DAAF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAAF1_HUMAN
• UniProt AC: Q8NEP3
• Protein Name: Dynein assembly factor 1, axonemal
• Gene Name: DNAAF1
• Organism: Homo sapiens (Human).
• Sequence Length: 725
• Subcellular Localization: Cell projection, cilium . Cytoplasm . Cytoplasm, cytoskeleton, spindle pole . In HEK293T cells, it is diffusely cytoplasmic and concentrates at the mitotic spindle poles, while in MDCK cells, it localizes in the cilium. In vivo, this protein is proba
• Protein Description: Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli..
• Protein Sequence: MHPEPSEPATGGAAELDCAQEPGVEESAGDHGSAGRGGCKEEINDPKEICVGSSDTSYHSQQKQSGDNGSGGHFAHPREDREDRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRTEDLETIRLETKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSDPELDYTSLPVLENLPTDTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQDTKSPRPLIQELSDEDPSGQLLMPPTCQRDAAPLTSSGDRDSDFLAASSPVPTESAATPPETCVGVAQPSQALPTWDLTAFPAPKAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100 (in isoform 2)	Phosphorylation	-	13.95	22210691
103	Phosphorylation	LCKQHKLYITPALND HHHHCCEEEECCCCC	13.93	18491316
105	Phosphorylation	KQHKLYITPALNDTL HHCCEEEECCCCCCE	6.75	18491316
267	Phosphorylation	QIPNYRRTVTVRLKH CCCCCCCEEEEEEEE	16.13	23927012
269	Phosphorylation	PNYRRTVTVRLKHLT CCCCCEEEEEEEECE	10.17	27966365
318	Phosphorylation	SRERKKITDSIEALA HHHHHHHHHHHHHHH	32.35	-
320	Phosphorylation	ERKKITDSIEALAMI HHHHHHHHHHHHHHH	17.43	-
358	Phosphorylation	DGENVPASAEGKEEP CCCCCCCCCCCCCCC	22.30	-
559	Phosphorylation	DLEDDDETGKSLEDQ CCCCCCCCCCCHHHH	57.83	-
562	Phosphorylation	DDDETGKSLEDQNMC CCCCCCCCHHHHCCC	38.03	-
583	Phosphorylation	ISSLSDDSDPELDYT ECCCCCCCCCCCCCC	61.12	-
642	Phosphorylation	IRKQDTKSPRPLIQE HHCCCCCCCCHHHHH	28.38	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DAAF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAAF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAAF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANKY2_HUMAN	ANKMY2	physical	27173435
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613193: Ciliary dyskinesia, primary, 13 (CILD13)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.