dbPTM

VP13D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VP13D_HUMAN
UniProt AC	Q5THJ4
Protein Name	Vacuolar protein sorting-associated protein 13D
Gene Name	VPS13D {ECO:0000312\|EMBL:CAE75586.1, ECO:0000312\|HGNC:HGNC:23595}
Organism	Homo sapiens (Human).
Sequence Length	4388
Subcellular Localization
Protein Description
Protein Sequence	MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGFIGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEKWKNDRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQNAVNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLEPVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTVRLDISAPQVIFPDDFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFDLLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQPLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGGTKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLAGREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKIPIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNKYPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLSNTSQKSLSVKEVKSFTQIQATFCISELQVQLSGDLTLGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLEKNPDSKYKNLMVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQRPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPLLRREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGTHSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHVCLLDCVVVDLQDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSLLTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIEEFMRPYDLQDPRIHTVLSGEVYTCMCFLIDMVNVSLELKDPKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMMAFDTRYAGQKTSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRVFLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVVTKRSSLPVSNERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHDTALSIVDPVQIQMELVGNSSYQNSSGLMDAFNSEDFPPVLEIQLQALDIRLSYNDVQLFLAIAKSIPEQANAAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLELQLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPLISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHFTLSGDYYNRALSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRLDINITSVLIDQYVSTKESWMADYCKDDKDIESAKSEDWMGSSVDPPCFGQSLPLVYLRTRSTASLTNLEHQIYARAEVKTPKRRQPFVPFALRNHTGCTLWFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEWREVLTGEEIPFEFEARGKLRHRHTHDLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPDKNSSSSTIGSPSSRTNIIHPQVYFSSLPPVRVVFAVTMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSWRLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPDYMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPINGTLKPGKEAALHTADTSQNIELGVSLENFPLCKELLIPPGTQNYMVRMRLYDVNRRQLNLTIRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLTVKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYTFSGLQEGTGRPVASNKAITCAELVLDVSPKTQRVILKKKEPGKRSQLWRMTGTGMLAHEGSSVPHNPNKPSAARSTEGSAILDIAGLAAVTDNRYEPLMLRKPDRRRSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFDGAEVVLGPDTSMELLGPVPPEQQFINQKMRPGSGMLSIRVIPDGPTRALQITDFCHRKSSRSYEVDELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLSLINKVPEELVFASLTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNENEVIETGPAVQVNAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAESEVEKYDENLHEKTAEQGGTPIRYYFENLKISIPQIKLSVFTSNKLPLDLKALKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGVTGLIKYGNVGGLIRNVTHGVSNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRCCTGPQGLLPRYSESQAEGQEQLFKLTDNIQDEFFIAVENIDSYCVLISSKAVYFLKSGDYVDREAIFLEVKYDDLYHCLVSKDHGKVYVQVTKKAVSTSSGVSIPGPSHQKPMVHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLSENREQLELDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LNTYLGKYVNNLNTD HHHHHHHHHHCCCHH	13.45	-
131	Phosphorylation	DRQQKGESYWYSVTA CHHHCCCCEEEEHHH	29.63	24043423
132	Phosphorylation	RQQKGESYWYSVTAS HHHCCCCEEEEHHHH	12.22	26552605
134	Phosphorylation	QKGESYWYSVTASVV HCCCCEEEEHHHHHH	5.75	24043423
135	Phosphorylation	KGESYWYSVTASVVT CCCCEEEEHHHHHHH	9.99	24043423
137	Phosphorylation	ESYWYSVTASVVTRI CCEEEEHHHHHHHHH	13.79	24043423
139	Phosphorylation	YWYSVTASVVTRIVE EEEEHHHHHHHHHHH	14.04	24043423
142	Phosphorylation	SVTASVVTRIVENIE EHHHHHHHHHHHCCE	16.72	24043423
262	Phosphorylation	KPLRSRHSPRIDCDI CCCCCCCCCCCCCCE	18.11	17081983
273	Phosphorylation	DCDIQLETIPLKLSQ CCCEEECCCCCCHHH	36.17	24719451
351	Phosphorylation	HRARDAVSYTDKYFN HHHHHHHHHHHHHHH	24.84	30387612
353	Phosphorylation	ARDAVSYTDKYFNKL HHHHHHHHHHHHHHH	20.64	30387612
386	Ubiquitination	EQSFEELKILRELVH CCCHHHHHHHHHHHH	42.87	29967540
545 (in isoform 2)	Phosphorylation	-	22.13	-
545	Phosphorylation	ESLPRRNSSLLSVRL HHCCCCCCCCCCEEE	22.13	20068231
546 (in isoform 2)	Phosphorylation	-	36.56	-
546	Phosphorylation	SLPRRNSSLLSVRLG HCCCCCCCCCCEEEC	36.56	20068231
549 (in isoform 2)	Phosphorylation	-	15.52	-
549	Phosphorylation	RRNSSLLSVRLGGLF CCCCCCCCEEECCEE	15.52	20068231
583	Phosphorylation	QKEVGRVSQSFGLQT HHCCCCCCHHCCCCC	20.81	23322592
583	O-linked_Glycosylation	QKEVGRVSQSFGLQT HHCCCCCCHHCCCCC	20.81	28657654
585	O-linked_Glycosylation	EVGRVSQSFGLQTTS CCCCCCHHCCCCCCC	17.49	28657654
585	Phosphorylation	EVGRVSQSFGLQTTS CCCCCCHHCCCCCCC	17.49	23322592
590 (in isoform 2)	Phosphorylation	-	27.97	-
590	Phosphorylation	SQSFGLQTTSADRSD CHHCCCCCCCCCCCC	27.97	23322592
591	Phosphorylation	QSFGLQTTSADRSDH HHCCCCCCCCCCCCC	14.68	23322592
592 (in isoform 2)	Phosphorylation	-	31.40	-
592	Phosphorylation	SFGLQTTSADRSDHY HCCCCCCCCCCCCCC	31.40	23322592
661	Phosphorylation	VHTSGFGYQSELELR EECCCCCCHHHHHHH	13.45	30108239
663	Phosphorylation	TSGFGYQSELELRVA CCCCCCHHHHHHHHH	35.35	28450419
