DX39A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DX39A_HUMAN
• UniProt AC: O00148
• Protein Name: ATP-dependent RNA helicase DDX39A
• Gene Name: DDX39A
• Organism: Homo sapiens (Human).
• Sequence Length: 427
• Subcellular Localization: Nucleus . Cytoplasm . Can translocate to the cytoplasm in the presence of MX1.
• Protein Description: Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus..
• Protein Sequence: MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEQDVEND ------CCCCHHHCC	24.13	22223895
13	Phosphorylation	VENDLLDYDEEEEPQ HHCCCCCCCCCCCCC	25.81	28355574
25	Phosphorylation	EPQAPQESTPAPPKK CCCCCCCCCCCCCCC	34.15	23401153
26	Phosphorylation	PQAPQESTPAPPKKD CCCCCCCCCCCCCCC	23.79	25159151
31	Ubiquitination	ESTPAPPKKDIKGSY CCCCCCCCCCCCCCE	63.12	23000965
31	Sumoylation	ESTPAPPKKDIKGSY CCCCCCCCCCCCCCE	63.12	28112733
32	Ubiquitination	STPAPPKKDIKGSYV CCCCCCCCCCCCCEE	71.15	23000965
32	Acetylation	STPAPPKKDIKGSYV CCCCCCCCCCCCCEE	71.15	25953088
35	Acetylation	APPKKDIKGSYVSIH CCCCCCCCCCEEEEE	52.52	19608861
35	Sumoylation	APPKKDIKGSYVSIH CCCCCCCCCCEEEEE	52.52	-
35	Ubiquitination	APPKKDIKGSYVSIH CCCCCCCCCCEEEEE	52.52	23000965
35	Sumoylation	APPKKDIKGSYVSIH CCCCCCCCCCEEEEE	52.52	28112733
35	Acetylation	APPKKDIKGSYVSIH CCCCCCCCCCEEEEE	52.52	-
35	Ubiquitination	APPKKDIKGSYVSIH CCCCCCCCCCEEEEE	52.52	-
37	Phosphorylation	PKKDIKGSYVSIHSS CCCCCCCCEEEEECC	19.84	23927012
38	Phosphorylation	KKDIKGSYVSIHSSG CCCCCCCEEEEECCC	13.59	23927012
40	Phosphorylation	DIKGSYVSIHSSGFR CCCCCEEEEECCCCH	13.32	23401153
43	Phosphorylation	GSYVSIHSSGFRDFL CCEEEEECCCCHHHH	30.41	23927012
44	Phosphorylation	SYVSIHSSGFRDFLL CEEEEECCCCHHHHC	27.99	23927012
50	Ubiquitination	SSGFRDFLLKPELLR CCCCHHHHCCHHHHH	7.62	22817900
52	Acetylation	GFRDFLLKPELLRAI CCHHHHCCHHHHHHH	38.30	25825284
52	Ubiquitination	GFRDFLLKPELLRAI CCHHHHCCHHHHHHH	38.30	23000965
52	Acetylation	GFRDFLLKPELLRAI CCHHHHCCHHHHHHH	38.30	-
52	Ubiquitination	GFRDFLLKPELLRAI CCHHHHCCHHHHHHH	38.30	21890473
52	Succinylation	GFRDFLLKPELLRAI CCHHHHCCHHHHHHH	38.30	23954790
52	Ubiquitination	GFRDFLLKPELLRAI CCHHHHCCHHHHHHH	38.30	21890473
57	Methylation	LLKPELLRAIVDCGF HCCHHHHHHHHHCCC	34.59	-
62	Ubiquitination	LLRAIVDCGFEHPSE HHHHHHHCCCCCCHH	4.69	21890473
64	Ubiquitination	RAIVDCGFEHPSEVQ HHHHHCCCCCCHHHH	11.09	23503661
68	Ubiquitination	DCGFEHPSEVQHECI HCCCCCCHHHHHCHH	52.92	23503661
78	Ubiquitination	QHECIPQAILGMDVL HHCHHCHHHHCHHHH	8.13	21890473
