TRAF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRAF6_HUMAN
• UniProt AC: Q9Y4K3
• Protein Name: TNF receptor-associated factor 6
• Gene Name: TRAF6
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Cytoplasm . Cytoplasm, cell cortex . Nucleus . Lipid droplet . Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein compl
• Protein Description: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production..
• Protein Sequence: MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	TASTGNLSSSFMEEI CCCCCCCCHHHHHHH	28.12	27690223
47	Phosphorylation	ASTGNLSSSFMEEIQ CCCCCCCHHHHHHHC	30.66	27690223
48	Phosphorylation	STGNLSSSFMEEIQG CCCCCCHHHHHHHCC	25.82	27690223
56	Phosphorylation	FMEEIQGYDVEFDPP HHHHHCCCCCCCCCC	10.63	27690223
104	Ubiquitination	SIRDAGHKCPVDNEI HHHHCCCCCCCCCHH	39.04	29967540
124	Ubiquitination	LFPDNFAKREILSLM CCCCCCHHHHHHHHH	46.56	18093978
124	Sumoylation	LFPDNFAKREILSLM CCCCCCHHHHHHHHH	46.56	17135271
124	Sumoylation	LFPDNFAKREILSLM CCCCCCHHHHHHHHH	46.56	-
142	Sumoylation	PNEGCLHKMELRHLE CCCCCCHHHHHHHHH	22.56	-
142	Sumoylation	PNEGCLHKMELRHLE CCCCCCHHHHHHHHH	22.56	18093978
188	Phosphorylation	DCPRRQVSCDNCAAS CCCCCCCCCCCCHHH	13.86	24247654
217	Phosphorylation	LANVICEYCNTILIR HHHHHHHHHCCEEEE	6.13	22468782
220	Phosphorylation	VICEYCNTILIREQM HHHHHHCCEEEECCC	17.38	22468782
266	Phosphorylation	ARHLQENTQSHMRML HHHHHHHHHHHHHHH	30.60	-
288	Phosphorylation	SVIPDSGYISEVRNF CCCCCCCCHHHHHCH	12.77	-
322	Phosphorylation	ELTAKMETQSMYVSE HHHHHHHHHHHHHHH	23.57	25907765
324	Phosphorylation	TAKMETQSMYVSELK HHHHHHHHHHHHHHH	21.36	25907765
326	Phosphorylation	KMETQSMYVSELKRT HHHHHHHHHHHHHHH	13.18	19658100
328	Phosphorylation	ETQSMYVSELKRTIR HHHHHHHHHHHHHHH	21.52	25907765
331	Ubiquitination	SMYVSELKRTIRTLE HHHHHHHHHHHHHHH	43.36	22817900
353	Phosphorylation	AQQCNGIYIWKIGNF HHHCCCEEEEEECCE	11.35	18083107
365	Ubiquitination	GNFGMHLKCQEEEKP CCEEEEEEECCCCCC	21.13	29967540
371	Ubiquitination	LKCQEEEKPVVIHSP EEECCCCCCEEEECC	46.52	29967540
390	Glutathionylation	GKPGYKLCMRLHLQL CCCHHHHHHHHCCCC	0.99	22833525
438	Phosphorylation	RLTILDQSEAPVRQN EEEEECCCCCCCCCC	35.08	27732954
453	Sumoylation	HEEIMDAKPELLAFQ HHHHHHCCHHHHHEE	34.46	18093978
453	Sumoylation	HEEIMDAKPELLAFQ HHHHHHCCHHHHHEE	34.46	-
486	Phosphorylation	LEALRQRTFIKDDTL HHHHHHCCCCCCCEE	22.75	-
489	Ubiquitination	LRQRTFIKDDTLLVR HHHCCCCCCCEEEEE	45.41	24816145
492	Phosphorylation	RTFIKDDTLLVRCEV CCCCCCCEEEEEEEE	31.93	-
507	Phosphorylation	STRFDMGSLRREGFQ ECCCCCCCCCCCCCC	16.44	30108239
518	Phosphorylation	EGFQPRSTDAGV--- CCCCCCCCCCCC---	31.02	25056879

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	PELI3	Q8N2H9	PMID:23042151
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:24578159
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF3IP2	O43734	PMID:19825828
