SC16A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC16A_HUMAN
• UniProt AC: O15027
• Protein Name: Protein transport protein Sec16A
• Gene Name: SEC16A
• Organism: Homo sapiens (Human).
• Sequence Length: 2179
• Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane ; Peripheral membrane protein . SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissoc
• Protein Description: Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization..
• Protein Sequence: MPGLDRPLSRQNPHDGVVTPAASPSLPQPGLQMPGQWGPVQGGPQPSGQHRSPCPEGPVPSGVPCATSVPHFPTPSILHQGPGHEQHSPLVAPPAALPSDGRDEVSHLQSGSHLANNSDPESTFRQNPRIVNHWASPELRQNPGVKNEHRPASALVNPLARGDSPENRTHHPLGAGAGSGCAPLEADSGASGALAMFFQGGETENEENLSSEKAGLSGQADFDDFCSSPGLGRPPAPTHVGAGSLCQALLPGPSNEAAGDVWGDTASTGVPDASGSQYENVENLEFVQNQEVLPSEPLNLDPSSPSDQFRYGPLPGPAVPRHGAVCHTGAPDATLHTVHPDSVSSSYSSRSHGRLSGSARPQELVGTFIQQEVGKPEDEASGSFFKQIDSSPVGGETDETTVSQNYRGSVSQPSTPSPPKPTGIFQTSANSSFEPVKSHLVGVKPFEADRANVVGEVRETCVRQKQCRPAAALPDASPGNLEQPPDNMETLCAPQVCPLPLNSTTEAVHMLPHAGAPPLDTVYPAPEKRPSARTQGPVKCESPATTLWAQSELPDFGGNVLLAPAAPALYVCAKPQPPVVQPPEEAMSGQQSRNPSSAAPVQSRGGIGASENLENPPKMGEEEALQSQASSGYASLLSSPPTESLQNPPVLIAQPDHSYNLAQPINFSVSLSNSHEKNQSWREALVGDRPAVSSWALGGDSGENTSLSGIPTSSVLSLSLPSSVAQSNFPQGSGASEMVSNQPANLLVQPPSQPVPENLVPESQKDRKAGSALPGFANSPAGSTSVVLVPPAHGTLVPDGNKANHSSHQEDTYGALDFTLSRTLENPVNVYNPSHSDSLASQQSVASHPRQSGPGAPNLDRFYQQVTKDAQGQPGLERAQQELVPPQQQASPPQLPKAMFSELSNPESLPAQGQAQNSAQSPASLVLVDAGQQLPPRPPQSSSVSLVSSGSGQAAVPSEQPWPQPVPALAPGPPPQDLAAYYYYRPLYDAYQPQYSLPYPPEPGAASLYYQDVYSLYEPRYRPYDGAASAYAQNYRYPEPERPSSRASHSSERPPPRQGYPEGYYSSKSGWSSQSDYYASYYSSQYDYGDPGHWDRYHYSARVRDPRTYDRRYWCDAEYDAYRREHSAFGDRPEKRDNNWRYDPRFTGSFDDDPDPHRDPYGEEVDRRSVHSEHSARSLHSAHSLASRRSSLSSHSHQSQIYRSHNVAAGSYEAPLPPGSFHGDFAYGTYRSNFSSGPGFPEYGYPADTVWPAMEQVSSRPTSPEKFSVPHVCARFGPGGQLIKVIPNLPSEGQPALVEVHSMEALLQHTSEQEEMRAFPGPLAKDDTHKVDVINFAQNKAMKCLQNENLIDKESASLLWNFIVLLCRQNGTVVGTDIAELLLRDHRTVWLPGKSPNEANLIDFTNEAVEQVEEEESGEAQLSFLTGGPAAAASSLERETERFRELLLYGRKKDALESAMKNGLWGHALLLASKMDSRTHARVMTRFANSLPINDPLQTVYQLMSGRMPAASTCCGDEKWGDWRPHLAMVLSNLNNNMDVESRTMATMGDTLASRGLLDAAHFCYLMAQAGFGVYTKKTTKLVLIGSNHSLPFLKFATNEAIQRTEAYEYAQSLGAETCPLPSFQVFKFIYSCRLAEMGLATQAFHYCEAIAKSILTQPHLYSPVLISQLVQMASQLRLFDPQLKEKPEEESLAAPTWLVHLQQVERQIKEGAGVWHQDGALPQQCPGTPSSEMEQLDRPGLSQPGALGIANPLLAVPAPSPEHSSPSVRLLPSAPQTLPDGPLASPARVPMFPVPLPPGPLEPGPGCVTPGPALGFLEPSGPGLPPGVPPLQERRHLLQEARSPDPGIVPQEAPVGNSLSELSEENFDGKFANLTPSRTVPDSEAPPGWDRADSGPTQPPLSLSPAPETKRPGQAAKKETKEPKKGESWFFRWLPGKKKTEAYLPDDKNKSIVWDEKKNQWVNLNEPEEEKKAPPPPPTSMPKTVQAAPPALPGPPGAPVNMYSRRAAGTRARYVDVLNPSGTQRSEPALAPADFVAPLAPLPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKVLSSAASLPGSELPSSRPEGSQGGELSRCSSMSSLSREVSQHFNQAPGDLPAAGGPPSGAMPFYNPAQLAQACATSGSSRLGRIGQRKHLVLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPGLDRPLSRQNPH -CCCCCCCCCCCCCC	34.06	28851738
9	Phosphorylation	PGLDRPLSRQNPHDG CCCCCCCCCCCCCCC	34.21	26074081
10	Phosphorylation	GLDRPLSRQNPHDGV CCCCCCCCCCCCCCC	48.23	28851738
19	Phosphorylation	NPHDGVVTPAASPSL CCCCCCCCCCCCCCC	12.56	23927012
23	Phosphorylation	GVVTPAASPSLPQPG CCCCCCCCCCCCCCC	19.68	23927012
25	Phosphorylation	VTPAASPSLPQPGLQ CCCCCCCCCCCCCCC	50.62	30108239
28	Phosphorylation	AASPSLPQPGLQMPG CCCCCCCCCCCCCCC	50.41	22167270
28	Phosphorylation	AASPSLPQPGLQMPG CCCCCCCCCCCCCCC	50.41	24719451
29	Phosphorylation	ASPSLPQPGLQMPGQ CCCCCCCCCCCCCCC	43.45	22167270
29	Phosphorylation	ASPSLPQPGLQMPGQ CCCCCCCCCCCCCCC	43.45	20068231
31	Phosphorylation	PSLPQPGLQMPGQWG CCCCCCCCCCCCCCC	5.12	25839225
31	Phosphorylation	PSLPQPGLQMPGQWG CCCCCCCCCCCCCCC	5.12	27642862
47	Phosphorylation	VQGGPQPSGQHRSPC CCCCCCCCCCCCCCC	45.93	20068231
64	Phosphorylation	GPVPSGVPCATSVPH CCCCCCCCCCCCCCC	12.92	22199227
64	Phosphorylation	GPVPSGVPCATSVPH CCCCCCCCCCCCCCC	12.92	27251275
65	Phosphorylation	PVPSGVPCATSVPHF CCCCCCCCCCCCCCC	6.32	25849741
65	Phosphorylation	PVPSGVPCATSVPHF CCCCCCCCCCCCCCC	6.32	24719451
69	Phosphorylation	GVPCATSVPHFPTPS CCCCCCCCCCCCCCC	3.57	22199227
70	Phosphorylation	VPCATSVPHFPTPSI CCCCCCCCCCCCCCC	24.14	27174698
71	Phosphorylation	PCATSVPHFPTPSIL CCCCCCCCCCCCCCC	38.88	27174698
73	Phosphorylation	ATSVPHFPTPSILHQ CCCCCCCCCCCCCCC	40.12	25159151
74	Phosphorylation	TSVPHFPTPSILHQG CCCCCCCCCCCCCCC	28.82	25159151
74	Phosphorylation	TSVPHFPTPSILHQG CCCCCCCCCCCCCCC	28.82	24719451
87	Phosphorylation	QGPGHEQHSPLVAPP CCCCCCCCCCCCCCC	28.53	22199227
97	Phosphorylation	LVAPPAALPSDGRDE CCCCCCCCCCCCCCH	4.54	25022875
102	Phosphorylation	AALPSDGRDEVSHLQ CCCCCCCCCHHHCCC	41.74	24719451
102	Phosphorylation	AALPSDGRDEVSHLQ CCCCCCCCCHHHCCC	41.74	24719451
103	Phosphorylation	ALPSDGRDEVSHLQS CCCCCCCCHHHCCCC	67.20	21815630
103	Phosphorylation	ALPSDGRDEVSHLQS CCCCCCCCHHHCCCC	67.20	27251275
106	Phosphorylation	SDGRDEVSHLQSGSH CCCCCHHHCCCCCCH	19.21	27732954
110	Phosphorylation	DEVSHLQSGSHLANN CHHHCCCCCCHHHCC	48.93	25850435
112	Phosphorylation	VSHLQSGSHLANNSD HHCCCCCCHHHCCCC	22.15	25850435
118	Phosphorylation	GSHLANNSDPESTFR CCHHHCCCCHHHHHC	55.11	23663014