705	Ubiquitination	GDFIEESKRWTVRLD HHHHHHHCCEEEEEE	56.06	-
705	Ubiquitination	GDFIEESKRWTVRLD HHHHHHHCCEEEEEE	56.06	-
756	Phosphorylation	RRKSRDGSASEETQF CCCCCCCCCCCCCCC	32.67	23927012
758	Phosphorylation	KSRDGSASEETQFSD CCCCCCCCCCCCCCC	37.35	23927012
761	Phosphorylation	DGSASEETQFSDDEY CCCCCCCCCCCCCCC	30.75	23927012
764	Phosphorylation	ASEETQFSDDEYKTP CCCCCCCCCCCCCCC	34.04	25159151
768	Phosphorylation	TQFSDDEYKTPLATP CCCCCCCCCCCCCCC	27.44	23927012
791	Phosphorylation	SSSNGEKTPPFSGVE CCCCCCCCCCCCCCC	31.71	25850435
795	Phosphorylation	GEKTPPFSGVEFSEE CCCCCCCCCCCCCHH	47.94	27080861
814	Phosphorylation	HLMSTKMYERYSLSF HHHCCCHHHHHCCCH	9.98	30576142
817	Phosphorylation	STKMYERYSLSFMDL CCCHHHHHCCCHHCH	11.30	30576142
820	Phosphorylation	MYERYSLSFMDLQIM HHHHHCCCHHCHHHH	16.75	30576142
846	Phosphorylation	QDIDVGPTHVVEKFN EECCCCCCCHHHEEE	22.75	26126808
911	Phosphorylation	PEMKTSDTQIKEKIF CCCCCCCCHHHHHHC	31.77	28857561
926	Phosphorylation	PQEEQRGSLQDSVMN CHHHHCCCHHHHHHH	25.66	26657352
930	Phosphorylation	QRGSLQDSVMNLTQS HCCCHHHHHHHHHHH	15.42	27050516
935	Phosphorylation	QDSVMNLTQSIVLLE HHHHHHHHHHHHHHH	18.44	21712546
992	Phosphorylation	AHFVKRPYDAEVSLT CEECCCCCCCCEEEE	31.64	26503514
997	Phosphorylation	RPYDAEVSLTVHGLL CCCCCCEEEEEEEEE	15.16	26503514
1027	Phosphorylation	MASHKNLSFDIPTGS HHCCCCCEEECCCCC	30.21	25159151
1032	Phosphorylation	NLSFDIPTGSLRDSR CCEEECCCCCCCCCC	39.47	30266825
1034	Phosphorylation	SFDIPTGSLRDSRAQ EEECCCCCCCCCCCC	23.78	30266825
1038 (in isoform 2)	Phosphorylation	-	24.07	-
1038	Phosphorylation	PTGSLRDSRAQSPVS CCCCCCCCCCCCCCC	24.07	30266825
1042 (in isoform 2)	Phosphorylation	-	26.70	-
1042	Phosphorylation	LRDSRAQSPVSGPNV CCCCCCCCCCCCCCE	26.70	29255136
1045 (in isoform 2)	Phosphorylation	-	52.49	-
1045	Phosphorylation	SRAQSPVSGPNVAHL CCCCCCCCCCCEEEC	52.49	30266825
1053	Phosphorylation	GPNVAHLTDGATLND CCCEEECCCCCCCCC	23.63	23403867
1057	Phosphorylation	AHLTDGATLNDRSAT EECCCCCCCCCCCCC	31.46	23403867
1062	Phosphorylation	GATLNDRSATSVSLD CCCCCCCCCCCCCHH	38.47	21712546
1064	Phosphorylation	TLNDRSATSVSLDKI CCCCCCCCCCCHHHH	30.79	28857561
1065	Phosphorylation	LNDRSATSVSLDKIL CCCCCCCCCCHHHHC	14.93	23312004
1067	Phosphorylation	DRSATSVSLDKILTK CCCCCCCCHHHHCCH	30.53	28857561
1078	Phosphorylation	ILTKEQESLIKLEYQ HCCHHHHHHHHHHHE	34.78	24719451
1138	Phosphorylation	PKEKDDLSPQPLMTD CCCCCCCCCCCCCCH	28.60	29255136
1144	Phosphorylation	LSPQPLMTDFERSFR CCCCCCCCHHHHHHH	45.26	23403867
1192	Ubiquitination	NREKYGRKIATASIG CHHHHCCEEEEEEEC	32.12	29967540
1197	Phosphorylation	GRKIATASIGGTKVN CCEEEEEEECCEEEE	19.88	24667141
1201	Phosphorylation	ATASIGGTKVNVSMG EEEEECCEEEEEECC	26.97	24667141
1331	Phosphorylation	KVTTVLATKTAEYSE HHHHHHEECCCHHHH	25.43	20068231