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF6	Q9Y4K3	PMID:17135271
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM23	P36406	PMID:15684077
-	K	Ubiquitination	E3 ubiquitin ligase	BIRC2	Q13490	PMID:20097753
-	K	Ubiquitination	E3 ubiquitin ligase	BIRC3	Q13489	PMID:20097753
-	K	Ubiquitination	E3 ubiquitin ligase	WWP1	Q9H0M0	PMID:23799152
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM38	O00635	PMID:22323536
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:31558697

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
63	K	ubiquitylation	LRRC19 induces 'Lys-63' ubiquitination.	25026888
63	K	ubiquitylation	This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules.	11460167
124	K	Sumoylation	Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.	17135271
124	K	ubiquitylation	Polyubiquitinated on Lys-124 by TRAF3IP2; after cell stimulation with IL17A.	17135271
124	K	ubiquitylation	Polyubiquitinated on Lys-124; after cell stimulation with IL1B or TGFB.	17135271
142	K	Sumoylation	Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.	18093978
453	K	Sumoylation	Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.	18093978

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRAF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EPIPL_HUMAN	EPPK1	physical	17353931
PUR4_HUMAN	PFAS	physical	17353931
C1TC_HUMAN	MTHFD1	physical	17353931
NASP_HUMAN	NASP	physical	17353931
SYVC_HUMAN	VARS	physical	17353931
TERA_HUMAN	VCP	physical	17353931
SYIC_HUMAN	IARS	physical	17353931
GANAB_HUMAN	GANAB	physical	17353931
DDX3X_HUMAN	DDX3X	physical	17353931
IF4E2_HUMAN	EIF4E2	physical	17353931
SYTC_HUMAN	TARS	physical	17353931
PUR6_HUMAN	PAICS	physical	17353931
ASXL2_HUMAN	ASXL2	physical	17353931
ZO2_HUMAN	TJP2	physical	17353931
VDAC1_HUMAN	VDAC1	physical	17353931
PYRG1_HUMAN	CTPS1	physical	17353931
MCM7_HUMAN	MCM7	physical	17353931
KCNQ1_HUMAN	KCNQ1	physical	14743216
PSB5_HUMAN	PSMB5	physical	14743216
PRS4_HUMAN	PSMC1	physical	14743216
PRS7_HUMAN	PSMC2	physical	14743216
PRS6A_HUMAN	PSMC3	physical	14743216
PSMD1_HUMAN	PSMD1	physical	14743216
PSD12_HUMAN	PSMD12	physical	14743216
PSD13_HUMAN	PSMD13	physical	14743216
PSMD3_HUMAN	PSMD3	physical	14743216
PSMD7_HUMAN	PSMD7	physical	14743216
M3K7_HUMAN	MAP3K7	physical	14633987
SIGIR_HUMAN	SIGIRR	physical	12925853
SRC_HUMAN	SRC	physical	10635328
M3K5_HUMAN	MAP3K5	physical	9774977
SQSTM_HUMAN	SQSTM1	physical	10747026
KPCZ_HUMAN	PRKCZ	physical	10747026
IRAK1_HUMAN	IRAK1	physical	10383454
IRAK2_HUMAN	IRAK2	physical	10383454
IRAK3_HUMAN	IRAK3	physical	10383454
TYDP2_HUMAN	TDP2	physical	10764746
XIAP_HUMAN	XIAP	physical	12048196
STRAB_HUMAN	STRADB	physical	12048196
IRAK1_HUMAN	IRAK1	physical	8837778