122	Phosphorylation	ANNSDPESTFRQNPR HCCCCHHHHHCCCCH	37.93	28731282
122	Phosphorylation	ANNSDPESTFRQNPR HCCCCHHHHHCCCCH	37.93	29255136
123	Phosphorylation	NNSDPESTFRQNPRI CCCCHHHHHCCCCHH	22.60	29255136
125	Phosphorylation	SDPESTFRQNPRIVN CCHHHHHCCCCHHHC	35.14	25850435
125	Phosphorylation	SDPESTFRQNPRIVN CCHHHHHCCCCHHHC	35.14	20068231
129	Phosphorylation	STFRQNPRIVNHWAS HHHCCCCHHHCCCCC	53.70	25159151
129	Phosphorylation	STFRQNPRIVNHWAS HHHCCCCHHHCCCCC	53.70	20068231
131	Phosphorylation	FRQNPRIVNHWASPE HCCCCHHHCCCCCHH	4.55	22199227
136	Phosphorylation	RIVNHWASPELRQNP HHHCCCCCHHHHCCC	17.45	23927012
140	Methylation	HWASPELRQNPGVKN CCCCHHHHCCCCCCC	32.35	115493511
153	Phosphorylation	KNEHRPASALVNPLA CCCCCCHHHHCCCHH	25.48	29255136
157	Phosphorylation	RPASALVNPLARGDS CCHHHHCCCHHCCCC	27.07	-
157	Phosphorylation	RPASALVNPLARGDS CCHHHHCCCHHCCCC	27.07	-
161	Phosphorylation	ALVNPLARGDSPENR HHCCCHHCCCCCCCC	58.07	-
161	Phosphorylation	ALVNPLARGDSPENR HHCCCHHCCCCCCCC	58.07	-
164	Phosphorylation	NPLARGDSPENRTHH CCHHCCCCCCCCCCC	36.62	25159151
169	Phosphorylation	GDSPENRTHHPLGAG CCCCCCCCCCCCCCC	35.80	28348404
169	Phosphorylation	GDSPENRTHHPLGAG CCCCCCCCCCCCCCC	35.80	26074081
170	Phosphorylation	DSPENRTHHPLGAGA CCCCCCCCCCCCCCC	19.82	28348404
170	Phosphorylation	DSPENRTHHPLGAGA CCCCCCCCCCCCCCC	19.82	27251275
179	Phosphorylation	PLGAGAGSGCAPLEA CCCCCCCCCCCCCCC	30.11	30576142
187	Phosphorylation	GCAPLEADSGASGAL CCCCCCCCCCCCCCC	37.92	28348404
187	Phosphorylation	GCAPLEADSGASGAL CCCCCCCCCCCCCCC	37.92	-
197	Phosphorylation	ASGALAMFFQGGETE CCCCCHHHHCCCCCC	3.26	20068231
201	Phosphorylation	LAMFFQGGETENEEN CHHHHCCCCCCCCHH	28.06	20068231
203	Phosphorylation	MFFQGGETENEENLS HHHCCCCCCCCHHCC	47.59	-
211	Phosphorylation	ENEENLSSEKAGLSG CCCHHCCCCCCCCCC	46.40	29496963
217	Phosphorylation	SSEKAGLSGQADFDD CCCCCCCCCCCCHHH	28.13	26074081
227	Phosphorylation	ADFDDFCSSPGLGRP CCHHHHHCCCCCCCC	39.29	26074081
228	Phosphorylation	DFDDFCSSPGLGRPP CHHHHHCCCCCCCCC	24.94	26074081
229	Methylation	FDDFCSSPGLGRPPA HHHHHCCCCCCCCCC	26.24	-
238	Phosphorylation	LGRPPAPTHVGAGSL CCCCCCCCCCCCCCH	31.16	26074081
244	Phosphorylation	PTHVGAGSLCQALLP CCCCCCCCHHHHHCC	25.99	26074081
254	Phosphorylation	QALLPGPSNEAAGDV HHHCCCCCCCCCCCC	53.90	26074081
288	Phosphorylation	VENLEFVQNQEVLPS CCCCEEEECCCCCCC	51.73	-
290	Phosphorylation	NLEFVQNQEVLPSEP CCEEEECCCCCCCCC	25.69	-
296	Phosphorylation	NQEVLPSEPLNLDPS CCCCCCCCCCCCCCC	52.44	24275569
301	Phosphorylation	PSEPLNLDPSSPSDQ CCCCCCCCCCCCCCC	39.71	-
303	Phosphorylation	EPLNLDPSSPSDQFR CCCCCCCCCCCCCCC	55.32	24275569
304	Phosphorylation	PLNLDPSSPSDQFRY CCCCCCCCCCCCCCC	33.54	25137130
311	Phosphorylation	SPSDQFRYGPLPGPA CCCCCCCCCCCCCCC	25.12	25394399
314	Phosphorylation	DQFRYGPLPGPAVPR CCCCCCCCCCCCCCC	7.13	18691976
318	Methylation	YGPLPGPAVPRHGAV CCCCCCCCCCCCCCE	29.84	-
328	Phosphorylation	RHGAVCHTGAPDATL CCCCEECCCCCCCEE	29.88	21945579
331	Phosphorylation	AVCHTGAPDATLHTV CEECCCCCCCEEEEC	32.87	24719451
334	Phosphorylation	HTGAPDATLHTVHPD CCCCCCCEEEECCCC	26.84	21945579
337	Phosphorylation	APDATLHTVHPDSVS CCCCEEEECCCCCCC	24.50	21945579
342	Phosphorylation	LHTVHPDSVSSSYSS EEECCCCCCCCCCCC	28.49	21945579
344	Phosphorylation	TVHPDSVSSSYSSRS ECCCCCCCCCCCCCC	19.95	21945579
345	Phosphorylation	VHPDSVSSSYSSRSH CCCCCCCCCCCCCCC	31.01	21945579
346	Phosphorylation	HPDSVSSSYSSRSHG CCCCCCCCCCCCCCC	22.87	21945579
347	Phosphorylation	PDSVSSSYSSRSHGR CCCCCCCCCCCCCCC	16.77	21945579
348	Phosphorylation	DSVSSSYSSRSHGRL CCCCCCCCCCCCCCC	22.63	21945579
349	Phosphorylation	SVSSSYSSRSHGRLS CCCCCCCCCCCCCCC	29.57	21945579
351	Phosphorylation	SSSYSSRSHGRLSGS CCCCCCCCCCCCCCC	32.04	30576142
356	Phosphorylation	SRSHGRLSGSARPQE CCCCCCCCCCCCHHH	29.37	25159151
358	Phosphorylation	SHGRLSGSARPQELV CCCCCCCCCCHHHHH	20.09	28387310
367	Phosphorylation	RPQELVGTFIQQEVG CHHHHHHHHHHHHCC	15.30	20068231
381	Phosphorylation	GKPEDEASGSFFKQI CCCCCCCCCCCCCCC	32.68	28258704
383	Phosphorylation	PEDEASGSFFKQIDS CCCCCCCCCCCCCCC	25.64	20873877
390	Phosphorylation	SFFKQIDSSPVGGET CCCCCCCCCCCCCCC	37.86	22167270
391	Phosphorylation	FFKQIDSSPVGGETD CCCCCCCCCCCCCCC	21.62	22167270
397	Phosphorylation	SSPVGGETDETTVSQ CCCCCCCCCCCCCCC	42.27	22167270
400	Phosphorylation	VGGETDETTVSQNYR CCCCCCCCCCCCCCC	34.99	23927012
401	Phosphorylation	GGETDETTVSQNYRG CCCCCCCCCCCCCCC	18.99	23927012
403	Phosphorylation	ETDETTVSQNYRGSV CCCCCCCCCCCCCCC	15.60	23927012
406	Phosphorylation	ETTVSQNYRGSVSQP CCCCCCCCCCCCCCC	14.55	23927012
409	Phosphorylation	VSQNYRGSVSQPSTP CCCCCCCCCCCCCCC	15.03	23927012
411	Phosphorylation	QNYRGSVSQPSTPSP CCCCCCCCCCCCCCC	37.76	23927012
414	Phosphorylation	RGSVSQPSTPSPPKP CCCCCCCCCCCCCCC	45.36	22167270
415	Phosphorylation	GSVSQPSTPSPPKPT CCCCCCCCCCCCCCC	34.17	22167270
417	Phosphorylation	VSQPSTPSPPKPTGI CCCCCCCCCCCCCCC	54.65	22167270
422	Phosphorylation	TPSPPKPTGIFQTSA CCCCCCCCCCEECCC	49.38	22167270