1341 (in isoform 2)	Phosphorylation	-	26.48	-
1341	Phosphorylation	AEYSEMVSLFETPRK CHHHHHHHHCCCCCC	26.48	22199227
1345	Phosphorylation	EMVSLFETPRKTREP HHHHHCCCCCCCCCC	22.51	22199227
1387	Phosphorylation	NIESPVVSIPRKPGS CCCCCEEECCCCCCC	27.40	24719451
1457	Phosphorylation	SRMFCPPSGSGSANS CEEECCCCCCCCCCC	30.63	27080861
1459	Phosphorylation	MFCPPSGSGSANSQE EECCCCCCCCCCCCH	33.63	27080861
1461	Phosphorylation	CPPSGSGSANSQEEA CCCCCCCCCCCCHHH	26.44	27080861
1464	Phosphorylation	SGSGSANSQEEAHFT CCCCCCCCCHHHHHC	38.39	27080861
1478	Phosphorylation	TRHDFFESLHRGQAF CHHHHHHHHHCCCEE	25.07	22985185
1511	Phosphorylation	RESELTFSLSPDDLG CCEEEEEEECHHHCC	23.78	28348404
1513	Phosphorylation	SELTFSLSPDDLGTS EEEEEEECHHHCCCC	25.69	28348404
1573	Phosphorylation	TSSPCPDSPLPPLST CCCCCCCCCCCCCCC	17.30	28985074
1595	Phosphorylation	RKENGLFSHSSLSNT CCCCCCCCCCCCCCC	27.74	23403867
1597	Phosphorylation	ENGLFSHSSLSNTSQ CCCCCCCCCCCCCCC	31.60	23186163
1598	Phosphorylation	NGLFSHSSLSNTSQK CCCCCCCCCCCCCCC	30.32	23403867
1600	Phosphorylation	LFSHSSLSNTSQKSL CCCCCCCCCCCCCCC	39.75	23403867
1602	Phosphorylation	SHSSLSNTSQKSLSV CCCCCCCCCCCCCCH	29.20	23186163
1603	Phosphorylation	HSSLSNTSQKSLSVK CCCCCCCCCCCCCHH	39.60	23403867
1606	Phosphorylation	LSNTSQKSLSVKEVK CCCCCCCCCCHHHHH	20.45	24719451
1685	Phosphorylation	EKNPDSKYKNLMVSR HHCCCHHHCCCEECC	14.73	30622161
1691	Phosphorylation	KYKNLMVSRGAPKPS HHCCCEECCCCCCCC	15.84	29514088
1698	Phosphorylation	SRGAPKPSSLAQKEY CCCCCCCCHHHHHHH	44.07	30108239
1699	Phosphorylation	RGAPKPSSLAQKEYL CCCCCCCHHHHHHHH	35.93	25159151
1705	Phosphorylation	SSLAQKEYLSQSCPS CHHHHHHHHCCCCCC	20.77	30108239
1707	Phosphorylation	LAQKEYLSQSCPSVS HHHHHHHCCCCCCCC	21.10	30108239
1709	Phosphorylation	QKEYLSQSCPSVSNV HHHHHCCCCCCCCCC	25.31	30278072
1712	Phosphorylation	YLSQSCPSVSNVEYP HHCCCCCCCCCCCCC	42.37	30278072
1714	Phosphorylation	SQSCPSVSNVEYPDM CCCCCCCCCCCCCCC	39.22	30108239
1718	Phosphorylation	PSVSNVEYPDMPRSL CCCCCCCCCCCCCCC	10.55	30108239
1724 (in isoform 2)	Phosphorylation	-	38.47	-
1724	Phosphorylation	EYPDMPRSLPSHMEE CCCCCCCCCCHHHHC	38.47	30266825
1727	Phosphorylation	DMPRSLPSHMEEAPN CCCCCCCHHHHCCCC	40.53	30266825
1739	Phosphorylation	APNVFQLYQRPTSAS CCCHHHHHCCCCCCC	7.53	23312004
1743 (in isoform 2)	Phosphorylation	-	38.83	-
1743	Phosphorylation	FQLYQRPTSASRKKQ HHHHCCCCCCCHHHH	38.83	25159151
1744 (in isoform 2)	Phosphorylation	-	27.25	-
1744	Phosphorylation	QLYQRPTSASRKKQK HHHCCCCCCCHHHHH	27.25	25159151
1746	Phosphorylation	YQRPTSASRKKQKEV HCCCCCCCHHHHHHC	44.38	23312004
1758	Phosphorylation	KEVQDKDYPLTPPPS HHCCCCCCCCCCCCC	13.09	30266825
1761 (in isoform 2)	Phosphorylation	-	29.28	-
1761	Phosphorylation	QDKDYPLTPPPSPTV CCCCCCCCCCCCCCC	29.28	29255136
1765 (in isoform 2)	Phosphorylation	-	38.69	-