TNAP3_HUMAN	TNFAIP3	physical	9928991
ZN675_HUMAN	ZNF675	physical	11751921
ZN675_HUMAN	ZNF675	genetic	11751921
TR13B_HUMAN	TNFRSF13B	physical	10880535
IRAK1_HUMAN	IRAK1	physical	12566447
IRAK1_HUMAN	IRAK1	physical	11960013
IRAK4_HUMAN	IRAK4	physical	11960013
ECSIT_MOUSE	Ecsit	physical	10465784
TAXB1_HUMAN	TAX1BP1	physical	10920205
IRAK1_HUMAN	IRAK1	physical	10920205
ZRAN1_HUMAN	ZRANB1	physical	11463333
OTU7B_HUMAN	OTUD7B	physical	11463333
TNAP3_HUMAN	TNFAIP3	physical	11463333
UBE2N_HUMAN	UBE2N	genetic	11057907
UBE2N_HUMAN	UBE2N	physical	11057907
UB2V1_HUMAN	UBE2V1	physical	11057907
TAB2_HUMAN	TAB2	physical	10882101
TAB1_HUMAN	TAB1	physical	10882101
M3K7_HUMAN	MAP3K7	physical	10882101
TAB1_HUMAN	TAB1	physical	10094049
M3K7_HUMAN	MAP3K7	physical	10094049
M3K7_HUMAN	MAP3K7	physical	10921914
M3K5_HUMAN	MAP3K5	physical	10921914
IRAK1_HUMAN	IRAK1	physical	9374458
IRAK2_HUMAN	IRAK2	physical	9374458
M3K7_HUMAN	MAP3K7	physical	19112497
TAB2_HUMAN	TAB2	physical	19112497
TAB1_HUMAN	TAB1	physical	19112497
PSN1_HUMAN	PSEN1	physical	19012753
HSPB2_HUMAN	HSPB2	physical	18950704
RUNX1_HUMAN	RUNX1	physical	18768464
FHL2_HUMAN	FHL2	physical	18768464
TGFR1_HUMAN	TGFBR1	physical	18758450
M3K7_HUMAN	MAP3K7	physical	18758450
PP4C_HUMAN	PPP4C	physical	18634786
TRAF6_HUMAN	TRAF6	physical	18617513
TAB2_HUMAN	TAB2	physical	18299187
SDCB1_HUMAN	SDCBP	physical	18234474
IRAK1_HUMAN	IRAK1	physical	18234474
TNAP3_HUMAN	TNFAIP3	physical	18164316
IRAK2_HUMAN	IRAK2	physical	17878161
I17RA_HUMAN	IL17RA	physical	17346928
NEMO_HUMAN	IKBKG	physical	17135271
M3K7_HUMAN	MAP3K7	physical	16543409
IRF8_HUMAN	IRF8	physical	16484229
IRF7_HUMAN	IRF7	physical	15361868
HSP74_HUMAN	HSPA4	physical	16697380
SMUF1_HUMAN	SMURF1	genetic	19937093
IRAK1_HUMAN	IRAK1	physical	11287640
NUMBL_HUMAN	NUMBL	physical	20079715
MARH5_HUMAN	MARCH5	physical	21625535
UBE2N_HUMAN	UBE2N	physical	19810754
RANB9_HUMAN	RANBP9	physical	21805090
PARK7_HUMAN	PARK7	physical	20634198
SYUA_HUMAN	SNCA	physical	20634198
UBE2N_HUMAN	UBE2N	physical	21113135
BIRC2_HUMAN	BIRC2	physical	20097753
BIRC3_HUMAN	BIRC3	physical	20097753
BECN1_HUMAN	BECN1	physical	20501938
M3K11_HUMAN	MAP3K11	physical	19586614
M3K3_HUMAN	MAP3K3	physical	19903815
SQSTM_HUMAN	SQSTM1	physical	19903815
IRAK1_HUMAN	IRAK1	physical	21220427
TNAP3_HUMAN	TNFAIP3	physical	21220427
RUSC1_HUMAN	RUSC1	physical	19365808
UBE2N_HUMAN	UBE2N	physical	19465916
TRAF6_HUMAN	TRAF6	physical	19465916
PEBP1_HUMAN	PEBP1	physical	20043910
M3K7_HUMAN	MAP3K7	physical	19675569
TRAF6_HUMAN	TRAF6	physical	19675569
TCAM1_HUMAN	TICAM1	physical	20047764
IRAK1_HUMAN	IRAK1	physical	22033459
UBC_HUMAN	UBC	physical	22033459
HD_HUMAN	HTT	physical	21454471
UBP4_HUMAN	USP4	physical	22029577
FOXG1_HUMAN	FOXG1	physical	19683680
