dbPTM

JHD2C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	JHD2C_HUMAN
UniProt AC	Q15652
Protein Name	Probable JmjC domain-containing histone demethylation protein 2C
Gene Name	JMJD1C
Organism	Homo sapiens (Human).
Sequence Length	2540
Subcellular Localization	Nucleus.
Protein Description	Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity)..
Protein Sequence	MAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAVYVEFDDLEWDKREWVKVYEDFSTFLVEYHLIWAKRNDPSQTQGSKSKQIQWPALTFKPLVERNIPSSVTAVEFLVDKQLDFLTEDSAFQPYQDDIDSLNPVLRDNPQLHEEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSDSSIPDEEKMKEEKYDYISRGENPKGKNKHLMNKRRKPEEDEKKLNMKRLRTDNVSDFSESSDSENSNKRIIDNSSEQKPENELKNKNTSKINGEEGKPHNNEKAGEETLKNSQPPWDQIQEDKKHEEAEKRKSVDTQLQEDMIIHSSEQSTVSDHNSNDLLPQECNMDKTHTMELLPKEKFVSRPPTPKCVIDITNDTNLEKVAQENSSTFGLQTLQKMDPNVSDSKHSIANAKFLETAKKDSDQSWVSDVVKVDLTQSSVTNASSGNDHLNMEKEKYVSYISPLSAVSVMEDKLHKRSPPPETIKSKLNTSVDTHKIKSSPSPEVVKPKITHSPDSVKSKATYVNSQATGERRLANKIEHELSRCSFHPIPTRSSTLETTKSPLIIDKNEHFTVYRDPALIGSETGANHISPFLSQHPFPLHSSSHRTCLNPGTHHPALTPAPHLLAGSSSQTPLPTINTHPLTSGPHHAVHHPHLLPTVLPGVPTASLLGGHPRLESAHASSLSHLALAHQQQQQLLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNSPSPWLHQPTPVTSADGIGLLSHIPVRPSSAEPHRPLKITAHSSPPLTKTLVDHHKEELERKAFMEPLRSVASTSAKNDLDLNRSQTGKDCHLHRHFVDPVLNQLQRPPQETGERLNKYKEEHRRILQESIDVAPFTTKIKGLEGERENYSRVASSSSSPKSHIIKQDMDVERSVSDLYKMKHSVPQSLPQSNYFTTLSNSVVNEPPRSYPSKEVSNIYGDKQSNALAAAAANPQTLTSFITSLSKPPPLIKHQPESEGLVGKIPEHLPHQIASHSVTTFRNDCRSPTHLTVSSTNTLRSMPALHRAPVFHPPIHHSLERKEGSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDSQANFKSSSEQSLTEMWRPNNNLSKEKTEWHVEKSSGKLQAAMASVIVRPSSSTKTDSMPAMQLASKDRVSERSSAGAHKTDCLKLAEAGETGRIILPNVNSDSVHTKSEKNFQAVSQGSVPSSVMSAVNTMCNTKTDVITSAADTTSVSSWGGSEVISSLSNTILASTSSECVSSKSVSQPVAQKQECKVSTTAPVTLASSKTGSVVQPSSGFSGTTDFIHLKKHKAALAAAQYKSSNASETEPNAIKNQTLSASLPLDSTVICSTINKANSVGNGQASQTSQPNYHTKLKKAWLTRHSEEDKNTNKMENSGNSVSEIIKPCSVNLIASTSSDIQNSVDSKIIVDKYVKDDKVNRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEIEEDLKPNGVLSRSAKERSKLKLQSNSNTGIPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEEPAHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENFEDDELDIETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHTLREKYGIKSHCHCTNKQNLQVGNFPTMNGVSQVLQNVLNHSNKISLCMPESQQQNTPPKSEKNGGSSPESDVGTDNKLTPPESQSPLHWLADLAEQKAREEKKENKELTLENQIKEEREQDNSESPNGRTSPLVSQNNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSMGAPSSKSGRTMPNILDDIIASVVENKIPPSKTSKINVKPELKEEPEESIISAVDENNKLYSDIPHSWICEKHILWLKDYKNSSNWKLFKECWKQGQPAVVSGVHKKMNISLWKAESISLDFGDHQADLLNCKDSIISNANVKEFWDGFEEVSKRQKNKSGETVVLKLKDWPSGEDFKTMMPARYEDLLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVVAAKDHDIGTTNLHIEVSDVVNILVYVGIAKGNGILSKAGILKKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVRTCTLIQFLGDAIVLPAGALHQVQNFHSCIQVTEDFVSPEHLVESFHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKIHEDEVEDMEEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	AGVIRAVSHRDSRNP HHHEEHHCCCCCCCC	16.30	24719451