427	Phosphorylation	KPTGIFQTSANSSFE CCCCCEECCCCCCCC	21.03	22167270
428	Phosphorylation	PTGIFQTSANSSFEP CCCCEECCCCCCCCC	18.05	30278072
431	Phosphorylation	IFQTSANSSFEPVKS CEECCCCCCCCCCHH	35.80	23927012
432	Phosphorylation	FQTSANSSFEPVKSH EECCCCCCCCCCHHH	33.17	23927012
438	Phosphorylation	SSFEPVKSHLVGVKP CCCCCCHHHCCCCCC	23.45	28555341
444	Acetylation	KSHLVGVKPFEADRA HHHCCCCCCCCCCCC	37.75	23954790
460	Phosphorylation	VVGEVRETCVRQKQC HHHHHHHHHHHHCCC	13.02	28555341
482	Phosphorylation	DASPGNLEQPPDNME CCCCCCCCCCCCCHH	66.11	-
489	Phosphorylation	EQPPDNMETLCAPQV CCCCCCHHCCCCCCC	44.90	-
520	Phosphorylation	HAGAPPLDTVYPAPE CCCCCCCCCCCCCCC	39.64	27251275
521	Phosphorylation	AGAPPLDTVYPAPEK CCCCCCCCCCCCCCC	29.62	26074081
523	Phosphorylation	APPLDTVYPAPEKRP CCCCCCCCCCCCCCC	8.86	26074081
525	Phosphorylation	PLDTVYPAPEKRPSA CCCCCCCCCCCCCCC	13.75	-
526	Phosphorylation	LDTVYPAPEKRPSAR CCCCCCCCCCCCCCC	43.04	-
529	Phosphorylation	VYPAPEKRPSARTQG CCCCCCCCCCCCCCC	28.83	20068231
531	Phosphorylation	PAPEKRPSARTQGPV CCCCCCCCCCCCCCC	34.12	26074081
534	Phosphorylation	EKRPSARTQGPVKCE CCCCCCCCCCCCCCC	37.28	26074081
536	Phosphorylation	RPSARTQGPVKCESP CCCCCCCCCCCCCCC	28.49	-
542	Phosphorylation	QGPVKCESPATTLWA CCCCCCCCCCEEEEE	29.34	26074081
545	Phosphorylation	VKCESPATTLWAQSE CCCCCCCEEEEEECC	26.30	26074081
546	Phosphorylation	KCESPATTLWAQSEL CCCCCCEEEEEECCC	23.55	26074081
551	Phosphorylation	ATTLWAQSELPDFGG CEEEEEECCCCCCCC	33.10	26074081
559	Phosphorylation	ELPDFGGNVLLAPAA CCCCCCCCEEEECCC	22.95	24719451
561	Phosphorylation	PDFGGNVLLAPAAPA CCCCCCEEEECCCCE	3.81	-
568	Phosphorylation	LLAPAAPALYVCAKP EEECCCCEEEEECCC	13.54	19664995
569	Phosphorylation	LAPAAPALYVCAKPQ EECCCCEEEEECCCC	2.99	19664995
570	Phosphorylation	APAAPALYVCAKPQP ECCCCEEEEECCCCC	8.79	-
575	Phosphorylation	ALYVCAKPQPPVVQP EEEEECCCCCCCCCC	33.13	19413330
584	Phosphorylation	PPVVQPPEEAMSGQQ CCCCCCCHHHHCCCC	66.14	-
587	Phosphorylation	VQPPEEAMSGQQSRN CCCCHHHHCCCCCCC	5.38	20068231
589	Phosphorylation	PPEEAMSGQQSRNPS CCHHHHCCCCCCCHH	19.23	17081983
592	Phosphorylation	EAMSGQQSRNPSSAA HHHCCCCCCCHHHCC	26.57	17081983
593	Phosphorylation	AMSGQQSRNPSSAAP HHCCCCCCCHHHCCC	55.53	17081983
595	Phosphorylation	SGQQSRNPSSAAPVQ CCCCCCCHHHCCCCC	28.66	17081983
596	Phosphorylation	GQQSRNPSSAAPVQS CCCCCCHHHCCCCCC	35.84	22199227
597	Phosphorylation	QQSRNPSSAAPVQSR CCCCCHHHCCCCCCC	29.70	22199227
600	Phosphorylation	RNPSSAAPVQSRGGI CCHHHCCCCCCCCCC	25.13	17081983
603	Phosphorylation	SSAAPVQSRGGIGAS HHCCCCCCCCCCCCC	32.88	24532841
604	Methylation	SAAPVQSRGGIGASE HCCCCCCCCCCCCCC	30.21	115493519
605	Phosphorylation	AAPVQSRGGIGASEN CCCCCCCCCCCCCCC	37.00	17081983
606	Phosphorylation	APVQSRGGIGASENL CCCCCCCCCCCCCCC	17.66	17081983
609	Phosphorylation	QSRGGIGASENLENP CCCCCCCCCCCCCCC	16.26	17081983
610	Phosphorylation	SRGGIGASENLENPP CCCCCCCCCCCCCCC	23.08	17081983
622	Acetylation	NPPKMGEEEALQSQA CCCCCCHHHHHHHHH	42.72	22635105
622	Acetylation	NPPKMGEEEALQSQA CCCCCCHHHHHHHHH	42.72	19608861
622	Ubiquitination	NPPKMGEEEALQSQA CCCCCCHHHHHHHHH	42.72	19608861
635	Phosphorylation	QASSGYASLLSSPPT HHHHCHHHHHCCCCC	22.74	26074081
638	Phosphorylation	SGYASLLSSPPTESL HCHHHHHCCCCCHHH	46.20	26074081
639	Phosphorylation	GYASLLSSPPTESLQ CHHHHHCCCCCHHHC	34.56	26074081
642	Phosphorylation	SLLSSPPTESLQNPP HHHCCCCCHHHCCCC	41.40	26074081
644	Phosphorylation	LSSPPTESLQNPPVL HCCCCCHHHCCCCEE	37.42	26074081
668	Phosphorylation	LAQPINFSVSLSNSH CCCCCEEEEECCCCC	13.30	-
720	Phosphorylation	SSVLSLSLPSSVAQS CCEEEECCCCHHHHC	6.06	-
770	Phosphorylation	SQKDRKAGSALPGFA HHHCCCCCCCCCCCC	19.25	-
771	Phosphorylation	QKDRKAGSALPGFAN HHCCCCCCCCCCCCC	31.34	28450419
774	Phosphorylation	RKAGSALPGFANSPA CCCCCCCCCCCCCCC	35.26	27251275
775	Phosphorylation	KAGSALPGFANSPAG CCCCCCCCCCCCCCC	34.84	-
779	Phosphorylation	ALPGFANSPAGSTSV CCCCCCCCCCCCEEE	16.82	23401153
782	Methylation	GFANSPAGSTSVVLV CCCCCCCCCEEEEEE	34.54	-
783	Phosphorylation	FANSPAGSTSVVLVP CCCCCCCCEEEEEEC	21.44	30278072
784	Phosphorylation	ANSPAGSTSVVLVPP CCCCCCCEEEEEECC	25.32	30278072
785	Phosphorylation	NSPAGSTSVVLVPPA CCCCCCEEEEEECCC	16.36	25159151
795	Phosphorylation	LVPPAHGTLVPDGNK EECCCCCCCCCCCCC	18.08	20068231
806	Phosphorylation	DGNKANHSSHQEDTY CCCCCCCCCCCCCCC	29.35	30576142
807	Phosphorylation	GNKANHSSHQEDTYG CCCCCCCCCCCCCCC	22.95	30576142
812	Phosphorylation	HSSHQEDTYGALDFT CCCCCCCCCCCHHHH	24.09	29978859
813	Phosphorylation	SSHQEDTYGALDFTL CCCCCCCCCCHHHHH	16.84	25884760
819	Phosphorylation	TYGALDFTLSRTLEN CCCCHHHHHHCCCCC	24.40	28555341
823	Phosphorylation	LDFTLSRTLENPVNV HHHHHHCCCCCCCCC	34.74	21945579
831	Phosphorylation	LENPVNVYNPSHSDS CCCCCCCCCCCCCCC	19.02	21945579
834	Phosphorylation	PVNVYNPSHSDSLAS CCCCCCCCCCCCHHH	31.80	21945579
836	O-linked_Glycosylation	NVYNPSHSDSLASQQ CCCCCCCCCCHHHHH	32.98	23301498
836	Phosphorylation	NVYNPSHSDSLASQQ CCCCCCCCCCHHHHH	32.98	21945579
838	Phosphorylation	YNPSHSDSLASQQSV CCCCCCCCHHHHHHH	28.93	21945579