TRAF6_HUMAN	TRAF6	physical	20512936
IRF7_HUMAN	IRF7	physical	22095711
TRAF2_HUMAN	TRAF2	physical	21903422
IRAK2_HUMAN	IRAK2	physical	21903422
RSAD2_MOUSE	Rsad2	physical	21435586
UBP7_HUMAN	USP7	physical	18952891
NLRX1_HUMAN	NLRX1	physical	21703539
NTRK1_HUMAN	NTRK1	physical	16246731
SRC_HUMAN	SRC	physical	22447928
IRAK1_HUMAN	IRAK1	physical	22447928
FYN_HUMAN	FYN	physical	22447928
IRAK1_HUMAN	IRAK1	physical	19716405
TLR3_HUMAN	TLR3	physical	12609980
TAB2_HUMAN	TAB2	physical	12609980
M3K7_HUMAN	MAP3K7	physical	12609980
ITCH_HUMAN	ITCH	physical	18246070
MYB_HUMAN	MYB	physical	18093978
CASP8_HUMAN	CASP8	physical	16920630
IKKB_HUMAN	IKBKB	physical	16920630
BCL10_HUMAN	BCL10	physical	16920630
SQSTM_HUMAN	SQSTM1	physical	15340068
UBE2N_HUMAN	UBE2N	physical	17327397
ARRB1_HUMAN	ARRB1	physical	16378096
ARRB2_HUMAN	ARRB2	physical	16378096
ARRB1_RAT	Arrb1	physical	16378096
ARRB2_RAT	Arrb2	physical	16378096
ARRS_BOVIN	SAG	physical	16378096
TRAF6_HUMAN	TRAF6	physical	16378096
TAB2_HUMAN	TAB2	physical	15327770
CBLB_HUMAN	CBLB	physical	17878343
PDLI7_HUMAN	PDLIM7	physical	16446357
M3K7_HUMAN	MAP3K7	physical	19843958
M3K3_HUMAN	MAP3K3	physical	19843958
TAB2_HUMAN	TAB2	physical	12242293
M3K7_HUMAN	MAP3K7	physical	12242293
NLRC3_HUMAN	NLRC3	physical	22863753
MAVS_HUMAN	MAVS	physical	22908223
TGFR2_HUMAN	TGFBR2	physical	18922473
TGFR1_HUMAN	TGFBR1	physical	18922473
IRAK1_HUMAN	IRAK1	physical	11397809
TRAF4_HUMAN	TRAF4	physical	16052631
TNR1B_HUMAN	TNFRSF1B	physical	9915784
TIRAP_HUMAN	TIRAP	physical	15247281
M3K5_HUMAN	MAP3K5	physical	17724081
TRAF2_HUMAN	TRAF2	physical	9500555
IRAK1_HUMAN	IRAK1	physical	17785851
M3K14_HUMAN	MAP3K14	physical	9275204
M3K3_HUMAN	MAP3K3	physical	14661019
TRAF6_HUMAN	TRAF6	physical	9718306
PELI3_HUMAN	PELI3	physical	12874243
IRAK1_HUMAN	IRAK1	physical	12496252
IL1R1_HUMAN	IL1R1	physical	12496252
M3K7_HUMAN	MAP3K7	physical	12496252
TAB2_HUMAN	TAB2	physical	12496252
PELI1_HUMAN	PELI1	physical	12496252
RIPK2_HUMAN	RIPK2	physical	21097508
PSN1_HUMAN	PSEN1	physical	18996842
PSN2_HUMAN	PSEN2	physical	18996842
TNR5_HUMAN	CD40	physical	12140561
TCAM1_HUMAN	TICAM1	physical	14530355
TNR16_HUMAN	NGFR	physical	14960584
TCAM2_HUMAN	TICAM2	physical	12721283
TIRAP_HUMAN	TIRAP	physical	19592497
MAVS_HUMAN	MAVS	physical	16153868
IRAK1_HUMAN	IRAK1	physical	16024789
IRF5_HUMAN	IRF5	physical	15665823
TNR5_HUMAN	CD40	physical	12220533
PELI3_HUMAN	PELI3	physical	23042151
NF2IP_HUMAN	NFATC2IP	physical	11435475
CASP4_HUMAN	CASP4	physical	18056395
IRAK1_HUMAN	IRAK1	physical	18056395
ZMY11_HUMAN	ZMYND11	physical	20138174
CAR11_HUMAN	CARD11	physical	18625728
UB2L3_HUMAN	UBE2L3	physical	16246731
UBE2N_HUMAN	UBE2N	physical	18617513
UB2V1_HUMAN	UBE2V1	physical	17135271
UBE2N_HUMAN	UBE2N	physical	15327770
