CHCH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHCH2_HUMAN
• UniProt AC: Q9Y6H1
• Protein Name: Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
• Gene Name: CHCHD2
• Organism: Homo sapiens (Human).
• Sequence Length: 151
• Subcellular Localization: Nucleus . Mitochondrion . Mitochondrion intermembrane space . Mainly localised in the intermembrane space.
• Protein Description: Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). [PubMed: 23303788]
• Protein Sequence: MPRGSRSRTSRMAPPASRAPQMRAAPRPAPVAQPPAAAPPSAVGSSAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGSNAEPARPDITYQEPQGTQPAQQQQPCLYEIKQFLECAQNQGDIKLCEGFNEVLKQCRLANGLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MPRGSRSRTSRM ---CCCCCCCCCCCC	28.50	21406692
7	Phosphorylation	-MPRGSRSRTSRMAP -CCCCCCCCCCCCCC	41.42	21406692
9	Phosphorylation	PRGSRSRTSRMAPPA CCCCCCCCCCCCCCH	23.18	21406692
10	Phosphorylation	RGSRSRTSRMAPPAS CCCCCCCCCCCCCHH	20.96	21406692
27	Methylation	PQMRAAPRPAPVAQP CCCCCCCCCCCCCCC	34.97	-
41	Phosphorylation	PPAAAPPSAVGSSAA CCCCCCCCCCCCCCC	34.23	30108239
45	Phosphorylation	APPSAVGSSAAAPRQ CCCCCCCCCCCCCCC	15.37	30108239
46	Phosphorylation	PPSAVGSSAAAPRQP CCCCCCCCCCCCCCC	18.92	30108239
99	Phosphorylation	PARPDITYQEPQGTQ CCCCCCCCCCCCCCC	15.94	-
132	Ubiquitination	AQNQGDIKLCEGFNE HHHHCCHHCCHHHHH	52.39	32015554
142	Ubiquitination	EGFNEVLKQCRLANG HHHHHHHHHHHHHHC	53.15	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
99	Y	Phosphorylation	Kinase	BCR-ABL1	A9UF07	PSP
99	Y	Phosphorylation	Kinase	ABL1	P00519	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHCH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHCH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL24_HUMAN	RPL24	physical	22939629
DSG2_HUMAN	DSG2	physical	22939629
MRP2_HUMAN	ABCC2	physical	22939629
COX5B_HUMAN	COX5B	physical	22939629
ATL4_HUMAN	ADAMTSL4	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
LHX4_HUMAN	LHX4	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
INCA1_HUMAN	INCA1	physical	25416956
IPYR2_HUMAN	PPA2	physical	26344197
CHC10_HUMAN	CHCHD10	physical	27499296
CLPX_HUMAN	CLPX	physical	27499296
NRDC_HUMAN	NRD1	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
RNH1_HUMAN	RNASEH1	physical	27499296
IDE_HUMAN	IDE	physical	27499296
MRRP1_HUMAN	TRMT10C	physical	27499296
GRSF1_HUMAN	GRSF1	physical	27499296
PDE12_HUMAN	PDE12	physical	27499296
THG1_HUMAN	THG1L	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
TIM44_HUMAN	TIMM44	physical	27499296
SYFM_HUMAN	FARS2	physical	27499296
PREP_HUMAN	PITRM1	physical	27499296
ATP5H_HUMAN	ATP5H	physical	27499296
PTH2_HUMAN	PTRH2	physical	27499296
COX6C_HUMAN	COX6C	physical	27499296
AFG32_HUMAN	AFG3L2	physical	27499296
CX6A1_HUMAN	COX6A1	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
GLRX5_HUMAN	GLRX5	physical	27499296
GHITM_HUMAN	GHITM	physical	27499296
TIM50_HUMAN	TIMM50	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
UQCC2_HUMAN	UQCC2	physical	27499296
TRM1_HUMAN	TRMT1	physical	27499296
AT5F1_HUMAN	ATP5F1	physical	27499296
RPOM_HUMAN	POLRMT	physical	27499296
USMG5_HUMAN	USMG5	physical	27499296
YBEY_HUMAN	YBEY	physical	27499296
SYNM_HUMAN	NARS2	physical	27499296
T126A_HUMAN	TMEM126A	physical	27499296
NIPS1_HUMAN	NIPSNAP1	physical	27499296
FKB10_HUMAN	FKBP10	physical	27499296
ATP5J_HUMAN	ATP5J	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
COX5A_HUMAN	COX5A	physical	27499296
SYSM_HUMAN	SARS2	physical	27499296
THOC4_HUMAN	ALYREF	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.