1765	Phosphorylation	YPLTPPPSPTVDEPK CCCCCCCCCCCCCCE	38.69	29255136
1767 (in isoform 2)	Phosphorylation	-	44.95	-
1767	Phosphorylation	LTPPPSPTVDEPKIL CCCCCCCCCCCCEEE	44.95	30266825
1862	Phosphorylation	VKLEPHASMESGLQD EEECCCCCCCCCCCC	21.76	27251275
1865	Phosphorylation	EPHASMESGLQDPVN CCCCCCCCCCCCCCC	35.84	-
1873	Phosphorylation	GLQDPVNTKLDLKVH CCCCCCCCCHHHHHH	32.97	-
1881	Phosphorylation	KLDLKVHSLSLVLNK CHHHHHHHHHHHHCC	23.73	30622161
1883	Phosphorylation	DLKVHSLSLVLNKTT HHHHHHHHHHHCCCH	21.32	30622161
1889	Phosphorylation	LSLVLNKTTSELAKA HHHHHCCCHHHHHHH	34.19	30622161
1890	Phosphorylation	SLVLNKTTSELAKAN HHHHCCCHHHHHHHH	23.08	30622161
1891	Phosphorylation	LVLNKTTSELAKANV HHHCCCHHHHHHHHH	35.53	30622161
1938	Phosphorylation	EFYRERFTTSGEEAL EEEHHHCCCCCCCEE	26.69	28258704
1949	Phosphorylation	EEALIFQTFKYGRPD CCEEEEEEECCCCCC	16.02	28258704
2038	Phosphorylation	PVLLIPESSRSNNLI CEEECCCCCCCCCEE	26.20	25850435
2039	Phosphorylation	VLLIPESSRSNNLIV EEECCCCCCCCCEEE	37.76	25850435
2074	Phosphorylation	FSLQDKESVPSASPT EECCCCCCCCCCCCC	45.10	30266825
2077	Phosphorylation	QDKESVPSASPTGIP CCCCCCCCCCCCCCC	38.94	30266825
2079 (in isoform 2)	Phosphorylation	-	27.60	-
2079	Phosphorylation	KESVPSASPTGIPKH CCCCCCCCCCCCCHH	27.60	23401153
2081 (in isoform 2)	Phosphorylation	-	45.29	-
2081	Phosphorylation	SVPSASPTGIPKHSL CCCCCCCCCCCHHCC	45.29	30266825
2087 (in isoform 2)	Phosphorylation	-	35.68	-
2087	Phosphorylation	PTGIPKHSLRKTTST CCCCCHHCCCCCCCC	35.68	18491316
2091	Phosphorylation	PKHSLRKTTSTEEPR CHHCCCCCCCCCCCC	21.39	26699800
2092	Phosphorylation	KHSLRKTTSTEEPRG HHCCCCCCCCCCCCC	36.36	26699800
2093	Phosphorylation	HSLRKTTSTEEPRGT HCCCCCCCCCCCCCC	38.77	26699800
2094	Phosphorylation	SLRKTTSTEEPRGTH CCCCCCCCCCCCCCC	42.13	26699800
2100	Phosphorylation	STEEPRGTHSQGQFT CCCCCCCCCCCCCCE	21.45	27251275
2102	Phosphorylation	EEPRGTHSQGQFTMP CCCCCCCCCCCCEEC	35.52	24719451
2114	Phosphorylation	TMPLAGMSLGSLKSE EECCCCCCCCCCCCC	28.76	22210691
2117	Phosphorylation	LAGMSLGSLKSEFVP CCCCCCCCCCCCCCC	37.61	22210691
2120	Phosphorylation	MSLGSLKSEFVPSTS CCCCCCCCCCCCCCC	41.37	22210691
2126	O-linked_Glycosylation	KSEFVPSTSTKQQGP CCCCCCCCCCCCCCC	34.05	28657654
2175	Phosphorylation	AERHPREYSKAPEDS HCCCCCHHCCCCCCC	19.42	-
2208	Ubiquitination	LTEPCRLKLQVERNL CCCCCCCEEHHHHCC	19.95	29967540
2344	Phosphorylation	HSMMAFDTRYAGQKT CCHHCCCCCCCCCCC	21.08	25690035
2351	Phosphorylation	TRYAGQKTSPGMTNV CCCCCCCCCCCCCCE	32.06	28348404
2352	Phosphorylation	RYAGQKTSPGMTNVF CCCCCCCCCCCCCEE	26.88	24719451
2371	Phosphorylation	QPAKNSSTTQGSIQI EECCCCCCCCCEEEE	23.98	-
2434	Phosphorylation	TPSRHRNSSSESAIV CCCCCCCCCCCCCCC	34.89	30266825
2435 (in isoform 2)	Phosphorylation	-	41.49	-
2435	Phosphorylation	PSRHRNSSSESAIVP CCCCCCCCCCCCCCC	41.49	29255136
