TMED7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMED7_HUMAN
• UniProt AC: Q9Y3B3
• Protein Name: Transmembrane emp24 domain-containing protein 7
• Gene Name: TMED7
• Organism: Homo sapiens (Human).
• Sequence Length: 224
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cyto
• Protein Description: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications..
• Protein Sequence: MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRVGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPRPGSAQRWAAV --CCCCCCHHHHHHH	24.74	30619164
46	Ubiquitination	FELPDNAKQCFYEDI EECCCCHHEEEHHHH	54.58	-
50	Phosphorylation	DNAKQCFYEDIAQGT CCHHEEEHHHHHCCC	21.96	28152594
57	Phosphorylation	YEDIAQGTKCTLEFQ HHHHHCCCEEEEEEE	15.74	28152594
83	Ubiquitination	RLEDPDGKVLYKEMK EEECCCCCEEEHHHH	36.13	21906983
83	Acetylation	RLEDPDGKVLYKEMK EEECCCCCEEEHHHH	36.13	27452117
87	Ubiquitination	PDGKVLYKEMKKQYD CCCCEEEHHHHHHHC	47.36	21906983
91	Ubiquitination	VLYKEMKKQYDSFTF EEEHHHHHHHCCEEE	53.43	21906983
93	Phosphorylation	YKEMKKQYDSFTFTA EHHHHHHHCCEEEEE	23.57	28152594
95	Phosphorylation	EMKKQYDSFTFTASK HHHHHHCCEEEEECC	22.66	28152594
97	Phosphorylation	KKQYDSFTFTASKNG HHHHCCEEEEECCCC	24.83	28152594
103	N-linked_Glycosylation	FTFTASKNGTYKFCF EEEEECCCCEEEEEE	45.61	UniProtKB CARBOHYD
105	Phosphorylation	FTASKNGTYKFCFSN EEECCCCEEEEEECC	32.69	-
142	Phosphorylation	FPSENRVSALTQMES CCCCCHHHHHHHHHH	17.83	20068231
145	O-linked_Glycosylation	ENRVSALTQMESACV CCHHHHHHHHHHHHH	26.11	OGP
153	Phosphorylation	QMESACVSIHEALKS HHHHHHHHHHHHHHH	20.36	20068231
164	Phosphorylation	ALKSVIDYQTHFRLR HHHHHHHHHHHHHHH	12.27	28152594
166	Phosphorylation	KSVIDYQTHFRLREA HHHHHHHHHHHHHHH	19.42	28152594
213	Phosphorylation	FLLKSFFSDKRTTTT HHHHHHHCCCCCCCC	39.96	28355574
215	Ubiquitination	LKSFFSDKRTTTTRV HHHHHCCCCCCCCCC	50.90	21906983
215	Acetylation	LKSFFSDKRTTTTRV HHHHHCCCCCCCCCC	50.90	27452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMED7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMED7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMED7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMPS3_HUMAN	TMPRSS3	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.