dbPTM

MADD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MADD_HUMAN
UniProt AC	Q8WXG6
Protein Name	MAP kinase-activating death domain protein
Gene Name	MADD {ECO:0000312\|EMBL:AAB57735.1, ECO:0000312\|HGNC:HGNC:6766}
Organism	Homo sapiens (Human).
Sequence Length	1647
Subcellular Localization	Membrane . Cytoplasm .
Protein Description	Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect..
Protein Sequence	MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	MSLRDDTSFVFTLTD HHCCCCCEEEEEEEE	26.80	23828894
122	Phosphorylation	GSRGKEGTHATCASE CCCCCCCCCCEECCC	14.93	28060719
125	Phosphorylation	GKEGTHATCASEEGG CCCCCCCEECCCCCC	10.86	28060719
128	Phosphorylation	GTHATCASEEGGTES CCCCEECCCCCCCCC	38.02	28060719
133	Phosphorylation	CASEEGGTESSESGS ECCCCCCCCCCCCCC	43.48	28060719
135	Phosphorylation	SEEGGTESSESGSSL CCCCCCCCCCCCCCC	38.96	28060719
136	Phosphorylation	EEGGTESSESGSSLQ CCCCCCCCCCCCCCC	29.56	28060719
138	Phosphorylation	GGTESSESGSSLQPL CCCCCCCCCCCCCCC	46.02	28060719
140	Phosphorylation	TESSESGSSLQPLSA CCCCCCCCCCCCCCC	36.83	28060719
141	Phosphorylation	ESSESGSSLQPLSAD CCCCCCCCCCCCCCC	34.25	28060719
146	Phosphorylation	GSSLQPLSADSTPDV CCCCCCCCCCCCCCC	36.39	28060719
149	Phosphorylation	LQPLSADSTPDVNQS CCCCCCCCCCCCCCC	41.37	25850435
150	Phosphorylation	QPLSADSTPDVNQSP CCCCCCCCCCCCCCH	24.85	28450419
156	Phosphorylation	STPDVNQSPRGKRRA CCCCCCCCHHHHHHH	16.03	30278072
169	Phosphorylation	RAKAGSRSRNSTLTS HHCCCCCCCCHHHHH	37.19	30576142
181	Phosphorylation	LTSLCVLSHYPFFST HHHHHHHHCCCCHHH	10.69	30576142
228	Phosphorylation	DTMWRIFTGSLLVEE HHHHHHHCCCCCCCC	24.40	29214152
230	Phosphorylation	MWRIFTGSLLVEEKS HHHHHCCCCCCCCHH	18.57	21815630
237	Phosphorylation	SLLVEEKSSALLHDL CCCCCCHHHHHHHCH	24.91	28060719
238	Phosphorylation	LLVEEKSSALLHDLR CCCCCHHHHHHHCHH	33.72	28060719
257	Phosphorylation	WIYRLLRSPVPVSGQ HHHHHHCCCCCCCCC	30.16	25627689
262	Phosphorylation	LRSPVPVSGQKRVDI HCCCCCCCCCCCEEE	29.45	28188228
288	Phosphorylation	TFALPDPSRFTLVDF HEECCCCCCCEEECC	47.62	25599653
425	Ubiquitination	EPESLELKKHLKQAL CCCHHHHHHHHHHHH	28.86	2190698
425 (in isoform 2)	Ubiquitination	-	28.86	21906983
425 (in isoform 1)	Ubiquitination	-	28.86	21906983
425 (in isoform 3)	Ubiquitination	-	28.86	21906983
425 (in isoform 4)	Ubiquitination	-	28.86	21906983
425 (in isoform 5)	Ubiquitination	-	28.86	21906983
425 (in isoform 6)	Ubiquitination	-	28.86	21906983
425 (in isoform 7)	Ubiquitination	-	28.86	21906983
426	Ubiquitination	PESLELKKHLKQALA CCHHHHHHHHHHHHH	67.79	-