101	Phosphorylation	DPSQTQGSKSKQIQW CCCCCCCCCCCCCCC	24.76	19651622
154	Phosphorylation	PYQDDIDSLNPVLRD CCCCCHHHCCHHHCC	30.31	18669648
197	Phosphorylation	NGYRVRVYRQDSATQ CCEEEEEEECCCCHH	7.62	24719451
201	Phosphorylation	VRVYRQDSATQWFTG EEEEECCCCHHHHCE	25.52	24719451
217	Phosphorylation	ITHHDLFTRTMIVMN EHHHHHCCCEEEEEC	32.31	24719451
236	Phosphorylation	EPQNVDPSMVQMTFL CCCCCCHHHHHHHHH	27.41	24043423
241	Phosphorylation	DPSMVQMTFLDDVVH CHHHHHHHHHHHHHH	12.17	24043423
249	Phosphorylation	FLDDVVHSLLKGENI HHHHHHHHHHCCCCC	24.64	24719451
259	Phosphorylation	KGENIGITSRRRSRA CCCCCCCCCHHHHHC	15.80	24732914
260	Phosphorylation	GENIGITSRRRSRAN CCCCCCCCHHHHHCC	23.13	22210691
284	Phosphorylation	YTRAQANSPRPAMNS HHHHHCCCCCCCCCC	25.87	21712546
291	Phosphorylation	SPRPAMNSQAAVPKQ CCCCCCCCCCCCCCC	14.22	23403867
317	Phosphorylation	RPNKRKGSDSSIPDE CCCCCCCCCCCCCCH	37.04	28355574
319	Phosphorylation	NKRKGSDSSIPDEEK CCCCCCCCCCCCHHH	31.68	29255136
320	Phosphorylation	KRKGSDSSIPDEEKM CCCCCCCCCCCHHHH	43.03	29255136
332	Phosphorylation	EKMKEEKYDYISRGE HHHHHHHCCHHHCCC	19.77	27642862
365	Acetylation	DEKKLNMKRLRTDNV HHHHHCHHHHCCCCH	47.40	12431487
369	Phosphorylation	LNMKRLRTDNVSDFS HCHHHHCCCCHHHCC	36.20	24732914
373	Phosphorylation	RLRTDNVSDFSESSD HHCCCCHHHCCCCCC	38.91	23401153
376	Phosphorylation	TDNVSDFSESSDSEN CCCHHHCCCCCCCCC	41.37	23927012
378	Phosphorylation	NVSDFSESSDSENSN CHHHCCCCCCCCCCC	37.94	23927012
379	Phosphorylation	VSDFSESSDSENSNK HHHCCCCCCCCCCCC	40.90	23927012
381	Phosphorylation	DFSESSDSENSNKRI HCCCCCCCCCCCCCC	40.40	23927012
384	Phosphorylation	ESSDSENSNKRIIDN CCCCCCCCCCCCCCC	39.41	23927012
430	Phosphorylation	GEETLKNSQPPWDQI CHHHHHCCCCCHHHH	42.34	17525332
475	Phosphorylation	STVSDHNSNDLLPQE CCCCCCCCCCCCCCC	28.44	-
501	Phosphorylation	LPKEKFVSRPPTPKC CCHHHHCCCCCCCCE	42.05	26055452
505	Phosphorylation	KFVSRPPTPKCVIDI HHCCCCCCCCEEEEC	37.75	30266825
528	Phosphorylation	VAQENSSTFGLQTLQ HHHHCCCCCCHHHHH	22.88	-
533	Phosphorylation	SSTFGLQTLQKMDPN CCCCCHHHHHHCCCC	35.88	-
547	Phosphorylation	NVSDSKHSIANAKFL CCCCCCHHHHHHHHH	27.42	-
552	Acetylation	KHSIANAKFLETAKK CHHHHHHHHHHHHHH	50.73	19608861
556	Phosphorylation	ANAKFLETAKKDSDQ HHHHHHHHHHHCCCC	46.02	-
564	Phosphorylation	AKKDSDQSWVSDVVK HHHCCCCCCCCCCEE	34.14	25599653
596	Phosphorylation	LNMEKEKYVSYISPL CCCCHHHHHHCCCCH	8.84	29759185
598	Phosphorylation	MEKEKYVSYISPLSA CCHHHHHHCCCCHHH	17.41	29759185
