| UniProt ID | TMED3_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y3Q3 | |
| Protein Name | Transmembrane emp24 domain-containing protein 3 | |
| Gene Name | TMED3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 217 | |
| Subcellular Localization |
Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane protein . Golgi apparatus, cis-Golgi network membrane Single-pass type I membrane protein . Golgi apparatus, Golgi stack membrane Single-pass type I membrane p |
|
| Protein Description | Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network.. | |
| Protein Sequence | MGSTVPRSASVLLLLLLLRRAEQPCGAELTFELPDNAKQCFHEEVEQGVKFSLDYQVITGGHYDVDCYVEDPQGNTIYRETKKQYDSFTYRAEVKGVYQFCFSNEFSTFSHKTVYFDFQVGDEPPILPDMGNRVTALTQMESACVTIHEALKTVIDSQTHYRLREAQDRARAEDLNSRVSYWSVGETIALFVVSFSQVLLLKSFFTEKRPISRAVHS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MGSTVPRSAS -----CCCCCCHHHH | 25.57 | 23312004 | |
| 4 | Phosphorylation | ----MGSTVPRSASV ----CCCCCCHHHHH | 28.88 | - | |
| 8 | Phosphorylation | MGSTVPRSASVLLLL CCCCCCHHHHHHHHH | 20.87 | - | |
| 10 | Phosphorylation | STVPRSASVLLLLLL CCCCHHHHHHHHHHH | 17.97 | - | |
| 55 | Phosphorylation | GVKFSLDYQVITGGH CCEEEEEEEEEECCC | 15.24 | - | |
| 68 | Phosphorylation | GHYDVDCYVEDPQGN CCCEEEEEEECCCCC | 11.47 | - | |
| 83 | Ubiquitination | TIYRETKKQYDSFTY EEEECCCHHCCCCEE | 62.60 | - | |
| 85 | Phosphorylation | YRETKKQYDSFTYRA EECCCHHCCCCEEEE | 23.57 | - | |
| 135 | O-linked_Glycosylation | PDMGNRVTALTQMES CCCCCHHHHHHHHHH | 16.83 | OGP | |
| 152 | Ubiquitination | VTIHEALKTVIDSQT HHHHHHHHHHHHHHH | 48.03 | - | |
| 208 | Ubiquitination | LKSFFTEKRPISRAV HHHHHCCCCCCCCCC | 61.49 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TMED3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TMED3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TMED3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CCPG1_HUMAN | CCPG1 | physical | 26186194 | |
| TMED4_HUMAN | TMED4 | physical | 26186194 | |
| OSBL8_HUMAN | OSBPL8 | physical | 26186194 | |
| TMED2_HUMAN | TMED2 | physical | 26186194 | |
| H1BP3_HUMAN | HS1BP3 | physical | 26186194 | |
| GO45_HUMAN | BLZF1 | physical | 26186194 | |
| CC50A_HUMAN | TMEM30A | physical | 26186194 | |
| LNP_HUMAN | KIAA1715 | physical | 26186194 | |
| TMEDA_HUMAN | TMED10 | physical | 26344197 | |
| GO45_HUMAN | BLZF1 | physical | 28514442 | |
| TMED4_HUMAN | TMED4 | physical | 28514442 | |
| H1BP3_HUMAN | HS1BP3 | physical | 28514442 | |
| CCPG1_HUMAN | CCPG1 | physical | 28514442 | |
| LNP_HUMAN | KIAA1715 | physical | 28514442 | |
| CC50A_HUMAN | TMEM30A | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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