429	Ubiquitination	LELKKHLKQALASMS HHHHHHHHHHHHHCC	32.99	-
471	Phosphorylation	DLQSTPSTEFNPLIY CCCCCCCCCCCCCCC	45.88	24173317
541	Ubiquitination	RQTPFAEKLARTQAV CCCCHHHHHHHCHHH	43.98	-
613	Phosphorylation	SVPPERDSDSEPTDD CCCCCCCCCCCCCCC	49.62	-
623	Phosphorylation	EPTDDSGSDSMDYDD CCCCCCCCCCCCCCC	30.39	21601212
631	Phosphorylation	DSMDYDDSSSSYSSL CCCCCCCCCCCCHHH	29.26	-
636	Phosphorylation	DDSSSSYSSLGDFVS CCCCCCCHHHHHHHH	22.49	-
669	Phosphorylation	HAALGDASEVEIDEL HHHCCCCHHHCHHHH	47.09	26657352
689	Phosphorylation	AEEPGPDSENSQENP CCCCCCCCCCCCCCC	41.64	21815630
692	Phosphorylation	PGPDSENSQENPPLR CCCCCCCCCCCCCCC	34.52	21815630
700	Phosphorylation	QENPPLRSSSSTTAS CCCCCCCCCCCCCCC	42.10	23663014
701	Phosphorylation	ENPPLRSSSSTTASS CCCCCCCCCCCCCCC	23.13	23663014
702	Phosphorylation	NPPLRSSSSTTASSS CCCCCCCCCCCCCCC	32.71	23663014
703	Phosphorylation	PPLRSSSSTTASSSP CCCCCCCCCCCCCCC	31.55	23663014
704	Phosphorylation	PLRSSSSTTASSSPS CCCCCCCCCCCCCCC	28.47	23663014
705	Phosphorylation	LRSSSSTTASSSPST CCCCCCCCCCCCCCC	26.87	23663014
707	Phosphorylation	SSSSTTASSSPSTVI CCCCCCCCCCCCCEE	29.29	23663014
708	Phosphorylation	SSSTTASSSPSTVIH CCCCCCCCCCCCEEE	43.75	23663014
709	Phosphorylation	SSTTASSSPSTVIHG CCCCCCCCCCCEEEC	22.00	25159151
711	Phosphorylation	TTASSSPSTVIHGAN CCCCCCCCCEEECCC	36.94	23663014
712	Phosphorylation	TASSSPSTVIHGANS CCCCCCCCEEECCCC	27.19	23663014
719	Phosphorylation	TVIHGANSEPADSTE CEEECCCCCCCCCCC	44.41	23663014
724	Phosphorylation	ANSEPADSTEMDDKA CCCCCCCCCCCCHHH	28.51	26074081
725	Phosphorylation	NSEPADSTEMDDKAA CCCCCCCCCCCHHHH	35.56	30576142
736	Phosphorylation	DKAAVGVSKPLPSVP HHHHCCCCCCCCCCC	23.72	24719451
741	Phosphorylation	GVSKPLPSVPPSIGK CCCCCCCCCCCCCCC	55.74	20068231
745	Phosphorylation	PLPSVPPSIGKSNVD CCCCCCCCCCCCCCC	37.59	20068231
762	Phosphorylation	QAEIGEGSVRRRIYD HHCCCCCHHHHHCCC	14.24	21815630
768	Phosphorylation	GSVRRRIYDNPYFEP CHHHHHCCCCCCCCC	14.09	27642862
770 (in isoform 4)	Phosphorylation	-	19.05	29116813
770 (in isoform 5)	Phosphorylation	-	19.05	29116813
770 (in isoform 6)	Phosphorylation	-	19.05	29116813
770 (in isoform 8)	Phosphorylation	-	19.05	29116813
772	Phosphorylation	RRIYDNPYFEPQYGF HHCCCCCCCCCCCCC	27.16	-
775 (in isoform 4)	Phosphorylation	-	23.85	25849741
775 (in isoform 5)	Phosphorylation	-	23.85	25849741
775 (in isoform 6)	Phosphorylation	-	23.85	25849741
775 (in isoform 8)	Phosphorylation	-	23.85	25849741
777	Phosphorylation	NPYFEPQYGFPPEED CCCCCCCCCCCCCCC	31.30	27642862