599	Phosphorylation	EKEKYVSYISPLSAV CHHHHHHCCCCHHHH	8.72	29759185
601	Phosphorylation	EKYVSYISPLSAVSV HHHHHCCCCHHHHHH	16.14	21815630
604	Phosphorylation	VSYISPLSAVSVMED HHCCCCHHHHHHHHH	29.97	27732954
607	Phosphorylation	ISPLSAVSVMEDKLH CCCHHHHHHHHHHHH	18.57	27732954
612	Acetylation	AVSVMEDKLHKRSPP HHHHHHHHHHCCCCC	38.90	25953088
617	Phosphorylation	EDKLHKRSPPPETIK HHHHHCCCCCCHHHH	46.70	23401153
622	Phosphorylation	KRSPPPETIKSKLNT CCCCCCHHHHHHCCC	39.21	26329039
626	Acetylation	PPETIKSKLNTSVDT CCHHHHHHCCCCCCC	40.53	25953088
629	Phosphorylation	TIKSKLNTSVDTHKI HHHHHCCCCCCCCCC	40.33	29396449
630	Phosphorylation	IKSKLNTSVDTHKIK HHHHCCCCCCCCCCC	19.54	25159151
638	Phosphorylation	VDTHKIKSSPSPEVV CCCCCCCCCCCCCCC	51.45	23927012
639	Phosphorylation	DTHKIKSSPSPEVVK CCCCCCCCCCCCCCC	25.13	25159151
641	Phosphorylation	HKIKSSPSPEVVKPK CCCCCCCCCCCCCCC	35.32	25159151
650	O-linked_Glycosylation	EVVKPKITHSPDSVK CCCCCCCCCCCCCHH	23.56	30059200
650	Phosphorylation	EVVKPKITHSPDSVK CCCCCCCCCCCCCHH	23.56	26657352
652	O-linked_Glycosylation	VKPKITHSPDSVKSK CCCCCCCCCCCHHHC	23.04	30059200
652	Phosphorylation	VKPKITHSPDSVKSK CCCCCCCCCCCHHHC	23.04	23401153
655	O-linked_Glycosylation	KITHSPDSVKSKATY CCCCCCCCHHHCCEE	34.52	30059200
655	Phosphorylation	KITHSPDSVKSKATY CCCCCCCCHHHCCEE	34.52	23403867
658	Phosphorylation	HSPDSVKSKATYVNS CCCCCHHHCCEEECC	25.93	26074081
659	Ubiquitination	SPDSVKSKATYVNSQ CCCCHHHCCEEECCC	38.74	-
661	Phosphorylation	DSVKSKATYVNSQAT CCHHHCCEEECCCHH	31.57	26074081
662	Phosphorylation	SVKSKATYVNSQATG CHHHCCEEECCCHHH	11.51	28796482
665	Phosphorylation	SKATYVNSQATGERR HCCEEECCCHHHHHH	15.91	26074081
676	Sumoylation	GERRLANKIEHELSR HHHHHHHHHHHHHHC	43.81	-
676	Sumoylation	GERRLANKIEHELSR HHHHHHHHHHHHHHC	43.81	-
676	Ubiquitination	GERRLANKIEHELSR HHHHHHHHHHHHHHC	43.81	-
691	O-linked_Glycosylation	CSFHPIPTRSSTLET CCCCCCCCCCCCCCC	43.85	30059200
698	Phosphorylation	TRSSTLETTKSPLII CCCCCCCCCCCCEEE	42.51	28450419
699	O-linked_Glycosylation	RSSTLETTKSPLIID CCCCCCCCCCCEEEC	21.83	30059200
699	Phosphorylation	RSSTLETTKSPLIID CCCCCCCCCCCEEEC	21.83	23312004
700	Ubiquitination	SSTLETTKSPLIIDK CCCCCCCCCCEEECC	58.45	-
701	Phosphorylation	STLETTKSPLIIDKN CCCCCCCCCEEECCC	23.89	21815630
734	Phosphorylation	NHISPFLSQHPFPLH CCCHHHHHCCCCCCC	27.16	-
742	Phosphorylation	QHPFPLHSSSHRTCL CCCCCCCCCCCCCCC	41.02	-
744	Phosphorylation	PFPLHSSSHRTCLNP CCCCCCCCCCCCCCC	21.72	-
897	Methylation	VNAEASLRRNSPSPW CCHHHHHHCCCCCCC	32.99	30761423
912	O-linked_Glycosylation	LHQPTPVTSADGIGL CCCCCCCCCCCCCCC	21.28	30059200
913	O-linked_Glycosylation	HQPTPVTSADGIGLL CCCCCCCCCCCCCCC	25.29	30059200
928	Phosphorylation	SHIPVRPSSAEPHRP CCCCCCCCCCCCCCC	31.45	28348404
