dbPTM

FA83H_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FA83H_HUMAN
UniProt AC	Q6ZRV2
Protein Name	Protein FAM83H {ECO:0000305}
Gene Name	FAM83H {ECO:0000312\|HGNC:HGNC:24797}
Organism	Homo sapiens (Human).
Sequence Length	1179
Subcellular Localization	Cytoplasm, cytoskeleton . Colocalizes with keratin filaments.
Protein Description	May play a major role in the structural organization and calcification of developing enamel. [PubMed: 18252228 May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration]
Protein Sequence	MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGSEAYSRFLATEGAPDFLCPEELEHVSRHLRPPQYVTREPPEGSLLDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLQHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAAALARMDAYALAPYAGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREEPPRMPGGALEPHAGLRPLSRRLEAEAGPAGELAGARGFFQARHLEMDAFKRHSFATEGAGAVENFAAARQVSRQTFLSHGDDFRFQTSHFHRDQLYQQQYQWDPQLTPARPQGLFEKLRGGRAGFADPDDFTLGAGPRFPELGPDGHQRLDYVPSSASREVRHGSDPAFAPGPRGLEPSGAPRPNLTQRFPCQAAARPGPDPAPEAEPERRGGPEGRAGLRRWRLASYLSGCHGEDGGDDGLPAPMEAEAYEDDVLAPGGRAPAGDLLPSAFRVPAAFPTKVPVPGPGSGGNGPEREGPEEPGLAKQDSFRSRLNPLVQRSSRLRSSLIFSTSQAEGAAGAAAATEKVQLLHKEQTVSETLGPGGEAVRSAASTKVAELLEKYKGPARDPGGGAGAITVASHSKAVVSQAWREEVAAPGAVGGERRSLESCLLDLRDSFAQQLHQEAERQPGAASLTAAQLLDTLGRSGSDRLPSRFLSAQSHSTSPQGLDSPLPLEGSGAHQVLHNESKGSPTSAYPERKGSPTPGFSTRRGSPTTGFIEQKGSPTSAYPERRGSPVPPVPERRSSPVPPVPERRGSLTLTISGESPKAGPAEEGPSGPMEVLRKGSLRLRQLLSPKGERRMEDEGGFPVPQENGQPESPRRLSLGQGDSTEAATEERGPRARLSSATANALYSSNLRDDTKAILEQISAHGQKHRAVPAPSPGPTHNSPELGRPPAAGVLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEASSPGAGEGPAEEGTRDSKVGKFVPKILGTFKSKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MARRSQSSSQGD ---CCCCCCCCCCCC	28.94	23927012
7	Phosphorylation	-MARRSQSSSQGDNP -CCCCCCCCCCCCCC	32.95	23927012
8	Phosphorylation	MARRSQSSSQGDNPL CCCCCCCCCCCCCCC	21.02	25159151
9	Phosphorylation	ARRSQSSSQGDNPLA CCCCCCCCCCCCCCC	43.35	23927012
19	Phosphorylation	DNPLAPGYLPPHYKE CCCCCCCCCCCHHHH	18.25	28450419
24	Phosphorylation	PGYLPPHYKEYYRLA CCCCCCHHHHHHHHH	15.99	23927012
40	Phosphorylation	DALAEGGSEAYSRFL HHHHCCCHHHHHHHH	29.88	19691289
43	Phosphorylation	AEGGSEAYSRFLATE HCCCHHHHHHHHHCC	9.05	20068231
44	Phosphorylation	EGGSEAYSRFLATEG CCCHHHHHHHHHCCC	24.49	27251275
297	Phosphorylation	ALARMDAYALAPYAG HHHHCCHHHHCCCCC	9.63	25106551
302	Phosphorylation	DAYALAPYAGAGPLV CHHHHCCCCCCCCCC	16.44	20068231
318	Phosphorylation	VPGVGAPTPFSFPKR CCCCCCCCCCCCCCH	36.11	20068231
321	Phosphorylation	VGAPTPFSFPKRAHL CCCCCCCCCCCHHHC	41.67	20068231
