| UniProt ID | XPP3_HUMAN | |
|---|---|---|
| UniProt AC | Q9NQH7 | |
| Protein Name | Xaa-Pro aminopeptidase 3 {ECO:0000312|HGNC:HGNC:28052} | |
| Gene Name | XPNPEP3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 507 | |
| Subcellular Localization |
Isoform 1: Mitochondrion . Cytoplasm . Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation. Isoform 2: Cytoplasm . |
|
| Protein Description | Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. [PubMed: 25609706] | |
| Protein Sequence | MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MPWLLSAPKLVPA --CCCCCCCCCHHHH | 40.11 | - | |
| 27 | Phosphorylation | LSGCMLCSQRRYSLQ CCCCEECCCCCCCCC | 23.82 | 24719451 | |
| 31 | Phosphorylation | MLCSQRRYSLQPVPE EECCCCCCCCCCCCC | 18.87 | 30576142 | |
| 32 | Phosphorylation | LCSQRRYSLQPVPER ECCCCCCCCCCCCCC | 20.79 | 30243723 | |
| 64 | Phosphorylation | LLRPGEVTPGLSQVE CCCCCCCCCCHHHHH | 13.82 | - | |
| 78 | Acetylation | EYALRRHKLMSLIQK HHHHHHHHHHHHHHH | 44.04 | 25038526 | |
| 168 | Phosphorylation | ELWDGPRSGTDGAIA CCCCCCCCCCCCEEE | 49.53 | - | |
| 177 | Phosphorylation | TDGAIALTGVDEAYT CCCEEEECCCCCCCC | 26.57 | - | |
| 199 | Phosphorylation | LPKMKAETNMVWYDW HHHCHHHCCCEEEEC | 33.21 | 22210691 | |
| 238 (in isoform 2) | Ubiquitination | - | 37.82 | 21906983 | |
| 244 (in isoform 2) | Ubiquitination | - | 36.23 | 21906983 | |
| 247 | Ubiquitination | IQRLRLIKSPAEIER HHHHHHCCCHHHHHH | 55.78 | - | |
| 248 | Phosphorylation | QRLRLIKSPAEIERM HHHHHCCCHHHHHHH | 23.50 | 22496350 | |
| 269 (in isoform 3) | Phosphorylation | - | 16.87 | 25159151 | |
| 283 | Phosphorylation | PVEEAFLYAKFEFEC CHHHHHHHHEEEEEE | 10.99 | 28152594 | |
| 317 (in isoform 1) | Ubiquitination | - | 42.91 | 21906983 | |
| 317 | Ubiquitination | SNTLHYVKNNQLIKD CCCEEEEECCEEECC | 42.91 | 21906983 | |
| 323 | Ubiquitination | VKNNQLIKDGEMVLL EECCEEECCCCEEEE | 69.17 | 2190698 | |
| 323 (in isoform 1) | Ubiquitination | - | 69.17 | 21906983 | |
| 354 | Phosphorylation | WPVNGRFTAPQAELY EEECCEEECCHHHHH | 35.75 | 20068231 | |
| 406 | Ubiquitination | LGIMKNIKENNAFKA CCCCCCCCCCCHHHH | 64.88 | - | |
| 412 | Acetylation | IKENNAFKAARKYCP CCCCCHHHHHHHHCC | 38.43 | 25953088 | |
| 412 | Succinylation | IKENNAFKAARKYCP CCCCCHHHHHHHHCC | 38.43 | 27452117 | |
| 449 | Phosphorylation | LQPGMVITIEPGIYI CCCCCEEEECCCEEC | 14.10 | 27251275 | |
| 455 | Phosphorylation | ITIEPGIYIPEDDKD EEECCCEECCCCCCC | 19.15 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of XPP3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of XPP3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of XPP3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| XPP3_HUMAN | XPNPEP3 | physical | 27499296 | |
| RT63_HUMAN | MRPL57 | physical | 27499296 | |
| NT5D2_HUMAN | NT5DC2 | physical | 27499296 | |
| PDIP2_HUMAN | POLDIP2 | physical | 27499296 | |
| ECH1_HUMAN | ECH1 | physical | 27499296 | |
| CHCH2_HUMAN | CHCHD2 | physical | 27499296 | |
| C1QBP_HUMAN | C1QBP | physical | 27499296 | |
| RM53_HUMAN | MRPL53 | physical | 27499296 | |
| IDE_HUMAN | IDE | physical | 27499296 | |
| VIME_HUMAN | VIM | physical | 27173435 | |
| ZY11B_HUMAN | ZYG11B | physical | 27173435 | |
| BGAL_HUMAN | GLB1 | physical | 27173435 | |
| CH037_HUMAN | C8orf37 | physical | 27173435 | |
| DAAF1_HUMAN | DNAAF1 | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| 613159 | Nephronophthisis-like nephropathy 1 (NPHPL1) | |||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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