929	Phosphorylation	HIPVRPSSAEPHRPL CCCCCCCCCCCCCCC	39.06	28348404
939	Phosphorylation	PHRPLKITAHSSPPL CCCCCEEEECCCCCC	19.41	30266825
942	Phosphorylation	PLKITAHSSPPLTKT CCEEEECCCCCCHHH	41.92	30266825
943	Phosphorylation	LKITAHSSPPLTKTL CEEEECCCCCCHHHH	22.22	30266825
947	Phosphorylation	AHSSPPLTKTLVDHH ECCCCCCHHHHHHHC	27.97	23927012
948	Ubiquitination	HSSPPLTKTLVDHHK CCCCCCHHHHHHHCH	47.77	-
961	Sumoylation	HKEELERKAFMEPLR CHHHHHHHHHHHHHH	36.28	-
961	Sumoylation	HKEELERKAFMEPLR CHHHHHHHHHHHHHH	36.28	-
961	Ubiquitination	HKEELERKAFMEPLR CHHHHHHHHHHHHHH	36.28	-
974	Phosphorylation	LRSVASTSAKNDLDL HHHHHCCCCCCCCCC	34.45	-
984	Phosphorylation	NDLDLNRSQTGKDCH CCCCCCHHHCCCCCH	30.90	28450419
986	Phosphorylation	LDLNRSQTGKDCHLH CCCCHHHCCCCCHHH	47.66	28450419
988	Ubiquitination	LNRSQTGKDCHLHRH CCHHHCCCCCHHHHH	61.64	-
1029	Phosphorylation	HRRILQESIDVAPFT HHHHHHHHCCCCCCC	15.89	28348404
1040	Sumoylation	APFTTKIKGLEGERE CCCCCCCCCCCCCCC	60.02	-
1040	Sumoylation	APFTTKIKGLEGERE CCCCCCCCCCCCCCC	60.02	-
1049	Phosphorylation	LEGERENYSRVASSS CCCCCCCHHHHCCCC	7.97	29449344
1050	Phosphorylation	EGERENYSRVASSSS CCCCCCHHHHCCCCC	31.68	25159151
1054	Phosphorylation	ENYSRVASSSSSPKS CCHHHHCCCCCCCCH	28.09	21949786
1055	Phosphorylation	NYSRVASSSSSPKSH CHHHHCCCCCCCCHH	25.22	24719451
1056	Phosphorylation	YSRVASSSSSPKSHI HHHHCCCCCCCCHHH	32.13	21949786
1057	Phosphorylation	SRVASSSSSPKSHII HHHCCCCCCCCHHHC	53.24	21949786
1058	Phosphorylation	RVASSSSSPKSHIIK HHCCCCCCCCHHHCC	37.99	28985074
1061	Phosphorylation	SSSSSPKSHIIKQDM CCCCCCCHHHCCCCC	24.25	21949786
1065	Sumoylation	SPKSHIIKQDMDVER CCCHHHCCCCCCCHH	39.37	-
1065	Sumoylation	SPKSHIIKQDMDVER CCCHHHCCCCCCCHH	39.37	-
1073	O-linked_Glycosylation	QDMDVERSVSDLYKM CCCCCHHHHHHHHHC	16.68	30059200
1075	Phosphorylation	MDVERSVSDLYKMKH CCCHHHHHHHHHCCC	24.12	28509920
1087	O-linked_Glycosylation	MKHSVPQSLPQSNYF CCCCCCCCCCCCCCC	35.63	30059200
1091	O-linked_Glycosylation	VPQSLPQSNYFTTLS CCCCCCCCCCCCCCC	31.40	30059200
1112	Ubiquitination	PPRSYPSKEVSNIYG CCCCCCCHHHHHHHC	58.60	-
1173	O-linked_Glycosylation	HLPHQIASHSVTTFR CCCCCHHHCCCEEEC	20.23	30059200
1185	Phosphorylation	TFRNDCRSPTHLTVS EECCCCCCCCEEEEC	40.25	23401153
1187	Phosphorylation	RNDCRSPTHLTVSST CCCCCCCCEEEECCC	30.66	30266825
1190	Phosphorylation	CRSPTHLTVSSTNTL CCCCCEEEECCCCHH	15.67	30266825
1192	O-linked_Glycosylation	SPTHLTVSSTNTLRS CCCEEEECCCCHHHC	26.64	30059200
1192	Phosphorylation	SPTHLTVSSTNTLRS CCCEEEECCCCHHHC	26.64	24732914
1193	Phosphorylation	PTHLTVSSTNTLRSM CCEEEECCCCHHHCC	22.72	24732914
1194	Phosphorylation	THLTVSSTNTLRSMP CEEEECCCCHHHCCC	25.39	24732914
1196	Phosphorylation	LTVSSTNTLRSMPAL EEECCCCHHHCCCHH	24.52	24732914