89	Ubiquitination	MDVLCQAKSGMGKTA HHHHHHHCCCCCHHH	22.97	29967540
89	Ubiquitination	MDVLCQAKSGMGKTA HHHHHHHCCCCCHHH	22.97	-
89	Acetylation	MDVLCQAKSGMGKTA HHHHHHHCCCCCHHH	22.97	25953088
95	Ubiquitination	AKSGMGKTAVFVLAT HCCCCCHHHHHHEEE	23.48	21890473
128	Ubiquitination	TRELAFQISKEYERF HHHHHHHHHHHHHHH	5.26	23000965
130	Ubiquitination	ELAFQISKEYERFSK HHHHHHHHHHHHHHH	66.98	21906983
130	Ubiquitination	ELAFQISKEYERFSK HHHHHHHHHHHHHHH	66.98	21890473
130	Acetylation	ELAFQISKEYERFSK HHHHHHHHHHHHHHH	66.98	26051181
137	Ubiquitination	KEYERFSKYMPSVKV HHHHHHHHHCCCCEE	42.74	21890473
137	Ubiquitination	KEYERFSKYMPSVKV HHHHHHHHHCCCCEE	42.74	-
137	Acetylation	KEYERFSKYMPSVKV HHHHHHHHHCCCCEE	42.74	25953088
138	Phosphorylation	EYERFSKYMPSVKVS HHHHHHHHCCCCEEE	17.04	29759185
145	Phosphorylation	YMPSVKVSVFFGGLS HCCCCEEEEEECCCC	13.90	21712546
154	Sumoylation	FFGGLSIKKDEEVLK EECCCCCCCCHHHHH	51.28	-
154	Ubiquitination	FFGGLSIKKDEEVLK EECCCCCCCCHHHHH	51.28	21890473
154	Sumoylation	FFGGLSIKKDEEVLK EECCCCCCCCHHHHH	51.28	28112733
154	Ubiquitination	FFGGLSIKKDEEVLK EECCCCCCCCHHHHH	51.28	-
155	Ubiquitination	FGGLSIKKDEEVLKK ECCCCCCCCHHHHHH	69.56	-
155	Acetylation	FGGLSIKKDEEVLKK ECCCCCCCCHHHHHH	69.56	26051181
161	Acetylation	KKDEEVLKKNCPHVV CCCHHHHHHCCCEEE	47.30	23749302
161	Ubiquitination	KKDEEVLKKNCPHVV CCCHHHHHHCCCEEE	47.30	21906983
161	Acetylation	KKDEEVLKKNCPHVV CCCHHHHHHCCCEEE	47.30	-
161	Ubiquitination	KKDEEVLKKNCPHVV CCCHHHHHHCCCEEE	47.30	21890473
162	Ubiquitination	KDEEVLKKNCPHVVV CCHHHHHHCCCEEEE	60.67	21906983
162	Ubiquitination	KDEEVLKKNCPHVVV CCHHHHHHCCCEEEE	60.67	-
162	Sumoylation	KDEEVLKKNCPHVVV CCHHHHHHCCCEEEE	60.67	28112733
171	Phosphorylation	CPHVVVGTPGRILAL CCEEEECCHHHHHHH	15.80	23927012
173	Ubiquitination	HVVVGTPGRILALVR EEEECCHHHHHHHHH	29.15	21890473
178	Ubiquitination	TPGRILALVRNRSFS CHHHHHHHHHCCCCC	3.13	22505724
180	Ubiquitination	GRILALVRNRSFSLK HHHHHHHHCCCCCCC	33.42	21890473
183	Phosphorylation	LALVRNRSFSLKNVK HHHHHCCCCCCCCCC	23.80	23401153
185	Phosphorylation	LVRNRSFSLKNVKHF HHHCCCCCCCCCCEE	39.41	30108239
187	Acetylation	RNRSFSLKNVKHFVL HCCCCCCCCCCEEHH	59.50	19608861
187	Ubiquitination	RNRSFSLKNVKHFVL HCCCCCCCCCCEEHH	59.50	21906983
187	Ubiquitination	RNRSFSLKNVKHFVL HCCCCCCCCCCEEHH	59.50	-
190	Ubiquitination	SFSLKNVKHFVLDEC CCCCCCCCEEHHHHH	40.49	29967540
190	Ubiquitination	SFSLKNVKHFVLDEC CCCCCCCCEEHHHHH	40.49	-
190	Acetylation	SFSLKNVKHFVLDEC CCCCCCCCEEHHHHH	40.49	26822725
199	Ubiquitination	FVLDECDKMLEQLDM EHHHHHHHHHHHHHH	57.98	29967540
