IF122_HUMAN - dbPTM
IF122_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IF122_HUMAN
UniProt AC Q9HBG6
Protein Name Intraflagellar transport protein 122 homolog
Gene Name IFT122
Organism Homo sapiens (Human).
Sequence Length 1241
Subcellular Localization Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Localizes to photoreceptor connecting cilia..
Protein Description Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)..
Protein Sequence MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10UbiquitinationAVLTWRDKAEHCIND
CEEEEHHHHHHHHCE		47.29-
10UbiquitinationAVLTWRDKAEHCIND
CEEEEHHHHHHHHCE		47.29-
10 (in isoform 4)Ubiquitination-47.29-
21UbiquitinationCINDIAFKPDGTQLI
HHCEEEECCCCCEEE		32.93-
21UbiquitinationCINDIAFKPDGTQLI
HHCEEEECCCCCEEE		32.93-
21 (in isoform 4)Ubiquitination-32.93-
50UbiquitinationGTLLQPLKGHKDTVY
CCEEECCCCCCCEEE		66.70-
50UbiquitinationGTLLQPLKGHKDTVY
CCEEECCCCCCCEEE		66.7021906983
50 (in isoform 1)Ubiquitination-66.7021890473
50 (in isoform 4)Ubiquitination-66.70-
53UbiquitinationLQPLKGHKDTVYCVA
EECCCCCCCEEEEEE		64.86-
53UbiquitinationLQPLKGHKDTVYCVA
EECCCCCCCEEEEEE		64.86-
53 (in isoform 4)Ubiquitination-64.86-
63UbiquitinationVYCVAYAKDGKRFAS
EEEEEEEECCCEECC		55.10-
63 (in isoform 3)Ubiquitination-55.10-
63 (in isoform 4)Ubiquitination-55.10-
66UbiquitinationVAYAKDGKRFASGSA
EEEEECCCEECCCCC		55.25-
72 (in isoform 4)Ubiquitination-30.69-
75UbiquitinationFASGSADKSVIIWTS
ECCCCCCCEEEEEEC		46.46-
75UbiquitinationFASGSADKSVIIWTS
ECCCCCCCEEEEEEC		46.46-
75 (in isoform 3)Ubiquitination-46.46-
82UbiquitinationKSVIIWTSKLEGILK
CEEEEEECCCCCHHH		21.90-
83UbiquitinationSVIIWTSKLEGILKY
EEEEEECCCCCHHHC		43.09-
83UbiquitinationSVIIWTSKLEGILKY
EEEEEECCCCCHHHC		43.09-
83 (in isoform 3)Ubiquitination-43.09-
116 (in isoform 4)Ubiquitination-10.53-
121UbiquitinationSDFGLWSPEQKSVSK
CCCCCCCHHHHCCCC		36.13-
124UbiquitinationGLWSPEQKSVSKHKS
CCCCHHHHCCCCCCC		51.68-
124 (in isoform 3)Ubiquitination-51.68-
125PhosphorylationLWSPEQKSVSKHKSS
CCCHHHHCCCCCCCC		31.1724275569
131PhosphorylationKSVSKHKSSSKIICC
HCCCCCCCCCCEEEE		39.2924275569
151 (in isoform 4)Ubiquitination-2.16-
156UbiquitinationLGMFNGIISIRNKNG
EEEECCEEEEECCCC		2.72-
160 (in isoform 4)Ubiquitination-40.24-
161AcetylationGIISIRNKNGEEKVK
CEEEEECCCCCCCEE		57.3826210075
165UbiquitinationIRNKNGEEKVKIERP
EECCCCCCCEEEECC		65.63-
180 (in isoform 4)Ubiquitination-5.75-
185UbiquitinationPIWSICWNPSSRWES
CCEEEECCCCHHHHH		23.36-
187PhosphorylationWSICWNPSSRWESFW
EEEECCCCHHHHHHE		29.35-
191 (in isoform 4)Ubiquitination-34.64-
192PhosphorylationNPSSRWESFWMNREN
CCCHHHHHHEECCCC		19.76-
196UbiquitinationRWESFWMNRENEDAE
HHHHHEECCCCCCHH		38.42-
198 (in isoform 4)Ubiquitination-61.03-
203UbiquitinationNRENEDAEDVIVNRY
CCCCCCHHHHHHHHH		66.20-
262UbiquitinationAVADWGQKVSFYQLS
EEECCCCCEEEEECC		35.59-
271UbiquitinationSFYQLSGKQIGKDRA
EEEECCCCCCCCCCC		35.05-
271 (in isoform 4)Ubiquitination-35.05-