1216	Phosphorylation	FHPPIHHSLERKEGS CCCCCCCHHCCCCCC	20.12	23312004
1223	Phosphorylation	SLERKEGSYSSLSPP HHCCCCCCCCCCCCC	23.96	23401153
1224	Phosphorylation	LERKEGSYSSLSPPT HCCCCCCCCCCCCCC	17.09	28122231
1225	Phosphorylation	ERKEGSYSSLSPPTL CCCCCCCCCCCCCCC	26.88	25159151
1226	Phosphorylation	RKEGSYSSLSPPTLT CCCCCCCCCCCCCCC	25.32	25159151
1228	Phosphorylation	EGSYSSLSPPTLTPV CCCCCCCCCCCCCCC	30.68	25159151
1231	Phosphorylation	YSSLSPPTLTPVMPV CCCCCCCCCCCCCCC	46.80	28102081
1233	O-linked_Glycosylation	SLSPPTLTPVMPVNA CCCCCCCCCCCCCCC	19.13	-
1233	Phosphorylation	SLSPPTLTPVMPVNA CCCCCCCCCCCCCCC	19.13	28348404
1252	Phosphorylation	QESQKPPTLIPEPKD CCCCCCCCCCCCCCC	45.94	28258704
1265	Methylation	KDSQANFKSSSEQSL CCCCCCCCCCCHHHH	49.59	115979475
1266	Phosphorylation	DSQANFKSSSEQSLT CCCCCCCCCCHHHHH	34.65	24043423
1267	Phosphorylation	SQANFKSSSEQSLTE CCCCCCCCCHHHHHH	38.18	24043423
1268	Phosphorylation	QANFKSSSEQSLTEM CCCCCCCCHHHHHHH	46.90	24043423
1271	Phosphorylation	FKSSSEQSLTEMWRP CCCCCHHHHHHHHCC	32.96	24043423
1273	Phosphorylation	SSSEQSLTEMWRPNN CCCHHHHHHHHCCCC	29.10	24043423
1287	Phosphorylation	NNLSKEKTEWHVEKS CCCCHHHHHHEEECC	45.45	-
1295	Phosphorylation	EWHVEKSSGKLQAAM HHEEECCCCCCEEEE	51.52	-
1297	Acetylation	HVEKSSGKLQAAMAS EEECCCCCCEEEEEE	39.10	25953088
1312	Phosphorylation	VIVRPSSSTKTDSMP EEECCCCCCCCCCCC	37.96	30576142
1315	Phosphorylation	RPSSSTKTDSMPAMQ CCCCCCCCCCCCHHH	33.14	30576142
1317	Phosphorylation	SSSTKTDSMPAMQLA CCCCCCCCCCHHHHH	31.71	30576142
1351	O-linked_Glycosylation	KLAEAGETGRIILPN HHHHCCCCCCEEECC	30.73	30059200
1361	Phosphorylation	IILPNVNSDSVHTKS EEECCCCCCCCCCCC	27.29	28387310
1363	Phosphorylation	LPNVNSDSVHTKSEK ECCCCCCCCCCCCHH	18.67	28387310
1376	O-linked_Glycosylation	EKNFQAVSQGSVPSS HHCEEHHHCCCCCHH	31.66	30059200
1405	Phosphorylation	VITSAADTTSVSSWG EEECCCCCCCCHHCC	19.08	-
1409	Phosphorylation	AADTTSVSSWGGSEV CCCCCCCHHCCHHHH	21.82	-
1414	Phosphorylation	SVSSWGGSEVISSLS CCHHCCHHHHHHHHC	25.42	-
1428	Phosphorylation	SNTILASTSSECVSS CCCEEEECCCHHHCC	30.57	-
1434	Phosphorylation	STSSECVSSKSVSQP ECCCHHHCCCCCCCC	43.64	-
1437	O-linked_Glycosylation	SECVSSKSVSQPVAQ CHHHCCCCCCCCCCC	29.02	30059200
1445	Acetylation	VSQPVAQKQECKVST CCCCCCCCCCCEEEC	38.02	23749302
1451	O-linked_Glycosylation	QKQECKVSTTAPVTL CCCCCEEECCCCEEE	12.92	30059200
1452	O-linked_Glycosylation	KQECKVSTTAPVTLA CCCCEEECCCCEEEE	29.93	32574038
1452	O-linked_Glycosylation	KQECKVSTTAPVTLA CCCCEEECCCCEEEE	29.93	20068230
1453	O-linked_Glycosylation	QECKVSTTAPVTLAS CCCEEECCCCEEEEC	22.81	32574038
1453	O-linked_Glycosylation	QECKVSTTAPVTLAS CCCEEECCCCEEEEC	22.81	20068230
