STRAB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STRAB_HUMAN
• UniProt AC: Q9C0K7
• Protein Name: STE20-related kinase adapter protein beta
• Gene Name: STRADB
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity)..
• Protein Sequence: MSLLDCFCTSRTQVESLRPEKQSETSIHQYLVDEPTLSWSRPSTRASEVLCSTNVSHYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSASSLLSHVFFKQMKEESQDSILSLLPPAYNKPSISLPPVLPWTEPECDFPDEKDSYWEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	TPTGTLVTIKITNLE CCCCCEEEEEEECCC	21.48	22210691
159	Phosphorylation	FPEGMSETLIRNILF CCCCCCHHHHHHHHH	21.85	18491316
297	Phosphorylation	DISIFPQSESRMKNS CEEECCCCHHHHHCC	37.46	29759185
299	Phosphorylation	SIFPQSESRMKNSQS EECCCCHHHHHCCCC	42.81	29759185
304	Phosphorylation	SESRMKNSQSGVDSG CHHHHHCCCCCCCCC	21.87	27050516
306	Phosphorylation	SRMKNSQSGVDSGIG HHHHCCCCCCCCCCC	40.37	21712546
310	Phosphorylation	NSQSGVDSGIGESVL CCCCCCCCCCCCEEE	29.88	-
315	Phosphorylation	VDSGIGESVLVSSGT CCCCCCCEEEEECCC	18.61	21712546
319	Phosphorylation	IGESVLVSSGTHTVN CCCEEEEECCCCEEC	20.91	26471730
320	Phosphorylation	GESVLVSSGTHTVNS CCEEEEECCCCEECC	39.99	26471730
322	Phosphorylation	SVLVSSGTHTVNSDR EEEEECCCCEECCCC	19.13	26471730
324	Phosphorylation	LVSSGTHTVNSDRLH EEECCCCEECCCCCC	22.63	26471730
327	Phosphorylation	SGTHTVNSDRLHTPS CCCCEECCCCCCCCC	21.55	26471730
370	Ubiquitination	LLSHVFFKQMKEESQ HHHHHHHHHHHHHCH	37.71	32015554
376	Phosphorylation	FKQMKEESQDSILSL HHHHHHHCHHHHHHH	40.14	29978859
379	Phosphorylation	MKEESQDSILSLLPP HHHHCHHHHHHHCCC	20.14	29978859
382	Phosphorylation	ESQDSILSLLPPAYN HCHHHHHHHCCCCCC	26.62	29978859
388	Phosphorylation	LSLLPPAYNKPSISL HHHCCCCCCCCCCCC	29.50	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STRAB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STRAB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STRAB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STK11_HUMAN	STK11	physical	28514442
CAB39_HUMAN	CAB39	physical	28514442
NBEA_HUMAN	NBEA	physical	28514442
KS6A2_HUMAN	RPS6KA2	physical	28514442
KS6A3_HUMAN	RPS6KA3	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.