324	Ubiquitination	PTPFSFPKRAHLLFP CCCCCCCCHHHCCCC	61.27	-
342	Phosphorylation	EEGLGFPSFLDPDRH CCCCCCCHHCCCCHH	35.86	27499020
352	Phosphorylation	DPDRHFLSAFRREEP CCCHHHHHHHHCCCC	25.15	24719451
361	Methylation	FRREEPPRMPGGALE HHCCCCCCCCCCCCC	55.43	-
377	Phosphorylation	HAGLRPLSRRLEAEA CCCCCHHHHHHHHHH	20.31	23312004
394	Methylation	AGELAGARGFFQARH HHHHHCHHCCHHHCC	41.35	-
408	Methylation	HLEMDAFKRHSFATE CCCHHHHHHHCCHHC	51.42	-
408	Ubiquitination	HLEMDAFKRHSFATE CCCHHHHHHHCCHHC	51.42	21906983
411	Phosphorylation	MDAFKRHSFATEGAG HHHHHHHCCHHCCCC	22.17	28731282
414	Phosphorylation	FKRHSFATEGAGAVE HHHHCCHHCCCCHHH	32.70	23927012
430	Phosphorylation	FAAARQVSRQTFLSH HHHHHHHHHHHHHHC	15.44	28555341
433	Phosphorylation	ARQVSRQTFLSHGDD HHHHHHHHHHHCCCC	25.98	28555341
436	Phosphorylation	VSRQTFLSHGDDFRF HHHHHHHHCCCCCCE	22.64	23312004
442	Methylation	LSHGDDFRFQTSHFH HHCCCCCCEECCCCC	29.74	-
445	Phosphorylation	GDDFRFQTSHFHRDQ CCCCCEECCCCCHHH	22.81	28555341
454	Phosphorylation	HFHRDQLYQQQYQWD CCCHHHHHHHHHCCC	9.91	27642862
458	Phosphorylation	DQLYQQQYQWDPQLT HHHHHHHHCCCCCCC	13.77	26356563
465	Phosphorylation	YQWDPQLTPARPQGL HCCCCCCCCCCCCCH	15.06	22617229
475	Ubiquitination	RPQGLFEKLRGGRAG CCCCHHHHHCCCCCC	35.83	21906983
477	Methylation	QGLFEKLRGGRAGFA CCHHHHHCCCCCCCC	57.50	-
480	Methylation	FEKLRGGRAGFADPD HHHHCCCCCCCCCCC	34.07	-
490	Phosphorylation	FADPDDFTLGAGPRF CCCCCCCCCCCCCCC	31.14	30087585
510	Phosphorylation	DGHQRLDYVPSSASR CCCCCCCCCCCCCCC	20.89	21945579
513	Phosphorylation	QRLDYVPSSASREVR CCCCCCCCCCCCHHH	28.61	29255136
514	Phosphorylation	RLDYVPSSASREVRH CCCCCCCCCCCHHHC	24.97	21945579
516	Phosphorylation	DYVPSSASREVRHGS CCCCCCCCCHHHCCC	30.81	29255136
523	Phosphorylation	SREVRHGSDPAFAPG CCHHHCCCCCCCCCC	34.00	29255136
532	Methylation	PAFAPGPRGLEPSGA CCCCCCCCCCCCCCC	69.14	-
541	Methylation	LEPSGAPRPNLTQRF CCCCCCCCCCCCCCC	32.00	-
545	Phosphorylation	GAPRPNLTQRFPCQA CCCCCCCCCCCCCHH	25.08	-
547	Methylation	PRPNLTQRFPCQAAA CCCCCCCCCCCHHHC	32.04	-
585	Phosphorylation	LRRWRLASYLSGCHG HHHHHHHHHHHCCCC	31.06	30624053
586	Phosphorylation	RRWRLASYLSGCHGE HHHHHHHHHHCCCCC	10.16	30576142
588	Phosphorylation	WRLASYLSGCHGEDG HHHHHHHHCCCCCCC	31.01	29116813
609	Phosphorylation	APMEAEAYEDDVLAP CCCEEHHCCCCCCCC	16.05	30624053
628	Phosphorylation	PAGDLLPSAFRVPAA CCCCCCCCCCCCCCC	39.75	25850435
638	Phosphorylation	RVPAAFPTKVPVPGP CCCCCCCCCCCCCCC	37.91	24732914
639	Ubiquitination	VPAAFPTKVPVPGPG CCCCCCCCCCCCCCC	44.79	21906983
647	Phosphorylation	VPVPGPGSGGNGPER CCCCCCCCCCCCCCC	46.81	29255136