797	Phosphorylation	ESYTPRFSQHVSGNR CCCCHHHHHHCCCCH	22.21	29396449
801	Phosphorylation	PRFSQHVSGNRAQKL HHHHHHCCCCHHHHH	28.38	25159151
813	Phosphorylation	QKLLRPNSLRLASDS HHHHCCCCEEECCCC	19.97	21712546
818	Phosphorylation	PNSLRLASDSDAESD CCCEEECCCCCCCCC	42.09	29255136
820	Phosphorylation	SLRLASDSDAESDSR CEEECCCCCCCCCCC	35.90	23401153
824	Phosphorylation	ASDSDAESDSRASSP CCCCCCCCCCCCCCC	42.48	29255136
826	Phosphorylation	DSDAESDSRASSPNS CCCCCCCCCCCCCCC	38.74	25849741
826	O-linked_Glycosylation	DSDAESDSRASSPNS CCCCCCCCCCCCCCC	38.74	28657654
829	Phosphorylation	AESDSRASSPNSTVS CCCCCCCCCCCCCCC	45.26	28450419
830	Phosphorylation	ESDSRASSPNSTVSN CCCCCCCCCCCCCCC	27.41	28464451
833	Phosphorylation	SRASSPNSTVSNTST CCCCCCCCCCCCCCC	33.30	28450419
834	O-linked_Glycosylation	RASSPNSTVSNTSTE CCCCCCCCCCCCCCC	34.29	28657654
834	Phosphorylation	RASSPNSTVSNTSTE CCCCCCCCCCCCCCC	34.29	28464451
836	Phosphorylation	SSPNSTVSNTSTEGF CCCCCCCCCCCCCCC	34.18	28450419
838	Phosphorylation	PNSTVSNTSTEGFGG CCCCCCCCCCCCCCH	29.53	28450419
839	Phosphorylation	NSTVSNTSTEGFGGI CCCCCCCCCCCCCHH	28.81	28450419
840	Phosphorylation	STVSNTSTEGFGGIM CCCCCCCCCCCCHHH	37.78	28464451
848	Phosphorylation	EGFGGIMSFASSLYR CCCCHHHHHHHHHHH	18.75	20068231
851	Phosphorylation	GGIMSFASSLYRNHS CHHHHHHHHHHHCCC	20.90	27080861
852	Phosphorylation	GIMSFASSLYRNHST HHHHHHHHHHHCCCC	26.45	27080861
854	Phosphorylation	MSFASSLYRNHSTSF HHHHHHHHHCCCCCC	16.00	27080861
858	Phosphorylation	SSLYRNHSTSFSLSN HHHHHCCCCCCEECC	29.33	23401153
859	Phosphorylation	SLYRNHSTSFSLSNL HHHHCCCCCCEECCC	26.66	25159151
860	Phosphorylation	LYRNHSTSFSLSNLT HHHCCCCCCEECCCC	18.82	25159151
862	Phosphorylation	RNHSTSFSLSNLTLP HCCCCCCEECCCCCC	30.56	23401153
864	Phosphorylation	HSTSFSLSNLTLPTK CCCCCEECCCCCCCC	28.70	28450419
867	Phosphorylation	SFSLSNLTLPTKGAR CCEECCCCCCCCCHH	34.64	28450419
870	Phosphorylation	LSNLTLPTKGAREKA ECCCCCCCCCHHCCC	45.26	24117733
871	Methylation	SNLTLPTKGAREKAT CCCCCCCCCHHCCCC	48.94	115972687
876	Ubiquitination	PTKGAREKATPFPSL CCCCHHCCCCCCCCC	52.59	-
878	Phosphorylation	KGAREKATPFPSLKV CCHHCCCCCCCCCEE	36.21	26074081
882	Phosphorylation	EKATPFPSLKVFGLN CCCCCCCCCEEECHH	41.00	23401153
884 (in isoform 3)	Methylation	-	39.60	-
884	Methylation	ATPFPSLKVFGLNTL CCCCCCCEEECHHHH	39.60	-
914	Ubiquitination	RRALVDQKSSVIKHS CCHHHCCCCHHCCCC	39.99	-
915	Phosphorylation	RALVDQKSSVIKHSP CHHHCCCCHHCCCCC	24.97	29396449
916	Phosphorylation	ALVDQKSSVIKHSPT HHHCCCCHHCCCCCC	34.59	28188228
919	Ubiquitination	DQKSSVIKHSPTVKR CCCCHHCCCCCCCCC	35.56	-
