| UniProt ID | CAB45_HUMAN | |
|---|---|---|
| UniProt AC | Q9BRK5 | |
| Protein Name | 45 kDa calcium-binding protein | |
| Gene Name | SDF4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 362 | |
| Subcellular Localization |
Isoform 1: Golgi apparatus lumen . Isoform 5: Cytoplasm . Cell membrane . Cell projection, bleb. Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs. |
|
| Protein Description | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.; Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.. | |
| Protein Sequence | MVWPWVAMASRWGPLIGLAPCCLWLLGAVLLMDASARPANHSSTRERVANREENEILPPDHLNGVKLEMDGHLNRGFHQEVFLGKDLGGFDEDAEPRRSRRKLMVIFSKVDVNTDRKISAKEMQRWIMEKTAEHFQEAMEESKTHFRAVDPDGDGHVSWDEYKVKFLASKGHSEKEVADAIRLNEELKVDEETQEVLENLKDRWYQADSPPADLLLTEEEFLSFLHPEHSRGMLRFMVKEIVRDLDQDGDKQLSVPEFISLPVGTVENQQGQDIDDNWVKDRKKEFEELIDSNHDGIVTAEELESYMDPMNEYNALNEAKQMIAVADENQNHHLEPEEVLKYSEFFTGSKLVDYARSVHEEF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | N-linked_Glycosylation | DASARPANHSSTRER CCCCCCCCCHHHHHH | 37.95 | UniProtKB CARBOHYD | |
| 69 | Sulfoxidation | LNGVKLEMDGHLNRG CCCCEEEECCCCCCC | 12.39 | 30846556 | |
| 85 | Ubiquitination | HQEVFLGKDLGGFDE CCHHHCCCCCCCCCC | 52.51 | 21890473 | |
| 85 (in isoform 4) | Ubiquitination | - | 52.51 | 21890473 | |
| 85 (in isoform 3) | Ubiquitination | - | 52.51 | 21890473 | |
| 85 (in isoform 2) | Ubiquitination | - | 52.51 | 21890473 | |
| 85 (in isoform 1) | Ubiquitination | - | 52.51 | 21890473 | |
| 85 | Ubiquitination | HQEVFLGKDLGGFDE CCHHHCCCCCCCCCC | 52.51 | 21890473 | |
| 98 (in isoform 2) | Ubiquitination | - | 45.27 | 21890473 | |
| 99 | Phosphorylation | EDAEPRRSRRKLMVI CCCCCCHHHCCEEEE | 37.40 | 23917254 | |
| 108 | Phosphorylation | RKLMVIFSKVDVNTD CCEEEEEEECCCCCC | 22.20 | 24719451 | |
| 108 | O-linked_Glycosylation | RKLMVIFSKVDVNTD CCEEEEEEECCCCCC | 22.20 | 55833783 | |
| 118 (in isoform 5) | Ubiquitination | - | 5.15 | 21890473 | |
| 121 | 2-Hydroxyisobutyrylation | TDRKISAKEMQRWIM CCCCCCHHHHHHHHH | 47.10 | - | |
| 121 | Ubiquitination | TDRKISAKEMQRWIM CCCCCCHHHHHHHHH | 47.10 | - | |
| 130 | Ubiquitination | MQRWIMEKTAEHFQE HHHHHHHHHHHHHHH | 35.34 | - | |
| 131 | Phosphorylation | QRWIMEKTAEHFQEA HHHHHHHHHHHHHHH | 24.79 | 29052541 | |
| 139 | Sulfoxidation | AEHFQEAMEESKTHF HHHHHHHHHHHHHCE | 6.05 | 21406390 | |
| 143 | Ubiquitination | QEAMEESKTHFRAVD HHHHHHHHHCEEEEC | 49.66 | - | |
| 158 | Phosphorylation | PDGDGHVSWDEYKVK CCCCCCCCHHHHHHE | 24.12 | 24275569 | |
| 162 | Phosphorylation | GHVSWDEYKVKFLAS CCCCHHHHHHEEECC | 20.71 | - | |
| 163 | 2-Hydroxyisobutyrylation | HVSWDEYKVKFLASK CCCHHHHHHEEECCC | 36.58 | - | |
| 163 | Ubiquitination | HVSWDEYKVKFLASK CCCHHHHHHEEECCC | 36.58 | - | |
| 165 | Ubiquitination | SWDEYKVKFLASKGH CHHHHHHEEECCCCC | 30.43 | - | |
| 170 | Ubiquitination | KVKFLASKGHSEKEV HHEEECCCCCCHHHH | 55.85 | - | |