199	Acetylation	FVLDECDKMLEQLDM EHHHHHHHHHHHHHH	57.98	26051181
204	Ubiquitination	CDKMLEQLDMRRDVQ HHHHHHHHHHHHHHH	4.00	21890473
205	Ubiquitination	DKMLEQLDMRRDVQE HHHHHHHHHHHHHHH	28.39	21890473
207	Methylation	MLEQLDMRRDVQEIF HHHHHHHHHHHHHHH	31.17	-
217	Phosphorylation	VQEIFRLTPHEKQCM HHHHHHCCCCHHHHH	20.53	23312004
221	Ubiquitination	FRLTPHEKQCMMFSA HHCCCCHHHHHHEEE	45.85	21906983
221	Ubiquitination	FRLTPHEKQCMMFSA HHCCCCHHHHHHEEE	45.85	-
221	Acetylation	FRLTPHEKQCMMFSA HHCCCCHHHHHHEEE	45.85	26051181
227	Phosphorylation	EKQCMMFSATLSKDI HHHHHHEEEECCCCC	11.49	21406692
229	Phosphorylation	QCMMFSATLSKDIRP HHHHEEEECCCCCHH	30.30	21406692
230	Ubiquitination	CMMFSATLSKDIRPV HHHEEEECCCCCHHH	6.31	21890473
231	Phosphorylation	MMFSATLSKDIRPVC HHEEEECCCCCHHHH	24.75	21406692
232	Ubiquitination	MFSATLSKDIRPVCR HEEEECCCCCHHHHH	61.36	-
240	Sumoylation	DIRPVCRKFMQDPME CCHHHHHHHCCCCCE	39.81	-
240	Ubiquitination	DIRPVCRKFMQDPME CCHHHHHHHCCCCCE	39.81	23000965
240	Sumoylation	DIRPVCRKFMQDPME CCHHHHHHHCCCCCE	39.81	28112733
240	Acetylation	DIRPVCRKFMQDPME CCHHHHHHHCCCCCE	39.81	25953088
255	Acetylation	VFVDDETKLTLHGLQ EEECCCCEEEEHHHH	37.11	156717
255	Ubiquitination	VFVDDETKLTLHGLQ EEECCCCEEEEHHHH	37.11	22817900
255	Sumoylation	VFVDDETKLTLHGLQ EEECCCCEEEEHHHH	37.11	28112733
264	Phosphorylation	TLHGLQQYYVKLKDS EEHHHHHEEEEECCC	9.39	28152594
264	Ubiquitination	TLHGLQQYYVKLKDS EEHHHHHEEEEECCC	9.39	21890473
265	Phosphorylation	LHGLQQYYVKLKDSE EHHHHHEEEEECCCH	6.18	28152594
267	Ubiquitination	GLQQYYVKLKDSEKN HHHHEEEEECCCHHH	33.43	33845483
267	Acetylation	GLQQYYVKLKDSEKN HHHHEEEEECCCHHH	33.43	25953088
269	Ubiquitination	QQYYVKLKDSEKNRK HHEEEEECCCHHHHH	54.19	23503661
273	Ubiquitination	VKLKDSEKNRKLFDL EEECCCHHHHHHHHH	67.04	23503661
283	Ubiquitination	KLFDLLDVLEFNQVI HHHHHHHHHHHCCCH	5.79	21890473
310	Ubiquitination	AQLLVEQNFPAIAIH HHHHHHCCCCHHHHH	31.22	21890473
329	Phosphorylation	QEERLSRYQQFKDFQ HHHHHHHHHHHHHHH	11.86	26074081
333	Acetylation	LSRYQQFKDFQRRIL HHHHHHHHHHHHHHH	53.98	23236377
333	Ubiquitination	LSRYQQFKDFQRRIL HHHHHHHHHHHHHHH	53.98	23000965
333	Sumoylation	LSRYQQFKDFQRRIL HHHHHHHHHHHHHHH	53.98	-
333	Succinylation	LSRYQQFKDFQRRIL HHHHHHHHHHHHHHH	53.98	23954790
338	Methylation	QFKDFQRRILVATNL HHHHHHHHHHHHHCC	18.79	-
343	Phosphorylation	QRRILVATNLFGRGM HHHHHHHHCCCCCCC	25.60	21712546
348	Methylation	VATNLFGRGMDIERV HHHCCCCCCCCCEEE	29.90	-
361	Phosphorylation	RVNIVFNYDMPEDSD EEEEEEECCCCCCCC	11.36	26552605