921	Phosphorylation	KSSVIKHSPTVKREP CCHHCCCCCCCCCCC	19.77	25159151
923	Phosphorylation	SVIKHSPTVKREPPS HHCCCCCCCCCCCCC	41.49	28188228
930	Phosphorylation	TVKREPPSPQGRSSN CCCCCCCCCCCCCCC	40.34	29255136
935	Phosphorylation	PPSPQGRSSNSSENQ CCCCCCCCCCCHHHH	40.47	25627689
936	Phosphorylation	PSPQGRSSNSSENQQ CCCCCCCCCCHHHHH	39.09	25627689
964	Ubiquitination	GVGWLNMKKVRRLLE CCCCCCHHHHHHHHH	47.22	-
972	Phosphorylation	KVRRLLESEQLRVFV HHHHHHHHHHHHHHH	30.52	25159151
981	Phosphorylation	QLRVFVLSKLNRMVQ HHHHHHHHHHHHHHC	29.78	-
982	Acetylation	LRVFVLSKLNRMVQS HHHHHHHHHHHHHCC	45.69	25953088
989	Phosphorylation	KLNRMVQSEDDARQD HHHHHHCCCCHHHHC	31.42	25404012
1047 (in isoform 5)	Phosphorylation	-	13.88	25849741
1047 (in isoform 6)	Phosphorylation	-	13.88	25849741
1047 (in isoform 8)	Phosphorylation	-	13.88	25849741
1056 (in isoform 5)	Phosphorylation	-	47.18	20873877
1056 (in isoform 6)	Phosphorylation	-	47.18	20873877
1056 (in isoform 8)	Phosphorylation	-	47.18	20873877
1059	Phosphorylation	EPDKRKRSPTESVNT CCCCCCCCCCCCCCC	38.93	19664994
1061	Phosphorylation	DKRKRSPTESVNTPV CCCCCCCCCCCCCCC	41.98	30266825
1063	Phosphorylation	RKRSPTESVNTPVGK CCCCCCCCCCCCCCC	24.12	30266825
1066	Phosphorylation	SPTESVNTPVGKDPG CCCCCCCCCCCCCCC	19.73	25159151
1067 (in isoform 4)	Phosphorylation	-	27.88	25849741
1070	Ubiquitination	SVNTPVGKDPGLAGR CCCCCCCCCCCCCCC	62.07	-
1071 (in isoform 5)	Phosphorylation	-	36.25	20873877
1071 (in isoform 6)	Phosphorylation	-	36.25	20873877
1071 (in isoform 8)	Phosphorylation	-	36.25	20873877
1076 (in isoform 4)	Phosphorylation	-	38.86	20873877
1090 (in isoform 3)	Phosphorylation	-	57.08	25849741
1091 (in isoform 4)	Phosphorylation	-	9.26	20873877
1099 (in isoform 3)	Phosphorylation	-	43.71	20873877
1110	Phosphorylation	PKELDTRSLKEENFI CCCCCCCCHHHHCHH	45.98	27422710
1110 (in isoform 2)	Phosphorylation	-	45.98	25849741
1114 (in isoform 3)	Phosphorylation	-	56.72	20873877
1119	Phosphorylation	KEENFIASIELWNKH HHHCHHHHHHHHHHH	16.27	24076635
1119 (in isoform 2)	Phosphorylation	-	16.27	20873877
1131	Acetylation	NKHQEVKKQKALEKQ HHHHHHHHHHHHHHH	63.31	7661891
1134 (in isoform 2)	Phosphorylation	-	20.61	20873877
1144	Acetylation	KQRPEVIKPVFDLGE HHCHHHHHCCCCCCC	40.06	7661899
1152 (in isoform 3)	Phosphorylation	-	47.87	30177828
1153 (in isoform 3)	Phosphorylation	-	64.61	30177828
1154 (in isoform 3)	Phosphorylation	-	73.53	30177828
1157	Phosphorylation	GETEEKKSQISADSG CCCHHHHHCCCCCCC	43.76	-