| 173 | Phosphorylation | FLASKGHSEKEVADA EECCCCCCHHHHHHH | 60.06 | 26699800 | |
| 173 | O-linked_Glycosylation | FLASKGHSEKEVADA EECCCCCCHHHHHHH | 60.06 | OGP | |
| 175 | Ubiquitination | ASKGHSEKEVADAIR CCCCCCHHHHHHHHH | 61.58 | - | |
| 188 (in isoform 1) | Ubiquitination | - | 51.42 | 21890473 | |
| 188 | Ubiquitination | IRLNEELKVDEETQE HHHCHHCCCCHHHHH | 51.42 | 21906983 | |
| 188 (in isoform 4) | Ubiquitination | - | 51.42 | 21890473 | |
| 193 | Phosphorylation | ELKVDEETQEVLENL HCCCCHHHHHHHHHH | 28.16 | 28355574 | |
| 201 (in isoform 4) | Ubiquitination | - | 57.75 | 21890473 | |
| 201 | Ubiquitination | QEVLENLKDRWYQAD HHHHHHHHHHHHCCC | 57.75 | 21906983 | |
| 201 (in isoform 1) | Ubiquitination | - | 57.75 | 21890473 | |
| 209 | Phosphorylation | DRWYQADSPPADLLL HHHHCCCCCCHHHEE | 35.48 | 25159151 | |
| 217 | Phosphorylation | PPADLLLTEEEFLSF CCHHHEECHHHHHHH | 41.12 | 30622161 | |
| 223 | Phosphorylation | LTEEEFLSFLHPEHS ECHHHHHHHHCHHHC | 30.96 | 30622161 | |
| 230 | Phosphorylation | SFLHPEHSRGMLRFM HHHCHHHCHHHHHHH | 28.94 | 30622161 | |
| 239 | Ubiquitination | GMLRFMVKEIVRDLD HHHHHHHHHHHHHHC | 29.90 | - | |
| 247 (in isoform 2) | Ubiquitination | - | 64.98 | 21890473 | |
| 251 | Ubiquitination | DLDQDGDKQLSVPEF HHCCCCCCCCCCCEE | 59.68 | - | |
| 254 | Phosphorylation | QDGDKQLSVPEFISL CCCCCCCCCCEEEEC | 32.88 | 28102081 | |
| 260 | Phosphorylation | LSVPEFISLPVGTVE CCCCEEEECCCCCEE | 31.76 | 29507054 | |
| 265 | Phosphorylation | FISLPVGTVENQQGQ EEECCCCCEECCCCC | 25.53 | 28102081 | |
| 265 | O-linked_Glycosylation | FISLPVGTVENQQGQ EEECCCCCEECCCCC | 25.53 | OGP | |
| 299 | Phosphorylation | SNHDGIVTAEELESY CCCCCCCCHHHHHHH | 26.82 | 14702039 | |
| 341 | Ubiquitination | LEPEEVLKYSEFFTG CCHHHHHHHHHHHCC | 52.48 | - | |
| 343 | O-linked_Glycosylation | PEEVLKYSEFFTGSK HHHHHHHHHHHCCCH | 26.75 | 55826533 | |
| 347 | O-linked_Glycosylation | LKYSEFFTGSKLVDY HHHHHHHCCCHHHHH | 45.96 | 55823899 | |
| 349 | O-linked_Glycosylation | YSEFFTGSKLVDYAR HHHHHCCCHHHHHHH | 21.54 | 55823905 | |
| 349 | Phosphorylation | YSEFFTGSKLVDYAR HHHHHCCCHHHHHHH | 21.54 | 29507054 | |
| 350 (in isoform 1) | Ubiquitination | - | 54.60 | 21890473 | |
| 350 | Ubiquitination | SEFFTGSKLVDYARS HHHHCCCHHHHHHHH | 54.60 | 21890473 | |
| 354 | Phosphorylation | TGSKLVDYARSVHEE CCCHHHHHHHHHHHC | 9.09 | 23403867 | |
| 357 | O-linked_Glycosylation | KLVDYARSVHEEF-- HHHHHHHHHHHCC-- | 21.47 | 54919541 | |
| 357 | Phosphorylation | KLVDYARSVHEEF-- HHHHHHHHHHHCC-- | 21.47 | 28355574 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CAB45_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CAB45_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CAB45_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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