2436	Phosphorylation	SRHRNSSSESAIVPK CCCCCCCCCCCCCCC	35.08	30266825
2438	Phosphorylation	HRNSSSESAIVPKTV CCCCCCCCCCCCCEE	25.83	30266825
2454	Phosphorylation	SGVVTKRSSLPVSNE CCCEECCCCCCCCCC	37.47	30108239
2455	Phosphorylation	GVVTKRSSLPVSNER CCEECCCCCCCCCCC	40.50	25159151
2459	Phosphorylation	KRSSLPVSNERHLEV CCCCCCCCCCCEEEE	30.91	30108239
2657	Ubiquitination	FSMDDCRKALLACQG CCHHHHHHHHHHHHH	50.12	29967540
2671	Phosphorylation	GQLKKAASWLFKNAE HHHHHHHHHHHHCCC	29.22	26657352
2682	Phosphorylation	KNAEPLKSLSLASTS HCCCCCCCCCCCCCC	30.76	23403867
2684	Phosphorylation	AEPLKSLSLASTSRD CCCCCCCCCCCCCCC	29.04	23403867
2687	Phosphorylation	LKSLSLASTSRDSPG CCCCCCCCCCCCCCC	32.01	23401153
2688	Phosphorylation	KSLSLASTSRDSPGA CCCCCCCCCCCCCCC	23.36	25159151
2689	Phosphorylation	SLSLASTSRDSPGAV CCCCCCCCCCCCCCC	31.43	25159151
2692	Phosphorylation	LASTSRDSPGAVAAP CCCCCCCCCCCCCCC	24.91	30266825
2702	Phosphorylation	AVAAPLISGVEIKAE CCCCCCCCCCEECEE	44.46	23312004
2812	Phosphorylation	TSVLIDQYVSTKESW EHEEHHHHCCCCHHH	7.82	25884760
2815	Phosphorylation	LIDQYVSTKESWMAD EHHHHCCCCHHHHCH	28.87	23403867
2823	Phosphorylation	KESWMADYCKDDKDI CHHHHCHHCCCCCCH	7.58	25884760
2859	Phosphorylation	LPLVYLRTRSTASLT CCEEEEECCCCCCCC	26.78	30576142
2861	Phosphorylation	LVYLRTRSTASLTNL EEEEECCCCCCCCCC	27.93	22617229
2862	Phosphorylation	VYLRTRSTASLTNLE EEEECCCCCCCCCCH	19.58	30576142
2864	Phosphorylation	LRTRSTASLTNLEHQ EECCCCCCCCCCHHH	35.50	30576142
2866	Phosphorylation	TRSTASLTNLEHQIY CCCCCCCCCCHHHHH	34.95	30576142
2873	Phosphorylation	TNLEHQIYARAEVKT CCCHHHHHEECCCCC	7.95	-
2880	Phosphorylation	YARAEVKTPKRRQPF HEECCCCCCCCCCCC	23.57	29449344
2915	Phosphorylation	TPTRAALSHSGSPGV CCCHHHHCCCCCCCC	36.71	24719451
2917	Phosphorylation	TRAALSHSGSPGVVP CHHHHCCCCCCCCCC	32.22	30624053
2919	Phosphorylation	AALSHSGSPGVVPEG HHHCCCCCCCCCCCC	43.02	27050516
2929	Phosphorylation	VVPEGNGTFLDDTHN CCCCCCCCCCCCCCC	8.15	22210691
2938	Phosphorylation	LDDTHNVSEWREVLT CCCCCCHHHHHHHHC	46.39	22210691
2983	Phosphorylation	VNGWEQVSPVSVDKV ECCEEECCCEEECCC	24.44	25850435
2986	Phosphorylation	WEQVSPVSVDKVGTF EEECCCEEECCCCCE	11.31	23186163
2988	Ubiquitination	QVSPVSVDKVGTFFR ECCCEEECCCCCEEE	40.17	-
2989	Ubiquitination	VSPVSVDKVGTFFRY CCCEEECCCCCEEEE	8.26	-
3000	Ubiquitination	FFRYAAPDKNSSSST EEEEECCCCCCCCCC	58.64	-
3001	Ubiquitination	FRYAAPDKNSSSSTI EEEECCCCCCCCCCC	55.28	-
3004	Phosphorylation	AAPDKNSSSSTIGSP ECCCCCCCCCCCCCC	31.18	19369195
3005	Phosphorylation	APDKNSSSSTIGSPS CCCCCCCCCCCCCCC	26.45	22199227
3006	Phosphorylation	PDKNSSSSTIGSPSS CCCCCCCCCCCCCCC	31.16	27251275
3007	Phosphorylation	DKNSSSSTIGSPSSR CCCCCCCCCCCCCCC	5.78	27251275
3010	Phosphorylation	SSSSTIGSPSSRTNI CCCCCCCCCCCCCCE	30.98	21815630
3012	Phosphorylation	SSTIGSPSSRTNIIH CCCCCCCCCCCCEEC	46.65	27251275