841	Phosphorylation	SHSDSLASQQSVASH CCCCCHHHHHHHHHC	33.76	21945579
844	Phosphorylation	DSLASQQSVASHPRQ CCHHHHHHHHHCCCC	16.41	21945579
846	Phosphorylation	LASQQSVASHPRQSG HHHHHHHHHCCCCCC	13.84	-
847	Phosphorylation	ASQQSVASHPRQSGP HHHHHHHHCCCCCCC	31.69	21945579
852	Phosphorylation	VASHPRQSGPGAPNL HHHCCCCCCCCCCCH	48.51	25159151
863	Phosphorylation	APNLDRFYQQVTKDA CCCHHHHHHHHHHCC	10.03	28796482
867	Phosphorylation	DRFYQQVTKDAQGQP HHHHHHHHHCCCCCC	20.90	29978859
868	Acetylation	RFYQQVTKDAQGQPG HHHHHHHHCCCCCCC	52.81	26051181
891	Phosphorylation	VPPQQQASPPQLPKA CCHHHCCCCCCCCHH	32.54	29255136
901	Phosphorylation	QLPKAMFSELSNPES CCCHHHHHHCCCCCC	25.25	26074081
957	Phosphorylation	GSGQAAVPSEQPWPQ CCCCCCCCCCCCCCC	27.67	20068231
961	Phosphorylation	AAVPSEQPWPQPVPA CCCCCCCCCCCCCCC	40.43	-
962	Phosphorylation	AVPSEQPWPQPVPAL CCCCCCCCCCCCCCC	12.12	18669648
984	Phosphorylation	DLAAYYYYRPLYDAY HHHHHHHCCCCCCCC	6.93	27642862
985	Phosphorylation	LAAYYYYRPLYDAYQ HHHHHHCCCCCCCCC	9.91	27642862
991	Phosphorylation	YRPLYDAYQPQYSLP CCCCCCCCCCCCCCC	20.16	27642862
996	Phosphorylation	DAYQPQYSLPYPPEP CCCCCCCCCCCCCCC	20.02	-
997	Phosphorylation	AYQPQYSLPYPPEPG CCCCCCCCCCCCCCC	3.92	-
1009	Phosphorylation	EPGAASLYYQDVYSL CCCCCEEEEEEHHHH	9.15	27642862
1010	Phosphorylation	PGAASLYYQDVYSLY CCCCEEEEEEHHHHH	11.97	-
1012	Phosphorylation	AASLYYQDVYSLYEP CCEEEEEEHHHHHCC	25.79	24719451
1014	Phosphorylation	SLYYQDVYSLYEPRY EEEEEEHHHHHCCCC	10.97	-
1015	Phosphorylation	LYYQDVYSLYEPRYR EEEEEHHHHHCCCCC	25.07	-
1016	Phosphorylation	YYQDVYSLYEPRYRP EEEEHHHHHCCCCCC	2.84	27251275
1017	Phosphorylation	YQDVYSLYEPRYRPY EEEHHHHHCCCCCCC	20.25	-
1019	Phosphorylation	DVYSLYEPRYRPYDG EHHHHHCCCCCCCCC	25.66	27251275
1021	Phosphorylation	YSLYEPRYRPYDGAA HHHHCCCCCCCCCHH	27.01	29978859
1022	Phosphorylation	SLYEPRYRPYDGAAS HHHCCCCCCCCCHHH	25.28	27251275
1024	Phosphorylation	YEPRYRPYDGAASAY HCCCCCCCCCHHHHH	20.29	28796482
1029	Phosphorylation	RPYDGAASAYAQNYR CCCCCHHHHHHHHCC	22.68	23898821
1030	Phosphorylation	PYDGAASAYAQNYRY CCCCHHHHHHHHCCC	10.04	27251275
1031	Phosphorylation	YDGAASAYAQNYRYP CCCHHHHHHHHCCCC	13.26	28796482
1035	Phosphorylation	ASAYAQNYRYPEPER HHHHHHHCCCCCCCC	10.23	28796482
1036	Methylation	SAYAQNYRYPEPERP HHHHHHCCCCCCCCC	48.34	80702339
1037	Phosphorylation	AYAQNYRYPEPERPS HHHHHCCCCCCCCCC	11.11	28985074
1041	Phosphorylation	NYRYPEPERPSSRAS HCCCCCCCCCCCCCC	75.47	27642862
1042	Methylation	YRYPEPERPSSRASH CCCCCCCCCCCCCCC	47.30	115383439
1044	Phosphorylation	YPEPERPSSRASHSS CCCCCCCCCCCCCCC	38.38	30266825
1045	Phosphorylation	PEPERPSSRASHSSE CCCCCCCCCCCCCCC	34.25	30266825
1046	Ubiquitination	EPERPSSRASHSSER CCCCCCCCCCCCCCC	44.43	-
1048	Phosphorylation	ERPSSRASHSSERPP CCCCCCCCCCCCCCC	23.85	27794612
1050	Phosphorylation	PSSRASHSSERPPPR CCCCCCCCCCCCCCC	31.25	25159151
1051	Phosphorylation	SSRASHSSERPPPRQ CCCCCCCCCCCCCCC	32.00	27794612
1060	Phosphorylation	RPPPRQGYPEGYYSS CCCCCCCCCCCCCCC	6.97	28152594
1064	Phosphorylation	RQGYPEGYYSSKSGW CCCCCCCCCCCCCCC	9.86	25839225
1065	Phosphorylation	QGYPEGYYSSKSGWS CCCCCCCCCCCCCCC	19.82	28555341
1066	Phosphorylation	GYPEGYYSSKSGWSS CCCCCCCCCCCCCCC	23.86	28555341
1069	Phosphorylation	EGYYSSKSGWSSQSD CCCCCCCCCCCCCHH	47.65	18669648
1072	Phosphorylation	YSSKSGWSSQSDYYA CCCCCCCCCCHHHHH	23.25	30576142
1073	Phosphorylation	SSKSGWSSQSDYYAS CCCCCCCCCHHHHHH	27.48	28348404
1075	Phosphorylation	KSGWSSQSDYYASYY CCCCCCCHHHHHHHC	29.54	24719451
1079	Phosphorylation	SSQSDYYASYYSSQY CCCHHHHHHHCCCCC	5.71	-
1083	Phosphorylation	DYYASYYSSQYDYGD HHHHHHCCCCCCCCC	11.61	-
1097	Phosphorylation	DPGHWDRYHYSARVR CCCCCCCCEEEEECC	11.57	-
1099	Phosphorylation	GHWDRYHYSARVRDP CCCCCCEEEEECCCC	8.62	30576142
1100	Phosphorylation	HWDRYHYSARVRDPR CCCCCEEEEECCCCC	9.04	24719451
1113	Phosphorylation	PRTYDRRYWCDAEYD CCCCCCCCCCCHHHH	15.98	-
1119	Phosphorylation	RYWCDAEYDAYRREH CCCCCHHHHHHHHHH	13.95	28796482
1122	Phosphorylation	CDAEYDAYRREHSAF CCHHHHHHHHHHHCC	13.80	28796482
1127	Phosphorylation	DAYRREHSAFGDRPE HHHHHHHHCCCCCCC	22.12	29255136
1135	Ubiquitination	AFGDRPEKRDNNWRY CCCCCCCCCCCCCCC	68.67	-
1135 (in isoform 5)	Ubiquitination	-	68.67	-
1142	Phosphorylation	KRDNNWRYDPRFTGS CCCCCCCCCCCCCCC	23.16	24719451
1147	Phosphorylation	WRYDPRFTGSFDDDP CCCCCCCCCCCCCCC	32.94	29255136
1149	Phosphorylation	YDPRFTGSFDDDPDP CCCCCCCCCCCCCCC	23.57	29255136
1161	Phosphorylation	PDPHRDPYGEEVDRR CCCCCCCCCCCCCHH	41.27	29255136
1169	Phosphorylation	GEEVDRRSVHSEHSA CCCCCHHCCCCHHHH	25.69	27362937
1172	Phosphorylation	VDRRSVHSEHSARSL CCHHCCCCHHHHHHH	34.54	27362937
1174	Phosphorylation	RRSVHSEHSARSLHS HHCCCCHHHHHHHHH	29.76	-
1175	Phosphorylation	RSVHSEHSARSLHSA HCCCCHHHHHHHHHH	22.71	27362937
1178	Phosphorylation	HSEHSARSLHSAHSL CCHHHHHHHHHHHHH	30.10	29255136
1181	Phosphorylation	HSARSLHSAHSLASR HHHHHHHHHHHHHHC	32.73	29255136
1184	Phosphorylation	RSLHSAHSLASRRSS HHHHHHHHHHHCHHH	25.91	23401153
1187	Phosphorylation	HSAHSLASRRSSLSS HHHHHHHHCHHHCCC	33.25	30266825
