MT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MT2_HUMAN
• UniProt AC: P02795
• Protein Name: Metallothionein-2
• Gene Name: MT2A
• Organism: Homo sapiens (Human).
• Sequence Length: 61
• Protein Description: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids..
• Protein Sequence: MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Sulfoxidation	-------MDPNCSCA -------CCCCCCCC	20.42	28465586
1	Acetylation	-------MDPNCSCA -------CCCCCCCC	20.42	19413330
6	Phosphorylation	--MDPNCSCAAGDSC --CCCCCCCCCCCCC	17.27	23927012
12	Phosphorylation	CSCAAGDSCTCAGSC CCCCCCCCCCCCCCC	15.48	23927012
14	Phosphorylation	CAAGDSCTCAGSCKC CCCCCCCCCCCCCCC	14.89	23927012
18	Phosphorylation	DSCTCAGSCKCKECK CCCCCCCCCCCCCCC	7.59	30576142
20	Acetylation	CTCAGSCKCKECKCT CCCCCCCCCCCCCCC	50.46	25953088
20	Ubiquitination	CTCAGSCKCKECKCT CCCCCCCCCCCCCCC	50.46	23503661
22	Ubiquitination	CAGSCKCKECKCTSC CCCCCCCCCCCCCCC	52.20	23503661
22	Acetylation	CAGSCKCKECKCTSC CCCCCCCCCCCCCCC	52.20	18528997
25	Ubiquitination	SCKCKECKCTSCKKS CCCCCCCCCCCCCCC	41.46	27667366
30	Ubiquitination	ECKCTSCKKSCCSCC CCCCCCCCCCCCCCC	47.70	23503661
31	Ubiquitination	CKCTSCKKSCCSCCP CCCCCCCCCCCCCCC	53.72	23503661
32	Phosphorylation	KCTSCKKSCCSCCPV CCCCCCCCCCCCCCC	13.07	22777824
35	Phosphorylation	SCKKSCCSCCPVGCA CCCCCCCCCCCCCCC	24.07	28258704
43	Ubiquitination	CCPVGCAKCAQGCIC CCCCCCCHHHCCCEE	33.89	29901268
43	Acetylation	CCPVGCAKCAQGCIC CCCCCCCHHHCCCEE	33.89	25953088
43	Neddylation	CCPVGCAKCAQGCIC CCCCCCCHHHCCCEE	33.89	32015554
51	Acetylation	CAQGCICKGASDKCS HHCCCEECCCCCCCC	37.28	16916647
51	Ubiquitination	CAQGCICKGASDKCS HHCCCEECCCCCCCC	37.28	23000965
54	Phosphorylation	GCICKGASDKCSCCA CCEECCCCCCCCCCC	46.39	23312004
56	Acetylation	ICKGASDKCSCCA-- EECCCCCCCCCCC--	26.08	26210075
56	Ubiquitination	ICKGASDKCSCCA-- EECCCCCCCCCCC--	26.08	23000965
58	Phosphorylation	KGASDKCSCCA---- CCCCCCCCCCC----	20.26	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPCD1_HUMAN	PRKD1	physical	14550308
ZN363_HUMAN	RCHY1	physical	21988832
JHD2C_HUMAN	JMJD1C	physical	23455924
ARF6_HUMAN	ARF6	physical	15923660

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00958: Carboplatin
• DB00515: Cisplatin
• DB00526: Oxaliplatin

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330

"Primary structure of human hepatic metallothionein.";
Kissling M.M., Kaegi J.H.R.;
FEBS Lett. 82:247-250(1977).
Cited for: PRELIMINARY PROTEIN SEQUENCE.
PubMed: 913597

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-51, AND MASS SPECTROMETRY.
PubMed: 16916647