1157 (in isoform 3)	Phosphorylation	-	43.76	30177828
1160	Phosphorylation	EEKKSQISADSGVSL HHHHHCCCCCCCCCC	20.56	20068231
1160 (in isoform 3)	Phosphorylation	-	20.56	30177828
1161 (in isoform 3)	Phosphorylation	-	19.33	30177828
1163 (in isoform 3)	Phosphorylation	-	40.59	30177828
1165 (in isoform 3)	Phosphorylation	-	4.99	30177828
1166	Phosphorylation	ISADSGVSLTSSSQR CCCCCCCCCCCCCCC	29.47	28555341
1166 (in isoform 3)	Phosphorylation	-	29.47	30177828
1168	Phosphorylation	ADSGVSLTSSSQRTD CCCCCCCCCCCCCCC	21.03	-
1170	Phosphorylation	SGVSLTSSSQRTDQD CCCCCCCCCCCCCCC	25.84	-
1174	Phosphorylation	LTSSSQRTDQDSVIG CCCCCCCCCCCCCCE	30.30	20068231
1178	Phosphorylation	SQRTDQDSVIGVSPA CCCCCCCCCCEECCE	15.25	19664994
1183	Phosphorylation	QDSVIGVSPAVMIRS CCCCCEECCEEEEEC	11.26	21815630
1187	Sulfoxidation	IGVSPAVMIRSSSQD CEECCEEEEECCCCC	1.98	21406390
1190	Phosphorylation	SPAVMIRSSSQDSEV CCEEEEECCCCCCCC	24.34	28450419
1191	Phosphorylation	PAVMIRSSSQDSEVS CEEEEECCCCCCCCE	23.36	28450419
1192	Phosphorylation	AVMIRSSSQDSEVST EEEEECCCCCCCCEE	38.97	28450419
1195	Phosphorylation	IRSSSQDSEVSTVVS EECCCCCCCCEEEEE	32.06	28270605
1198	Phosphorylation	SSQDSEVSTVVSNSS CCCCCCCEEEEECCC	16.07	28270605
1198 (in isoform 8)	Phosphorylation	-	16.07	-
1199	Phosphorylation	SQDSEVSTVVSNSSG CCCCCCEEEEECCCC	30.06	28450419
1200 (in isoform 8)	Phosphorylation	-	3.28	-
1202	Phosphorylation	SEVSTVVSNSSGETL CCCEEEEECCCCCEE	27.02	28450419
1202 (in isoform 5)	Phosphorylation	-	27.02	-
1202 (in isoform 6)	Phosphorylation	-	27.02	-
1204	Phosphorylation	VSTVVSNSSGETLGA CEEEEECCCCCEECC	32.01	28270605
1204 (in isoform 5)	Phosphorylation	-	32.01	-
1204 (in isoform 6)	Phosphorylation	-	32.01	-
1205	Phosphorylation	STVVSNSSGETLGAD EEEEECCCCCEECCC	44.92	28270605
1208	Phosphorylation	VSNSSGETLGADSDL EECCCCCEECCCCCC	33.73	28270605
1213	Phosphorylation	GETLGADSDLSSNAG CCEECCCCCCCCCCC	39.66	-
1222 (in isoform 4)	Phosphorylation	-	23.10	-
1224 (in isoform 4)	Phosphorylation	-	52.92	-
1233	Phosphorylation	EGSVHLASSRGTLSD CCCEEEEECCCCCCH	27.25	26074081
1234	Phosphorylation	GSVHLASSRGTLSDS CCEEEEECCCCCCHH	29.17	26074081
1237	Phosphorylation	HLASSRGTLSDSEIE EEEECCCCCCHHHHC	23.21	29255136
1239	Phosphorylation	ASSRGTLSDSEIETN EECCCCCCHHHHCCC	38.64	19664994
1241	Phosphorylation	SRGTLSDSEIETNSA CCCCCCHHHHCCCCC	36.78	29255136
1244 (in isoform 3)	Phosphorylation	-	37.57	-
1245	Phosphorylation	LSDSEIETNSATSTI CCHHHHCCCCCCCHH	39.88	30266825
1246 (in isoform 3)	Phosphorylation	-	19.50	-