276UbiquitinationSGKQIGKDRALNFDP
CCCCCCCCCCCCCCC		35.55-
291UbiquitinationCCISYFTKGEYILLG
CEEEEEECCCEEEEC		39.59-
294PhosphorylationSYFTKGEYILLGGSD
EEEECCCEEEECCCC		12.92-
302UbiquitinationILLGGSDKQVSLFTK
EEECCCCCEEEEEEC		55.05-
309UbiquitinationKQVSLFTKDGVRLGT
CEEEEEECCCEEECC		45.19-
352 (in isoform 4)Ubiquitination-7.33-
357UbiquitinationLIFSTVHGLYKDRYA
HHHHHHHHHHCCCCC		26.77-
366 (in isoform 4)Ubiquitination-22.74-
371UbiquitinationAYRDSMTDVIVQHLI
CHHHHCHHHHHHHHH		21.36-
382UbiquitinationQHLITEQKVRIKCKE
HHHHCCCCHHHHHHH		27.52-
412PhosphorylationLPEKILIYELYSEDL
CCHHEEEEECCCCCC		9.09-
415PhosphorylationKILIYELYSEDLSDM
HEEEEECCCCCCCCC		9.70-
417 (in isoform 4)Ubiquitination-49.79-
421UbiquitinationLYSEDLSDMHYRVKE
CCCCCCCCCHHHHHH		34.86-
422UbiquitinationYSEDLSDMHYRVKEK
CCCCCCCCHHHHHHH		2.41-
424PhosphorylationEDLSDMHYRVKEKII
CCCCCCHHHHHHHHH		15.51-
463UbiquitinationCLSFSGVKEREWQME
HHHCCCCCCCHHHHH		55.36-
468 (in isoform 4)Ubiquitination-22.47-
477UbiquitinationESLIRYIKVIGGPPG
HHHHHHHHHHCCCCC		20.90-
513UbiquitinationFAIVLLKQATAVRCL
HHHHHHHHHHHHHHC		43.8721890473
513UbiquitinationFAIVLLKQATAVRCL
HHHHHHHHHHHHHHC		43.8721906983
520 (in isoform 4)Ubiquitination-4.31-
523PhosphorylationAVRCLDMSASRKKLA
HHHHCCCCCCCCCEE		23.82-
525UbiquitinationRCLDMSASRKKLAVV
HHCCCCCCCCCEEEE		37.01-
525PhosphorylationRCLDMSASRKKLAVV
HHCCCCCCCCCEEEE		37.01-
528UbiquitinationDMSASRKKLAVVDEN
CCCCCCCCEEEECCC		40.34-
544UbiquitinationTCLVYDIDTKELLFQ
CEEEEECCCCCEEEC		49.1521906983
552 (in isoform 4)Ubiquitination-32.94-
553 (in isoform 4)Ubiquitination-34.16-
557UbiquitinationFQEPNANSVAWNTQC
ECCCCCCCCCEECCC		15.7121890473
558UbiquitinationQEPNANSVAWNTQCE
CCCCCCCCCEECCCC		7.79-
581UbiquitinationGYLNIKASTFPVHRQ
CEEEEEEECCCCCHH		26.11-
587UbiquitinationASTFPVHRQKLQGFV
EECCCCCHHHCCEEE		35.25-
594 (in isoform 4)Ubiquitination-4.11-
600 (in isoform 4)Ubiquitination-20.95-
603UbiquitinationGYNGSKIFCLHVFSI
EECCCEEEEEEEEEE		4.1021890473
603UbiquitinationGYNGSKIFCLHVFSI
EECCCEEEEEEEEEE		4.1021906983
621UbiquitinationEVPQSAPMYQYLDRK
ECCCCCCHHHHHCHH		3.05-
621UbiquitinationEVPQSAPMYQYLDRK
ECCCCCCHHHHHCHH		3.0521906983
624UbiquitinationQSAPMYQYLDRKLFK
CCCCHHHHHCHHHHH		7.96-
624PhosphorylationQSAPMYQYLDRKLFK
CCCCHHHHHCHHHHH		7.96-
629UbiquitinationYQYLDRKLFKEAYQI
HHHHCHHHHHHHHHH		8.4721890473
631UbiquitinationYLDRKLFKEAYQIAC
HHCHHHHHHHHHHHH		52.45-
634 (in isoform 4)Ubiquitination-11.09-
637 (in isoform 4)Ubiquitination-2.72-
641UbiquitinationYQIACLGVTDTDWRE
HHHHHHCCCCCCHHH		2.56-
642 (in isoform 4)Ubiquitination-31.23-
655UbiquitinationELAMEALEGLDFETA
HHHHHHHCCCCHHHH		65.83-
663UbiquitinationGLDFETAKKAFIRVQ
CCCHHHHHHHEEEHH		52.6421906983
663 (in isoform 1)Ubiquitination-52.6421890473
674PhosphorylationIRVQDLRYLELISSI
EEHHHHHHHHHHHHH		16.3021712546
679PhosphorylationLRYLELISSIEERKK
HHHHHHHHHHHHHHH		37.5821712546
680UbiquitinationRYLELISSIEERKKR