1453	Phosphorylation	QECKVSTTAPVTLAS CCCEEECCCCEEEEC	22.81	24425749
1457	O-linked_Glycosylation	VSTTAPVTLASSKTG EECCCCEEEECCCCC	18.62	32574038
1457	O-linked_Glycosylation	VSTTAPVTLASSKTG EECCCCEEEECCCCC	18.62	20068230
1457	Phosphorylation	VSTTAPVTLASSKTG EECCCCEEEECCCCC	18.62	-
1460	Phosphorylation	TAPVTLASSKTGSVV CCCEEEECCCCCCEE	35.16	-
1461	Phosphorylation	APVTLASSKTGSVVQ CCEEEECCCCCCEEC	28.73	-
1483	Acetylation	TTDFIHLKKHKAALA CCCEEEHHHHHHHHH	38.37	25953088
1486	Ubiquitination	FIHLKKHKAALAAAQ EEEHHHHHHHHHHHH	44.21	-
1511	Phosphorylation	PNAIKNQTLSASLPL CCHHHCCCCCEECCC	31.88	26714015
1513	Phosphorylation	AIKNQTLSASLPLDS HHHCCCCCEECCCCC	21.14	26714015
1515	Phosphorylation	KNQTLSASLPLDSTV HCCCCCEECCCCCEE	27.43	26714015
1532	Phosphorylation	STINKANSVGNGQAS EECCCCCCCCCCCCC	35.94	28111955
1539	Phosphorylation	SVGNGQASQTSQPNY CCCCCCCCCCCCCCH	26.55	28111955
1541	Phosphorylation	GNGQASQTSQPNYHT CCCCCCCCCCCCHHH	27.17	25599653
1542	Phosphorylation	NGQASQTSQPNYHTK CCCCCCCCCCCHHHH	35.68	28111955
1546	Phosphorylation	SQTSQPNYHTKLKKA CCCCCCCHHHHHHHH	19.97	28111955
1548	Phosphorylation	TSQPNYHTKLKKAWL CCCCCHHHHHHHHHH	27.93	30576142
1621	Phosphorylation	NRRKAKRTYESGSES CHHHHCHHHCCCCCC	30.82	28102081
1622	Phosphorylation	RRKAKRTYESGSESG HHHHCHHHCCCCCCC	16.48	28102081
1624	Phosphorylation	KAKRTYESGSESGDS HHCHHHCCCCCCCCC	36.89	28985074
1626	Phosphorylation	KRTYESGSESGDSDE CHHHCCCCCCCCCCC	37.56	28102081
1628	Phosphorylation	TYESGSESGDSDESE HHCCCCCCCCCCCCC	49.99	28985074
1631	Phosphorylation	SGSESGDSDESESKS CCCCCCCCCCCCCHH	46.96	25159151
1634	Phosphorylation	ESGDSDESESKSEQR CCCCCCCCCCHHHHH	52.76	25159151
1636	Phosphorylation	GDSDESESKSEQRTK CCCCCCCCHHHHHHH	51.24	28102081
1675	Phosphorylation	LKPNGVLSRSAKERS CCCCCCCCCCHHHHH	23.06	24719451
1677	Phosphorylation	PNGVLSRSAKERSKL CCCCCCCCHHHHHCC	40.07	-
1682	Phosphorylation	SRSAKERSKLKLQSN CCCHHHHHCCCCCCC	43.35	-
1685	Ubiquitination	AKERSKLKLQSNSNT HHHHHCCCCCCCCCC	48.49	-
1730	Acetylation	EIGPNLQKCRECRLI CCCCCHHHHHHCCCH	38.12	26051181
1739	Phosphorylation	RECRLIRSKKGEEPA HHCCCHHCCCCCCCC	31.55	29214152
1748	Phosphorylation	KGEEPAHSPVFCRFY CCCCCCCCCCCCCCE	25.51	28985074
1761	Phosphorylation	FYYFRRLSFSKNGVV CEEEEEECCCCCCEE	26.18	24719451
1763	Phosphorylation	YFRRLSFSKNGVVRI EEEEECCCCCCEEEE	23.10	-
1822	O-linked_Glycosylation	QLVTSEKTALSWVKK HHHHCCCHHHHHHHH	28.87	30059200
1832	Ubiquitination	SWVKKDAKIAWKRAV HHHHHHHHHHHHHHH	42.99	-
1905	Phosphorylation	DHKHLMPTQIIPGSV CCCCCCCCCCCCHHH	20.59	24719451
1911	Phosphorylation	PTQIIPGSVLTDLLD CCCCCCHHHHHHHHH	14.48	24719451
1914	Phosphorylation	IIPGSVLTDLLDAMH CCCHHHHHHHHHHHH	23.57	24719451
1930	Ubiquitination	LREKYGIKSHCHCTN HHHHHCCCCCEEECC	29.77	-