664	Ubiquitination	PEEPGLAKQDSFRSR CCCCCCCCHHHHHHH	60.73	2190698
667	Phosphorylation	PGLAKQDSFRSRLNP CCCCCHHHHHHHHHH	21.77	23927012
670	Phosphorylation	AKQDSFRSRLNPLVQ CCHHHHHHHHHHHHH	38.83	23312004
684	Phosphorylation	QRSSRLRSSLIFSTS HHHHHHHHHEEEECC	33.80	26434776
685	Phosphorylation	RSSRLRSSLIFSTSQ HHHHHHHHEEEECCH	21.03	28857561
689	Phosphorylation	LRSSLIFSTSQAEGA HHHHEEEECCHHCCH	21.83	26434776
690	Phosphorylation	RSSLIFSTSQAEGAA HHHEEEECCHHCCHH	17.70	26657352
691	Phosphorylation	SSLIFSTSQAEGAAG HHEEEECCHHCCHHH	26.62	28857561
703	Phosphorylation	AAGAAAATEKVQLLH HHHHHHHHHHHHHHH	31.45	-
714	Phosphorylation	QLLHKEQTVSETLGP HHHHCCCCHHHCCCC	27.39	20068231
716	Phosphorylation	LHKEQTVSETLGPGG HHCCCCHHHCCCCCH	28.40	25849741
718	Phosphorylation	KEQTVSETLGPGGEA CCCCHHHCCCCCHHH	29.52	20068231
728	Phosphorylation	PGGEAVRSAASTKVA CCHHHHHHHHHHHHH	22.91	23403867
731	Phosphorylation	EAVRSAASTKVAELL HHHHHHHHHHHHHHH	28.60	23403867
732	Phosphorylation	AVRSAASTKVAELLE HHHHHHHHHHHHHHH	25.47	23403867
733	Ubiquitination	VRSAASTKVAELLEK HHHHHHHHHHHHHHH	36.63	-
756	Phosphorylation	GGGAGAITVASHSKA CCCCCCEEEECCCHH	14.97	25849741
759	Phosphorylation	AGAITVASHSKAVVS CCCEEEECCCHHHHC	24.77	25159151
761	Phosphorylation	AITVASHSKAVVSQA CEEEECCCHHHHCHH	21.58	25849741
785	Phosphorylation	AVGGERRSLESCLLD CCCCCCCCHHHHHHH	42.59	29255136
788	Phosphorylation	GERRSLESCLLDLRD CCCCCHHHHHHHHHH	18.50	27987026
796	Phosphorylation	CLLDLRDSFAQQLHQ HHHHHHHHHHHHHHH	18.95	28348404
813	Phosphorylation	ERQPGAASLTAAQLL HHCCCHHHHHHHHHH	26.22	26657352
815	Phosphorylation	QPGAASLTAAQLLDT CCCHHHHHHHHHHHH	19.90	29255136
822	Phosphorylation	TAAQLLDTLGRSGSD HHHHHHHHHCCCCCC	30.95	29255136
826	Phosphorylation	LLDTLGRSGSDRLPS HHHHHCCCCCCCCCH	40.63	25159151
828	Phosphorylation	DTLGRSGSDRLPSRF HHHCCCCCCCCCHHH	22.32	25849741
837	Phosphorylation	RLPSRFLSAQSHSTS CCCHHHHHCCCCCCC	22.88	20873877
840	Phosphorylation	SRFLSAQSHSTSPQG HHHHHCCCCCCCCCC	21.08	30576142
842	Phosphorylation	FLSAQSHSTSPQGLD HHHCCCCCCCCCCCC	35.51	30576142
843	Phosphorylation	LSAQSHSTSPQGLDS HHCCCCCCCCCCCCC	38.72	26657352
844	Phosphorylation	SAQSHSTSPQGLDSP HCCCCCCCCCCCCCC	20.45	23927012
850	Phosphorylation	TSPQGLDSPLPLEGS CCCCCCCCCCCCCCC	33.12	23927012
857	Phosphorylation	SPLPLEGSGAHQVLH CCCCCCCCCCCHHHC	24.35	29496963
867	Phosphorylation	HQVLHNESKGSPTSA CHHHCCCCCCCCCCC	47.86	20873877
870	Phosphorylation	LHNESKGSPTSAYPE HCCCCCCCCCCCCCC	28.83	29255136
872	Phosphorylation	NESKGSPTSAYPERK CCCCCCCCCCCCCCC	27.90	29255136
873	Phosphorylation	ESKGSPTSAYPERKG CCCCCCCCCCCCCCC	29.23	30266825