HHHHHHHHHHHHHHH		27.3321890473
680UbiquitinationRYLELISSIEERKKR
HHHHHHHHHHHHHHH		27.3321906983
686UbiquitinationSSIEERKKRGETNND
HHHHHHHHHCCCCCC		72.38-
693UbiquitinationKRGETNNDLFLADVF
HHCCCCCCCCHHHHH		40.65-
705UbiquitinationDVFSYQGKFHEAAKL
HHHHHCCCHHHHHHH		28.20-
706UbiquitinationVFSYQGKFHEAAKLY
HHHHCCCHHHHHHHH		8.8921890473
706 (in isoform 4)Ubiquitination-8.89-
711UbiquitinationGKFHEAAKLYKRSGH
CCHHHHHHHHHHCCC		60.44-
711UbiquitinationGKFHEAAKLYKRSGH
CCHHHHHHHHHHCCC		60.44-
719 (in isoform 4)Ubiquitination-58.42-
745UbiquitinationFLGSGDPKETKMLIT
HHCCCCHHHHEEEEH		80.77-
748UbiquitinationSGDPKETKMLITKQA
CCCHHHHEEEEHHHH		32.57-
753UbiquitinationETKMLITKQADWARN
HHEEEEHHHHHHHHH		36.1721906983
753 (in isoform 1)Ubiquitination-36.1721890473
762UbiquitinationADWARNIKEPKAAVE
HHHHHHCCCCHHHHE		72.08-
765UbiquitinationARNIKEPKAAVEMYI
HHHCCCCHHHHEEHH		50.50-
776 (in isoform 4)Ubiquitination-45.27-
816UbiquitinationLLCATYLKKLDSPGY
HHHHHHHHHCCCCCC		40.66-
817UbiquitinationLCATYLKKLDSPGYA
HHHHHHHHCCCCCCC		55.73-
830UbiquitinationYAAETYLKMGDLKSL
CCHHHHHCCCCHHHH		30.3521906983
830 (in isoform 1)Ubiquitination-30.3521890473
835UbiquitinationYLKMGDLKSLVQLHV
HHCCCCHHHHHHHHH		46.62-
846UbiquitinationQLHVETQRWDEAFAL
HHHHHHCCHHHHHHH		50.67-
856UbiquitinationEAFALGEKHPEFKDD
HHHHHCCCCCCCCCC		63.76-
861UbiquitinationGEKHPEFKDDIYMPY
CCCCCCCCCCCCHHH		53.48-
864UbiquitinationHPEFKDDIYMPYAQW
CCCCCCCCCHHHHHH		4.56-
872UbiquitinationYMPYAQWLAENDRFE
CHHHHHHHHHCCCHH		2.59-
874UbiquitinationPYAQWLAENDRFEEA
HHHHHHHHCCCHHHH		58.45-
877 (in isoform 4)Ubiquitination-53.08-
881UbiquitinationENDRFEEAQKAFHKA
HCCCHHHHHHHHHHH		14.69-
883UbiquitinationDRFEEAQKAFHKAGR
CCHHHHHHHHHHHHH		61.13-
884UbiquitinationRFEEAQKAFHKAGRQ
CHHHHHHHHHHHHHH		10.33-
885 (in isoform 4)Ubiquitination-8.60-
887 (in isoform 4)Ubiquitination-46.19-
894 (in isoform 4)Ubiquitination-10.14-
897 (in isoform 4)Ubiquitination-5.23-
898UbiquitinationQREAVQVLEQLTNNA
HHHHHHHHHHHHCCH		1.62-
910UbiquitinationNNAVAESRFNDAAYY
CCHHHHHHHCHHHHH		26.37-
911AcetylationNAVAESRFNDAAYYY
CHHHHHHHCHHHHHH		15.7119608861
911 (in isoform 4)Ubiquitination-15.71-
922UbiquitinationAYYYWMLSMQCLDIA
HHHHHHHHHHHHHHH		7.24-
923UbiquitinationYYYWMLSMQCLDIAQ
HHHHHHHHHHHHHHC		2.6221890473
923UbiquitinationYYYWMLSMQCLDIAQ
HHHHHHHHHHHHHHC		2.6221890473
923 (in isoform 4)Ubiquitination-2.62-
935 (in isoform 4)Ubiquitination-58.22-
962AcetylationYHAIHRHTEDPFSVH
CCHHCCCCCCCCCCC		41.8819608861
974UbiquitinationSVHRPETLFNISRFL
CCCCHHHHHHHHHHH		2.7021890473
974 (in isoform 3)Ubiquitination-2.70-
974UbiquitinationSVHRPETLFNISRFL
CCCCHHHHHHHHHHH		2.7021890473
987UbiquitinationFLLHSLPKDTPSGIS
HHHHCCCCCCCCCCH		78.50-
991UbiquitinationSLPKDTPSGISKVKI
CCCCCCCCCCHHHHH		51.3421890473
995UbiquitinationDTPSGISKVKILFTL
CCCCCCHHHHHHHHH		45.70-
997UbiquitinationPSGISKVKILFTLAK
CCCCHHHHHHHHHHH		37.11-
1001PhosphorylationSKVKILFTLAKQSKA
HHHHHHHHHHHHHHH		23.51-