1190	Phosphorylation	HSLASRRSSLSSHSH HHHHHCHHHCCCCCH	34.22	23927012
1191	Phosphorylation	SLASRRSSLSSHSHQ HHHHCHHHCCCCCHH	30.38	23927012
1193	Phosphorylation	ASRRSSLSSHSHQSQ HHCHHHCCCCCHHHH	28.14	21945579
1194	Phosphorylation	SRRSSLSSHSHQSQI HCHHHCCCCCHHHHH	34.01	21945579
1196	Phosphorylation	RSSLSSHSHQSQIYR HHHCCCCCHHHHHHH	25.77	21945579
1199	Phosphorylation	LSSHSHQSQIYRSHN CCCCCHHHHHHHHCC	17.08	21945579
1202	Phosphorylation	HSHQSQIYRSHNVAA CCHHHHHHHHCCCCC	9.83	21945579
1204	Phosphorylation	HQSQIYRSHNVAAGS HHHHHHHHCCCCCCC	11.48	29978859
1207	Phosphorylation	QIYRSHNVAAGSYEA HHHHHCCCCCCCCCC	3.02	24719451
1209	Phosphorylation	YRSHNVAAGSYEAPL HHHCCCCCCCCCCCC	11.81	27642862
1211	Phosphorylation	SHNVAAGSYEAPLPP HCCCCCCCCCCCCCC	18.31	23927012
1212	Phosphorylation	HNVAAGSYEAPLPPG CCCCCCCCCCCCCCC	18.39	23927012
1213	Phosphorylation	NVAAGSYEAPLPPGS CCCCCCCCCCCCCCC	45.57	-
1214	Methylation	VAAGSYEAPLPPGSF CCCCCCCCCCCCCCC	11.60	-
1215	Phosphorylation	AAGSYEAPLPPGSFH CCCCCCCCCCCCCCC	33.20	-
1220	Methylation	EAPLPPGSFHGDFAY CCCCCCCCCCCCCCC	21.61	-
1220	Phosphorylation	EAPLPPGSFHGDFAY CCCCCCCCCCCCCCC	21.61	23401153
1222	Phosphorylation	PLPPGSFHGDFAYGT CCCCCCCCCCCCCCC	36.29	24719451
1223	Phosphorylation	LPPGSFHGDFAYGTY CCCCCCCCCCCCCCC	29.71	24719451
1226	Phosphorylation	GSFHGDFAYGTYRSN CCCCCCCCCCCCCCC	13.44	24719451
1227	Phosphorylation	SFHGDFAYGTYRSNF CCCCCCCCCCCCCCC	15.25	23927012
1229	Phosphorylation	HGDFAYGTYRSNFSS CCCCCCCCCCCCCCC	11.77	23927012
1230	Phosphorylation	GDFAYGTYRSNFSSG CCCCCCCCCCCCCCC	14.00	28464451
1232	Phosphorylation	FAYGTYRSNFSSGPG CCCCCCCCCCCCCCC	31.64	23663014
1235	Phosphorylation	GTYRSNFSSGPGFPE CCCCCCCCCCCCCCC	38.34	25022875
1236	Phosphorylation	TYRSNFSSGPGFPEY CCCCCCCCCCCCCCC	44.89	25022875
1242	Phosphorylation	SSGPGFPEYGYPADT CCCCCCCCCCCCHHH	49.70	27642862
1243	Phosphorylation	SGPGFPEYGYPADTV CCCCCCCCCCCHHHH	23.38	25022875
1244	O-linked_Glycosylation	GPGFPEYGYPADTVW CCCCCCCCCCHHHHH	21.93	23301498
1244	Phosphorylation	GPGFPEYGYPADTVW CCCCCCCCCCHHHHH	21.93	27642862
1245	Phosphorylation	PGFPEYGYPADTVWP CCCCCCCCCHHHHHH	8.37	25022875
1249	Phosphorylation	EYGYPADTVWPAMEQ CCCCCHHHHHHHHHH	26.95	25022875
1250	Phosphorylation	YGYPADTVWPAMEQV CCCCHHHHHHHHHHH	6.24	-
1253	Phosphorylation	PADTVWPAMEQVSSR CHHHHHHHHHHHHCC	9.83	24719451
1258	Phosphorylation	WPAMEQVSSRPTSPE HHHHHHHHCCCCCHH	21.96	26503892
1259	Phosphorylation	PAMEQVSSRPTSPEK HHHHHHHCCCCCHHH	43.34	26503892
1261	Phosphorylation	MEQVSSRPTSPEKFS HHHHHCCCCCHHHCC	38.89	-
1262	Phosphorylation	EQVSSRPTSPEKFSV HHHHCCCCCHHHCCC	56.66	21955146
1263	Phosphorylation	QVSSRPTSPEKFSVP HHHCCCCCHHHCCCC	33.47	21955146
1268	Phosphorylation	PTSPEKFSVPHVCAR CCCHHHCCCCCHHHH	45.89	30108239
1278	Phosphorylation	HVCARFGPGGQLIKV CHHHHCCCCCCEEEE	40.82	24719451
1291	Phosphorylation	KVIPNLPSEGQPALV EEECCCCCCCCCCEE	58.48	27642862
1297	Phosphorylation	PSEGQPALVEVHSME CCCCCCCEEEEECHH	4.25	27642862
1300	Phosphorylation	GQPALVEVHSMEALL CCCCEEEEECHHHHH	2.93	27642862
1305	Phosphorylation	VEVHSMEALLQHTSE EEEECHHHHHHCCCH	12.63	24719451
1313	Ubiquitination	LLQHTSEQEEMRAFP HHHCCCHHHHHHCCC	52.28	-
1313	Ubiquitination	LLQHTSEQEEMRAFP HHHCCCHHHHHHCCC	52.28	-
1320	Phosphorylation	QEEMRAFPGPLAKDD HHHHHCCCCCCCCCC	42.37	24719451
1325	Phosphorylation	AFPGPLAKDDTHKVD CCCCCCCCCCCCCCC	64.91	20166139
1327	Phosphorylation	PGPLAKDDTHKVDVI CCCCCCCCCCCCCHH	50.43	17081983
1347	Phosphorylation	KAMKCLQNENLIDKE HHHHHHHCCCCCCHH	27.46	20068231
1350	Phosphorylation	KCLQNENLIDKESAS HHHHCCCCCCHHHHH	4.34	20068231
1353	Phosphorylation	QNENLIDKESASLLW HCCCCCCHHHHHHHH	46.72	20068231
1356	Phosphorylation	NLIDKESASLLWNFI CCCCHHHHHHHHHHH	12.80	17081983
1359	Phosphorylation	DKESASLLWNFIVLL CHHHHHHHHHHHHHH	3.05	19691289
1362	Phosphorylation	SASLLWNFIVLLCRQ HHHHHHHHHHHHHHH	2.50	17081983
1365	Phosphorylation	LLWNFIVLLCRQNGT HHHHHHHHHHHHCCE	2.98	24719451
1368	Phosphorylation	NFIVLLCRQNGTVVG HHHHHHHHHCCEEEE	32.73	27642862
1369	Phosphorylation	FIVLLCRQNGTVVGT HHHHHHHHCCEEEEC	52.27	20068231
1371	Phosphorylation	VLLCRQNGTVVGTDI HHHHHHCCEEEECCH	16.14	24719451
1372	Phosphorylation	LLCRQNGTVVGTDIA HHHHHCCEEEECCHH	21.40	20068231
1374	Phosphorylation	CRQNGTVVGTDIAEL HHHCCEEEECCHHHH	7.39	24719451
1376	Phosphorylation	QNGTVVGTDIAELLL HCCEEEECCHHHHHH	16.78	20068231
1380	Phosphorylation	VVGTDIAELLLRDHR EEECCHHHHHHCCCC	40.04	27642862
1389	Phosphorylation	LLRDHRTVWLPGKSP HHCCCCEEECCCCCC	5.08	24719451
1390	Phosphorylation	LRDHRTVWLPGKSPN HCCCCEEECCCCCCC	9.02	27642862
1395	Phosphorylation	TVWLPGKSPNEANLI EEECCCCCCCCCCCC	38.58	24275569
1398	Phosphorylation	LPGKSPNEANLIDFT CCCCCCCCCCCCHHC	42.17	18669648
1405	Phosphorylation	EANLIDFTNEAVEQV CCCCCHHCHHHHHHH	28.53	27642862
1407	Phosphorylation	NLIDFTNEAVEQVEE CCCHHCHHHHHHHHH	51.54	27642862
1413	Phosphorylation	NEAVEQVEEEESGEA HHHHHHHHHHHCCCC	60.43	27251275
1417	Phosphorylation	EQVEEEESGEAQLSF HHHHHHHCCCCEEHH	45.25	22468782
1421	Phosphorylation	EEESGEAQLSFLTGG HHHCCCCEEHHHHCC	33.08	27642862
