CHSTB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHSTB_HUMAN
• UniProt AC: Q9NPF2
• Protein Name: Carbohydrate sulfotransferase 11
• Gene Name: CHST11
• Organism: Homo sapiens (Human).
• Sequence Length: 352
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor..
• Protein Sequence: MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAVLHQMRRDQVTDTCRANSATSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNISFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKPALLEVM ------CCHHHHHHH	38.71	-
143	Ubiquitination	MVLTGRGKYSDPMEI HHHHCCCCCCCCCCC	39.97	-
162	Ubiquitination	AHVSANLKTLNQYSI CCHHCCCCHHHHCCC	51.26	-
205	N-linked_Glycosylation	NKFTQKYNISFHKRY CCCCHHCCEEEHHHH	30.39	UniProtKB CARBOHYD
210	Ubiquitination	KYNISFHKRYGTKII HCCEEEHHHHCHHHH	45.35	-
223	N-linked_Glycosylation	IIKRQRKNATQEALR HHHHHHHCHHHHHHH	50.86	UniProtKB CARBOHYD
321	N-linked_Glycosylation	MTTEFFQNISSEHQT HHHHHHHHCCHHHHH	30.84	UniProtKB CARBOHYD
328	O-linked_Glycosylation	NISSEHQTQLYEVYK HCCHHHHHHHEEEEE	23.58	OGP
342	N-linked_Glycosylation	KLDFLMFNYSVPSYL ECCEEEECCCCCCCC	17.76	15628971

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHSTB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHSTB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHSTB_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CHSTB_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.