGRGTSQLAE CCHHCCCCCHHHHHC	41.76	24129315
1006	Phosphorylation	METRGRGTSQLAEGA HHCCCCCHHHHHCHH	16.37	25627689
1007	Phosphorylation	ETRGRGTSQLAEGAT HCCCCCHHHHHCHHH	26.48	25159151
1019	Phosphorylation	GATAKAISDLAVRRA HHHHHHHHHHHHHHH	31.28	21815630
1032	Phosphorylation	RARHRLLSGDSTEKR HHHHHHHCCCCCCCC	45.18	23401153
1035	Phosphorylation	HRLLSGDSTEKRTAR HHHHCCCCCCCCCCC	41.83	29255136
1036	Phosphorylation	RLLSGDSTEKRTARP HHHCCCCCCCCCCCC	50.71	29255136
1050	Phosphorylation	PVNKVIKSASATALS CHHHHHHHHCHHHHH	19.14	28348404
1052	Phosphorylation	NKVIKSASATALSLL HHHHHHHCHHHHHHH	32.99	28348404
1054	Phosphorylation	VIKSASATALSLLIP HHHHHCHHHHHHHCC	26.15	28348404
1088	Phosphorylation	SNPSSRDSSPSRDFL CCCCCCCCCCCCCCH	42.93	30108239
1089	Phosphorylation	NPSSRDSSPSRDFLP CCCCCCCCCCCCCHH	31.05	30108239
1091	Phosphorylation	SSRDSSPSRDFLPAL CCCCCCCCCCCHHHH	46.56	29523821
1117	Phosphorylation	AGKKYGFTLRAIRVY CCHHHCEEEEEEEEE	15.80	24719451
1180	Phosphorylation	VVELILKSGNKVAIS HHHHHHHCCCEEEEE	44.12	29759185
1183	Ubiquitination	LILKSGNKVAISTTP HHHHCCCEEEEECCC	36.25	-
1187	Phosphorylation	SGNKVAISTTPLENT CCCEEEEECCCCCCC	19.25	29759185
1188	Phosphorylation	GNKVAISTTPLENTS CCEEEEECCCCCCCC	26.73	29759185
1189	Phosphorylation	NKVAISTTPLENTSI CEEEEECCCCCCCCC	21.05	29759185
1194	Phosphorylation	STTPLENTSIKVGPA ECCCCCCCCCEECCC	23.58	29759185
1195	Phosphorylation	TTPLENTSIKVGPAR CCCCCCCCCEECCCC	31.81	21712546
1197	Ubiquitination	PLENTSIKVGPARKG CCCCCCCEECCCCCC	40.69	-
1203	Acetylation	IKVGPARKGSYKAKM CEECCCCCCCHHHHH	55.07	7670053
1203 (in isoform 2)	Phosphorylation	-	55.07	25056879
1207	Acetylation	PARKGSYKAKMARRS CCCCCCHHHHHHHHH	43.14	12439283
1209	Acetylation	RKGSYKAKMARRSKR CCCCHHHHHHHHHHH	29.01	7670063
1209 (in isoform 2)	Phosphorylation	-	29.01	25056879
1230	Phosphorylation	QESRKRSSLFRKITK HHHHHHHHHHHHHHH	35.24	24719451
1237	Ubiquitination	SLFRKITKQASLLHT HHHHHHHHHHHHHHH	47.54	-
1240	Phosphorylation	RKITKQASLLHTSRS HHHHHHHHHHHHHCC	29.04	28674151
1244	Phosphorylation	KQASLLHTSRSLSSL HHHHHHHHHCCHHHH	26.29	24702127
1245	Phosphorylation	QASLLHTSRSLSSLN HHHHHHHHCCHHHHH	14.77	25159151
1247	Phosphorylation	SLLHTSRSLSSLNRS HHHHHHCCHHHHHHH	32.16	30266825
1249	Phosphorylation	LHTSRSLSSLNRSLS HHHHCCHHHHHHHHC	33.74	30266825
1250	Phosphorylation	HTSRSLSSLNRSLSS HHHCCHHHHHHHHCC	34.65	30266825
1254	Phosphorylation	SLSSLNRSLSSGESG CHHHHHHHHCCCCCC	31.37	23403867
1256	Phosphorylation	SSLNRSLSSGESGPG HHHHHHHCCCCCCCC	37.23	23927012
1257	Phosphorylation	SLNRSLSSGESGPGS HHHHHHCCCCCCCCC	52.45	23403867
1260	Phosphorylation	RSLSSGESGPGSPTH HHHCCCCCCCCCCCC	54.54	26657352
1264	Phosphorylation	SGESGPGSPTHSHSL CCCCCCCCCCCCCCC	29.74	25849741
1266	Phosphorylation	ESGPGSPTHSHSLSP CCCCCCCCCCCCCCC	37.39	23403867
