ALX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALX4_HUMAN
• UniProt AC: Q9H161
• Protein Name: Homeobox protein aristaless-like 4
• Gene Name: ALX4
• Organism: Homo sapiens (Human).
• Sequence Length: 411
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development..
• Protein Sequence: MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRAFPGGDKFGTTFLSAAAKAQGFGDAKSRARYGAGQQDLATPLESGAGARGSFNKFQPQPSTPQPQPPPQPQPQQQQPQPQPPAQPHLYLQRGACKTPPDGSLKLQEGSSGHSAALQVPCYAKESSLGEPELPPDSDTVGMDSSYLSVKEAGVKGPQDRASSDLPSPLEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWLGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSVTDFLSVSGAGSHVGQTHMGSLFGAASLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAISWAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	NAETCVSYCESPAAA CHHHHHHHHCCHHHH	4.65	30576142
22	Phosphorylation	AAMDAYYSPVSQSRE HHHHHHCCCCCCCCC	13.22	30576142
25	Phosphorylation	DAYYSPVSQSREGSS HHHCCCCCCCCCCCC	26.31	30576142
32	Phosphorylation	SQSREGSSPFRAFPG CCCCCCCCCCCCCCC	38.63	24719451
49	Phosphorylation	KFGTTFLSAAAKAQG CCCHHHHHHHHHHCC	16.21	28555341
66	Phosphorylation	DAKSRARYGAGQQDL CHHHHHHCCCCCCCC	15.44	46162821
75	Phosphorylation	AGQQDLATPLESGAG CCCCCCCCCCCCCCC	35.39	28555341
86	Phosphorylation	SGAGARGSFNKFQPQ CCCCCCCCCCCCCCC	21.79	28555341
96	Phosphorylation	KFQPQPSTPQPQPPP CCCCCCCCCCCCCCC	32.40	28555341
131	Phosphorylation	LQRGACKTPPDGSLK ECCCCCCCCCCCCEE	39.68	28857561
143	Phosphorylation	SLKLQEGSSGHSAAL CEEECCCCCCCCEEE	32.18	28555341
177	Phosphorylation	SDTVGMDSSYLSVKE CCCCCCCHHHEEHHH	16.40	28165663
196	Phosphorylation	GPQDRASSDLPSPLE CCCCCCCCCCCCHHH	42.03	27251275
200	Phosphorylation	RASSDLPSPLEKADS CCCCCCCCHHHHCCC	49.79	11106354
209	Phosphorylation	LEKADSESNKGKKRR HHHCCCCCCCCCCCC	48.03	24719451
220	Phosphorylation	KKRRNRTTFTSYQLE CCCCCCCCCCHHHHH	22.98	28555341
238	Phosphorylation	KVFQKTHYPDVYARE HHHHHHCCCCHHHHH	13.32	10993587
289	Phosphorylation	RTHFSTAYELPLLTR HHHHCHHHHHHHHHH	20.35	27642862
391	Phosphorylation	GEPDRKTSSIAALRM CCCCCCHHHHHHHHH	23.84	22280047
392	Phosphorylation	EPDRKTSSIAALRMK CCCCCHHHHHHHHHH	22.83	22280055
411	O-linked_Glycosylation	SAAISWAT------- HHCEECCC-------	32.65	30620550

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALX4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALX4_HUMAN	ALX4	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.