3013	Phosphorylation	STIGSPSSRTNIIHP CCCCCCCCCCCEECC	35.81	27251275
3050	Phosphorylation	RKVITVRSALIVRNR CEEEEEEEEEHHHCC	7.25	22210691
3104	Ubiquitination	RLQARPKGLGVFFCK EECCCCCCCEEEEEC	7.07	29967540
3129	Ubiquitination	TAEISSSKRECHSMD HEEECCCCCHHHCCC	54.44	29967540
3265	Phosphorylation	NRRQLNLTIRIVCRA CHHHCCEEEEEEEEC	2.97	24719451
3277	Ubiquitination	CRAEGSLKIFISAPY EECCCCEEEEEECCE	4.49	29967540
3281	Phosphorylation	GSLKIFISAPYWLIN CCEEEEEECCEEEEC	9.08	30622161
3284	Phosphorylation	KIFISAPYWLINKTG EEEEECCEEEECCCC	6.96	30622161
3302	Ubiquitination	IFRQDNAKTDAAGQF EECCCCCCCCCCCCC	28.58	29967540
3317	Phosphorylation	EEHELARSLSPLLFC CHHHHHHHHCHHHHH	5.21	28348404
3319	Phosphorylation	HELARSLSPLLFCYA HHHHHHHCHHHHHHC	38.07	28348404
3391	Phosphorylation	VKKGRGRYIDTCMVI EECCCCCCCCEEEEE	3.22	-
3403	Phosphorylation	MVIFAPRYLLDNKSS EEEEECHHHHCCCCH	5.24	-
3410	Phosphorylation	YLLDNKSSHKLAFAQ HHHCCCCHHHHHHHH	35.92	28555341
3435	Phosphorylation	NPEGYISTLPGSSVV CCCCEEEECCCCEEE	3.45	-
3439	Phosphorylation	YISTLPGSSVVFHWP EEEECCCCEEEEECC	28.37	-
3440	Phosphorylation	ISTLPGSSVVFHWPR EEECCCCEEEEECCC	5.96	-
3497	Phosphorylation	FFLRVEITLRGATYR EEEEEEEEECCCEEE	6.13	26074081
3499 (in isoform 2)	Acetylation	-	25.94	-
3499	Acetylation	LRVEITLRGATYRIS EEEEEEECCCEEEEE	25.94	19608861
3502	Phosphorylation	EITLRGATYRISFSD EEEECCCEEEEECCC	12.86	26074081
3503	Phosphorylation	ITLRGATYRISFSDT EEECCCEEEEECCCC	17.45	26074081
3506	Phosphorylation	RGATYRISFSDTDQL CCCEEEEECCCCCCC	7.73	26074081
3508	Phosphorylation	ATYRISFSDTDQLPP CEEEEECCCCCCCCC	52.90	26074081
3510	Phosphorylation	YRISFSDTDQLPPPF EEEECCCCCCCCCCE	53.67	26074081
3518	Dimethylation	DQLPPPFRIDNFSKV CCCCCCEECCCCCCC	5.34	-
3518	Methylation	DQLPPPFRIDNFSKV CCCCCCEECCCCCCC	5.34	30763431
3523	Phosphorylation	PFRIDNFSKVPVVFT CEECCCCCCCCEEEE	46.55	26074081
3523	Acetylation	PFRIDNFSKVPVVFT CEECCCCCCCCEEEE	46.55	-
3524	Acetylation	FRIDNFSKVPVVFTQ EECCCCCCCCEEEEC	4.16	19608861
3524	Malonylation	FRIDNFSKVPVVFTQ EECCCCCCCCEEEEC	4.16	26320211
3628	Phosphorylation	AELVLDVSPKTQRVI EEEEEECCHHHCEEE	43.49	24719451
3691	Phosphorylation	IAGLAAVTDNRYEPL HHCEEEECCCCCCCC	30.89	24719451
3695	Phosphorylation	AAVTDNRYEPLMLRK EEECCCCCCCCCCCC	28.81	24719451
3708	Phosphorylation	RKPDRRRSTTQTWSF CCCCCCCCCCCCEEE	22.55	29083192
3709	Phosphorylation	KPDRRRSTTQTWSFR CCCCCCCCCCCEEEC	25.83	29083192
3710	Phosphorylation	PDRRRSTTQTWSFRE CCCCCCCCCCEEECC	40.85	29083192
3712	Phosphorylation	RRRSTTQTWSFREGK CCCCCCCCEEECCCE	5.90	29083192
3714	Phosphorylation	RSTTQTWSFREGKLT CCCCCCEEECCCEEE	6.59	29083192
3770	Methylation	QFINQKMRPGSGMLS HCCCCCCCCCCCCEE	37.49	24396593
3777	Phosphorylation	RPGSGMLSIRVIPDG CCCCCCEEEEECCCC	3.43	24719451