1268	Phosphorylation	GPGSPTHSHSLSPRS CCCCCCCCCCCCCCC	19.76	23403867
1270	Phosphorylation	GSPTHSHSLSPRSPT CCCCCCCCCCCCCCC	33.29	23403867
1272	Phosphorylation	PTHSHSLSPRSPTQG CCCCCCCCCCCCCCC	22.68	23403867
1275	Phosphorylation	SHSLSPRSPTQGYRV CCCCCCCCCCCCCCC	35.37	28985074
1277	Phosphorylation	SLSPRSPTQGYRVTP CCCCCCCCCCCCCCC	35.55	29449344
1299	Phosphorylation	GNSSQSSSPSSSVPS CCCCCCCCCCCCCCC	33.76	23312004
1301	Phosphorylation	SSQSSSPSSSVPSSP CCCCCCCCCCCCCCC	36.87	23312004
1302	Phosphorylation	SQSSSPSSSVPSSPA CCCCCCCCCCCCCCC	38.45	23312004
1303	Phosphorylation	QSSSPSSSVPSSPAG CCCCCCCCCCCCCCC	42.24	23312004
1306	Phosphorylation	SPSSSVPSSPAGSGH CCCCCCCCCCCCCCC	46.96	23312004
1307	Phosphorylation	PSSSVPSSPAGSGHT CCCCCCCCCCCCCCC	16.82	23312004
1311	Phosphorylation	VPSSPAGSGHTRPSS CCCCCCCCCCCCCHH	29.52	23312004
1314	Phosphorylation	SPAGSGHTRPSSLHG CCCCCCCCCCHHHHC	48.04	23312004
1317	Phosphorylation	GSGHTRPSSLHGLAP CCCCCCCHHHHCHHH	42.09	23312004
1318	Phosphorylation	SGHTRPSSLHGLAPK CCCCCCHHHHCHHHH	27.37	23312004
1337	Phosphorylation	YRSPRRKSAGSIPLS HCCCCCCCCCCCCCC	35.73	23927012
1340	Phosphorylation	PRRKSAGSIPLSPLA CCCCCCCCCCCCCCC	22.28	28152594
1344	Phosphorylation	SAGSIPLSPLAHTPS CCCCCCCCCCCCCCC	16.71	26657352
1349	Phosphorylation	PLSPLAHTPSPPPPT CCCCCCCCCCCCCCC	21.61	28152594
1351	Phosphorylation	SPLAHTPSPPPPTAS CCCCCCCCCCCCCCC	51.71	25850435
1356	Phosphorylation	TPSPPPPTASPQRSP CCCCCCCCCCCCCCC	45.61	30576142
1358	Phosphorylation	SPPPPTASPQRSPSP CCCCCCCCCCCCCCC	24.84	25850435
1362	Phosphorylation	PTASPQRSPSPLSGH CCCCCCCCCCCCCHH	25.20	22167270
1364	Phosphorylation	ASPQRSPSPLSGHVA CCCCCCCCCCCHHHH	39.45	22167270
1367	Phosphorylation	QRSPSPLSGHVAQAF CCCCCCCCHHHHHHC	30.18	23403867
1376	Phosphorylation	HVAQAFPTKLHLSPP HHHHHCCCCCCCCCC	39.52	23403867
1381	Phosphorylation	FPTKLHLSPPLGRQL CCCCCCCCCCCCCCC	17.45	30266825
1389	Phosphorylation	PPLGRQLSRPKSAEP CCCCCCCCCCCCCCC	37.89	23312004
1393	Phosphorylation	RQLSRPKSAEPPRSP CCCCCCCCCCCCCCH	40.31	30266825
1399	Phosphorylation	KSAEPPRSPLLKRVQ CCCCCCCCHHHHHHH	26.18	23401153
1403	Methylation	PPRSPLLKRVQSAEK CCCCHHHHHHHHHHH	59.20	-
1407	Phosphorylation	PLLKRVQSAEKLAAA HHHHHHHHHHHHHHH	35.22	28464451
1418	Phosphorylation	LAAALAASEKKLATS HHHHHHHHHHHHHHC	44.32	28674419
1425	Phosphorylation	SEKKLATSRKHSLDL HHHHHHHCCCCCCCC	33.45	-
1429	Phosphorylation	LATSRKHSLDLPHSE HHHCCCCCCCCCHHH	26.98	25159151
1435	Phosphorylation	HSLDLPHSELKKELP CCCCCCHHHHHHHCC	42.56	25159151
1447	Phosphorylation	ELPPREVSPLEVVGA HCCCCCCCCCEEEEC	21.00	21815630
1503	Phosphorylation	EAIREVDSSEDDTEE HHHHHCCCCCCCCCC	40.58	25159151
1504	Phosphorylation	AIREVDSSEDDTEEG HHHHCCCCCCCCCCC	40.35	25159151
1508	Phosphorylation	VDSSEDDTEEGPENS CCCCCCCCCCCCCCC	48.54	12117771
1515	Phosphorylation	TEEGPENSQGAQELS CCCCCCCCCCCHHHH	28.47	25850435
