COX7R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COX7R_HUMAN
• UniProt AC: O14548
• Protein Name: Cytochrome c oxidase subunit 7A-related protein, mitochondrial
• Gene Name: COX7A2L
• Organism: Homo sapiens (Human).
• Sequence Length: 114
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity)..
• Protein Sequence: MYYKFSGFTQKLAGAWASEAYSPQGLKPVVSTEAPPIIFATPTKLTSDSTVYDYAGKNKVPELQKFFQKADGVPVYLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASQPKNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MYYKFSGFTQK ----CCCCCCCHHHH	18.63	25825284
11	Ubiquitination	KFSGFTQKLAGAWAS CCCCHHHHHHHHHHC	36.93	21890473
27	Ubiquitination	AYSPQGLKPVVSTEA CCCCCCCCCCCCCCC	42.46	-
46	Phosphorylation	FATPTKLTSDSTVYD EECCCCCCCCCCCCC	31.85	28111955
47	Phosphorylation	ATPTKLTSDSTVYDY ECCCCCCCCCCCCCC	39.75	28111955
49	Phosphorylation	PTKLTSDSTVYDYAG CCCCCCCCCCCCCCC	21.38	28152594
50	Phosphorylation	TKLTSDSTVYDYAGK CCCCCCCCCCCCCCC	28.24	28152594
52	Phosphorylation	LTSDSTVYDYAGKNK CCCCCCCCCCCCCCC	11.88	25884760
54	Phosphorylation	SDSTVYDYAGKNKVP CCCCCCCCCCCCCCH	10.28	28152594
57	Ubiquitination	TVYDYAGKNKVPELQ CCCCCCCCCCCHHHH	45.48	-
65	Acetylation	NKVPELQKFFQKADG CCCHHHHHHHHHCCC	61.85	25038526
69	Ubiquitination	ELQKFFQKADGVPVY HHHHHHHHCCCCEEE	43.20	19608861
69	Acetylation	ELQKFFQKADGVPVY HHHHHHHHCCCCEEE	43.20	19608861
69	Malonylation	ELQKFFQKADGVPVY HHHHHHHHCCCCEEE	43.20	32601280
69	Succinylation	ELQKFFQKADGVPVY HHHHHHHHCCCCEEE	43.20	23954790
78	Ubiquitination	DGVPVYLKRGLPDQM CCCEEEECCCCCHHH	27.08	-
78	2-Hydroxyisobutyrylation	DGVPVYLKRGLPDQM CCCEEEECCCCCHHH	27.08	-
87	Phosphorylation	GLPDQMLYRTTMALT CCCHHHHHHHHHHHH	10.69	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COX7R_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COX7R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COX7R_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U2AF2_HUMAN	U2AF2	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-69, AND MASS SPECTROMETRY.
PubMed: 19608861