HXB13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXB13_HUMAN
• UniProt AC: Q92826
• Protein Name: Homeobox protein Hox-B13
• Gene Name: HOXB13
• Organism: Homo sapiens (Human).
• Sequence Length: 284
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. [PubMed: 28473536]
• Protein Sequence: MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSPLTSHPAAPTLMPAVNYAPLDLPGSAEPPKQCHPCPGVPQGTSPAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTAGEEYPSRPTEFAFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKNSATP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEPGNYATLDGAK --CCCCCCCCCCCCC	13.59	28509920
8	Phosphorylation	MEPGNYATLDGAKDI CCCCCCCCCCCCCCH	18.28	28509920
31	Phosphorylation	GRNLVAHSPLTSHPA CCCEEECCCCCCCCC	16.33	29978859
34	Phosphorylation	LVAHSPLTSHPAAPT EEECCCCCCCCCCCC	28.51	29978859
35	Phosphorylation	VAHSPLTSHPAAPTL EECCCCCCCCCCCCC	34.85	29978859
41	Phosphorylation	TSHPAAPTLMPAVNY CCCCCCCCCCCCCCC	30.84	25002506
48	Phosphorylation	TLMPAVNYAPLDLPG CCCCCCCCCCCCCCC	11.73	27642862
202	Phosphorylation	WKAAFADSSGQHPPD HHHHHCCCCCCCCCC	32.70	30631047
203	Phosphorylation	KAAFADSSGQHPPDA HHHHCCCCCCCCCCC	42.91	30631047
239	Ubiquitination	EREYAANKFITKDKR HHHHHHHHCCCHHHH	33.16	-
250	Phosphorylation	KDKRRKISAATSLSE HHHHHHCHHHCCCCH	18.19	-
254	Phosphorylation	RKISAATSLSERQIT HHCHHHCCCCHHHHH	25.77	-
270	Acetylation	WFQNRRVKEKKVLAK EECCCCCCCHHHHHH	63.10	164241
277	Acetylation	KEKKVLAKVKNSATP CCHHHHHHHHHCCCC	49.97	164245

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXB13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXB13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXB13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN490_HUMAN	ZNF490	physical	20211142
ALX4_HUMAN	ALX4	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.