1247	Phosphorylation	DSEIETNSATSTIFG HHHHCCCCCCCHHHC	40.10	30266825
1249	Phosphorylation	EIETNSATSTIFGKA HHCCCCCCCHHHCCH	26.65	23403867
1250	Phosphorylation	IETNSATSTIFGKAH HCCCCCCCHHHCCHH	21.15	23403867
1251	Phosphorylation	ETNSATSTIFGKAHS CCCCCCCHHHCCHHH	18.90	23403867
1258	Phosphorylation	TIFGKAHSLKPSIKE HHHCCHHHCCHHHHH	42.84	23312004
1260	Ubiquitination	FGKAHSLKPSIKEKL HCCHHHCCHHHHHHH	39.47	-
1262	Phosphorylation	KAHSLKPSIKEKLAG CHHHCCHHHHHHHCC	44.71	-
1265 (in isoform 2)	Phosphorylation	-	52.19	-
1267 (in isoform 2)	Phosphorylation	-	7.37	-
1270	Phosphorylation	IKEKLAGSPIRTSED HHHHHCCCCCCCCCC	16.14	9796103
1274	Phosphorylation	LAGSPIRTSEDVSQR HCCCCCCCCCCHHHH	36.87	22199227
1275	Phosphorylation	AGSPIRTSEDVSQRV CCCCCCCCCCHHHHH	23.19	22199227
1279	Phosphorylation	IRTSEDVSQRVYLYE CCCCCCHHHHHHHHH	25.29	23312004
1283	Phosphorylation	EDVSQRVYLYEGLLG CCHHHHHHHHHCCCC	13.02	-
1285	Phosphorylation	VSQRVYLYEGLLGRD HHHHHHHHHCCCCCC	7.11	-
1352	Phosphorylation	PQEMIDRYLSLGEHD HHHHHHHHHHCCHHH	9.26	28060719
1354	Phosphorylation	EMIDRYLSLGEHDRK HHHHHHHHCCHHHHH	25.95	28060719
1380	Phosphorylation	TLLHNLISYMLLMKV HHHHHHHHHHHHHHC	13.99	21214269
1381	Phosphorylation	LLHNLISYMLLMKVN HHHHHHHHHHHHHCC	5.70	21214269
1432	Phosphorylation	GRDLSIWSSGSRHMK CCCCEEECCCCCCCC	24.13	28555341
1433	Phosphorylation	RDLSIWSSGSRHMKK CCCEEECCCCCCCCC	26.28	24719451
1488	Phosphorylation	EKLINMTYCPKTKVL HHHHCCCCCCCCCEE	8.93	-
1503	Phosphorylation	CLWRRNGSETQLNKF EEEECCCCHHHHHHH	40.81	28348404
1535	Phosphorylation	RAAARQQSIKPGPEL HHHHHHCCCCCCCCC	25.00	28555341
1537	Ubiquitination	AARQQSIKPGPELGG HHHHCCCCCCCCCCC	49.52	-
1606	Phosphorylation	PEIKEVVSHKYKTPM HHHHHHHCCCCCCCC	21.31	29496907
1608	Ubiquitination	IKEVVSHKYKTPMAH HHHHHCCCCCCCCHH	40.72	-
1609	Phosphorylation	KEVVSHKYKTPMAHE HHHHCCCCCCCCHHH	18.05	29496907
1646	Phosphorylation	RTPPRPVSS------ CCCCCCCCC------	32.77	28348404
1647	Phosphorylation	TPPRPVSS------- CCCCCCCC-------	44.46	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MADD_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MADD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MADD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
VP13D_HUMAN	VPS13D	physical	12421765

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MADD_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818; SER-820; SER-921AND SER-1270, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1237, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1237, AND MASSSPECTROMETRY.	19369195 [Abstract]