NBEA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NBEA_HUMAN
• UniProt AC: Q8NFP9
• Protein Name: Neurobeachin
• Gene Name: NBEA
• Organism: Homo sapiens (Human).
• Sequence Length: 2946
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity)..
• Protein Sequence: MASEKPGPGPGLEPQPVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGSGSVMLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVSDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKEDLPNSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSISERDLASSTKGLEYAEMTATTLETESSSSKIVPNIDAGSIISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQEVPQSVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETTRTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEEQVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKGINVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
168	Phosphorylation	EQVLLKMSAVDDMIA HHHHHHHHHHHHHHH	24.45	25022875
187	Phosphorylation	DMLGVLASYSITVKE HHHHHHHHCCCCHHH	18.43	25022875
188	Phosphorylation	MLGVLASYSITVKEL HHHHHHHCCCCHHHH	9.85	25022875
189	Phosphorylation	LGVLASYSITVKELK HHHHHHCCCCHHHHH	14.86	25022875
191	Phosphorylation	VLASYSITVKELKLL HHHHCCCCHHHHHHH	21.42	25022875
206	Phosphorylation	FSMLRGESGIWPRHA HHHHCCCCCCCHHHH	38.10	-
281	Phosphorylation	DKDKPYLYCFRTSKG CCCCCEEEEEECCCC	5.45	28634298
285	Phosphorylation	PYLYCFRTSKGVGYS CEEEEEECCCCCCCC	17.97	28634298
286	Phosphorylation	YLYCFRTSKGVGYSA EEEEEECCCCCCCCE	24.13	28634298
326	Phosphorylation	DFQPRKWYMISIVHI CCCCCEEEEEEEEEH	6.39	26074081
329	Phosphorylation	PRKWYMISIVHIYNR CCEEEEEEEEEHHHC	11.30	26074081
334	Phosphorylation	MISIVHIYNRWRNSE EEEEEEHHHCCCCCC	5.47	26074081
340	Phosphorylation	IYNRWRNSEIRCYVN HHHCCCCCCCEEEEC	26.31	26074081
422	Phosphorylation	TFKFKSESDIHLAEH EEEECCHHHCCCHHH	49.29	26074081
435	Phosphorylation	EHHKQVLYDGKLASS HHHCEEEECCCCCEE	24.64	26074081
646	Ubiquitination	TVLQLMHTLKYYYWV HHHHHHHHHHEEEEE	15.81	21890473
758	Phosphorylation	YKLLASKSESIWVQA HHHHHCCCCCHHHHH	33.80	-
760	Phosphorylation	LLASKSESIWVQALK HHHCCCCCHHHHHHH	28.92	-
870	Phosphorylation	EVRRLFLSDMIKLFS HHHHHHHHHHHHHHC	20.14	29449344
901	Phosphorylation	DWMFSLGYINPKNSE HHHHHCCCCCCCCCH	11.65	-
913	Phosphorylation	NSEEQKITEMVYNIF CCHHHHHHHHHHHHH	25.68	24719451
917	Phosphorylation	QKITEMVYNIFRILL HHHHHHHHHHHHHHH	10.96	24719451
1007	Phosphorylation	IREIEDLSQSQSPES EEEEHHHHCCCCCCC	39.86	27732954
1009	Phosphorylation	EIEDLSQSQSPESET EEHHHHCCCCCCCCC	29.29	27732954
1011	Phosphorylation	EDLSQSQSPESETDY HHHHCCCCCCCCCCC	35.56	18510355
1014	Phosphorylation	SQSQSPESETDYPVS HCCCCCCCCCCCCCC	49.53	29978859
1016	Phosphorylation	SQSPESETDYPVSTD CCCCCCCCCCCCCCC	50.54	27732954
1018	Phosphorylation	SPESETDYPVSTDTR CCCCCCCCCCCCCHH	16.98	29978859
1021	Phosphorylation	SETDYPVSTDTRDLL CCCCCCCCCCHHHHH	18.96	27732954
1022	Phosphorylation	ETDYPVSTDTRDLLM CCCCCCCCCHHHHHH	41.44	27732954
1024	Phosphorylation	DYPVSTDTRDLLMST CCCCCCCHHHHHHCC	26.60	27732954
1114	Phosphorylation	LQNNVHGSVGIIKKN HHHCCCCCEEEEECC	11.42	27251275