1003UbiquitinationVKILFTLAKQSKALG
HHHHHHHHHHHHHHH		12.5621890473
1004UbiquitinationKILFTLAKQSKALGA
HHHHHHHHHHHHHHH		59.21-
1006PhosphorylationLFTLAKQSKALGAYR
HHHHHHHHHHHHHHH		21.13-
1007UbiquitinationFTLAKQSKALGAYRL
HHHHHHHHHHHHHHH		45.17-
1014AcetylationKALGAYRLARHAYDK
HHHHHHHHHHHHHHH		2.9819608861
1018UbiquitinationAYRLARHAYDKLRGL
HHHHHHHHHHHHCCC		14.5221890473
1021AcetylationLARHAYDKLRGLYIP
HHHHHHHHHCCCCCC		27.6619608861
1021UbiquitinationLARHAYDKLRGLYIP
HHHHHHHHHCCCCCC		27.6619608861
1030UbiquitinationRGLYIPARFQKSIEL
CCCCCCHHHHCCEEE		29.2221890473
1031 (in isoform 4)Ubiquitination-13.41-
1033UbiquitinationYIPARFQKSIELGTL
CCCHHHHCCEEECEE		51.1721890473
1033 (in isoform 1)Ubiquitination-51.1721890473
1034UbiquitinationIPARFQKSIELGTLT
CCHHHHCCEEECEEE		15.5421890473
1045UbiquitinationGTLTIRAKPFHDSEE
CEEEEEEEECCCCHH		38.07-
1061UbiquitinationVPLCYRCSTNNPLLN
HHCHHHHCCCCCHHC		25.77-
1072AcetylationPLLNNLGNVCINCRQ
CHHCCCCCEECCCCC		28.7519608861
1074 (in isoform 4)Ubiquitination-1.83-
1084UbiquitinationCRQPFIFSASSYDVL
CCCCEEEECCHHHHH		23.5621890473
1131PhosphorylationQLEIANNSSQILRLV
CEEECCCHHHHHHHE		24.3528555341
1132PhosphorylationLEIANNSSQILRLVE
EEECCCHHHHHHHEE		24.3028555341
1141UbiquitinationILRLVETKDSIGDED
HHHHEECCCCCCCCC		35.6521906983
1141 (in isoform 1)Ubiquitination-35.6521890473
1142 (in isoform 2)Ubiquitination-53.56-
1143PhosphorylationRLVETKDSIGDEDPF
HHEECCCCCCCCCCC		29.9927251275
1153UbiquitinationDEDPFTAKLSFEQGG
CCCCCEEEEEECCCC		41.422190698
1153 (in isoform 1)Ubiquitination-41.4221890473
1154 (in isoform 2)Ubiquitination-7.04-
1155PhosphorylationDPFTAKLSFEQGGSE
CCCEEEEEECCCCCC		26.4828348404
1175PhosphorylationVSRLVLRSMSRRDVL
HHHHHHHHCCCCCCH		19.5624043423
1177PhosphorylationRLVLRSMSRRDVLIK
HHHHHHCCCCCCHHH		25.9624043423
1184UbiquitinationSRRDVLIKRWPPPLR
CCCCCHHHCCCCCCH		44.22-
1194PhosphorylationPPPLRWQYFRSLLPD
CCCCHHHHHHHHCCC		8.2627251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IF122_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IF122_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IF122_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IF140_HUMANIFT140physical
26186194
WDR35_HUMANWDR35physical
26186194
CAB45_HUMANSDF4physical
26186194
WDR19_HUMANWDR19physical
26186194
IFT43_HUMANIFT43physical
26186194
PIHD1_HUMANPIH1D1physical
26186194
WDR35_HUMANWDR35physical
28514442
WDR19_HUMANWDR19physical
28514442
IF140_HUMANIFT140physical
28514442
DNJC7_HUMANDNAJC7physical
28514442
IFT43_HUMANIFT43physical
27173435
WDR35_HUMANWDR35physical
27173435
TT21B_HUMANTTC21Bphysical
27173435
PFKAP_HUMANPFKPphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
218330Cranioectodermal dysplasia 1 (CED1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IF122_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1021, AND MASS SPECTROMETRY.

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