UB2V1_HUMAN	UBE2V1	physical	15327770
UB2V1_HUMAN	UBE2V1	physical	20501938
UB2V1_HUMAN	UBE2V1	physical	19675569
UB2D3_HUMAN	UBE2D3	physical	19675569
A4_HUMAN	APP	physical	21832049
WDR34_HUMAN	WDR34	physical	19521662
TRAF6_HUMAN	TRAF6	physical	22643835
NUMBL_HUMAN	NUMBL	physical	22593207
M3K11_HUMAN	MAP3K11	physical	23172226
STAT3_HUMAN	STAT3	physical	23185365
IRAK1_HUMAN	IRAK1	physical	23244239
UBP2_HUMAN	USP2	physical	23264041
MALT1_HUMAN	MALT1	physical	17948050
UBE2O_HUMAN	UBE2O	physical	23381138
MYD88_HUMAN	MYD88	physical	23381138
LTP_EBVB9	BPLF1	physical	23365429
SQSTM_HUMAN	SQSTM1	physical	16874300
SPHK1_HUMAN	SPHK1	physical	17124500
M3K14_HUMAN	MAP3K14	physical	16286467
UBC_HUMAN	UBC	physical	23437331
NOD2_HUMAN	NOD2	physical	23437331
CIKS_HUMAN	TRAF3IP2	physical	22851696
IRAK1_HUMAN	IRAK1	physical	17197697
MYD88_HUMAN	MYD88	physical	16517750
LAT_HUMAN	LAT	physical	23514740
HSP74_HUMAN	HSPA4	physical	14702098
UCHL1_HUMAN	UCHL1	physical	23717208
ULK1_HUMAN	ULK1	physical	23524951
AMRA1_HUMAN	AMBRA1	physical	23524951
SQSTM_HUMAN	SQSTM1	physical	23017601
TNR16_HUMAN	NGFR	physical	23017601
PSN1_HUMAN	PSEN1	physical	23707529
PSN2_HUMAN	PSEN2	physical	23707529
AKT1_HUMAN	AKT1	physical	19713527
UB2V1_HUMAN	UBE2V1	physical	19713527
WWP1_HUMAN	WWP1	physical	23799152
PINK1_HUMAN	PINK1	physical	23885119
UBE2N_HUMAN	UBE2N	physical	23885119
UB2V1_HUMAN	UBE2V1	physical	23885119
TRI25_HUMAN	TRIM25	physical	22493164
TRAF5_HUMAN	TRAF5	physical	22493164
TRAF6_HUMAN	TRAF6	physical	22493164
RN114_HUMAN	RNF114	physical	22493164
RNF37_HUMAN	UBOX5	physical	22493164
RPTOR_HUMAN	RPTOR	physical	23911927
MTOR_HUMAN	MTOR	physical	23911927
SQSTM_HUMAN	SQSTM1	physical	23911927
RRAGC_HUMAN	RRAGC	physical	23911927
YBOX1_HUMAN	YBX1	physical	21988832
TRAF6_HUMAN	TRAF6	physical	21988832
TAB2_HUMAN	TAB2	physical	24061540
ERN1_HUMAN	ERN1	physical	23942232
TRAD1_HUMAN	TRAFD1	physical	16221674
IRAK1_HUMAN	IRAK1	physical	24434549
M3K7_HUMAN	MAP3K7	physical	24434549
NEMO_HUMAN	IKBKG	physical	24270048
TRAF6_HUMAN	TRAF6	physical	24586659
AKT1_HUMAN	AKT1	physical	21816939
IRF7_HUMAN	IRF7	physical	18710948
UBE2N_HUMAN	UBE2N	physical	18710948
UB2V1_HUMAN	UBE2V1	physical	18710948
CHIP_HUMAN	STUB1	physical	24578159
LGMN_HUMAN	LGMN	physical	24610907
PKHO1_HUMAN	PLEKHO1	physical	24777252
BIRC3_HUMAN	BIRC3	physical	24464131
IRAK1_HUMAN	IRAK1	physical	24735611
KI2L4_HUMAN	KIR2DL4	physical	24337384
HIF1A_HUMAN	HIF1A	physical	23722539
MAVS_HUMAN	MAVS	physical	23545497
M3K7_HUMAN	MAP3K7	physical	22924441
TAB2_HUMAN	TAB2	physical	22924441
EDAD_HUMAN	EDARADD	physical	22924441
TRAF6_HUMAN	TRAF6	physical	22924441
RASK_HUMAN	KRAS	physical	24026882
OTU7A_HUMAN	OTUD7A	physical	23792447
DCBD2_HUMAN	DCBLD2	physical	25061874
PSN1_HUMAN	PSEN1	physical	24399296