1142	Phosphorylation	EKEDLPNSSTSFLFD CCCCCCCCCHHCHHC	32.81	26074081
1143	Phosphorylation	KEDLPNSSTSFLFDK CCCCCCCCHHCHHCC	34.41	26074081
1144	Phosphorylation	EDLPNSSTSFLFDKI CCCCCCCHHCHHCCC	24.26	26074081
1145	Phosphorylation	DLPNSSTSFLFDKIP CCCCCCHHCHHCCCC	23.15	26074081
1212	Phosphorylation	EKEFKIHTTSDGMSS EEEEEEEECCCCCCC	31.31	-
1213	Phosphorylation	KEFKIHTTSDGMSSI EEEEEEECCCCCCCC	15.62	27732954
1214	Phosphorylation	EFKIHTTSDGMSSIS EEEEEECCCCCCCCC	33.07	27732954
1218	Phosphorylation	HTTSDGMSSISERDL EECCCCCCCCCHHHH	30.01	28857561
1219	Phosphorylation	TTSDGMSSISERDLA ECCCCCCCCCHHHHH	22.65	28857561
1221	Phosphorylation	SDGMSSISERDLASS CCCCCCCCHHHHHHC	28.64	27732954
1234	Phosphorylation	SSTKGLEYAEMTATT HCCCCHHHHEEEEEE	16.95	28796482
1238	Phosphorylation	GLEYAEMTATTLETE CHHHHEEEEEEEECC	16.62	28985074
1240	Phosphorylation	EYAEMTATTLETESS HHHEEEEEEEECCCC	23.81	28985074
1241	Phosphorylation	YAEMTATTLETESSS HHEEEEEEEECCCCC	21.82	28985074
1244	Phosphorylation	MTATTLETESSSSKI EEEEEEECCCCCCCC	44.26	27251275
1246	Phosphorylation	ATTLETESSSSKIVP EEEEECCCCCCCCCC	42.83	27251275
1247	Phosphorylation	TTLETESSSSKIVPN EEEECCCCCCCCCCC	32.19	27251275
1248	Phosphorylation	TLETESSSSKIVPNI EEECCCCCCCCCCCC	44.95	-
1249	Phosphorylation	LETESSSSKIVPNID EECCCCCCCCCCCCC	28.48	-
1259	Phosphorylation	VPNIDAGSIISDTER CCCCCCCCCCCCCCC	20.61	22199227
1262	Phosphorylation	IDAGSIISDTERSDD CCCCCCCCCCCCCCC	36.49	23898821
1264	Phosphorylation	AGSIISDTERSDDGK CCCCCCCCCCCCCCC	26.89	22617229
1267	Phosphorylation	IISDTERSDDGKESG CCCCCCCCCCCCCCC	33.55	22617229
1273	Phosphorylation	RSDDGKESGKEIRKI CCCCCCCCCHHEEEC	59.66	28857561
1283	O-linked_Glycosylation	EIRKIQTTTTTQAVQ HEEECEEECCCHHHC	13.03	28657654
1283	Phosphorylation	EIRKIQTTTTTQAVQ HEEECEEECCCHHHC	13.03	-
1321	Phosphorylation	EEQRRQFSPGPRTTM HHHHHCCCCCCCCCC	22.17	23898821
1512	Phosphorylation	QEVPQSVTATAASKT CCCCCCHHCCCCCCC	24.44	-
1517	Phosphorylation	SVTATAASKTPLENV CHHCCCCCCCCCCCC	34.30	-
1529	Phosphorylation	ENVPGNLSPIKDPDR CCCCCCCCCCCCHHH	28.69	25159151
1557	Phosphorylation	VFRDVDDSKQAQFLA EEECCCCHHHHHHHH	23.39	25332170
1606	Phosphorylation	NIRQEINSPTSTVVV CHHHHCCCCCCEEEE	34.90	28857561
1608	Phosphorylation	RQEINSPTSTVVVIP HHHCCCCCCEEEEEC	36.53	28857561
1635	Phosphorylation	AKLIPEQSFGHSFYK HHHCCCCCCCCCCCC	31.37	28857561
1639	Phosphorylation	PEQSFGHSFYKETPA CCCCCCCCCCCCCCC	30.56	28857561
1714	Phosphorylation	LSSEVKKSQESLTEN HCHHHHHHHHHHCCC	33.20	20363803
1717	Phosphorylation	EVKKSQESLTENPSE HHHHHHHHHCCCCCC	32.71	20363803
1719	Phosphorylation	KKSQESLTENPSETL HHHHHHHCCCCCCCC	42.89	27732954
1723	Phosphorylation	ESLTENPSETLKPAT HHHCCCCCCCCCCCC	55.59	29449344
1725	Phosphorylation	LTENPSETLKPATSI HCCCCCCCCCCCCCC	44.40	29449344
1730	Phosphorylation	SETLKPATSISSISQ CCCCCCCCCCHHHHC	34.81	23312004
1731	Phosphorylation	ETLKPATSISSISQT CCCCCCCCCHHHHCC	23.68	29449344
1733	Phosphorylation	LKPATSISSISQTKG CCCCCCCHHHHCCCC	22.76	29449344