1967	Phosphorylation	LNHSNKISLCMPESQ HHCCCCCEEECCHHH	19.68	28450419
1973	Phosphorylation	ISLCMPESQQQNTPP CEEECCHHHCCCCCC	27.67	25159151
1978	Phosphorylation	PESQQQNTPPKSEKN CHHHCCCCCCCCCCC	36.31	25159151
1982	Phosphorylation	QQNTPPKSEKNGGSS CCCCCCCCCCCCCCC	60.62	25159151
1988	Phosphorylation	KSEKNGGSSPESDVG CCCCCCCCCCHHHCC	44.08	23663014
1989	Phosphorylation	SEKNGGSSPESDVGT CCCCCCCCCHHHCCC	35.64	25159151
1992	Phosphorylation	NGGSSPESDVGTDNK CCCCCCHHHCCCCCC	40.77	23663014
1996	Phosphorylation	SPESDVGTDNKLTPP CCHHHCCCCCCCCCC	35.93	25921289
2001	Phosphorylation	VGTDNKLTPPESQSP CCCCCCCCCCHHCCH	38.11	22115753
2005	Phosphorylation	NKLTPPESQSPLHWL CCCCCCHHCCHHHHH	41.55	25159151
2007	Phosphorylation	LTPPESQSPLHWLAD CCCCHHCCHHHHHHH	38.41	25159151
2031	O-linked_Glycosylation	KKENKELTLENQIKE HHHHHHHCHHHHHHH	32.87	30059200
2045	Phosphorylation	EEREQDNSESPNGRT HHHHHHCCCCCCCCC	47.98	23927012
2047	Phosphorylation	REQDNSESPNGRTSP HHHHCCCCCCCCCCC	24.40	25159151
2052	O-linked_Glycosylation	SESPNGRTSPLVSQN CCCCCCCCCCCCCCC	35.77	30059200
2052	Phosphorylation	SESPNGRTSPLVSQN CCCCCCCCCCCCCCC	35.77	23401153
2053	Phosphorylation	ESPNGRTSPLVSQNN CCCCCCCCCCCCCCC	18.18	19664994
2057	O-linked_Glycosylation	GRTSPLVSQNNEQGS CCCCCCCCCCCCCCC	34.57	30059200
2057	Phosphorylation	GRTSPLVSQNNEQGS CCCCCCCCCCCCCCC	34.57	23927012
2064	Phosphorylation	SQNNEQGSTLRDLLT CCCCCCCCHHHHHHH	24.78	23927012
2065	Phosphorylation	QNNEQGSTLRDLLTT CCCCCCCHHHHHHHH	32.41	23403867
2076	Acetylation	LLTTTAGKLRVGSTD HHHHCCCCEECCCCC	30.56	25953088
2076	Ubiquitination	LLTTTAGKLRVGSTD HHHHCCCCEECCCCC	30.56	-
2081	Phosphorylation	AGKLRVGSTDAGIAF CCCEECCCCCCCEEE	21.91	28348404
2082	Phosphorylation	GKLRVGSTDAGIAFA CCEECCCCCCCEEEE	24.76	27251275
2092	Phosphorylation	GIAFAPVYSMGAPSS CEEEEEEECCCCCCC	7.59	22210691
2098	Phosphorylation	VYSMGAPSSKSGRTM EECCCCCCCCCCCCC	50.27	22210691
2099	Phosphorylation	YSMGAPSSKSGRTMP ECCCCCCCCCCCCCC	29.76	22210691
2100	Ubiquitination	SMGAPSSKSGRTMPN CCCCCCCCCCCCCCC	62.36	-
2101	Phosphorylation	MGAPSSKSGRTMPNI CCCCCCCCCCCCCCH	35.14	26270265
2104	Phosphorylation	PSSKSGRTMPNILDD CCCCCCCCCCCHHHH	40.27	26270265
2115	Phosphorylation	ILDDIIASVVENKIP HHHHHHHHHHHCCCC	19.11	26270265
2132	Sumoylation	KTSKINVKPELKEEP CCCCCCCCHHHCCCC	28.43	28112733
2136	Sumoylation	INVKPELKEEPEESI CCCCHHHCCCCCHHH	59.37	28112733
2142	Phosphorylation	LKEEPEESIISAVDE HCCCCCHHHHHEECC	24.46	28555341
2154	Phosphorylation	VDENNKLYSDIPHSW ECCCCCCCCCCCHHH	13.10	27134283
2155	Phosphorylation	DENNKLYSDIPHSWI CCCCCCCCCCCHHHH	39.23	27134283
2183	Ubiquitination	SSNWKLFKECWKQGQ CCCHHHHHHHHHCCC	63.50	-
2226	Ubiquitination	QADLLNCKDSIISNA HHHHHCCCHHHHCCC	54.13	-