PP4R1_HUMAN	PPP4R1	physical	25134449
CIKS_HUMAN	TRAF3IP2	physical	25202827
UBC_HUMAN	UBC	physical	15125833
TRAF6_HUMAN	TRAF6	physical	15125833
NEMO_HUMAN	IKBKG	physical	15125833
UB2V1_HUMAN	UBE2V1	physical	15125833
TRAF6_HUMAN	TRAF6	physical	19549727
UBE2N_HUMAN	UBE2N	physical	19549727
UB2D1_HUMAN	UBE2D1	physical	19549727
UB2D2_HUMAN	UBE2D2	physical	19549727
UB2D3_HUMAN	UBE2D3	physical	19549727
UB2E1_HUMAN	UBE2E1	physical	19549727
TRAF6_HUMAN	TRAF6	physical	25340740
TAU_HUMAN	MAPT	physical	15953362
UB2L3_HUMAN	UBE2L3	physical	15953362
UBE2N_HUMAN	UBE2N	physical	24610907
UB2V1_HUMAN	UBE2V1	physical	24610907
CALX_HUMAN	CANX	physical	23514740
TRAF6_HUMAN	TRAF6	physical	25416956
YES_HUMAN	YES1	physical	25416956
UBP2_HUMAN	USP2	physical	25416956
CIKS_HUMAN	TRAF3IP2	physical	25416956
POLI_HUMAN	POLI	physical	25416956
PKHF2_HUMAN	PLEKHF2	physical	25416956
EDAD_HUMAN	EDARADD	physical	25416956
IRAK1_HUMAN	IRAK1	physical	18347055
TNAP3_HUMAN	TNFAIP3	physical	23737552
TRAF6_HUMAN	TRAF6	physical	21185369
UBC_HUMAN	UBC	physical	15327770
CYLD_HUMAN	CYLD	physical	26056944
IFIT3_HUMAN	IFIT3	physical	21813773
CIKS_HUMAN	TRAF3IP2	physical	21822258
M3K7_HUMAN	MAP3K7	physical	21822258
TRAF6_HUMAN	TRAF6	physical	25527291
UB2D3_HUMAN	UBE2D3	physical	25527291
TRAF6_HUMAN	TRAF6	physical	25425640
DDB1_HUMAN	DDB1	physical	25499913
AMRA1_HUMAN	AMBRA1	physical	25499913
TCAM2_HUMAN	TICAM2	physical	24812060
PKHF2_HUMAN	PLEKHF2	physical	21516116
RACK1_HUMAN	GNB2L1	physical	26038599
M3K7_HUMAN	MAP3K7	physical	25963657
UBC_HUMAN	UBC	physical	25494483
MAVS_HUMAN	MAVS	physical	26385923
TRADD_HUMAN	TRADD	physical	24758719
UBP20_HUMAN	USP20	physical	26839314
ARRB2_RAT	Arrb2	physical	26839314
UBE2N_HUMAN	UBE2N	physical	25548215
NEMO_HUMAN	IKBKG	physical	25548215
RN166_HUMAN	RNF166	physical	26456228
TGFR1_HUMAN	TGFBR1	physical	25622187
STK26_HUMAN	STK26	physical	25642822
TRAF6_HUMAN	TRAF6	physical	25642822
IRF7_HUMAN	IRF7	physical	26224488
TANK_HUMAN	TANK	physical	25861989
UBP10_HUMAN	USP10	physical	25861989
ZC12A_HUMAN	ZC3H12A	physical	25861989
M3K7_HUMAN	MAP3K7	physical	26038599
MP2K6_HUMAN	MAP2K6	physical	26038599
UBP20_HUMAN	USP20	physical	21525354
UBP33_HUMAN	USP33	physical	21525354
SOCS1_HUMAN	SOCS1	physical	26633718
SOCS3_HUMAN	SOCS3	physical	26633718
SMN_HUMAN	SMN1	physical	28214532
TRAF6_HUMAN	TRAF6	physical	28214532
NEMO_HUMAN	IKBKG	physical	28214532
CRBN_HUMAN	CRBN	physical	27468689
TRAF6_HUMAN	TRAF6	physical	27791197
UBE2N_HUMAN	UBE2N	physical	27791197
TBK1_HUMAN	TBK1	physical	28049150
BAG6_RAT	Bag6	physical	27501752
TRAF6_HUMAN	TRAF6	physical	27501752
M3K7_HUMAN	MAP3K7	physical	27501752
DDX3X_HUMAN	DDX3X	physical	27507811
DDX17_HUMAN	DDX17	physical	27507811
CPN2_HUMAN	CPN2	physical	27507811