1734	Phosphorylation	KPATSISSISQTKGI CCCCCCHHHHCCCCC	25.29	27251275
1736	Phosphorylation	ATSISSISQTKGINV CCCCHHHHCCCCCCH	33.47	29449344
1738	Phosphorylation	SISSISQTKGINVKE CCHHHHCCCCCCHHH	25.17	27251275
1786	Phosphorylation	ILPMQFHSFDRSVVV EECCCCCCCCCEEEE	30.08	28348404
1849	Phosphorylation	AVDSGSSSSSSSSSF CCCCCCCCCCCCCCC	35.62	-
1850	Phosphorylation	VDSGSSSSSSSSSFV CCCCCCCCCCCCCCC	35.87	-
1851	Phosphorylation	DSGSSSSSSSSSFVN CCCCCCCCCCCCCCC	35.87	-
1852	Phosphorylation	SGSSSSSSSSSFVNG CCCCCCCCCCCCCCC	35.87	-
1887	Acetylation	ENMSITAKLERALEK HHCCHHHHHHHHHHH	42.08	18530645
2014	Dimethylation	CAQYAADRREEEKMC HHHHHHHHHHHHHHH	43.09	-
2014	Methylation	CAQYAADRREEEKMC HHHHHHHHHHHHHHH	43.09	30760477
2015	Dimethylation	AQYAADRREEEKMCD HHHHHHHHHHHHHHH	57.11	-
2015	Methylation	AQYAADRREEEKMCD HHHHHHHHHHHHHHH	57.11	30762673
2048	Phosphorylation	QKILNILTNKHGAWG HHHHHHHCCCCCCCC	38.12	22673903
2126	Phosphorylation	IVNQNAETELMLEGD HHCCCCCCEEEECCC	31.82	28102081
2138	Phosphorylation	EGDDDAVSLLQEKEI CCCCCHHHHHHHHCC	25.69	30278072
2235	Phosphorylation	EVFMANRTSVMFNFP HHHHCCCCEEEECCC	26.02	22210691
2236	Phosphorylation	VFMANRTSVMFNFPD HHHCCCCEEEECCCC	14.35	22210691
2246	Phosphorylation	FNFPDQATVKKVVYS ECCCCHHHHEEEEEE	27.50	22210691
2311	Phosphorylation	NTIAGRTYNDLNQYP HHHCCCCCHHHHCCC	12.81	28985074
2327	Phosphorylation	FPWVLTNYESEELDL CCEEECCCCCCCCCC	18.65	28985074
2329	Phosphorylation	WVLTNYESEELDLTL EEECCCCCCCCCCCC	26.47	28985074
2344	Phosphorylation	PGNFRDLSKPIGALN CCCHHHCCCCCCCCC	40.45	20860994
2345	Ubiquitination	GNFRDLSKPIGALNP CCHHHCCCCCCCCCH	48.21	21890473
2345 (in isoform 1)	Ubiquitination	-	48.21	21890473
2353	Ubiquitination	PIGALNPKRAVFYAE CCCCCCHHHEEEEEE	52.49	2190698
2353 (in isoform 1)	Ubiquitination	-	52.49	21890473
2564	Phosphorylation	IEPHPPRSSAMHLCF ECCCCCCCCCCEEEE	28.37	24117733
2565	Phosphorylation	EPHPPRSSAMHLCFL CCCCCCCCCCEEEEC	30.78	24117733
2575	Phosphorylation	HLCFLPQSPLMFKDQ EEEECCCCCCCCCHH	20.33	22199227
2709	Phosphorylation	FRVYSTETGKLTQIV EEEEECCCCCEEEEE	39.44	27251275
2713	Phosphorylation	STETGKLTQIVFGHW ECCCCCEEEEEECCC	21.53	27251275
2724	Phosphorylation	FGHWDVVTCLARSES ECCCCHHHHHHCCCC	11.14	27251275
2729	Phosphorylation	VVTCLARSESYIGGD HHHHHHCCCCCCCCC	25.86	-
2731	Phosphorylation	TCLARSESYIGGDCY HHHHCCCCCCCCCEE	24.24	-
2747	Phosphorylation	VSGSRDATLLLWYWS EECCCCCEEEEEEEE	23.41	-
2767	Phosphorylation	IGDNPNSSDYPAPRA CCCCCCCCCCCCCCE	48.05	27050516
2847	Phosphorylation	YYERGRFSNFSINGK EEECCCCCCEEECCE	35.29	22210691
2865	Phosphorylation	QMEINDSTRAILLSS EEEECCCCCEEEECC	27.30	22210691
2898	Phosphorylation	ACDFKQLYIYPGCDA ECCCCEEEEECCCCC	8.91	26503892
2913	Phosphorylation	GIRAMDLSHDQRTLI CCEEECCCCCCCCEE	22.28	26503892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NBEA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NBEA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NBEA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NBEA_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.