1522	Phosphorylation	SQGAQELSLAPHPEV CCCCHHHHCCCCCCH	23.02	24144214
1541	Phosphorylation	APKGAGESGEEDPFP CCCCCCCCCCCCCCC	51.06	30266825
1554	Phosphorylation	FPSRDPRSLGPMVPS CCCCCHHHCCCCHHH	42.96	28348404
1564	Phosphorylation	PMVPSLLTGITLGPP CCHHHHHHCCEECCC	31.65	-
1567	Phosphorylation	PSLLTGITLGPPRME HHHHHCCEECCCCCC	27.32	-
1577	Phosphorylation	PPRMESPSGPHRRLG CCCCCCCCCCCCCCC	74.39	28985074
1585	Phosphorylation	GPHRRLGSPQAIEEA CCCCCCCCHHHHHHH	20.59	28348404
1631	Phosphorylation	TQALTALSPSTSGLT HHHHHHHCCCCCCCC	17.84	21712546
1633	Phosphorylation	ALTALSPSTSGLTPT HHHHHCCCCCCCCCC	31.65	23312004
1634	Phosphorylation	LTALSPSTSGLTPTS HHHHCCCCCCCCCCC	30.14	23312004
1635	Phosphorylation	TALSPSTSGLTPTSS HHHCCCCCCCCCCCC	35.82	23312004
1638	Phosphorylation	SPSTSGLTPTSSCSP CCCCCCCCCCCCCCC	28.22	28450419
1640	Phosphorylation	STSGLTPTSSCSPPS CCCCCCCCCCCCCCC	28.21	30576142
1641	Phosphorylation	TSGLTPTSSCSPPSS CCCCCCCCCCCCCCC	30.47	26657352
1642	Phosphorylation	SGLTPTSSCSPPSST CCCCCCCCCCCCCCC	22.54	30576142
1644	Phosphorylation	LTPTSSCSPPSSTSG CCCCCCCCCCCCCCC	41.62	30576142
1647	Phosphorylation	TSSCSPPSSTSGKLS CCCCCCCCCCCCCEE	50.02	28450419
1648	Phosphorylation	SSCSPPSSTSGKLSM CCCCCCCCCCCCEEE	32.16	28450419
1649	Phosphorylation	SCSPPSSTSGKLSMW CCCCCCCCCCCEEEC	45.92	28450419
1650	Phosphorylation	CSPPSSTSGKLSMWS CCCCCCCCCCEEECC	35.56	28450419
1659	Methylation	KLSMWSWKSLIEGPD CEEECCHHHHHCCCC	29.84	115972795
1660	Phosphorylation	LSMWSWKSLIEGPDR EEECCHHHHHCCCCC	28.46	23090842
1669	Phosphorylation	IEGPDRASPSRKATM HCCCCCCCHHHHHHH	25.05	25159151
1671	Phosphorylation	GPDRASPSRKATMAG CCCCCCHHHHHHHHH	43.87	25627689
1690	Phosphorylation	LQDLENTTPAQPKNL HHHHHCCCCCCCCCC	28.36	28555341
1698	Phosphorylation	PAQPKNLSPREQGKT CCCCCCCCHHHCCCC	31.16	25849741
1717	Phosphorylation	APRLAHPSYEDPSQG CCCCCCCCCCCCCCC	31.15	25159151
1768	Phosphorylation	GCPLTQKSEPSLRRG CCCCCCCCCCCCCCC	44.94	20363803
1771	Phosphorylation	LTQKSEPSLRRGQEP CCCCCCCCCCCCCCC	30.38	20363803
1798	Phosphorylation	PDELLKQT------- CHHHHHCC-------	38.70	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MAST2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MAST2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MAST2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCN1_HUMAN	GCN1L1	physical	17353931
TRAF6_HUMAN	TRAF6	physical	15308666
TRAF2_HUMAN	TRAF2	physical	15308666
A4_HUMAN	APP	physical	21832049
SUMO2_HUMAN	SUMO2	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MAST2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-148, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-900, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1503 AND THR-1508, ANDMASS SPECTROMETRY.	17081983 [Abstract]