367	Phosphorylation	NYDMPEDSDTYLHRV ECCCCCCCCCHHHHH	30.14	26552605
369	Phosphorylation	DMPEDSDTYLHRVAR CCCCCCCCHHHHHHH	31.75	26552605
370	Phosphorylation	MPEDSDTYLHRVARA CCCCCCCHHHHHHHC	12.90	26552605
382	Phosphorylation	ARAGRFGTKGLAITF HHCCCCCCCCEEEEE	21.16	-
383	Ubiquitination	RAGRFGTKGLAITFV HCCCCCCCCEEEEEE	52.91	33845483
383	Acetylation	RAGRFGTKGLAITFV HCCCCCCCCEEEEEE	52.91	26051181
391	Phosphorylation	GLAITFVSDENDAKI CEEEEEECCCCHHHH	34.71	21712546
397	Acetylation	VSDENDAKILNDVQD ECCCCHHHHHHHHHH	51.06	11793901
397	Sumoylation	VSDENDAKILNDVQD ECCCCHHHHHHHHHH	51.06	-
420	Phosphorylation	LPEEIDISTYIEQSR CCCCCCHHHHHHCCC	16.06	23663014
421	Phosphorylation	PEEIDISTYIEQSR- CCCCCHHHHHHCCC-	28.93	23663014
422	Phosphorylation	EEIDISTYIEQSR-- CCCCHHHHHHCCC--	8.82	23663014
426	Phosphorylation	ISTYIEQSR------ HHHHHHCCC------	27.45	25159151
426	Ubiquitination	ISTYIEQSR------ HHHHHHCCC------	27.45	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DX39A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DX39A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DX39A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SARNP_HUMAN	SARNP	physical	16189514
THOC4_HUMAN	ALYREF	physical	17196963
SARNP_HUMAN	SARNP	physical	17196963
DX39A_HUMAN	DDX39A	physical	25416956
SARNP_HUMAN	SARNP	physical	25416956
CELR1_HUMAN	CELSR1	physical	26186194
FAT3_HUMAN	FAT3	physical	26186194
FAT4_HUMAN	FAT4	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
WDR19_HUMAN	WDR19	physical	26186194
FREM2_HUMAN	FREM2	physical	26186194
GANP_HUMAN	MCM3AP	physical	26186194
PCDH7_HUMAN	PCDH7	physical	26186194
TERF2_HUMAN	TERF2	physical	26186194
CELR2_HUMAN	CELSR2	physical	26186194
BBS7_HUMAN	BBS7	physical	26186194
OST48_HUMAN	DDOST	physical	26344197
DX39B_HUMAN	DDX39B	physical	26344197
IF6_HUMAN	EIF6	physical	26344197
ETFA_HUMAN	ETFA	physical	26344197
PHOCN_HUMAN	MOB4	physical	26344197
PABP1_HUMAN	PABPC1	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197
PAWR_HUMAN	PAWR	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
TMCO1_HUMAN	TMCO1	physical	26344197
SARNP_HUMAN	SARNP	physical	21516116
TERF2_HUMAN	TERF2	physical	28514442
FAT4_HUMAN	FAT4	physical	28514442
FAT3_HUMAN	FAT3	physical	28514442
CELR2_HUMAN	CELSR2	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-35 AND LYS-187, AND MASSSPECTROMETRY.
PubMed: 19608861

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND THR-171, AND MASSSPECTROMETRY.
PubMed: 18669648