875	Phosphorylation	KGSPTSAYPERKGSP CCCCCCCCCCCCCCC	12.85	23927012
881	Phosphorylation	AYPERKGSPTPGFST CCCCCCCCCCCCCCC	28.74	29255136
883	Phosphorylation	PERKGSPTPGFSTRR CCCCCCCCCCCCCCC	37.43	30266825
887	Phosphorylation	GSPTPGFSTRRGSPT CCCCCCCCCCCCCCC	27.24	22167270
888	Phosphorylation	SPTPGFSTRRGSPTT CCCCCCCCCCCCCCC	23.32	22167270
892	Phosphorylation	GFSTRRGSPTTGFIE CCCCCCCCCCCCCEE	19.77	29255136
894	Phosphorylation	STRRGSPTTGFIEQK CCCCCCCCCCCEEEC	41.05	29255136
895	Phosphorylation	TRRGSPTTGFIEQKG CCCCCCCCCCEEECC	33.22	30266825
903	Phosphorylation	GFIEQKGSPTSAYPE CCEEECCCCCCCCCC	31.85	29255136
905	Phosphorylation	IEQKGSPTSAYPERR EEECCCCCCCCCCCC	27.90	29255136
906	Phosphorylation	EQKGSPTSAYPERRG EECCCCCCCCCCCCC	29.23	30266825
908	Phosphorylation	KGSPTSAYPERRGSP CCCCCCCCCCCCCCC	12.85	23927012
914	Phosphorylation	AYPERRGSPVPPVPE CCCCCCCCCCCCCCC	22.40	29255136
924	Phosphorylation	PPVPERRSSPVPPVP CCCCCCCCCCCCCCC	45.26	29255136
925	Phosphorylation	PVPERRSSPVPPVPE CCCCCCCCCCCCCCC	28.27	29255136
936	Phosphorylation	PVPERRGSLTLTISG CCCCCCCEEEEEECC	19.17	29255136
938	Phosphorylation	PERRGSLTLTISGES CCCCCEEEEEECCCC	24.45	30266825
940	Phosphorylation	RRGSLTLTISGESPK CCCEEEEEECCCCCC	14.09	30266825
942	Phosphorylation	GSLTLTISGESPKAG CEEEEEECCCCCCCC	31.13	30266825
945	Phosphorylation	TLTISGESPKAGPAE EEEECCCCCCCCCCC	34.91	30266825
956	Phosphorylation	GPAEEGPSGPMEVLR CCCCCCCCCCHHHHH	67.40	20071362
974	Phosphorylation	LRLRQLLSPKGERRM HHHHHHHCCCCCCCC	32.91	28355574
998	Phosphorylation	QENGQPESPRRLSLG CCCCCCCCCCCCCCC	30.32	30266825
1003	Phosphorylation	PESPRRLSLGQGDST CCCCCCCCCCCCCCH	28.74	29255136
1009	Phosphorylation	LSLGQGDSTEAATEE CCCCCCCCHHHHHHH	34.66	22167270
1010	Phosphorylation	SLGQGDSTEAATEER CCCCCCCHHHHHHHC	34.09	23927012
1014	Phosphorylation	GDSTEAATEERGPRA CCCHHHHHHHCCCCH	45.48	23927012
1024	Phosphorylation	RGPRARLSSATANAL CCCCHHHHHHHHHHH	16.63	21945579
1025	Phosphorylation	GPRARLSSATANALY CCCHHHHHHHHHHHH	33.94	25159151
1027	Phosphorylation	RARLSSATANALYSS CHHHHHHHHHHHHHC	23.53	21945579
1032	Phosphorylation	SATANALYSSNLRDD HHHHHHHHHCCCCHH	13.98	21945579
1033	Phosphorylation	ATANALYSSNLRDDT HHHHHHHHCCCCHHH	17.38	21945579
1034	Phosphorylation	TANALYSSNLRDDTK HHHHHHHCCCCHHHH	26.74	21945579
1040	Phosphorylation	SSNLRDDTKAILEQI HCCCCHHHHHHHHHH	27.02	21945579
1041	Ubiquitination	SNLRDDTKAILEQIS CCCCHHHHHHHHHHH	40.19	-
1048	Phosphorylation	KAILEQISAHGQKHR HHHHHHHHHCCCCCC	17.57	20068231
1053	Ubiquitination	QISAHGQKHRAVPAP HHHHCCCCCCCCCCC	39.38	-
1061	Phosphorylation	HRAVPAPSPGPTHNS CCCCCCCCCCCCCCC	44.59	30278072