1423	Phosphorylation	ESGEAQLSFLTGGPA HCCCCEEHHHHCCHH	13.21	26074081
1426	Phosphorylation	EAQLSFLTGGPAAAA CCEEHHHHCCHHHHH	37.77	26074081
1436	Phosphorylation	PAAAASSLERETERF HHHHHHHHHHHHHHH	7.15	19651622
1437	Phosphorylation	AAAASSLERETERFR HHHHHHHHHHHHHHH	50.87	19651622
1440	Phosphorylation	ASSLERETERFRELL HHHHHHHHHHHHHHH	38.39	18669648
1441	Phosphorylation	SSLERETERFRELLL HHHHHHHHHHHHHHH	45.10	18669648
1446	Phosphorylation	ETERFRELLLYGRKK HHHHHHHHHHHCHHH	3.30	24719451
1449	Phosphorylation	RFRELLLYGRKKDAL HHHHHHHHCHHHHHH	18.17	-
1462	Sumoylation	ALESAMKNGLWGHAL HHHHHHHCCHHHHHH	37.39	-
1462	Ubiquitination	ALESAMKNGLWGHAL HHHHHHHCCHHHHHH	37.39	-
1503	Ubiquitination	PLQTVYQLMSGRMPA HHHHHHHHHHCCCCC	1.29	-
1508	Ubiquitination	YQLMSGRMPAASTCC HHHHHCCCCCHHHCC	2.78	-
1518	Ubiquitination	ASTCCGDEKWGDWRP HHHCCCCCCCCCCHH	35.67	-
1521	Ubiquitination	CCGDEKWGDWRPHLA CCCCCCCCCCHHHHH	35.35	-
1532	Phosphorylation	PHLAMVLSNLNNNMD HHHHHHHHHCCCCCC	28.06	20860994
1544	Phosphorylation	NMDVESRTMATMGDT CCCHHHHHHHHHHHH	22.04	21406692
1547	Phosphorylation	VESRTMATMGDTLAS HHHHHHHHHHHHHHH	15.74	21406692
1550	Phosphorylation	RTMATMGDTLASRGL HHHHHHHHHHHHCCH	27.94	20068231
1551	Phosphorylation	TMATMGDTLASRGLL HHHHHHHHHHHCCHH	20.63	21406692
1554	Phosphorylation	TMGDTLASRGLLDAA HHHHHHHHCCHHHHH	29.96	21406692
1573	Phosphorylation	LMAQAGFGVYTKKTT HHHHCCCCEEECCCC	15.59	24275569
1576	Phosphorylation	QAGFGVYTKKTTKLV HCCCCEEECCCCEEE	24.53	-
1579	Phosphorylation	FGVYTKKTTKLVLIG CCEEECCCCEEEEEC	30.62	28555341
1580	Phosphorylation	GVYTKKTTKLVLIGS CEEECCCCEEEEECC	31.12	28555341
1583	Phosphorylation	TKKTTKLVLIGSNHS ECCCCEEEEECCCCC	3.79	-
1590	Phosphorylation	VLIGSNHSLPFLKFA EEECCCCCCCHHHHH	41.82	28555341
1595	Phosphorylation	NHSLPFLKFATNEAI CCCCCHHHHHHCHHH	33.07	27251275
1595 (in isoform 5)	Ubiquitination	-	33.07	-
1601	Phosphorylation	LKFATNEAIQRTEAY HHHHHCHHHHHHHHH	12.80	24275569
1623	Phosphorylation	AETCPLPSFQVFKFI CCCCCCCHHHHHHHH	35.67	-
1632	Phosphorylation	QVFKFIYSCRLAEMG HHHHHHHHHHHHHHC	6.48	-
1663	Phosphorylation	LTQPHLYSPVLISQL HCCHHHCCHHHHHHH	18.20	-
1685 (in isoform 5)	Ubiquitination	-	59.45	-
1687 (in isoform 5)	Ubiquitination	-	57.02	-
1729	Phosphorylation	LPQQCPGTPSSEMEQ CCCCCCCCCCHHHHH	12.73	28464451
1731	Phosphorylation	QQCPGTPSSEMEQLD CCCCCCCCHHHHHCC	38.48	28464451
1732	Phosphorylation	QCPGTPSSEMEQLDR CCCCCCCHHHHHCCC	42.01	23927012
1743	Phosphorylation	QLDRPGLSQPGALGI HCCCCCCCCCCCCCC	40.00	28464451
1754	Phosphorylation	ALGIANPLLAVPAPS CCCCCCCCEECCCCC	4.87	-
1761	Phosphorylation	LLAVPAPSPEHSSPS CEECCCCCCCCCCCC	45.05	23927012
1765	Phosphorylation	PAPSPEHSSPSVRLL CCCCCCCCCCCEEEC	42.13	25850435
1766	Phosphorylation	APSPEHSSPSVRLLP CCCCCCCCCCEEECC	24.09	25850435
1768	Phosphorylation	SPEHSSPSVRLLPSA CCCCCCCCEEECCCC	23.09	25850435
1773	Ubiquitination	SPSVRLLPSAPQTLP CCCEEECCCCCCCCC	32.79	-
1773	Ubiquitination	SPSVRLLPSAPQTLP CCCEEECCCCCCCCC	32.79	-
1774	Phosphorylation	PSVRLLPSAPQTLPD CCEEECCCCCCCCCC	53.18	23403867
1778	Phosphorylation	LLPSAPQTLPDGPLA ECCCCCCCCCCCCCC	38.92	22167270
1786	Phosphorylation	LPDGPLASPARVPMF CCCCCCCCCCCCCCC	27.12	29255136
1801	Phosphorylation	PVPLPPGPLEPGPGC CCCCCCCCCCCCCCC	39.05	-
1810	Phosphorylation	EPGPGCVTPGPALGF CCCCCCCCCCCCCCC	26.97	28348404
1821	Phosphorylation	ALGFLEPSGPGLPPG CCCCCCCCCCCCCCC	48.52	29496963
1841	Phosphorylation	ERRHLLQEARSPDPG HHHHHHHHHHCCCCC	46.12	-
1844	Phosphorylation	HLLQEARSPDPGIVP HHHHHHHCCCCCCCC	40.48	25159151
1859	Phosphorylation	QEAPVGNSLSELSEE CCCCCCCCHHHHCHH	27.61	30266825
1861	Phosphorylation	APVGNSLSELSEENF CCCCCCHHHHCHHCC	35.99	30266825
1863	Ubiquitination	VGNSLSELSEENFDG CCCCHHHHCHHCCCC	7.59	-
1864	Phosphorylation	GNSLSELSEENFDGK CCCHHHHCHHCCCCC	38.52	30278072
1865	Ubiquitination	NSLSELSEENFDGKF CCHHHHCHHCCCCCC	70.37	-
1865	Ubiquitination	NSLSELSEENFDGKF CCHHHHCHHCCCCCC	70.37	-
1876	Phosphorylation	DGKFANLTPSRTVPD CCCCCCCCCCCCCCC	21.01	19664994
1878	Phosphorylation	KFANLTPSRTVPDSE CCCCCCCCCCCCCCC	35.03	30266825
1880	Phosphorylation	ANLTPSRTVPDSEAP CCCCCCCCCCCCCCC	40.50	28555341
1884	Phosphorylation	PSRTVPDSEAPPGWD CCCCCCCCCCCCCCC	29.59	27251275
1895	Phosphorylation	PGWDRADSGPTQPPL CCCCCCCCCCCCCCC	45.76	22167270
1898	Phosphorylation	DRADSGPTQPPLSLS CCCCCCCCCCCCCCC	58.18	22167270
1903	Phosphorylation	GPTQPPLSLSPAPET CCCCCCCCCCCCCCC	32.35	22167270
1905	Phosphorylation	TQPPLSLSPAPETKR CCCCCCCCCCCCCCC	18.68	19664994
1907	Phosphorylation	PPLSLSPAPETKRPG CCCCCCCCCCCCCCC	15.93	24275569
1910	Phosphorylation	SLSPAPETKRPGQAA CCCCCCCCCCCCCCC	31.15	29255136
1919	Acetylation	RPGQAAKKETKEPKK CCCCCCCCCCCCCCC	66.93	20167786
1921	Phosphorylation	GQAAKKETKEPKKGE CCCCCCCCCCCCCCC	49.97	20860994
1925	Acetylation	KKETKEPKKGESWFF CCCCCCCCCCCCCHH	74.61	20167786
1926	Acetylation	KETKEPKKGESWFFR CCCCCCCCCCCCHHH	77.84	20167786
1929	Phosphorylation	KEPKKGESWFFRWLP CCCCCCCCCHHHCCC	37.54	28857561
