COX5A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COX5A_HUMAN
• UniProt AC: P20674
• Protein Name: Cytochrome c oxidase subunit 5A, mitochondrial
• Gene Name: COX5A
• Organism: Homo sapiens (Human).
• Sequence Length: 150
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport..
• Protein Sequence: MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	VRCYSHGSQETDEEF EEEECCCCCCCCHHH	21.30	28787133
48	Phosphorylation	YSHGSQETDEEFDAR ECCCCCCCCHHHCHH	40.86	28787133
62	Acetylation	RWVTYFNKPDIDAWE HHHHCCCCCCCCHHH	33.88	23954790
62	Ubiquitination	RWVTYFNKPDIDAWE HHHHCCCCCCCCHHH	33.88	21890473
76	Phosphorylation	ELRKGINTLVTYDMV HHHCCCCEEEECCCC	22.23	20068231
79	Phosphorylation	KGINTLVTYDMVPEP CCCCEEEECCCCCCH	19.54	20068231
80	Phosphorylation	GINTLVTYDMVPEPK CCCEEEECCCCCCHH	8.44	20068231
87	Acetylation	YDMVPEPKIIDAALR CCCCCCHHHHHHHHH	51.11	26051181
105	Phosphorylation	RLNDFASTVRILEVV HHHHHHHHHHHHHHH	15.46	24532841
113	Acetylation	VRILEVVKDKAGPHK HHHHHHHHCCCCCCC	59.70	26051181
113	2-Hydroxyisobutyrylation	VRILEVVKDKAGPHK HHHHHHHHCCCCCCC	59.70	-
115	2-Hydroxyisobutyrylation	ILEVVKDKAGPHKEI HHHHHHCCCCCCCCH	49.91	-
140	Phosphorylation	TLNELGISTPEELGL HHHHHCCCCHHHHCC	35.79	27762562
141	Phosphorylation	LNELGISTPEELGLD HHHHCCCCHHHHCCC	32.57	28247525
149	Acetylation	PEELGLDKV------ HHHHCCCCC------	55.69	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COX5A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COX5A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COX5A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN6_HUMAN	COPS6	physical	16169070
COX5B_HUMAN	COX5B	physical	22939629
QCR7_HUMAN	UQCRB	physical	22939629
ROA0_HUMAN	HNRNPA0	physical	22939629
RT29_HUMAN	DAP3	physical	22939629
S38A2_HUMAN	SLC38A2	physical	22939629
RAB8A_HUMAN	RAB8A	physical	22939629
EXOS8_HUMAN	EXOSC8	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
CY1_HUMAN	CYC1	physical	26344197
COX41_HUMAN	COX4I1	physical	28514442
COX7R_HUMAN	COX7A2L	physical	28514442
ZNT9_HUMAN	SLC30A9	physical	28514442
COX1_HUMAN	COX1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB02659: Cholic Acid