2228	Phosphorylation	DLLNCKDSIISNANV HHHCCCHHHHCCCCH	13.81	27251275
2231	Phosphorylation	NCKDSIISNANVKEF CCCHHHHCCCCHHHH	28.37	27251275
2236	Ubiquitination	IISNANVKEFWDGFE HHCCCCHHHHHHCHH	47.18	-
2247	Ubiquitination	DGFEEVSKRQKNKSG HCHHHHHHHHCCCCC	65.11	-
2260	Ubiquitination	SGETVVLKLKDWPSG CCCEEEEEECCCCCC	41.71	-
2262	Ubiquitination	ETVVLKLKDWPSGED CEEEEEECCCCCCCC	57.04	-
2271	Ubiquitination	WPSGEDFKTMMPARY CCCCCCHHHCCCHHH	48.08	-
2283	Ubiquitination	ARYEDLLKSLPLPEY HHHHHHHHHCCCCCC	58.19	-
2296	Ubiquitination	EYCNPEGKFNLASHL CCCCCCCCCCHHHCC	29.44	-
2366	Acetylation	SKAGILKKFEEEDLD HHHCHHHHHCCCCHH	55.34	26051181
2366	Ubiquitination	SKAGILKKFEEEDLD HHHCHHHHHCCCCHH	55.34	-
2397	Ubiquitination	LWHIYAGKDVDKIRE HHHHHCCCCHHHHHH	46.54	-
2425	Dimethylation	LPEHDPIRDQSWYVN CCCCCCCCCCHHHHC	41.10	-
2425	Methylation	LPEHDPIRDQSWYVN CCCCCCCCCCHHHHC	41.10	115372827
2433	Ubiquitination	DQSWYVNKKLRQRLL CCHHHHCHHHHHHHH	43.04	-
2443	Phosphorylation	RQRLLEEYGVRTCTL HHHHHHHHCCCHHHH	16.14	25690035
2509	Ubiquitination	EEINYDDKLQVKNIL HHCCCCCHHHHHHHH	37.61	-
2517	Phosphorylation	LQVKNILYHAVKEMV HHHHHHHHHHHHHHH	5.50	27642862
2521	Acetylation	NILYHAVKEMVRALK HHHHHHHHHHHHHHH	40.66	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of JHD2C_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of JHD2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
365	Acetylation	372 (7)	M ⇒ V	rs41274072	Immature fraction of reticulocytes	27863252
373	Phosphorylation	372 (1)	M ⇒ V	rs41274072	Immature fraction of reticulocytes	27863252
376	Phosphorylation	372 (4)	M ⇒ V	rs41274072	Immature fraction of reticulocytes	27863252
378	Phosphorylation	372 (6)	M ⇒ V	rs41274072	Immature fraction of reticulocytes	27863252
379	Phosphorylation	372 (7)	M ⇒ V	rs41274072	Immature fraction of reticulocytes	27863252
381	Phosphorylation	372 (9)	M ⇒ V	rs41274072	Immature fraction of reticulocytes	27863252
547	Phosphorylation	553 (6)	M ⇒ V	rs41274072	Immature fraction of reticulocytes High light scatter reticulocyte count	27863252
552	Acetylation	553 (1)	M ⇒ V	rs41274072	Immature fraction of reticulocytes High light scatter reticulocyte count	27863252
556	Phosphorylation	553 (3)	M ⇒ V	rs41274072	Immature fraction of reticulocytes High light scatter reticulocyte count	27863252

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ANDR_HUMAN	AR	physical	17353003

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of JHD2C_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-552, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376; SER-379;SER-638 AND SER-641, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, AND MASSSPECTROMETRY.	17525332 [Abstract]