PYRD_HUMAN - dbPTM
PYRD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PYRD_HUMAN
UniProt AC Q02127
Protein Name Dihydroorotate dehydrogenase (quinone), mitochondrial
Gene Name DHODH
Organism Homo sapiens (Human).
Sequence Length 395
Subcellular Localization Mitochondrion inner membrane
Single-pass membrane protein .
Protein Description Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor..
Protein Sequence MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationGGGLLFASYLMATGD
CCHHHHHHHHHHHCC		16.0922210691
27PhosphorylationGGLLFASYLMATGDE
CHHHHHHHHHHHCCH		9.3222210691
40UbiquitinationDERFYAEHLMPTLQG
CHHHHHHHHHHHHHH		21.1822817900
42UbiquitinationRFYAEHLMPTLQGLL
HHHHHHHHHHHHHHC		2.2822817900
62PhosphorylationHRLAVRFTSLGLLPR
HHHHHHHHHCCCCCC		16.69-
63PhosphorylationRLAVRFTSLGLLPRA
HHHHHHHHCCCCCCC		20.09-
74UbiquitinationLPRARFQDSDMLEVR
CCCCCCCCCCCEEEE		43.8422817900
76UbiquitinationRARFQDSDMLEVRVL
CCCCCCCCCEEEEHH		54.7122817900
86UbiquitinationEVRVLGHKFRNPVGI
EEEHHCCCCCCCCCE		44.19-
99AcetylationGIAAGFDKHGEAVDG
CEECCCCCCCCCHHH		51.7727452117
99UbiquitinationGIAAGFDKHGEAVDG
CEECCCCCCCCCHHH		51.7729967540
992-HydroxyisobutyrylationGIAAGFDKHGEAVDG
CEECCCCCCCCCHHH		51.77-
119PhosphorylationFGFVEIGSVTPKPQE
CCEEEEEEECCCCCC		28.6024719451
121PhosphorylationFVEIGSVTPKPQEGN
EEEEEEECCCCCCCC		27.5620058876
146PhosphorylationDQAVINRYGFNSHGL
CHHHHHHHCCCHHCH		22.91-
155UbiquitinationFNSHGLSVVEHRLRA
CCHHCHHHHHHHHHH		7.6222817900
157UbiquitinationSHGLSVVEHRLRARQ
HHCHHHHHHHHHHHH		22.5722817900
163UbiquitinationVEHRLRARQQKQAKL
HHHHHHHHHHHHHHC		32.7822817900
169UbiquitinationARQQKQAKLTEDGLP
HHHHHHHHCCCCCCC		54.1429967540
171PhosphorylationQQKQAKLTEDGLPLG
HHHHHHCCCCCCCCC		31.1829083192
183UbiquitinationPLGVNLGKNKTSVDA
CCCCCCCCCCCCCHH		59.4422817900
185UbiquitinationGVNLGKNKTSVDAAE
CCCCCCCCCCCHHHH		45.7421906983
194PhosphorylationSVDAAEDYAEGVRVL
CCHHHHHHHHHCEEH		9.69-
197UbiquitinationAAEDYAEGVRVLGPL
HHHHHHHHCEEHHHC		12.3622817900
201UbiquitinationYAEGVRVLGPLADYL
HHHHCEEHHHCCCEE		4.0222817900
214PhosphorylationYLVVNVSSPNTAGLR
EEEEECCCCCCCCHH		20.20-
217PhosphorylationVNVSSPNTAGLRSLQ
EECCCCCCCCHHHHC		26.0324275569
226UbiquitinationGLRSLQGKAELRRLL
CHHHHCCHHHHHHHH		26.2329967540
235UbiquitinationELRRLLTKVLQERDG
HHHHHHHHHHHHCCC		40.7022817900
254UbiquitinationHRPAVLVKIAPDLTS
CCCEEEEEECCCCCC		29.0529967540
264UbiquitinationPDLTSQDKEDIASVV
CCCCCCCHHHHHHHH		50.0429967540
278UbiquitinationVKELGIDGLIVTNTT
HHHHCCCEEEEECCC		18.5122817900
306UbiquitinationETGGLSGKPLRDLST
CCCCCCCCCCHHCCH		37.1921906983
316UbiquitinationRDLSTQTIREMYALT
HHCCHHHHHHHHHHH		2.2322817900
344UbiquitinationSGQDALEKIRAGASL
CCHHHHHHHHHCCHH		38.0422817900
355PhosphorylationGASLVQLYTALTFWG
CCHHHHHHHHHHHHC		3.48-
356PhosphorylationASLVQLYTALTFWGP
CHHHHHHHHHHHHCC		24.63-
359PhosphorylationVQLYTALTFWGPPVV
HHHHHHHHHHCCCCH		18.19-
378UbiquitinationRELEALLKEQGFGGV
HHHHHHHHHCCCCCH		49.1729967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PYRD_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PYRD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PYRD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSBP_HUMANSSBP1physical
22939629
MT2_HUMANMT2Aphysical
21988832
TMEDA_HUMANTMED10physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
263750Postaxial acrofacial dysostosis (POADS)
Kegg Drug
D00749 Leflunomide (JAN/USAN/INN); Arava (TN)
D03154 Brequinar sodium (USAN)
D10172 Teriflunomide (USAN); Aubagio (TN)
DrugBank
DB01117Atovaquone
DB01097Leflunomide
DB08880Teriflunomide
Regulatory Network of PYRD_HUMAN

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Related Literatures of Post-Translational Modification

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