TMED2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMED2_HUMAN
• UniProt AC: Q15363
• Protein Name: Transmembrane emp24 domain-containing protein 2
• Gene Name: TMED2
• Organism: Homo sapiens (Human).
• Sequence Length: 201
• Subcellular Localization: Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, COPI-coated vesicle membrane ; Single-pass type I membrane protein . Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein . Golgi appara
• Protein Description: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing..
• Protein Sequence: MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Ubiquitination	PDNKGIYKGDRESSG CCCCCCCCCCCCCCC	53.03	-
79	2-Hydroxyisobutyrylation	GDRESSGKYTFAAHM CCCCCCCCEEEEEEC	42.96	-
79	Acetylation	GDRESSGKYTFAAHM CCCCCCCCEEEEEEC	42.96	25038526
99	Phosphorylation	FCFSNRMSTMTPKIV EEECCCCCCCCCEEE	16.28	26437602
121	Sulfoxidation	EAPKGQDMETEAHQN CCCCCCCCCCHHHHH	5.44	30846556
129	Ubiquitination	ETEAHQNKLEEMINE CCHHHHHHHHHHHHH	51.18	-
142	Phosphorylation	NELAVAMTAVKHEQE HHHHHHHHHHHHHHH	20.68	20068231
142	O-linked_Glycosylation	NELAVAMTAVKHEQE HHHHHHHHHHHHHHH	20.68	OGP
150	Phosphorylation	AVKHEQEYMEVRERI HHHHHHHHHHHHHHH	9.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMED2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMED2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMED2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMED4_HUMAN	TMED4	physical	22939629
ERGI1_HUMAN	ERGIC1	physical	26344197
HNRL1_HUMAN	HNRNPUL1	physical	26344197
DHB12_HUMAN	HSD17B12	physical	26344197
RS10_HUMAN	RPS10	physical	26344197
TM9S4_HUMAN	TM9SF4	physical	26344197
TMEDA_HUMAN	TMED10	physical	26344197
TMED3_HUMAN	TMED3	physical	26344197
TMED4_HUMAN	TMED4	physical	26344197
TMED9_HUMAN	TMED9	physical	26344197
GOGB1_HUMAN	GOLGB1	physical	28514442
TMED4_HUMAN	TMED4	physical	28514442
TMED7_HUMAN	TMED7	physical	28514442
TMED3_HUMAN	TMED3	physical	28514442
DJC30_HUMAN	DNAJC30	physical	28514442
UBP22_HUMAN	USP22	physical	28514442
FGRL1_HUMAN	FGFRL1	physical	28514442
ATP9A_HUMAN	ATP9A	physical	28514442
PNPT1_HUMAN	PNPT1	physical	28514442
TMED1_HUMAN	TMED1	physical	28514442
OSBL6_HUMAN	OSBPL6	physical	28514442
AT8B2_HUMAN	ATP8B2	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
TMED5_HUMAN	TMED5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.