SYCC_HUMAN	CARS	physical	27507811
EF1A1_HUMAN	EEF1A1	physical	27507811
FUS_HUMAN	FUS	physical	27507811
K2C1_HUMAN	KRT1	physical	27507811
K22E_HUMAN	KRT2	physical	27507811
K2C3_HUMAN	KRT3	physical	27507811
K2C5_HUMAN	KRT5	physical	27507811
K1C9_HUMAN	KRT9	physical	27507811
K1C10_HUMAN	KRT10	physical	27507811
K1C12_HUMAN	KRT12	physical	27507811
NF1_HUMAN	NF1	physical	27507811
SPD2A_HUMAN	SH3PXD2A	physical	27507811
SIA4A_HUMAN	ST3GAL1	physical	27507811
UBC_HUMAN	UBC	physical	27507811
VAV3_HUMAN	VAV3	physical	27507811
ZN326_HUMAN	ZNF326	physical	27507811
ZW10_HUMAN	ZW10	physical	27507811
K2C8_HUMAN	KRT8	physical	27586056
TRAF6_HUMAN	TRAF6	physical	27586056
DCP1A_HUMAN	DCP1A	physical	27315556
KPCD_HUMAN	PRKCD	physical	22528498
MALT1_HUMAN	MALT1	physical	22528498
CRTC2_HUMAN	CRTC2	physical	27990298
BASI_HUMAN	BSG	physical	26769849
CUL5_HUMAN	CUL5	physical	27233966
M3K7_HUMAN	MAP3K7	physical	27249171
P53_HUMAN	TP53	physical	27818144
TRI13_HUMAN	TRIM13	physical	28087809
UBE2N_HUMAN	UBE2N	physical	27173435
FANCA_HUMAN	FANCA	physical	28215707
H2AX_HUMAN	H2AFX	physical	27918549
HIF1A_HUMAN	HIF1A	physical	27918549
TRAF6_HUMAN	TRAF6	physical	27918549
UBE2N_HUMAN	UBE2N	physical	27918549
NEMO_HUMAN	IKBKG	physical	27695001
UBE2N_HUMAN	UBE2N	physical	27695001
CUL5_HUMAN	CUL5	physical	28522566
TRAF6_HUMAN	TRAF6	physical	28522566
OTU1_HUMAN	YOD1	physical	28244869
TRAF6_HUMAN	TRAF6	physical	28244869
UBE2N_HUMAN	UBE2N	physical	28244869
TNAP3_HUMAN	TNFAIP3	physical	28244869
SQSTM_HUMAN	SQSTM1	physical	28244869
TRAF6_HUMAN	TRAF6	physical	28884970
UBC_HUMAN	UBC	physical	29176576
TRAF6_HUMAN	TRAF6	physical	29176576
IPMK_HUMAN	IPMK	physical	28439546
MAVS_HUMAN	MAVS	physical	29125880
TBK1_HUMAN	TBK1	physical	29125880
IKKE_HUMAN	IKBKE	physical	29125880
UBP4_HUMAN	USP4	physical	22262844

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Sumoylation

"Nuclear tumor necrosis factor receptor-associated factor 6 inlymphoid cells negatively regulates c-Myb-mediated transactivationthrough small ubiquitin-related modifier-1 modification.";
Pham L.V., Zhou H.J., Lin-Lee Y.C., Tamayo A.T., Yoshimura L.C.,Fu L., Darnay B.G., Ford R.J.;
J. Biol. Chem. 283:5081-5089(2008).
Cited for: SUBCELLULAR LOCATION, FUNCTION, SUMOYLATION AT LYS-124; LYS-142 ANDLYS-453, UBIQUITINATION, INTERACTION WITH HDAC1 AND RANGAP1, ANDMUTAGENESIS OF LYS-124; LYS-142 AND LYS-453.
PubMed: 18093978

"Site-specific Lys-63-linked tumor necrosis factor receptor-associatedfactor 6 auto-ubiquitination is a critical determinant of I kappa Bkinase activation.";
Lamothe B., Besse A., Campos A.D., Webster W.K., Wu H., Darnay B.G.;
J. Biol. Chem. 282:4102-4112(2007).
Cited for: MUTAGENESIS OF CYS-70 AND LYS-124, UBIQUITINATION AT LYS-124, ANDFUNCTION.
PubMed: 17135271