TMEDA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMEDA_HUMAN
• UniProt AC: P49755
• Protein Name: Transmembrane emp24 domain-containing protein 10
• Gene Name: TMED10
• Organism: Homo sapiens (Human).
• Sequence Length: 219
• Subcellular Localization: Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane p
• Protein Description: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus..
• Protein Sequence: MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	SFHLPINSRKCLREE HCCCCCCCCHHHHHH	33.56	-
42	Ubiquitination	HLPINSRKCLREEIH CCCCCCCHHHHHHHH	37.12	-
50	2-Hydroxyisobutyrylation	CLREEIHKDLLVTGA HHHHHHHHHHEEECC	56.59	-
50	Ubiquitination	CLREEIHKDLLVTGA HHHHHHHHHHEEECC	56.59	-
55	O-linked_Glycosylation	IHKDLLVTGAYEISD HHHHHEEECCEEECC	18.96	55830839
58	Phosphorylation	DLLVTGAYEISDQSG HHEEECCEEECCCCC	18.36	-
75	Ubiquitination	GGLRSHLKITDSAGH CCHHHEEEEECCCCC	37.83	21890473
75	2-Hydroxyisobutyrylation	GGLRSHLKITDSAGH CCHHHEEEEECCCCC	37.83	-
75	Ubiquitination	GGLRSHLKITDSAGH CCHHHEEEEECCCCC	37.83	21890473
77	O-linked_Glycosylation	LRSHLKITDSAGHIL HHHEEEEECCCCCEE	23.47	55825583
79	Phosphorylation	SHLKITDSAGHILYS HEEEEECCCCCEEEE	27.74	28152594
85	Phosphorylation	DSAGHILYSKEDATK CCCCCEEEEHHHCCC	19.66	28152594
86	Phosphorylation	SAGHILYSKEDATKG CCCCEEEEHHHCCCC	26.56	28152594
87	Ubiquitination	AGHILYSKEDATKGK CCCEEEEHHHCCCCE	46.16	21890473
87	Acetylation	AGHILYSKEDATKGK CCCEEEEHHHCCCCE	46.16	26822725
87	2-Hydroxyisobutyrylation	AGHILYSKEDATKGK CCCEEEEHHHCCCCE	46.16	-
87	Ubiquitination	AGHILYSKEDATKGK CCCEEEEHHHCCCCE	46.16	21890473
91	Phosphorylation	LYSKEDATKGKFAFT EEEHHHCCCCEEEEE	53.29	28152594
92	Ubiquitination	YSKEDATKGKFAFTT EEHHHCCCCEEEEEC	62.92	-
94	Ubiquitination	KEDATKGKFAFTTED HHHCCCCEEEEECCC	34.77	-
114	O-linked_Glycosylation	VCFESKGTGRIPDQL HHHCCCCCCCCCCEE	27.33	OGP
126	Sulfoxidation	DQLVILDMKHGVEAK CEEEEEECCCCCCCC	2.86	28465586
127	2-Hydroxyisobutyrylation	QLVILDMKHGVEAKN EEEEEECCCCCCCCC	36.55	-
127	Acetylation	QLVILDMKHGVEAKN EEEEEECCCCCCCCC	36.55	26051181
127	Ubiquitination	QLVILDMKHGVEAKN EEEEEECCCCCCCCC	36.55	21890473
133	Ubiquitination	MKHGVEAKNYEEIAK CCCCCCCCCHHHHHH	46.70	-
133	Succinylation	MKHGVEAKNYEEIAK CCCCCCCCCHHHHHH	46.70	23954790
135	Phosphorylation	HGVEAKNYEEIAKVE CCCCCCCHHHHHHHH	17.77	28152594
140	Acetylation	KNYEEIAKVEKLKPL CCHHHHHHHHHCCCH	57.50	25825284
140	Ubiquitination	KNYEEIAKVEKLKPL CCHHHHHHHHHCCCH	57.50	21890473
143	Ubiquitination	EEIAKVEKLKPLEVE HHHHHHHHCCCHHHH	65.87	-
143	2-Hydroxyisobutyrylation	EEIAKVEKLKPLEVE HHHHHHHHCCCHHHH	65.87	-
145	Ubiquitination	IAKVEKLKPLEVELR HHHHHHCCCHHHHHH	59.63	21890473
152	Methylation	KPLEVELRRLEDLSE CCHHHHHHHHHHHHH	27.86	115918609
167	Phosphorylation	SIVNDFAYMKKREEE HHHHHHHHHHHHHHH	14.95	-
168	Sulfoxidation	IVNDFAYMKKREEEM HHHHHHHHHHHHHHH	3.56	28183972
169	Acetylation	VNDFAYMKKREEEMR HHHHHHHHHHHHHHH	35.68	26051181
169	Ubiquitination	VNDFAYMKKREEEMR HHHHHHHHHHHHHHH	35.68	21890473
170	Ubiquitination	NDFAYMKKREEEMRD HHHHHHHHHHHHHHC	48.81	-
171	Methylation	DFAYMKKREEEMRDT HHHHHHHHHHHHHCC	51.55	-
176	Methylation	KKREEEMRDTNESTN HHHHHHHHCCCCCCC	51.38	-
179	N-linked_Glycosylation	EEEMRDTNESTNTRV HHHHHCCCCCCCHHH	45.57	UniProtKB CARBOHYD
182	Phosphorylation	MRDTNESTNTRVLYF HHCCCCCCCHHHHHH	34.14	22210691
184	Phosphorylation	DTNESTNTRVLYFSI CCCCCCCHHHHHHHH	23.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMEDA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMEDA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMEDA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAMP2_HUMAN	VAMP2	physical	22939629
TMED1_HUMAN	TMED1	physical	26186194
GOGB1_HUMAN	GOLGB1	physical	26186194
TMED4_HUMAN	TMED4	physical	26186194
TMED2_HUMAN	TMED2	physical	26186194
TMED7_HUMAN	TMED7	physical	26186194
TMED3_HUMAN	TMED3	physical	26186194
TMED5_HUMAN	TMED5	physical	26186194
EMC7_HUMAN	EMC7	physical	26186194
TMED4_HUMAN	TMED4	physical	26344197
TMED9_HUMAN	TMED9	physical	26344197
COPG2_HUMAN	COPG2	physical	11056392
COPG1_HUMAN	COPG1	physical	11056392
TMED4_HUMAN	TMED4	physical	28514442
GOGB1_HUMAN	GOLGB1	physical	28514442
TMED1_HUMAN	TMED1	physical	28514442
TMED3_HUMAN	TMED3	physical	28514442
TMED7_HUMAN	TMED7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.