WDR19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR19_HUMAN
• UniProt AC: Q8NEZ3
• Protein Name: WD repeat-containing protein 19
• Gene Name: WDR19
• Organism: Homo sapiens (Human).
• Sequence Length: 1342
• Subcellular Localization: Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Cell projection, cilium, photoreceptor outer segment . Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and alo
• Protein Description: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. [PubMed: 20889716 Involved in cilia function and/or assembly (By similarity Associates with the BBSome complex to mediate ciliary transport (By similarity]
• Protein Sequence: MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDKMITVSNQEGDTIRQTQVRSEPSNMQFFLMKMDDRTSAAESMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWYGDGRIMIGFSCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKIQDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEYLGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGAKVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLAQNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYFEGEKRYLQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLGENDGMPKDAKYLFRLYMALKQYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEATTPCPFCKFLLPECELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCDFPALYSELKIMLNTESTCPMCSERLNAAQLKKISDCTQYLRTEEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKRIFSLLEKTWL --CCHHHHHHHHHCC	29.67	24719451
28	Phosphorylation	WQKTSGNYLAVTGAD EEECCCCEEEEECCC	10.28	-
36	Phosphorylation	LAVTGADYIVKIFDR EEEECCCEEEEEEHH	13.69	-
89	Phosphorylation	WDANTNKTSQLDNGM EECCCCCCCCCCCCH	24.63	22210691
90	Phosphorylation	DANTNKTSQLDNGMR ECCCCCCCCCCCCHH	30.29	22210691
110	Phosphorylation	LLWSKVGSFLAVGTV HHHHCCCCEEEEEEE	21.78	22210691
179	Phosphorylation	IRQTQVRSEPSNMQF EEEEEECCCCCCCEE	55.81	24719451
182	Phosphorylation	TQVRSEPSNMQFFLM EEECCCCCCCEEEEE	40.66	24719451
275	Ubiquitination	IFQARNHKDNLTSIA HHHHHCCCCCCHHHH	52.43	-
519	Ubiquitination	RHPVSVKKIFPDPNG CCCEEEEEEECCCCC	47.63	-
536	Phosphorylation	LVFIDEKSDGFVYCP EEEEECCCCCEEEEE	40.70	22468782
541	Phosphorylation	EKSDGFVYCPVNDAT CCCCCEEEEECCCEE	6.70	22468782
548	Phosphorylation	YCPVNDATYEIPDFS EEECCCEEEECCCCC	25.26	22468782
644	Phosphorylation	FLSNLKDTGPDELRP HHHCCCCCCHHHHHH	49.37	-
761	Phosphorylation	RDLQHWDSALQLAKH HHHHCHHHHHHHHHH	26.20	24247654
836	Ubiquitination	RGVNQALKHPSRVLK HHHHHHHHCHHHHHH	57.39	-
854	Ubiquitination	GAILENMKQFSEAAQ HHHHHHHHHHHHHHH	60.83	-
857	Phosphorylation	LENMKQFSEAAQLYE HHHHHHHHHHHHHHH	24.67	30243723
865	Ubiquitination	EAAQLYEKGLYYDKA HHHHHHHCCCCCCCC	40.43	-
871	Ubiquitination	EKGLYYDKAASVYIR HCCCCCCCCEEEEEE	29.72	-
893	Phosphorylation	GDLLPHVSSPKIHLQ HHCCCCCCCCCCHHE	37.58	25159151
894	Phosphorylation	DLLPHVSSPKIHLQY HCCCCCCCCCCHHEE	29.17	25159151
911	Phosphorylation	AKEADGRYKEAVVAY HHHCCCCCEEEEEEC	20.79	18083107
912	Ubiquitination	KEADGRYKEAVVAYE HHCCCCCEEEEEECC	37.52	-
918	Phosphorylation	YKEAVVAYENAKQWQ CEEEEEECCCHHHHH	9.71	-
940	Ubiquitination	DHLNNPEKAVNIVRE HHCCCHHHHHHHHHH	59.91	-
955	Ubiquitination	TQSLDGAKMVARFFL HCCCCHHHHHHHHHH	39.16	-
1102	Phosphorylation	LYMALKQYREAAQTA HHHHHHHHHHHHHHE	14.61	22210691
1108	Phosphorylation	QYREAAQTAIIIARE HHHHHHHHEEEEEEH	18.33	29978859
1118	Phosphorylation	IIAREEQSAGNYRNA EEEEHHHCCCCCCCH	41.23	29978859
1122	Phosphorylation	EEQSAGNYRNAHDVL HHHCCCCCCCHHHHH	12.34	29978859
1230	Phosphorylation	RSKIDAKYKKKIEGM HHHCCHHHHHHHCCC	29.75	-
1233	Malonylation	IDAKYKKKIEGMVRR CCHHHHHHHCCCCCC	41.67	26320211
1273	Phosphorylation	LCPGCKNSIPYCIAT ECCCCCCCCCCCEEC	15.50	-
1276	Phosphorylation	GCKNSIPYCIATGRH CCCCCCCCCEECCCC	8.53	-
1328	Ubiquitination	LNAAQLKKISDCTQY CCHHHHHHHHHHHHH	56.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF122_HUMAN	IFT122	physical	27173435
WDR35_HUMAN	WDR35	physical	27173435
IFT43_HUMAN	IFT43	physical	27173435
TT21B_HUMAN	TTC21B	physical	27173435
PFKAP_HUMAN	PFKP	physical	27173435
SCO1_HUMAN	SCO1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614378: Cranioectodermal dysplasia 4 (CED4)
• 614376: Short-rib thoracic dysplasia 5 with or without polydactyly (SRTD5)
• 614377: Nephronophthisis 13 (NPHP13)
• 616307: Senior-Loken syndrome 8 (SLSN8)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.