1939	Phosphorylation	FRWLPGKKKTEAYLP HHCCCCCCCCCEECC	71.49	24275569
1940	Acetylation	RWLPGKKKTEAYLPD HCCCCCCCCCEECCC	55.90	26051181
1944	Phosphorylation	GKKKTEAYLPDDKNK CCCCCCEECCCCCCC	16.73	18083107
1946	Phosphorylation	KKTEAYLPDDKNKSI CCCCEECCCCCCCCC	34.77	-
1949	Acetylation	EAYLPDDKNKSIVWD CEECCCCCCCCCEEE	73.91	26051181
1952	Phosphorylation	LPDDKNKSIVWDEKK CCCCCCCCCEEECCC	31.59	21815630
1956	Phosphorylation	KNKSIVWDEKKNQWV CCCCCEEECCCCCEE	47.12	27251275
1964	Phosphorylation	EKKNQWVNLNEPEEE CCCCCEECCCCCHHH	33.90	19664995
1980	O-linked_Glycosylation	KAPPPPPTSMPKTVQ CCCCCCCCCCCCCCC	43.35	55829511
1980	Phosphorylation	KAPPPPPTSMPKTVQ CCCCCCCCCCCCCCC	43.35	28555341
1981	Phosphorylation	APPPPPTSMPKTVQA CCCCCCCCCCCCCCC	38.57	28674419
1988	Phosphorylation	SMPKTVQAAPPALPG CCCCCCCCCCCCCCC	20.01	27251275
2004	Phosphorylation	PGAPVNMYSRRAAGT CCCCCCCCCCCCCCC	8.20	18083107
2005	Phosphorylation	GAPVNMYSRRAAGTR CCCCCCCCCCCCCCC	12.43	-
2015	Phosphorylation	AAGTRARYVDVLNPS CCCCCCEEEEEECCC	10.46	28796482
2022	Phosphorylation	YVDVLNPSGTQRSEP EEEEECCCCCCCCCC	54.09	18691976
2024	Phosphorylation	DVLNPSGTQRSEPAL EEECCCCCCCCCCCC	25.75	28555341
2027	Phosphorylation	NPSGTQRSEPALAPA CCCCCCCCCCCCCCC	37.81	28348404
2037	Phosphorylation	ALAPADFVAPLAPLP CCCCCCEEECCCCCC	5.73	24719451
2039	Phosphorylation	APADFVAPLAPLPIP CCCCEEECCCCCCCC	24.61	-
2042	Phosphorylation	DFVAPLAPLPIPSNL CEEECCCCCCCCCCC	46.48	19690332
2053	Phosphorylation	PSNLFVPTPDAEEPQ CCCCEECCCCCCCCC	28.62	28464451
2054	Phosphorylation	SNLFVPTPDAEEPQL CCCEECCCCCCCCCC	32.51	19664994
2056	Phosphorylation	LFVPTPDAEEPQLPD CEECCCCCCCCCCCC	25.02	23186163
2064 (in isoform 5)	Phosphorylation	-	28.29	30619164
2073	Phosphorylation	GREGPAAARGLANPE CCCCHHHHHCCCCCC	14.26	20068231
2074 (in isoform 5)	Phosphorylation	-	35.61	21712546
2075 (in isoform 5)	Phosphorylation	-	25.15	26055452
2076	Phosphorylation	GPAAARGLANPEPAP CHHHHHCCCCCCCCC	3.29	18669648
2081	Phosphorylation	RGLANPEPAPEPKVL HCCCCCCCCCCCCCC	55.14	17081983
2083	Phosphorylation	LANPEPAPEPKVLSS CCCCCCCCCCCCCCC	69.96	19664994
2087 (in isoform 5)	Phosphorylation	-	10.30	27251275
2088 (in isoform 4)	Phosphorylation	-	4.12	22210691
2089	Phosphorylation	APEPKVLSSAASLPG CCCCCCCCCCCCCCC	22.40	29255136
2090	Phosphorylation	PEPKVLSSAASLPGS CCCCCCCCCCCCCCC	24.56	29255136
2093	Phosphorylation	KVLSSAASLPGSELP CCCCCCCCCCCCCCC	34.51	29255136
2097	Acetylation	SAASLPGSELPSSRP CCCCCCCCCCCCCCC	33.74	-
2097	Phosphorylation	SAASLPGSELPSSRP CCCCCCCCCCCCCCC	33.74	23401153
2099	Phosphorylation	ASLPGSELPSSRPEG CCCCCCCCCCCCCCC	5.51	-
2101	Phosphorylation	LPGSELPSSRPEGSQ CCCCCCCCCCCCCCC	52.16	23401153
2102	Phosphorylation	PGSELPSSRPEGSQG CCCCCCCCCCCCCCC	50.33	30278072
2103	Acetylation	GSELPSSRPEGSQGG CCCCCCCCCCCCCCC	37.31	-
2104	Acetylation	SELPSSRPEGSQGGE CCCCCCCCCCCCCCC	52.85	-
2107	Phosphorylation	PSSRPEGSQGGELSR CCCCCCCCCCCCCHH	24.80	17525332
2113	Phosphorylation	GSQGGELSRCSSMSS CCCCCCCHHHHHHHH	27.26	29255136
2116	Phosphorylation	GGELSRCSSMSSLSR CCCCHHHHHHHHHHH	28.15	30108239
2117	Phosphorylation	GELSRCSSMSSLSRE CCCHHHHHHHHHHHH	26.72	23401153
2119	Phosphorylation	LSRCSSMSSLSREVS CHHHHHHHHHHHHHH	30.03	20363803
2120	Phosphorylation	SRCSSMSSLSREVSQ HHHHHHHHHHHHHHH	23.02	20363803
2122	Phosphorylation	CSSMSSLSREVSQHF HHHHHHHHHHHHHHH	28.48	29396449
2126	Phosphorylation	SSLSREVSQHFNQAP HHHHHHHHHHHHHCC	17.12	27251275
2129	Ubiquitination	SREVSQHFNQAPGDL HHHHHHHHHHCCCCC	5.86	-
2130	Phosphorylation	REVSQHFNQAPGDLP HHHHHHHHHCCCCCC	34.67	27251275
2137	Ubiquitination	NQAPGDLPAAGGPPS HHCCCCCCCCCCCCC	25.46	-
2158	O-linked_Glycosylation	NPAQLAQACATSGSS CHHHHHHHHHHCCCC	4.55	-
2161	Phosphorylation	QLAQACATSGSSRLG HHHHHHHHCCCCCCC	33.24	-
2162	Phosphorylation	LAQACATSGSSRLGR HHHHHHHCCCCCCCC	20.39	-
2164	Phosphorylation	QACATSGSSRLGRIG HHHHHCCCCCCCCCC	16.44	-
2182	Phosphorylation	HLVLN---------- CCCCC----------		-
2183	Phosphorylation	LVLN----------- CCCC-----------		-
2193	Phosphorylation	--------------------- ---------------------		27642862
2231	Phosphorylation	----------------------------------------------------------- -----------------------------------------------------------		27251275
2253	Phosphorylation	--------------------------------------------------------------------------------- ---------------------------------------------------------------------------------		27251275
2271	Phosphorylation	--------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------		23186163
2275	Phosphorylation	------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------		-
2279	Phosphorylation	----------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------		27251275
2285	Phosphorylation	----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------		17525332
2291	Phosphorylation	----------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------		24719451
2295	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------		24719451