1065	Phosphorylation	PAPSPGPTHNSPELG CCCCCCCCCCCCCCC	39.34	29255136
1068	Phosphorylation	SPGPTHNSPELGRPP CCCCCCCCCCCCCCC	16.49	29255136
1085	Phosphorylation	GVLAPDMSDKDKCSA CCCCCCCCCHHHHCH	49.22	24732914
1091	Phosphorylation	MSDKDKCSAIFRSDS CCCHHHHCHHHCCCC	30.09	27251275
1096	Phosphorylation	KCSAIFRSDSLGTQG HHCHHHCCCCCCCCC	22.32	26657352
1098	Phosphorylation	SAIFRSDSLGTQGRL CHHHCCCCCCCCCCH	29.91	29255136
1101	Phosphorylation	FRSDSLGTQGRLSRT HCCCCCCCCCCHHCC	32.89	22617229
1106	Phosphorylation	LGTQGRLSRTLPASA CCCCCCHHCCCCCCH	23.12	20068231
1108	Phosphorylation	TQGRLSRTLPASAEE CCCCHHCCCCCCHHH	33.45	29255136
1112	Phosphorylation	LSRTLPASAEERDRL HHCCCCCCHHHHHHH	33.98	21815630
1133	Phosphorylation	MRKEKRVYSRFEVFC HHHHHHHHHHEEEEE	9.73	26074081
1134	Phosphorylation	RKEKRVYSRFEVFCK HHHHHHHHHEEEEEC	27.86	26074081
1146	Phosphorylation	FCKKEEASSPGAGEG EECHHHCCCCCCCCC	40.10	29255136
1147	Phosphorylation	CKKEEASSPGAGEGP ECHHHCCCCCCCCCC	34.11	29255136
1159	Phosphorylation	EGPAEEGTRDSKVGK CCCCCCCCCCCHHHH	34.28	-
1166	Acetylation	TRDSKVGKFVPKILG CCCCHHHHHHHHHHH	46.29	26051181
1176	Methylation	PKILGTFKSKK---- HHHHHHHCCCC----	62.29	-
1178	Methylation	ILGTFKSKK------ HHHHHCCCC------	64.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FA83H_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FA83H_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FA83H_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KC1A_HUMAN	CSNK1A1	physical	26496610
KC1D_HUMAN	CSNK1D	physical	26496610
KC1E_HUMAN	CSNK1E	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
RUSC1_HUMAN	RUSC1	physical	26496610
PPHLN_HUMAN	PPHLN1	physical	26496610
LYAR_HUMAN	LYAR	physical	26496610
CTF18_HUMAN	CHTF18	physical	26496610
DDX54_HUMAN	DDX54	physical	26496610
ORML1_HUMAN	ORMDL1	physical	26496610
BD1L1_HUMAN	BOD1L1	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
130900	Amelogenesis imperfecta 3 (AI3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FA83H_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513; SER-523; SER-881;SER-892; SER-903; SER-914; SER-924; SER-925; SER-936 AND SER-1003, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523; SER-647; SER-881;THR-883; SER-892; SER-903; SER-914; SER-936; SER-945; SER-1003;SER-1024 AND SER-1025, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523; SER-647; SER-785;SER-881; SER-892; SER-903 AND SER-1003, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523; SER-914 ANDSER-1003, AND MASS SPECTROMETRY.	17081983 [Abstract]