FOXG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXG1_HUMAN
• UniProt AC: P55316
• Protein Name: Forkhead box protein G1
• Gene Name: FOXG1
• Organism: Homo sapiens (Human).
• Sequence Length: 489
• Subcellular Localization: Nucleus .
• Protein Description: Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon..
• Protein Sequence: MLDMGDRKEVKMIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHHPPPPAPQPPPPPQQQQPPPPPPPAPQPPQTRGAPAADDDKGPQQLLLPPPPPPPPAAALDGAKADGLGGKGEPGGGPGELAPVGPDEKEKGAGAGGEEKKGAGEGGKDGEGGKEGEKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTSQSSTSMSARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQGSSSNPLIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	MGDRKEVKMIPKSSF CCCHHHEEECCCCCC	32.00	18604419
19	Phosphorylation	MIPKSSFSINSLVPE ECCCCCCCCCHHCCH	23.86	22817900
186	Phosphorylation	YEKPPFSYNALIMMA CCCCCCCHHHHHHHH	12.58	22817900
228	Phosphorylation	NKQGWQNSIRHNLSL CCCCHHHHHHHCCCC	13.10	27251275
234	Phosphorylation	NSIRHNLSLNKCFVK HHHHHCCCCCCCEEE	34.90	21712546
246	Phosphorylation	FVKVPRHYDDPGKGN EEECCCCCCCCCCCC	24.26	-
254	Phosphorylation	DDPGKGNYWMLDPSS CCCCCCCCEECCCCC	10.81	-
277	Phosphorylation	TGKLRRRSTTSRAKL CCCCCCCCCCHHHHH	33.94	-
278	Phosphorylation	GKLRRRSTTSRAKLA CCCCCCCCCHHHHHH	27.29	-
279	Phosphorylation	KLRRRSTTSRAKLAF CCCCCCCCHHHHHHH	19.91	22817900
280	Phosphorylation	LRRRSTTSRAKLAFK CCCCCCCHHHHHHHH	30.26	-
442	O-linked_Glycosylation	SARAASSSTSPQAPS HHHHHCCCCCCCCCC	30.34	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
19	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
279	T	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1G_HUMAN	EEF1G	physical	16169070
GDF9_HUMAN	GDF9	physical	16169070
FOXH1_HUMAN	FOXH1	physical	10938097
FOXH1_HUMAN	FOXH1	physical	20211142
CHD4_HUMAN	CHD4	physical	25609649
HXD13_HUMAN	HOXD13	physical	25609649
DPOE1_HUMAN	POLE	physical	25609649
ADNP_HUMAN	ADNP	physical	25609649
ZMYM3_HUMAN	ZMYM3	physical	25609649
KDM1A_HUMAN	KDM1A	physical	25609649
SMCA5_HUMAN	SMARCA5	physical	25609649
NSMA3_HUMAN	SMPD4	physical	25609649
BTAF1_HUMAN	BTAF1	physical	25609649
PDS5A_HUMAN	PDS5A	physical	25609649
SCRIB_HUMAN	SCRIB	physical	25609649
HEAT1_HUMAN	HEATR1	physical	25609649
LRWD1_HUMAN	LRWD1	physical	25609649
SYVC_HUMAN	VARS	physical	25609649
ZMYM2_HUMAN	ZMYM2	physical	25609649
DX39A_HUMAN	DDX39A	physical	25609649
HELLS_HUMAN	HELLS	physical	25609649
NSDHL_HUMAN	NSDHL	physical	25609649
PUM1_HUMAN	PUM1	physical	25609649
SATB2_HUMAN	SATB2	physical	25609649
CUX1_HUMAN	CUX1	physical	25609649
CASP_HUMAN	CUX1	physical	25609649
HDAC2_HUMAN	HDAC2	physical	25609649
HXB13_HUMAN	HOXB13	physical	25609649
CND1_HUMAN	NCAPD2	physical	25609649
COT1_HUMAN	NR2F1	physical	25609649
SALL1_HUMAN	SALL1	physical	25609649
DSRAD_HUMAN	ADAR	physical	25609649
EF1D_HUMAN	EEF1D	physical	25609649
P66B_HUMAN	GATAD2B	physical	25609649
TF3C3_HUMAN	GTF3C3	physical	25609649
TF3C5_HUMAN	GTF3C5	physical	25609649
HXC13_HUMAN	HOXC13	physical	25609649
NDUV2_HUMAN	NDUFV2	physical	25609649
ORC2_HUMAN	ORC2	physical	25609649
PKHG4_HUMAN	PLEKHG4	physical	25609649
POGZ_HUMAN	POGZ	physical	25609649
RIF1_HUMAN	RIF1	physical	25609649
SATB1_HUMAN	SATB1	physical	25609649
SMCA1_HUMAN	SMARCA1	physical	25609649
SMC3_HUMAN	SMC3	physical	25609649
SYMPK_HUMAN	SYMPK	physical	25609649
WIZ_HUMAN	WIZ	physical	25609649
KAISO_HUMAN	ZBTB33	physical	25609649
SNX9_HUMAN	SNX9	physical	25609649
AKAP8_HUMAN	AKAP8	physical	25609649
LARP1_HUMAN	LARP1	physical	25609649
MAGT1_HUMAN	MAGT1	physical	25609649
P4HA1_HUMAN	P4HA1	physical	25609649
SMC1A_HUMAN	SMC1A	physical	25609649
U520_HUMAN	SNRNP200	physical	25609649
MOV10_HUMAN	MOV10	physical	25609649
NU205_HUMAN	NUP205	physical	25609649
RN219_HUMAN	RNF219	physical	25609649
P53_HUMAN	TP53	physical	25609649
CPSM_HUMAN	CPS1	physical	25609649
GBF1_HUMAN	GBF1	physical	25609649
HNRL2_HUMAN	HNRNPUL2	physical	25609649
LG3BP_HUMAN	LGALS3BP	physical	25609649
MYO9B_HUMAN	MYO9B	physical	25609649
CNDD3_HUMAN	NCAPD3	physical	25609649
RRBP1_HUMAN	RRBP1	physical	25609649
SMC4_HUMAN	SMC4	physical	25609649
TCRG1_HUMAN	TCERG1	physical	25609649
UBR5_HUMAN	UBR5	physical	25609649

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613454: Rett syndrome congenital variant (RTTCV)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.