3792	Ubiquitination	PTRALQITDFCHRKS CCCEEEEHHHCCCCC	45.89	29967540
3799	Phosphorylation	TDFCHRKSSRSYEVD HHHCCCCCCCCEECC	28.42	25159151
3800	Phosphorylation	DFCHRKSSRSYEVDE HHCCCCCCCCEECCC	50.80	25159151
3802	Phosphorylation	CHRKSSRSYEVDELP CCCCCCCCEECCCCC	20.89	30576142
3803	Phosphorylation	HRKSSRSYEVDELPV CCCCCCCEECCCCCC	44.75	30576142
3817	Ubiquitination	VTEQELQKLKNPDTE CCHHHHHHHCCCCCH	4.12	29967540
3823	Phosphorylation	QKLKNPDTEQELEVL HHHCCCCCHHHHHHH	49.81	29255136
3840	Phosphorylation	LEGGIGLSLINKVPE HCCCCCHHHHCCCCH	6.34	24719451
3924	Phosphorylation	FPSKSALTNIYKHLM CCCHHHHHHHHHHHH	36.12	-
3927	Phosphorylation	KSALTNIYKHLMITA HHHHHHHHHHHHHHC	26.85	-
3947	Ubiquitination	QIEEKLLLKLLSFFG HHHHHHHHHHHHHHC	47.56	29967540
3972	Ubiquitination	YDENLHEKTAEQGGT HHHCHHHHHHHHCCC	32.23	29967540
3973	Phosphorylation	DENLHEKTAEQGGTP HHCHHHHHHHHCCCC	20.41	-
4010	Acetylation	NKLPLDLKALKSTLG CCCCCCHHHHHHHHC	27.76	26210075
4077 (in isoform 2)	Phosphorylation	-	4.21	-
4081 (in isoform 2)	Phosphorylation	-	31.34	-
4083 (in isoform 2)	Phosphorylation	-	18.12	-
4091	Phosphorylation	GVTGLIKYGNVGGLI CCHHHHHCCCHHHHH	19.83	29978859
4102	Phosphorylation	GGLIRNVTHGVSNSA HHHHHHCCCCCCHHH	30.30	18452278
4106	Phosphorylation	RNVTHGVSNSAAKFA HHCCCCCCHHHHHHH	33.01	18452278
4108	Phosphorylation	VTHGVSNSAAKFAGT CCCCCCHHHHHHHHH	20.94	18452278
4115	Phosphorylation	SAAKFAGTLSDGLGK HHHHHHHHHCCCCCC	4.26	28258704
4117	Phosphorylation	AKFAGTLSDGLGKTM HHHHHHHCCCCCCCC	60.49	28258704
4214	Phosphorylation	TAQAVRDTATLSGPR HHHHHHHHCCCCCCC	15.72	23403867
4243	Phosphorylation	PQGLLPRYSESQAEG CCCCCCCCCHHHHCC	31.86	27732954
4244	Phosphorylation	QGLLPRYSESQAEGQ CCCCCCCCHHHHCCH	37.63	27732954
4246	Phosphorylation	LLPRYSESQAEGQEQ CCCCCCHHHHCCHHH	39.11	27732954
4304	Phosphorylation	AIFLEVKYDDLYHCL EEEEEEEEHHHEEEE	33.45	22210691
4318	Acetylation	LVSKDHGKVYVQVTK EEECCCCEEEEEEEC	7.19	7960979
4325	Acetylation	KVYVQVTKKAVSTSS EEEEEEECCEEECCC	44.66	7960991

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VP13D_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VP13D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VP13D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
2AAA_HUMAN	PPP2R1A	physical	26344197
PRS4_HUMAN	PSMC1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VP13D_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-3523, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1761 AND SER-2435, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3004, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1761; SER-1765 ANDSER-2079, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1042, AND MASSSPECTROMETRY.	18220336 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1761 AND THR-1767, ANDMASS SPECTROMETRY.	18669648 [Abstract]