2297	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------		-
2298	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------		-
2304	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
593	T	Phosphorylation	Kinase	ERK1	P27361	PSP
846	S	Phosphorylation	Kinase	ULK1	O75385	PSP
846	S	Phosphorylation	Kinase	ULK2	Q8IYT8	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC16A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC16A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF3_HUMAN	TRAF3	physical	22792062
USO1_HUMAN	USO1	physical	22792062
TRAF2_HUMAN	TRAF2	physical	22792062
AP2A1_HUMAN	AP2A1	physical	26496610
C4BPA_HUMAN	C4BPA	physical	26496610
PYR1_HUMAN	CAD	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
KC1A_HUMAN	CSNK1A1	physical	26496610
DCTN1_HUMAN	DCTN1	physical	26496610
DESP_HUMAN	DSP	physical	26496610
ERF_HUMAN	ERF	physical	26496610
GAK_HUMAN	GAK	physical	26496610
GOGA2_HUMAN	GOLGA2	physical	26496610
ROA1_HUMAN	HNRNPA1	physical	26496610
HNRH3_HUMAN	HNRNPH3	physical	26496610
HNRPK_HUMAN	HNRNPK	physical	26496610
IMDH1_HUMAN	IMPDH1	physical	26496610
IMDH2_HUMAN	IMPDH2	physical	26496610
K1C18_HUMAN	KRT18	physical	26496610
HNRPM_HUMAN	HNRNPM	physical	26496610
PFD2_HUMAN	PFDN2	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
PKP2_HUMAN	PKP2	physical	26496610
KAP2_HUMAN	PRKAR2A	physical	26496610
RBM4_HUMAN	RBM4	physical	26496610
ATX2_HUMAN	ATXN2	physical	26496610
SEC13_HUMAN	SEC13	physical	26496610
TRPS1_HUMAN	TRPS1	physical	26496610
VINC_HUMAN	VCL	physical	26496610
ZKSC1_HUMAN	ZKSCAN1	physical	26496610
CLH2_HUMAN	CLTCL1	physical	26496610
USO1_HUMAN	USO1	physical	26496610
TNK1_HUMAN	TNK1	physical	26496610
HDAC3_HUMAN	HDAC3	physical	26496610
FUBP3_HUMAN	FUBP3	physical	26496610
P4HA2_HUMAN	P4HA2	physical	26496610
MAP7_HUMAN	MAP7	physical	26496610
BAG3_HUMAN	BAG3	physical	26496610
RBM39_HUMAN	RBM39	physical	26496610
NCOR2_HUMAN	NCOR2	physical	26496610
SC24C_HUMAN	SEC24C	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
PUM1_HUMAN	PUM1	physical	26496610
SMG7_HUMAN	SMG7	physical	26496610
SC24B_HUMAN	SEC24B	physical	26496610
RBM14_HUMAN	RBM14	physical	26496610
SC23B_HUMAN	SEC23B	physical	26496610
SC23A_HUMAN	SEC23A	physical	26496610
SC24A_HUMAN	SEC24A	physical	26496610
IASPP_HUMAN	PPP1R13L	physical	26496610
PKP3_HUMAN	PKP3	physical	26496610
BTBD3_HUMAN	BTBD3	physical	26496610
SPART_HUMAN	SPG20	physical	26496610
F120A_HUMAN	FAM120A	physical	26496610
TRI29_HUMAN	TRIM29	physical	26496610
KANK2_HUMAN	KANK2	physical	26496610
AKP8L_HUMAN	AKAP8L	physical	26496610
GTSE1_HUMAN	GTSE1	physical	26496610
PKHA5_HUMAN	PLEKHA5	physical	26496610
ANKH1_HUMAN	ANKHD1	physical	26496610
F120C_HUMAN	FAM120C	physical	26496610
PIHD1_HUMAN	PIH1D1	physical	26496610
WDR33_HUMAN	WDR33	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
SKT_HUMAN	KIAA1217	physical	26496610
4ET_HUMAN	EIF4ENIF1	physical	26496610
CCAR2_HUMAN	CCAR2	physical	26496610
SAV1_HUMAN	SAV1	physical	26496610
P3H1_HUMAN	P3H1	physical	26496610
CPSF7_HUMAN	CPSF7	physical	26496610
FIP1_HUMAN	FIP1L1	physical	26496610
FA83D_HUMAN	FAM83D	physical	26496610
CHD6_HUMAN	CHD6	physical	26496610
PRC2B_HUMAN	PRRC2B	physical	26496610
FA83A_HUMAN	FAM83A	physical	26496610
WDR92_HUMAN	WDR92	physical	26496610
HNRL2_HUMAN	HNRNPUL2	physical	26496610
FA83B_HUMAN	FAM83B	physical	26496610
FA83H_HUMAN	FAM83H	physical	26496610
XPP3_HUMAN	XPNPEP3	physical	27173435
AIPL1_HUMAN	AIPL1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-444, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1786; SER-1844; SER-1864AND SER-1905, AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390; SER-1786 ANDSER-1905, AND MASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391; THR-397; SER-891;SER-1786 AND SER-1905, AND MASS SPECTROMETRY.
PubMed: 19413330

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1149, AND MASSSPECTROMETRY.
PubMed: 18318008

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-391; SER-411;SER-414; THR-415; SER-417; SER-891; SER-1786; SER-1844; THR-1876 ANDSER-1905, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-391; SER-1786;SER-1844; THR-1876 AND SER-1905, PHOSPHORYLATION [LARGE SCALEANALYSIS] AT SER-410 (ISOFORM 5), AND MASS SPECTROMETRY.
PubMed: 18691976

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1905, AND MASSSPECTROMETRY.
PubMed: 18187866

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2107, AND MASSSPECTROMETRY.
PubMed: 17525332

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136 AND SER-1786, ANDMASS SPECTROMETRY.
PubMed: 17924679

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1786; SER-1844; THR-1876AND SER-1905, AND MASS SPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-1149; SER-1169;SER-1190; SER-1191; SER-1786; SER-1903 AND SER-1905, AND MASSSPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-415; SER-417 ANDSER-1905, AND MASS SPECTROMETRY.
PubMed: 15302935