CY1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CY1_HUMAN
• UniProt AC: P08574
• Protein Name: Cytochrome c1, heme protein, mitochondrial
• Gene Name: CYC1
• Organism: Homo sapiens (Human).
• Sequence Length: 325
• Subcellular Localization: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.
• Protein Description: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain..
• Protein Sequence: MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAAAAASLRGVVLG -CCHHHHHCCCEEEC	17.55	29457462
41	Phosphorylation	PGQLPLRTPQAVALS CCCCCCCCCCHHHHH	27.69	17929957
50	Ubiquitination	QAVALSSKSGLSRGR CHHHHHCCCCCCHHH	45.21	21906983
62	Phosphorylation	RGRKVMLSALGMLAA HHHHHHHHHHHHHHH	11.89	24043423
80	Phosphorylation	GLAMALHSAVSASDL HHHHHHHHHCCHHHH	31.08	24043423
83	Phosphorylation	MALHSAVSASDLELH HHHHHHCCHHHHCCC	23.05	24043423
85	Phosphorylation	LHSAVSASDLELHPP HHHHCCHHHHCCCCC	34.91	24043423
93	Phosphorylation	DLELHPPSYPWSHRG HHCCCCCCCCCCCCC	48.56	24043423
94	Phosphorylation	LELHPPSYPWSHRGL HCCCCCCCCCCCCCH	17.94	24043423
97	Phosphorylation	HPPSYPWSHRGLLSS CCCCCCCCCCCHHHH	9.98	24043423
103	Phosphorylation	WSHRGLLSSLDHTSI CCCCCHHHHCCCHHH	33.62	20068231
104	Phosphorylation	SHRGLLSSLDHTSIR CCCCHHHHCCCHHHH	37.47	20068231
108	Phosphorylation	LLSSLDHTSIRRGFQ HHHHCCCHHHHHHHH	26.05	29449344
109	Phosphorylation	LSSLDHTSIRRGFQV HHHCCCHHHHHHHHH	15.63	23312004
111	Ubiquitination	SLDHTSIRRGFQVYK HCCCHHHHHHHHHHH	32.22	21890473
112	Methylation	LDHTSIRRGFQVYKQ CCCHHHHHHHHHHHH	48.92	-
118	Ubiquitination	RRGFQVYKQVCASCH HHHHHHHHHHHHHCC	37.08	27667366
132	Nitration	HSMDFVAYRHLVGVC CCCCHHHHHHHHEEE	8.02	-
170	2-Hydroxyisobutyrylation	EMFMRPGKLFDYFPK CEEECCCCCCCCCCC	48.98	-
170	Ubiquitination	EMFMRPGKLFDYFPK CEEECCCCCCCCCCC	48.98	21906983
174	Phosphorylation	RPGKLFDYFPKPYPN CCCCCCCCCCCCCCC	17.91	28152594
177	Acetylation	KLFDYFPKPYPNSEA CCCCCCCCCCCCHHH	47.48	26051181
177	Ubiquitination	KLFDYFPKPYPNSEA CCCCCCCCCCCCHHH	47.48	21906983
179	Phosphorylation	FDYFPKPYPNSEAAR CCCCCCCCCCHHHHH	22.60	28152594
182	Phosphorylation	FPKPYPNSEAARAAN CCCCCCCHHHHHHHH	24.90	28348404
199	Phosphorylation	ALPPDLSYIVRARHG CCCCCHHHHHHHCCC	15.67	-
223	Phosphorylation	TGYCEPPTGVSLREG ECCCCCCCCCCCCCC	62.01	28348404
226	Phosphorylation	CEPPTGVSLREGLYF CCCCCCCCCCCCCCC	24.05	28348404
278	Phosphorylation	CTFLRWASEPEHDHR HHHHHHHCCCCCHHH	46.88	-
304	Phosphorylation	ALLVPLVYTIKRHKW HHHHHHHHHHHHHCH	15.49	21406692
305	Phosphorylation	LLVPLVYTIKRHKWS HHHHHHHHHHHHCHH	16.73	21406692
307	Acetylation	VPLVYTIKRHKWSVL HHHHHHHHHHCHHHH	40.42	12433371
310	2-Hydroxyisobutyrylation	VYTIKRHKWSVLKSR HHHHHHHCHHHHHHC	45.24	-
310	Acetylation	VYTIKRHKWSVLKSR HHHHHHHCHHHHHHC	45.24	25825284
315	Acetylation	RHKWSVLKSRKLAYR HHCHHHHHHCCCCCC	46.16	26051181
315	Ubiquitination	RHKWSVLKSRKLAYR HHCHHHHHHCCCCCC	46.16	27667366
318	Ubiquitination	WSVLKSRKLAYRPPK HHHHHHCCCCCCCCC	44.56	29967540
321	Phosphorylation	LKSRKLAYRPPK--- HHHCCCCCCCCC---	33.80	28152594
325	Acetylation	KLAYRPPK------- CCCCCCCC-------	75.54	2380211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CY1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CY1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CY1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUS4_HUMAN	NDUFS4	physical	22939629
NDUS8_HUMAN	NDUFS8	physical	22939629
NDUAC_HUMAN	NDUFA12	physical	22939629
NDUBA_HUMAN	NDUFB10	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
PYRD_HUMAN	DHODH	physical	22939629
RM04_HUMAN	MRPL4	physical	22939629
NDUF3_HUMAN	NDUFAF3	physical	22939629
SAM50_HUMAN	SAMM50	physical	22939629
SSBP_HUMAN	SSBP1	physical	22939629
RUSD4_HUMAN	RPUSD4	physical	22939629
RM15_HUMAN	MRPL15	physical	22939629
ICT1_HUMAN	ICT1	physical	22939629
TAP1_HUMAN	TAP1	physical	22939629
QCR9_HUMAN	UQCR10	physical	26186194
QCR7_HUMAN	UQCRB	physical	26186194
AFG32_HUMAN	AFG3L2	physical	26344197
ATD3A_HUMAN	ATAD3A	physical	26344197
ATD3B_HUMAN	ATAD3B	physical	26344197
ATP5I_HUMAN	ATP5I	physical	26344197
ATPO_HUMAN	ATP5O	physical	26344197
CLH1_HUMAN	CLTC	physical	26344197
DHB12_HUMAN	HSD17B12	physical	26344197
RM37_HUMAN	MRPL37	physical	26344197
CYB_HUMAN	CYTB	physical	26344197
MYH7B_HUMAN	MYH7B	physical	26344197
NDUBA_HUMAN	NDUFB10	physical	26344197
NDUS3_HUMAN	NDUFS3	physical	26344197
NDUS4_HUMAN	NDUFS4	physical	26344197
PHB_HUMAN	PHB	physical	26344197
PHB2_HUMAN	PHB2	physical	26344197
2AAA_HUMAN	PPP2R1A	physical	26344197
SGPL1_HUMAN	SGPL1	physical	26344197
MPCP_HUMAN	SLC25A3	physical	26344197
QCR7_HUMAN	UQCRB	physical	26344197
VDAC1_HUMAN	VDAC1	physical	26344197
VDAC2_HUMAN	VDAC2	physical	26344197
VDAC3_HUMAN	VDAC3	physical	26344197
QCR7_HUMAN	UQCRB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615453: Mitochondrial complex III deficiency, nuclear 6 (MC3DN6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.