ZY11B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZY11B_HUMAN
• UniProt AC: Q9C0D3
• Protein Name: Protein zyg-11 homolog B
• Gene Name: ZYG11B
• Organism: Homo sapiens (Human).
• Sequence Length: 744
• Protein Description: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC..
• Protein Sequence: MPEDQAGAAMEEASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESLDISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTDKAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMRNHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILDSLEKHIVRHGRPPPCKKQPQARLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Phosphorylation	VNADITITDIISGLG CCCCEEHHHHHHCCC	16.70	-
126	Phosphorylation	ITITDIISGLGSNKW EEHHHHHHCCCCCHH	28.44	-
130	Phosphorylation	DIISGLGSNKWIQQN HHHHCCCCCHHHHHH	40.03	-
162	Phosphorylation	ERCFSRLSGLRALSI HHHHHHHHCCHHHHH	34.37	24719451
184	Phosphorylation	EDLAEVASLPRLESL CCHHHHHCCCCCCCC	44.04	24719451
213	Phosphorylation	ACKDRLKSLTMHHLK HCHHHHHHCHHHHHH	33.39	22210691
215	Phosphorylation	KDRLKSLTMHHLKCL HHHHHHCHHHHHHHH	22.88	28787133
220	Ubiquitination	SLTMHHLKCLKMTTT HCHHHHHHHHHHHHH	32.91	-
225	Phosphorylation	HLKCLKMTTTQILDV HHHHHHHHHHHHHHH	25.71	22210691
226	Phosphorylation	LKCLKMTTTQILDVV HHHHHHHHHHHHHHH	17.13	22210691
227	Phosphorylation	KCLKMTTTQILDVVR HHHHHHHHHHHHHHH	12.40	22210691
237	Ubiquitination	LDVVRELKHLNHLDI HHHHHHHHHCCCCCC	41.09	-
248	Ubiquitination	HLDISDDKQFTSDIA CCCCCCCCCHHHHHH	52.91	-
252	Phosphorylation	SDDKQFTSDIALRLL CCCCCHHHHHHHHHH	28.45	24247654
262	Ubiquitination	ALRLLEQKDILPNLV HHHHHHHCCCCCCCE	37.04	21906983
262 (in isoform 1)	Ubiquitination	-	37.04	21906983
262 (in isoform 2)	Ubiquitination	-	37.04	21906983
274	Phosphorylation	NLVSLDVSGRKHVTD CCEEECCCCCCCCCH	32.33	27732954
282	Ubiquitination	GRKHVTDKAVEAFIQ CCCCCCHHHHHHHHH	44.99	-
332	Ubiquitination	TQIAEALKRYSERAF HHHHHHHHHHHHHHH	57.23	2190698
332 (in isoform 1)	Ubiquitination	-	57.23	21906983
332 (in isoform 2)	Ubiquitination	-	57.23	21906983
550	Phosphorylation	LFMRVLESFPTESSI HHHHHHHHCCCCHHH	32.15	25907765
553	Phosphorylation	RVLESFPTESSIQQK HHHHHCCCCHHHHHH	46.63	25907765
555	Phosphorylation	LESFPTESSIQQKVL HHHCCCCHHHHHHHH	34.91	25907765
556	Phosphorylation	ESFPTESSIQQKVLG HHCCCCHHHHHHHHH	20.41	25907765
622	Phosphorylation	QAWTLSRSQRNSLLD HHHHCCHHHHCHHHH	30.07	-
687	Phosphorylation	KNPSRYCSMLIEEGG CCHHHHHHHHECCCC	14.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZY11B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZY11B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZY11B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL2_HUMAN	CUL2	physical	17304241

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.